HUP0300963A2 - Polymeric micelle compositions - Google Patents

Polymeric micelle compositions

Info

Publication number
HUP0300963A2
HUP0300963A2 HU0300963A HUP0300963A HUP0300963A2 HU P0300963 A2 HUP0300963 A2 HU P0300963A2 HU 0300963 A HU0300963 A HU 0300963A HU P0300963 A HUP0300963 A HU P0300963A HU P0300963 A2 HUP0300963 A2 HU P0300963A2
Authority
HU
Hungary
Prior art keywords
polymeric micelle
micelle compositions
preparations
delivery
pyrrolidone
Prior art date
Application number
HU0300963A
Other languages
Hungarian (hu)
Inventor
Amina Souad Benahmed
Jean-Christophe Leroux
Original Assignee
Labopharm, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm, Inc. filed Critical Labopharm, Inc.
Publication of HUP0300963A2 publication Critical patent/HUP0300963A2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány tárgyát polimer micellákat tartalmazó készítményekképezik. A készítményeket az jellemezi, hogy egy hidrofil héjjalkörülvett, poli(N-vinil-2-pirrolidon)-ból álló hidrofób magottartalmaznak. A találmány szerinti készítmények terápiás ágensek,például rákellenes gyógyszerek szállítására, illetve célbajuttatásárahasználhatók. ÓThe subject of the invention is preparations containing polymer micelles. The preparations are characterized by the fact that they contain a hydrophobic core consisting of poly(N-vinyl-2-pyrrolidone) surrounded by a hydrophilic shell. The preparations according to the invention can be used for the delivery and targeted delivery of therapeutic agents, such as anti-cancer drugs. HE

HU0300963A 2000-06-29 2001-06-28 Polymeric micelle compositions HUP0300963A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,398 US6338859B1 (en) 2000-06-29 2000-06-29 Polymeric micelle compositions
PCT/CA2001/000963 WO2002000194A2 (en) 2000-06-29 2001-06-28 Polymeric micelle compositions

Publications (1)

Publication Number Publication Date
HUP0300963A2 true HUP0300963A2 (en) 2003-09-29

Family

ID=24427804

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300963A HUP0300963A2 (en) 2000-06-29 2001-06-28 Polymeric micelle compositions

Country Status (23)

Country Link
US (1) US6338859B1 (en)
EP (1) EP1296647B1 (en)
JP (1) JP5134179B2 (en)
KR (1) KR20030039332A (en)
CN (1) CN1258358C (en)
AT (1) ATE336229T1 (en)
AU (2) AU2001270405B2 (en)
BR (1) BR0112054A (en)
CA (1) CA2414241C (en)
CZ (1) CZ302369B6 (en)
DE (1) DE60122335T2 (en)
DK (1) DK1296647T3 (en)
ES (1) ES2271039T3 (en)
HK (1) HK1059395A1 (en)
HU (1) HUP0300963A2 (en)
IL (2) IL153655A0 (en)
MX (1) MXPA03000065A (en)
NO (1) NO20026255L (en)
NZ (1) NZ523645A (en)
PL (1) PL202475B1 (en)
PT (1) PT1296647E (en)
RU (1) RU2308943C2 (en)
WO (1) WO2002000194A2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
US7282215B2 (en) 2000-05-08 2007-10-16 The University Of British Columbia Supports for photosensitizer formulations
HUP0303719A2 (en) * 2000-10-16 2004-03-01 Neopharm, Inc. Liposomal pharmaceutical composition of mitoxantrone and process for their preparation
CA2428784A1 (en) * 2000-11-09 2002-05-16 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
KR100481540B1 (en) * 2002-02-26 2005-04-07 한국전자통신연구원 Manufacturing Method of Smart Nano Particles including Medicines
JP2005524657A (en) * 2002-02-27 2005-08-18 ファーメイン, エルティーディー. Compositions for delivering therapeutic agents and other substances, and methods of making and using said compositions
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
WO2003082303A1 (en) * 2002-03-29 2003-10-09 Wisconsin Alumni Research Foundation Polymeric micelle formulations of hydrophobic compounds and methods
EP1393718A1 (en) * 2002-08-29 2004-03-03 OctoPlus Sciences B.V. Colloidal drug carrier system
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
KR101424980B1 (en) * 2002-10-29 2014-08-01 인스메드 인코포레이티드 Sustained release of antiinfectives
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
WO2004045641A2 (en) * 2002-11-20 2004-06-03 Crucell Holland B.V. Antigen-complexes
US7491395B2 (en) 2002-11-20 2009-02-17 Bestewil Holding B.V. Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination
WO2004098569A1 (en) * 2003-04-18 2004-11-18 Northeastern University Micelle delivery system loaded with a pharmaceutical agent
US7262253B2 (en) * 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
CN100386115C (en) * 2004-10-14 2008-05-07 孔庆忠 Anti-cancer medicine composition
EP1827395A2 (en) 2004-11-02 2007-09-05 Tel-Aviv University Future Technology Development L.P. Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles, their manufacturing and their use for diagnostics and therapy
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
EP1909771A1 (en) * 2005-08-02 2008-04-16 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
ES2594368T3 (en) 2005-12-08 2016-12-19 Insmed Incorporated Lipid-based compositions of anti-infectives to treat lung infections
KR101872061B1 (en) 2005-12-19 2018-06-27 파마인 코포레이션 Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CA2634830A1 (en) * 2005-12-27 2007-07-05 Labopharm Inc. Degradable polymeric microsphere composition
EP2011516A4 (en) * 2006-04-24 2010-06-23 Nanocarrier Co Ltd Method of producing polymer micelle having low molecular chemical encapsulated therein
CN100434120C (en) * 2006-09-14 2008-11-19 同济大学 Amphipathic fluorescence target nano micelle and its preparation method
KR20090080046A (en) * 2006-09-22 2009-07-23 라보팜 인코포레이트 Compositions and methods for ph targeted drug delivery
MX2009003680A (en) * 2006-10-05 2009-07-17 Univ Johns Hopkins Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles.
US7758635B2 (en) * 2007-02-13 2010-07-20 Boston Scientific Scimed, Inc. Medical device including cylindrical micelles
US20100196455A1 (en) * 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
WO2009064442A1 (en) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US8524784B2 (en) * 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
EP2424359A4 (en) 2009-04-30 2014-01-15 Intezyne Technologies Inc Polymer micelles containing anthracylines for the treatment of cancer
WO2011119262A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
EP2563349A4 (en) * 2010-04-23 2014-03-19 Paladin Labs Inc Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof
WO2012030822A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Process for reducing moisture in a biodegradable implant device
CN101953804A (en) * 2010-09-26 2011-01-26 苏州同科生物材料有限公司 Shell layer dropping type nanometer medicine carrier preparation based on amphiphilic block copolymer and preparation method thereof
US8546521B2 (en) 2011-01-28 2013-10-01 Cerulean Pharma Inc. Method for fabricating nanoparticles
CN102793678B (en) * 2011-05-26 2017-06-30 邓世明 A kind of preparation method of the Docetaxel injection without tween
CN103857702B (en) * 2011-10-03 2018-01-26 南洋理工大学 Cationic peptide polysaccharide with excellent broad spectrum antimicrobial acivity and high selectivity
RU2480479C1 (en) * 2011-11-01 2013-04-27 Елена Викторовна Свирщевская Heterologous peptide mini-antigene in polymer particle for making anti-allergy vaccine
WO2013120055A1 (en) * 2012-02-10 2013-08-15 E. I. Du Pont De Nemours And Company Preparation, purification and use of high-x diblock copolymers
RU2501570C1 (en) * 2012-05-11 2013-12-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Trifunctional ethylene oxide and propylene oxide block copolymers for active substance delivery to living cells
HRP20220158T1 (en) 2012-05-21 2022-04-15 Insmed Incorporated Systems for treating pulmonary infections
CN104884047A (en) 2012-11-29 2015-09-02 英斯梅德股份有限公司 Stabilized vancomycin formulations
CN104434876B (en) * 2013-09-13 2018-04-27 布里吉·P·吉里 For cancer therapy and the anoxic of imaging-target polymerization micella
CA2949078C (en) 2014-05-15 2022-09-20 Insmed Incorporated Methods for treating pulmonary non-tuberculous mycobacterial infections
KR102088663B1 (en) * 2018-03-20 2020-03-13 한국세라믹기술원 Thermosponge nanoparticle platform for co-delivery of hydrophilic and hydrophobic drugs and its use
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
CN111592663B (en) * 2020-03-27 2022-09-16 青岛大学 Preparation method and application of crown ether modified block copolymer micelle
CN114246831B (en) * 2020-09-22 2024-10-15 鲁南制药集团股份有限公司 Polymer micelle freeze-dried preparation of taxane antitumor drug for injection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
JP2517760B2 (en) * 1989-05-11 1996-07-24 新技術事業団 Water-soluble polymerized pharmaceutical preparation
US5484778C1 (en) * 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
KR0180334B1 (en) * 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
ES2185801T3 (en) * 1995-09-29 2003-05-01 Japan Science & Tech Corp NEW DERIVATIVES OF ANTHRACICLINE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
JP3523821B2 (en) * 2000-02-09 2004-04-26 ナノキャリア株式会社 Method for producing polymer micelle in which drug is encapsulated and polymer micelle composition
EP1286643A2 (en) * 2000-05-17 2003-03-05 Labopharm Inc. Drug containing polymeric micelles

Also Published As

Publication number Publication date
MXPA03000065A (en) 2004-04-02
RU2308943C2 (en) 2007-10-27
CA2414241C (en) 2011-04-12
DE60122335T2 (en) 2007-08-30
NZ523645A (en) 2004-09-24
CZ302369B6 (en) 2011-04-13
PT1296647E (en) 2006-12-29
WO2002000194A3 (en) 2002-08-08
EP1296647A2 (en) 2003-04-02
JP5134179B2 (en) 2013-01-30
JP2004501180A (en) 2004-01-15
WO2002000194A2 (en) 2002-01-03
CZ20024268A3 (en) 2003-05-14
AU7040501A (en) 2002-01-08
CN1447683A (en) 2003-10-08
ATE336229T1 (en) 2006-09-15
EP1296647B1 (en) 2006-08-16
AU2001270405B2 (en) 2005-01-20
ES2271039T3 (en) 2007-04-16
DK1296647T3 (en) 2006-12-27
DE60122335D1 (en) 2006-09-28
PL202475B1 (en) 2009-06-30
NO20026255D0 (en) 2002-12-27
CN1258358C (en) 2006-06-07
KR20030039332A (en) 2003-05-17
NO20026255L (en) 2003-02-25
BR0112054A (en) 2003-09-30
HK1059395A1 (en) 2004-07-02
PL360262A1 (en) 2004-09-06
US6338859B1 (en) 2002-01-15
IL153655A (en) 2008-11-26
IL153655A0 (en) 2003-07-06
CA2414241A1 (en) 2002-01-03

Similar Documents

Publication Publication Date Title
HUP0300963A2 (en) Polymeric micelle compositions
DE60220519D1 (en) MICELLAR DRUG DISPERSION SYSTEM FOR HYDROPHOBIC DRUGS
TNSN99252A1 (en) NOVEL MODULATORS OF CHIMIOKINE CCR5 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU2001295017A1 (en) Solid dose nanoparticulate compositions
EP1183538A4 (en) Cyclodextrin polymers for use as drug carriers
BRPI0414017A8 (en) multi-arm polymer prodrugs
HK1054918A1 (en) Compounds and compositions for delivering active agents
BR0212475A (en) Pharmaceutical Compositions
CY1105953T1 (en) COMPOSITIONS FOR RELEASE OF DRUG COMBINATIONS
BRPI0411872A (en) pharmaceutical composition
HUP0201042A2 (en) Antibiotic/antibiotica-polymer combinations
ATE324907T1 (en) COMPOUND AND MEDICINAL COMPOSITION FOR ADMINISTRATION OF ACTIVE INGREDIENTS
TR200400295T2 (en) Lung delivery of chemically modified insulin
DE60044459D1 (en) ORGANIC SOLVENTS SOLUBLE BIODEGRADABLE POLY (ALKYLENE OXIDE) - POLY (p-DIOXANONE) BLOCK COPOLYMERS AND THE COMPOSITION FOR THE ADMINISTRATIVE ADMINISTRATION CONTAINING THEM
DK0839026T3 (en) Micellar polyether block copolymer compositions for targeting biological agents
MXPA04000354A (en) Amphiphilic star-like macromolecules for drug delivery.
EP2308479A3 (en) Compounds and compositions for delivering active agents
BR9812316A (en) Formulations of liposomal camptothecin
WO2002015959A3 (en) Compounds and compositions for delivering active agents
TW200509998A (en) Controlled release of highly soluble agents
HK1098352A1 (en) Pharmaceutical composition comprising a zinc-hyaluronate complex for the treatment of multiple sclerosis
DE60225844D1 (en) MICELLE COMPOSITIONS CONTAIN PEGYLATED PHOSPHOLIPIDES AND A PHOTOSENSIBILIZER
WO2004018010A3 (en) Methods of drug delivery using sulphated chitinous polymers
WO2004087105A8 (en) Combination formulations of platinum agents and fluoropyrimidines
SE0004780D0 (en) Novel compunds