HUP0500463A2 - Pyridine derivatives of dialkyl-oxindoles - Google Patents

Pyridine derivatives of dialkyl-oxindoles

Info

Publication number
HUP0500463A2
HUP0500463A2 HU0500463A HUP0500463A HUP0500463A2 HU P0500463 A2 HUP0500463 A2 HU P0500463A2 HU 0500463 A HU0500463 A HU 0500463A HU P0500463 A HUP0500463 A HU P0500463A HU P0500463 A2 HUP0500463 A2 HU P0500463A2
Authority
HU
Hungary
Prior art keywords
alkyl
gen
halogen
derivatives
halo
Prior art date
Application number
HU0500463A
Other languages
Hungarian (hu)
Inventor
Balazs Volk
Jozsef Dr Barkoczy
Gyula Dr Simig
Tibor Dr Mezei
Dezsoefi Rita Kapillerne
Istvan Gacsalyi
Katalin Pallagi
Gabor Gigler
Gyoergy Dr Levay
Krisztina Moricz
Csilla Leveleki
Nora Sziray
Gabor Dr Szenasi
Andras Dr Egyed
Laszlo Gabor Dr Harsing
Original Assignee
Egis Gyogyszergyar Nyilvanosan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan filed Critical Egis Gyogyszergyar Nyilvanosan
Priority to HU0500463A priority Critical patent/HUP0500463A3/en
Priority to PL381614A priority patent/PL381614A1/en
Priority to PCT/HU2005/000051 priority patent/WO2005108390A1/en
Priority to SI200530178T priority patent/SI1751138T1/en
Priority to KR1020067025313A priority patent/KR20070014189A/en
Priority to CA002566426A priority patent/CA2566426A1/en
Priority to DE602005004024T priority patent/DE602005004024T2/en
Priority to US11/596,471 priority patent/US20070232662A1/en
Priority to EP05745439A priority patent/EP1751138B9/en
Priority to PT05745439T priority patent/PT1751138E/en
Priority to JP2007512358A priority patent/JP2007537228A/en
Priority to SK5106-2006A priority patent/SK51062006A3/en
Priority to EA200602082A priority patent/EA010865B1/en
Priority to AU2005240844A priority patent/AU2005240844A1/en
Priority to CZ20060772A priority patent/CZ2006772A3/en
Priority to RSP-2006/0622A priority patent/RS20060622A/en
Priority to AT05745439T priority patent/ATE382045T1/en
Priority to PL05745439T priority patent/PL1751138T3/en
Priority to ES05745439T priority patent/ES2299033T3/en
Priority to MXPA06013065A priority patent/MXPA06013065A/en
Publication of HU0500463D0 publication Critical patent/HU0500463D0/en
Priority to IL179030A priority patent/IL179030A0/en
Priority to HR20060403A priority patent/HRP20060403A2/en
Priority to NO20065661A priority patent/NO20065661L/en
Priority to BG109770A priority patent/BG109770A/en
Publication of HUP0500463A2 publication Critical patent/HUP0500463A2/en
Priority to HR20080129T priority patent/HRP20080129T3/en
Publication of HUP0500463A3 publication Critical patent/HUP0500463A3/en
Priority to US12/500,335 priority patent/US20090281137A1/en

Links

Abstract

Pyridine containing 3,3-disubstituted indol-2-one derivatives (I) or their salts are new. Pyridine containing 3,3-disubstituted indol-2-one derivatives (I) or their salts are new. R 1 and R 2H, halo, 1-7C alkyl or sulfamoyl; R 3H or straight or branched 1-7C alkyl; R 41-7C alkyl; R 5H; R 6phenyl (optionally mono to tri substituted by halo) or 1-7C alkyl (mono to tri substituted by halogen); R 5+R 6tetrahydropyridine ring, phenyl or 5 or 6 membered heterocyclic ring containing sulfur and optionally substituted by halogen); and m : 1 - 6. Independent claims are included for the following: (1) preparation of (I); (2) compound of formula (II); and (3) preparation of (II). L : hydroxy, alkyl, arylsulfonyloxy or halogen such as chlorine or bromine. [Image] [Image] ACTIVITY : CNS Gen.; Tranquilizer; Neuroleptic; Neuroprotective; Antidepressant; Antimanic; Nootropic; Gastrointestinal Gen.; Cardiovascular Gen.; Endocrine Gen.; Cerebroprotective; Vasotropic. MECHANISM OF ACTION : None given.
HU0500463A 2004-05-11 2005-05-05 Pyridine derivatives of dialkyl-oxindoles HUP0500463A3 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
HU0500463A HUP0500463A3 (en) 2005-05-05 2005-05-05 Pyridine derivatives of dialkyl-oxindoles
AU2005240844A AU2005240844A1 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
CZ20060772A CZ2006772A3 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives intended for treating central nervous system disorders and disorders of gastrointestinal and cardiovascular systems
SI200530178T SI1751138T1 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
KR1020067025313A KR20070014189A (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
CA002566426A CA2566426A1 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
DE602005004024T DE602005004024T2 (en) 2004-05-11 2005-05-11 INDOL-2 ON DERIVATIVES FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, DISORDERS OF THE STOMACH DARM TRAKTS AND CARDIAC DISORDER
US11/596,471 US20070232662A1 (en) 2004-05-11 2005-05-11 Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders
EP05745439A EP1751138B9 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
PT05745439T PT1751138E (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
PCT/HU2005/000051 WO2005108390A1 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
SK5106-2006A SK51062006A3 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
EA200602082A EA010865B1 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
PL381614A PL381614A1 (en) 2004-05-11 2005-05-11 Indoline 2 derivatives for treating central nervous system diseases, digestive system diseases and cardiovascular system diseases
JP2007512358A JP2007537228A (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of diseases of the central nervous system, gastrointestinal system and circulatory system
MXPA06013065A MXPA06013065A (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders.
AT05745439T ATE382045T1 (en) 2004-05-11 2005-05-11 INDOL-2 ONES DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES, GASTROINTESTINAL DISEASES AND CARDIOVASCULAR DISEASES
PL05745439T PL1751138T3 (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
ES05745439T ES2299033T3 (en) 2004-05-11 2005-05-11 DERIVATIVES OF INDOL-2-ONA FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEMS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS.
RSP-2006/0622A RS20060622A (en) 2004-05-11 2005-05-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
IL179030A IL179030A0 (en) 2004-05-11 2006-11-02 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
HR20060403A HRP20060403A2 (en) 2004-05-11 2006-11-20 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
NO20065661A NO20065661L (en) 2004-05-11 2006-12-06 Indol-2-Derivatives for the Treatment of Central Nervous, Gastrointestinal and Cardiovascular Disorders
BG109770A BG109770A (en) 2004-05-11 2006-12-11 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
HR20080129T HRP20080129T3 (en) 2004-05-11 2008-03-20 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
US12/500,335 US20090281137A1 (en) 2004-05-11 2009-07-09 Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0500463A HUP0500463A3 (en) 2005-05-05 2005-05-05 Pyridine derivatives of dialkyl-oxindoles

Publications (3)

Publication Number Publication Date
HU0500463D0 HU0500463D0 (en) 2005-07-28
HUP0500463A2 true HUP0500463A2 (en) 2007-12-28
HUP0500463A3 HUP0500463A3 (en) 2009-04-28

Family

ID=89985997

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500463A HUP0500463A3 (en) 2004-05-11 2005-05-05 Pyridine derivatives of dialkyl-oxindoles

Country Status (1)

Country Link
HU (1) HUP0500463A3 (en)

Also Published As

Publication number Publication date
HUP0500463A3 (en) 2009-04-28
HU0500463D0 (en) 2005-07-28

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished