HUP0300963A2 - Polymeric micelle compositions - Google Patents
Polymeric micelle compositionsInfo
- Publication number
- HUP0300963A2 HUP0300963A2 HU0300963A HUP0300963A HUP0300963A2 HU P0300963 A2 HUP0300963 A2 HU P0300963A2 HU 0300963 A HU0300963 A HU 0300963A HU P0300963 A HUP0300963 A HU P0300963A HU P0300963 A2 HUP0300963 A2 HU P0300963A2
- Authority
- HU
- Hungary
- Prior art keywords
- polymeric micelle
- micelle compositions
- preparations
- delivery
- pyrrolidone
- Prior art date
Links
- 239000000693 micelle Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 3
- -1 poly(N-vinyl-2-pyrrolidone) Polymers 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgyát polimer micellákat tartalmazó készítményekképezik. A készítményeket az jellemezi, hogy egy hidrofil héjjalkörülvett, poli(N-vinil-2-pirrolidon)-ból álló hidrofób magottartalmaznak. A találmány szerinti készítmények terápiás ágensek,például rákellenes gyógyszerek szállítására, illetve célbajuttatásárahasználhatók. ÓThe subject of the invention is preparations containing polymer micelles. The preparations are characterized by the fact that they contain a hydrophobic core consisting of poly(N-vinyl-2-pyrrolidone) surrounded by a hydrophilic shell. The preparations according to the invention can be used for the delivery and targeted delivery of therapeutic agents, such as anti-cancer drugs. HE
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/606,398 US6338859B1 (en) | 2000-06-29 | 2000-06-29 | Polymeric micelle compositions |
PCT/CA2001/000963 WO2002000194A2 (en) | 2000-06-29 | 2001-06-28 | Polymeric micelle compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0300963A2 true HUP0300963A2 (en) | 2003-09-29 |
Family
ID=24427804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300963A HUP0300963A2 (en) | 2000-06-29 | 2001-06-28 | Polymeric micelle compositions |
Country Status (23)
Country | Link |
---|---|
US (1) | US6338859B1 (en) |
EP (1) | EP1296647B1 (en) |
JP (1) | JP5134179B2 (en) |
KR (1) | KR20030039332A (en) |
CN (1) | CN1258358C (en) |
AT (1) | ATE336229T1 (en) |
AU (2) | AU2001270405B2 (en) |
BR (1) | BR0112054A (en) |
CA (1) | CA2414241C (en) |
CZ (1) | CZ302369B6 (en) |
DE (1) | DE60122335T2 (en) |
DK (1) | DK1296647T3 (en) |
ES (1) | ES2271039T3 (en) |
HK (1) | HK1059395A1 (en) |
HU (1) | HUP0300963A2 (en) |
IL (2) | IL153655A0 (en) |
MX (1) | MXPA03000065A (en) |
NO (1) | NO20026255L (en) |
NZ (1) | NZ523645A (en) |
PL (1) | PL202475B1 (en) |
PT (1) | PT1296647E (en) |
RU (1) | RU2308943C2 (en) |
WO (1) | WO2002000194A2 (en) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
US7282215B2 (en) | 2000-05-08 | 2007-10-16 | The University Of British Columbia | Supports for photosensitizer formulations |
HUP0303719A2 (en) * | 2000-10-16 | 2004-03-01 | Neopharm, Inc. | Liposomal pharmaceutical composition of mitoxantrone and process for their preparation |
CA2428784A1 (en) * | 2000-11-09 | 2002-05-16 | Astrazeneca Ab | Oral pharmaceutical composition containing a block copolymer |
US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
CA2451187C (en) | 2001-06-22 | 2012-08-14 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
KR100481540B1 (en) * | 2002-02-26 | 2005-04-07 | 한국전자통신연구원 | Manufacturing Method of Smart Nano Particles including Medicines |
JP2005524657A (en) * | 2002-02-27 | 2005-08-18 | ファーメイン, エルティーディー. | Compositions for delivering therapeutic agents and other substances, and methods of making and using said compositions |
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
US7018655B2 (en) * | 2002-03-18 | 2006-03-28 | Labopharm, Inc. | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions |
US6780324B2 (en) * | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
WO2003082303A1 (en) * | 2002-03-29 | 2003-10-09 | Wisconsin Alumni Research Foundation | Polymeric micelle formulations of hydrophobic compounds and methods |
EP1393718A1 (en) * | 2002-08-29 | 2004-03-03 | OctoPlus Sciences B.V. | Colloidal drug carrier system |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
KR101424980B1 (en) * | 2002-10-29 | 2014-08-01 | 인스메드 인코포레이티드 | Sustained release of antiinfectives |
KR100508518B1 (en) * | 2002-11-13 | 2005-08-17 | 한미약품 주식회사 | Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby |
WO2004045641A2 (en) * | 2002-11-20 | 2004-06-03 | Crucell Holland B.V. | Antigen-complexes |
US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
WO2004098569A1 (en) * | 2003-04-18 | 2004-11-18 | Northeastern University | Micelle delivery system loaded with a pharmaceutical agent |
US7262253B2 (en) * | 2003-12-02 | 2007-08-28 | Labopharm, Inc. | Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers |
CN100386115C (en) * | 2004-10-14 | 2008-05-07 | 孔庆忠 | Anti-cancer medicine composition |
EP1827395A2 (en) | 2004-11-02 | 2007-09-05 | Tel-Aviv University Future Technology Development L.P. | Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles, their manufacturing and their use for diagnostics and therapy |
US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
EP1909771A1 (en) * | 2005-08-02 | 2008-04-16 | Miv Therapeutics Inc. | Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same |
US8882747B2 (en) * | 2005-11-09 | 2014-11-11 | The Invention Science Fund I, Llc | Substance delivery system |
ES2594368T3 (en) | 2005-12-08 | 2016-12-19 | Insmed Incorporated | Lipid-based compositions of anti-infectives to treat lung infections |
KR101872061B1 (en) | 2005-12-19 | 2018-06-27 | 파마인 코포레이션 | Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same |
CA2634830A1 (en) * | 2005-12-27 | 2007-07-05 | Labopharm Inc. | Degradable polymeric microsphere composition |
EP2011516A4 (en) * | 2006-04-24 | 2010-06-23 | Nanocarrier Co Ltd | Method of producing polymer micelle having low molecular chemical encapsulated therein |
CN100434120C (en) * | 2006-09-14 | 2008-11-19 | 同济大学 | Amphipathic fluorescence target nano micelle and its preparation method |
KR20090080046A (en) * | 2006-09-22 | 2009-07-23 | 라보팜 인코포레이트 | Compositions and methods for ph targeted drug delivery |
MX2009003680A (en) * | 2006-10-05 | 2009-07-17 | Univ Johns Hopkins | Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles. |
US7758635B2 (en) * | 2007-02-13 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical device including cylindrical micelles |
US20100196455A1 (en) * | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
WO2009064442A1 (en) * | 2007-11-13 | 2009-05-22 | Brookwood Pharmaceuticals, Inc. | Viscous terpolymers as drug delivery platform |
US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
US20100168807A1 (en) * | 2008-12-23 | 2010-07-01 | Burton Kevin W | Bioactive terpolymer compositions and methods of making and using same |
US9415197B2 (en) * | 2008-12-23 | 2016-08-16 | Surmodics, Inc. | Implantable suction cup composites and implants comprising same |
US9480643B2 (en) | 2008-12-23 | 2016-11-01 | Surmodics Pharmaceuticals, Inc. | Implantable composites and implants comprising same |
US8974808B2 (en) | 2008-12-23 | 2015-03-10 | Surmodics, Inc. | Elastic implantable composites and implants comprising same |
US8951546B2 (en) * | 2008-12-23 | 2015-02-10 | Surmodics Pharmaceuticals, Inc. | Flexible implantable composites and implants comprising same |
US8524784B2 (en) * | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
EP2424359A4 (en) | 2009-04-30 | 2014-01-15 | Intezyne Technologies Inc | Polymer micelles containing anthracylines for the treatment of cancer |
WO2011119262A1 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
EP2563349A4 (en) * | 2010-04-23 | 2014-03-19 | Paladin Labs Inc | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
WO2012030822A1 (en) | 2010-08-30 | 2012-03-08 | Surmodics Pharmaceuticals, Inc. | Process for reducing moisture in a biodegradable implant device |
CN101953804A (en) * | 2010-09-26 | 2011-01-26 | 苏州同科生物材料有限公司 | Shell layer dropping type nanometer medicine carrier preparation based on amphiphilic block copolymer and preparation method thereof |
US8546521B2 (en) | 2011-01-28 | 2013-10-01 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
CN102793678B (en) * | 2011-05-26 | 2017-06-30 | 邓世明 | A kind of preparation method of the Docetaxel injection without tween |
CN103857702B (en) * | 2011-10-03 | 2018-01-26 | 南洋理工大学 | Cationic peptide polysaccharide with excellent broad spectrum antimicrobial acivity and high selectivity |
RU2480479C1 (en) * | 2011-11-01 | 2013-04-27 | Елена Викторовна Свирщевская | Heterologous peptide mini-antigene in polymer particle for making anti-allergy vaccine |
WO2013120055A1 (en) * | 2012-02-10 | 2013-08-15 | E. I. Du Pont De Nemours And Company | Preparation, purification and use of high-x diblock copolymers |
RU2501570C1 (en) * | 2012-05-11 | 2013-12-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) | Trifunctional ethylene oxide and propylene oxide block copolymers for active substance delivery to living cells |
HRP20220158T1 (en) | 2012-05-21 | 2022-04-15 | Insmed Incorporated | Systems for treating pulmonary infections |
CN104884047A (en) | 2012-11-29 | 2015-09-02 | 英斯梅德股份有限公司 | Stabilized vancomycin formulations |
CN104434876B (en) * | 2013-09-13 | 2018-04-27 | 布里吉·P·吉里 | For cancer therapy and the anoxic of imaging-target polymerization micella |
CA2949078C (en) | 2014-05-15 | 2022-09-20 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
KR102088663B1 (en) * | 2018-03-20 | 2020-03-13 | 한국세라믹기술원 | Thermosponge nanoparticle platform for co-delivery of hydrophilic and hydrophobic drugs and its use |
EP3773505A4 (en) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
CN111592663B (en) * | 2020-03-27 | 2022-09-16 | 青岛大学 | Preparation method and application of crown ether modified block copolymer micelle |
CN114246831B (en) * | 2020-09-22 | 2024-10-15 | 鲁南制药集团股份有限公司 | Polymer micelle freeze-dried preparation of taxane antitumor drug for injection |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3378250D1 (en) * | 1982-04-22 | 1988-11-24 | Ici Plc | Continuous release formulations |
JP2517760B2 (en) * | 1989-05-11 | 1996-07-24 | 新技術事業団 | Water-soluble polymerized pharmaceutical preparation |
US5484778C1 (en) * | 1990-07-17 | 2001-05-08 | Univ Cleveland Hospitals | Phthalocynine photosensitizers for photodynamic therapy and methods for their use |
US5484612A (en) * | 1993-09-22 | 1996-01-16 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin |
KR0180334B1 (en) * | 1995-09-21 | 1999-03-20 | 김윤 | Drug messenger using el-2l-2 micelle and method for sealing drug to it |
ES2185801T3 (en) * | 1995-09-29 | 2003-05-01 | Japan Science & Tech Corp | NEW DERIVATIVES OF ANTHRACICLINE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
US5702717A (en) * | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
JP3523821B2 (en) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | Method for producing polymer micelle in which drug is encapsulated and polymer micelle composition |
EP1286643A2 (en) * | 2000-05-17 | 2003-03-05 | Labopharm Inc. | Drug containing polymeric micelles |
-
2000
- 2000-06-29 US US09/606,398 patent/US6338859B1/en not_active Expired - Lifetime
-
2001
- 2001-06-28 BR BR0112054-9A patent/BR0112054A/en not_active Application Discontinuation
- 2001-06-28 CN CNB018144446A patent/CN1258358C/en not_active Expired - Fee Related
- 2001-06-28 HU HU0300963A patent/HUP0300963A2/en unknown
- 2001-06-28 PT PT01949161T patent/PT1296647E/en unknown
- 2001-06-28 DK DK01949161T patent/DK1296647T3/en active
- 2001-06-28 PL PL360262A patent/PL202475B1/en not_active IP Right Cessation
- 2001-06-28 ES ES01949161T patent/ES2271039T3/en not_active Expired - Lifetime
- 2001-06-28 EP EP01949161A patent/EP1296647B1/en not_active Expired - Lifetime
- 2001-06-28 AT AT01949161T patent/ATE336229T1/en not_active IP Right Cessation
- 2001-06-28 WO PCT/CA2001/000963 patent/WO2002000194A2/en active IP Right Grant
- 2001-06-28 CZ CZ20024268A patent/CZ302369B6/en not_active IP Right Cessation
- 2001-06-28 AU AU2001270405A patent/AU2001270405B2/en not_active Ceased
- 2001-06-28 RU RU2003102439/15A patent/RU2308943C2/en not_active IP Right Cessation
- 2001-06-28 IL IL15365501A patent/IL153655A0/en active IP Right Grant
- 2001-06-28 CA CA2414241A patent/CA2414241C/en not_active Expired - Lifetime
- 2001-06-28 DE DE60122335T patent/DE60122335T2/en not_active Expired - Lifetime
- 2001-06-28 NZ NZ523645A patent/NZ523645A/en unknown
- 2001-06-28 MX MXPA03000065A patent/MXPA03000065A/en active IP Right Grant
- 2001-06-28 AU AU7040501A patent/AU7040501A/en active Pending
- 2001-06-28 KR KR1020027018038A patent/KR20030039332A/en not_active Application Discontinuation
- 2001-06-28 JP JP2002504976A patent/JP5134179B2/en not_active Expired - Lifetime
-
2002
- 2002-12-25 IL IL153655A patent/IL153655A/en not_active IP Right Cessation
- 2002-12-27 NO NO20026255A patent/NO20026255L/en not_active Application Discontinuation
-
2004
- 2004-03-31 HK HK04102359A patent/HK1059395A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA03000065A (en) | 2004-04-02 |
RU2308943C2 (en) | 2007-10-27 |
CA2414241C (en) | 2011-04-12 |
DE60122335T2 (en) | 2007-08-30 |
NZ523645A (en) | 2004-09-24 |
CZ302369B6 (en) | 2011-04-13 |
PT1296647E (en) | 2006-12-29 |
WO2002000194A3 (en) | 2002-08-08 |
EP1296647A2 (en) | 2003-04-02 |
JP5134179B2 (en) | 2013-01-30 |
JP2004501180A (en) | 2004-01-15 |
WO2002000194A2 (en) | 2002-01-03 |
CZ20024268A3 (en) | 2003-05-14 |
AU7040501A (en) | 2002-01-08 |
CN1447683A (en) | 2003-10-08 |
ATE336229T1 (en) | 2006-09-15 |
EP1296647B1 (en) | 2006-08-16 |
AU2001270405B2 (en) | 2005-01-20 |
ES2271039T3 (en) | 2007-04-16 |
DK1296647T3 (en) | 2006-12-27 |
DE60122335D1 (en) | 2006-09-28 |
PL202475B1 (en) | 2009-06-30 |
NO20026255D0 (en) | 2002-12-27 |
CN1258358C (en) | 2006-06-07 |
KR20030039332A (en) | 2003-05-17 |
NO20026255L (en) | 2003-02-25 |
BR0112054A (en) | 2003-09-30 |
HK1059395A1 (en) | 2004-07-02 |
PL360262A1 (en) | 2004-09-06 |
US6338859B1 (en) | 2002-01-15 |
IL153655A (en) | 2008-11-26 |
IL153655A0 (en) | 2003-07-06 |
CA2414241A1 (en) | 2002-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0300963A2 (en) | Polymeric micelle compositions | |
DE60220519D1 (en) | MICELLAR DRUG DISPERSION SYSTEM FOR HYDROPHOBIC DRUGS | |
TNSN99252A1 (en) | NOVEL MODULATORS OF CHIMIOKINE CCR5 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
AU2001295017A1 (en) | Solid dose nanoparticulate compositions | |
EP1183538A4 (en) | Cyclodextrin polymers for use as drug carriers | |
BRPI0414017A8 (en) | multi-arm polymer prodrugs | |
HK1054918A1 (en) | Compounds and compositions for delivering active agents | |
BR0212475A (en) | Pharmaceutical Compositions | |
CY1105953T1 (en) | COMPOSITIONS FOR RELEASE OF DRUG COMBINATIONS | |
BRPI0411872A (en) | pharmaceutical composition | |
HUP0201042A2 (en) | Antibiotic/antibiotica-polymer combinations | |
ATE324907T1 (en) | COMPOUND AND MEDICINAL COMPOSITION FOR ADMINISTRATION OF ACTIVE INGREDIENTS | |
TR200400295T2 (en) | Lung delivery of chemically modified insulin | |
DE60044459D1 (en) | ORGANIC SOLVENTS SOLUBLE BIODEGRADABLE POLY (ALKYLENE OXIDE) - POLY (p-DIOXANONE) BLOCK COPOLYMERS AND THE COMPOSITION FOR THE ADMINISTRATIVE ADMINISTRATION CONTAINING THEM | |
DK0839026T3 (en) | Micellar polyether block copolymer compositions for targeting biological agents | |
MXPA04000354A (en) | Amphiphilic star-like macromolecules for drug delivery. | |
EP2308479A3 (en) | Compounds and compositions for delivering active agents | |
BR9812316A (en) | Formulations of liposomal camptothecin | |
WO2002015959A3 (en) | Compounds and compositions for delivering active agents | |
TW200509998A (en) | Controlled release of highly soluble agents | |
HK1098352A1 (en) | Pharmaceutical composition comprising a zinc-hyaluronate complex for the treatment of multiple sclerosis | |
DE60225844D1 (en) | MICELLE COMPOSITIONS CONTAIN PEGYLATED PHOSPHOLIPIDES AND A PHOTOSENSIBILIZER | |
WO2004018010A3 (en) | Methods of drug delivery using sulphated chitinous polymers | |
WO2004087105A8 (en) | Combination formulations of platinum agents and fluoropyrimidines | |
SE0004780D0 (en) | Novel compunds |