HUP0500463A2 - Pyridine derivatives of dialkyl-oxindoles - Google Patents
Pyridine derivatives of dialkyl-oxindolesInfo
- Publication number
- HUP0500463A2 HUP0500463A2 HU0500463A HUP0500463A HUP0500463A2 HU P0500463 A2 HUP0500463 A2 HU P0500463A2 HU 0500463 A HU0500463 A HU 0500463A HU P0500463 A HUP0500463 A HU P0500463A HU P0500463 A2 HUP0500463 A2 HU P0500463A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- gen
- halogen
- derivatives
- halo
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- -1 3,3-disubstituted indol-2-one Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003561 anti-manic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 230000001966 cerebroprotective effect Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Abstract
Pyridine containing 3,3-disubstituted indol-2-one derivatives (I) or their salts are new. Pyridine containing 3,3-disubstituted indol-2-one derivatives (I) or their salts are new. R 1 and R 2H, halo, 1-7C alkyl or sulfamoyl; R 3H or straight or branched 1-7C alkyl; R 41-7C alkyl; R 5H; R 6phenyl (optionally mono to tri substituted by halo) or 1-7C alkyl (mono to tri substituted by halogen); R 5+R 6tetrahydropyridine ring, phenyl or 5 or 6 membered heterocyclic ring containing sulfur and optionally substituted by halogen); and m : 1 - 6. Independent claims are included for the following: (1) preparation of (I); (2) compound of formula (II); and (3) preparation of (II). L : hydroxy, alkyl, arylsulfonyloxy or halogen such as chlorine or bromine. [Image] [Image] ACTIVITY : CNS Gen.; Tranquilizer; Neuroleptic; Neuroprotective; Antidepressant; Antimanic; Nootropic; Gastrointestinal Gen.; Cardiovascular Gen.; Endocrine Gen.; Cerebroprotective; Vasotropic. MECHANISM OF ACTION : None given.
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0500463A HUP0500463A3 (en) | 2005-05-05 | 2005-05-05 | Pyridine derivatives of dialkyl-oxindoles |
AU2005240844A AU2005240844A1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
CZ20060772A CZ2006772A3 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives intended for treating central nervous system disorders and disorders of gastrointestinal and cardiovascular systems |
SI200530178T SI1751138T1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
KR1020067025313A KR20070014189A (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
CA002566426A CA2566426A1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
DE602005004024T DE602005004024T2 (en) | 2004-05-11 | 2005-05-11 | INDOL-2 ON DERIVATIVES FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, DISORDERS OF THE STOMACH DARM TRAKTS AND CARDIAC DISORDER |
US11/596,471 US20070232662A1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders |
EP05745439A EP1751138B9 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
PT05745439T PT1751138E (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
PCT/HU2005/000051 WO2005108390A1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
SK5106-2006A SK51062006A3 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
EA200602082A EA010865B1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
PL381614A PL381614A1 (en) | 2004-05-11 | 2005-05-11 | Indoline 2 derivatives for treating central nervous system diseases, digestive system diseases and cardiovascular system diseases |
JP2007512358A JP2007537228A (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of diseases of the central nervous system, gastrointestinal system and circulatory system |
MXPA06013065A MXPA06013065A (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders. |
AT05745439T ATE382045T1 (en) | 2004-05-11 | 2005-05-11 | INDOL-2 ONES DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES, GASTROINTESTINAL DISEASES AND CARDIOVASCULAR DISEASES |
PL05745439T PL1751138T3 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
ES05745439T ES2299033T3 (en) | 2004-05-11 | 2005-05-11 | DERIVATIVES OF INDOL-2-ONA FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEMS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS. |
RSP-2006/0622A RS20060622A (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
IL179030A IL179030A0 (en) | 2004-05-11 | 2006-11-02 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
HR20060403A HRP20060403A2 (en) | 2004-05-11 | 2006-11-20 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
NO20065661A NO20065661L (en) | 2004-05-11 | 2006-12-06 | Indol-2-Derivatives for the Treatment of Central Nervous, Gastrointestinal and Cardiovascular Disorders |
BG109770A BG109770A (en) | 2004-05-11 | 2006-12-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
HR20080129T HRP20080129T3 (en) | 2004-05-11 | 2008-03-20 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
US12/500,335 US20090281137A1 (en) | 2004-05-11 | 2009-07-09 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0500463A HUP0500463A3 (en) | 2005-05-05 | 2005-05-05 | Pyridine derivatives of dialkyl-oxindoles |
Publications (3)
Publication Number | Publication Date |
---|---|
HU0500463D0 HU0500463D0 (en) | 2005-07-28 |
HUP0500463A2 true HUP0500463A2 (en) | 2007-12-28 |
HUP0500463A3 HUP0500463A3 (en) | 2009-04-28 |
Family
ID=89985997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500463A HUP0500463A3 (en) | 2004-05-11 | 2005-05-05 | Pyridine derivatives of dialkyl-oxindoles |
Country Status (1)
Country | Link |
---|---|
HU (1) | HUP0500463A3 (en) |
-
2005
- 2005-05-05 HU HU0500463A patent/HUP0500463A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0500463A3 (en) | 2009-04-28 |
HU0500463D0 (en) | 2005-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |