HUP0302688A2 - Processes for preparing cilostazol - Google Patents

Processes for preparing cilostazol

Info

Publication number
HUP0302688A2
HUP0302688A2 HU0302688A HUP0302688A HUP0302688A2 HU P0302688 A2 HUP0302688 A2 HU P0302688A2 HU 0302688 A HU0302688 A HU 0302688A HU P0302688 A HUP0302688 A HU P0302688A HU P0302688 A2 HUP0302688 A2 HU P0302688A2
Authority
HU
Hungary
Prior art keywords
processes
cilostazol
preparing cilostazol
preparing
acilostazol
Prior art date
Application number
HU0302688A
Other languages
Hungarian (hu)
Inventor
Nina Finkelstein
Marioara Mendelovichi
Gideon Pilarksi
Original Assignee
Teva Pharmaceutical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries, Ltd. filed Critical Teva Pharmaceutical Industries, Ltd.
Publication of HUP0302688A2 publication Critical patent/HUP0302688A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Jelen találmány az (I) képlet szerinti 6-[4-(1-ciklohexil-1H-tetrazol-5-il)butoxi]-3,4-dihidro2(1H)-kinolinon előállítási eljárásairavonatkozik, amely a cilostazol generikus név alatt is ismert. Acilostazol a vérlemezek aggregációját gátolja, és a claudicatiointermittens betegek kezelésére használják. ÓThe present invention relates to processes for the production of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro2(1H)-quinolinone according to the formula (I), which is also known under the generic name cilostazol . Acilostazol inhibits platelet aggregation and is used to treat patients with intermittent claudication. HE

HU0302688A 2000-08-14 2001-08-14 Processes for preparing cilostazol HUP0302688A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22536200P 2000-08-14 2000-08-14
PCT/US2001/025398 WO2002014283A1 (en) 2000-08-14 2001-08-14 Processes for preparing cilostazol

Publications (1)

Publication Number Publication Date
HUP0302688A2 true HUP0302688A2 (en) 2003-12-29

Family

ID=22844569

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302688A HUP0302688A2 (en) 2000-08-14 2001-08-14 Processes for preparing cilostazol

Country Status (17)

Country Link
EP (1) EP1311485A4 (en)
JP (2) JP3845059B2 (en)
KR (1) KR20030024865A (en)
CN (1) CN1469864A (en)
AU (1) AU2001284887A1 (en)
CA (1) CA2419181A1 (en)
CZ (1) CZ2003667A3 (en)
HK (1) HK1053116A1 (en)
HU (1) HUP0302688A2 (en)
IL (1) IL154458A0 (en)
IS (1) IS6716A (en)
MX (1) MXPA03001470A (en)
NO (1) NO20030699L (en)
NZ (1) NZ524363A (en)
PL (1) PL365672A1 (en)
SK (1) SK2992003A3 (en)
WO (1) WO2002014283A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045547A1 (en) 2001-05-02 2003-03-06 Shinji Aki Process for producing carbostyril derivatives
US7399864B2 (en) 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US20050101631A1 (en) 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
CN1257902C (en) 2002-09-10 2006-05-31 大塚制药株式会社 Method for producing cilostazol
CN1914176A (en) 2004-02-05 2007-02-14 特瓦制药工业有限公司 Process for preparing aripiprazole
KR100633232B1 (en) * 2004-08-25 2006-10-11 주식회사유한양행 A novel method for purification of 6-[4-1-cyclohexyl-1h-tetrazol-5-ylbutoxy-3,4-dihydro-21h-quinolinone having high purity
US20070270590A1 (en) * 2006-04-20 2007-11-22 Marioara Mendelovici Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
TW200848041A (en) 2007-03-30 2008-12-16 Otsuka Pharma Co Ltd A medicament for treating schizophrenia comprising cilostazol
ES2401914T3 (en) 2007-04-25 2013-04-25 Concert Pharmaceuticals Inc. Cilostazol analogues
CN101434598B (en) * 2008-12-19 2012-11-07 重庆康乐制药有限公司 Preparation of cilostazol
CN102086190B (en) * 2011-01-28 2013-07-10 海南美兰史克制药有限公司 Cilostazol compound and novel preparation method thereof
CN107382970A (en) * 2017-07-26 2017-11-24 浙江金立源药业有限公司 A kind of synthetic method of Cilostazol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPH01265051A (en) * 1988-04-14 1989-10-23 Fuji Photo Film Co Ltd Production of diaryloxyalkane

Also Published As

Publication number Publication date
HK1053116A1 (en) 2003-10-10
CN1469864A (en) 2004-01-21
NO20030699D0 (en) 2003-02-13
AU2001284887A1 (en) 2002-02-25
CA2419181A1 (en) 2002-02-21
KR20030024865A (en) 2003-03-26
EP1311485A1 (en) 2003-05-21
JP3845059B2 (en) 2006-11-15
JP2004506043A (en) 2004-02-26
IS6716A (en) 2003-02-13
IL154458A0 (en) 2003-09-17
MXPA03001470A (en) 2005-06-30
JP2005350474A (en) 2005-12-22
EP1311485A4 (en) 2004-05-12
NZ524363A (en) 2004-03-26
WO2002014283A1 (en) 2002-02-21
SK2992003A3 (en) 2003-10-07
NO20030699L (en) 2003-04-10
CZ2003667A3 (en) 2003-08-13
PL365672A1 (en) 2005-01-10

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