HUP0300738A2 - Method for producing lhrh-peptide salts, their use, and pharmaceutical preparations containing these peptide salts - Google Patents
Method for producing lhrh-peptide salts, their use, and pharmaceutical preparations containing these peptide saltsInfo
- Publication number
- HUP0300738A2 HUP0300738A2 HU0300738A HUP0300738A HUP0300738A2 HU P0300738 A2 HUP0300738 A2 HU P0300738A2 HU 0300738 A HU0300738 A HU 0300738A HU P0300738 A HUP0300738 A HU P0300738A HU P0300738 A2 HUP0300738 A2 HU P0300738A2
- Authority
- HU
- Hungary
- Prior art keywords
- peptide salts
- peptide
- lhrh
- producing
- pharmaceutical preparations
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Preparation of a peptide acid addition salt (I) comprises: (a) reacting a starting acid addition salt (II) of a basic peptide with a mixed bed ion exchanger (or a mixture of acidic and basic ion exchangers) in presence of a diluent; (b) reacting the obtained free basic peptide with an inorganic or organic acid to give (I); and (c) removing the diluent. Independent claims are included for: (i) (I) obtained by the process (specifically in lyophilized form); (ii) a pharmaceutical preparation containing (I) obtained by the process, together with auxiliaries, carriers and/or structuring agents; and (iii) the production of a preparation as in (ii), by adding the auxiliaries, carriers and/or structuring agents at least partially before removing the solvent.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040700A DE10040700A1 (en) | 2000-08-17 | 2000-08-17 | Salts of biologically active peptides, their production and use |
PCT/EP2001/009219 WO2002014347A2 (en) | 2000-08-17 | 2001-08-09 | Method for producing peptide salts, their use, and pharmaceutical preparations containing these peptide salts |
CA002355573A CA2355573A1 (en) | 2000-08-17 | 2001-08-22 | Method for the synthesis of peptide salts, their use and the pharmaceutical preparations, containing peptide salts |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300738A2 true HUP0300738A2 (en) | 2003-09-29 |
HUP0300738A3 HUP0300738A3 (en) | 2004-08-30 |
Family
ID=27805895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300738A HUP0300738A3 (en) | 2000-08-17 | 2001-08-09 | Method for producing lhrh-peptide salts, their use, and pharmaceutical preparations containing these peptide salts |
Country Status (30)
Country | Link |
---|---|
US (1) | US6780972B2 (en) |
EP (1) | EP1309607B1 (en) |
JP (1) | JP2004506647A (en) |
CN (1) | CN1187369C (en) |
AR (1) | AR030371A1 (en) |
AT (1) | ATE280779T1 (en) |
AU (2) | AU1043902A (en) |
BG (1) | BG107612A (en) |
BR (1) | BR0113296A (en) |
CA (1) | CA2355573A1 (en) |
CZ (1) | CZ2003688A3 (en) |
DE (2) | DE10040700A1 (en) |
DK (1) | DK1309607T3 (en) |
EE (1) | EE200300065A (en) |
ES (1) | ES2230371T3 (en) |
HK (1) | HK1058366A1 (en) |
HU (1) | HUP0300738A3 (en) |
IL (1) | IL154150A0 (en) |
MX (1) | MXPA03001448A (en) |
NO (1) | NO20030618L (en) |
NZ (1) | NZ524023A (en) |
PL (1) | PL204496B1 (en) |
PT (1) | PT1309607E (en) |
RU (1) | RU2266296C2 (en) |
SI (1) | SI1309607T1 (en) |
SK (1) | SK3032003A3 (en) |
TW (1) | TWI236910B (en) |
UA (1) | UA74005C2 (en) |
WO (1) | WO2002014347A2 (en) |
ZA (1) | ZA200300777B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
US7098305B2 (en) * | 2001-09-06 | 2006-08-29 | Ardana Bioscience Limited | Sustained release of microcrystalline peptide suspensions |
EP1674082A1 (en) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Process for the manufacture of sterile suspensions or lyophilisates of low-soluble basic peptide complexes, pharmaceutical formulations comprising these complexes and their use as medicament |
RU2525661C2 (en) * | 2012-11-15 | 2014-08-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова" Российской академии медицинских наук (ФГБУ "НИИВС им. И.И. Мечникова" РАМН) | Method of obtaining high-titre antimicrobial serum for estimation of antigen activity of anti-staphylococcal vaccines |
CN107056894B (en) * | 2017-05-26 | 2021-07-20 | 济南康和医药科技有限公司 | Method for solid-phase synthesis of ganirelix acetate by fragment method |
EP3590526A1 (en) * | 2018-07-05 | 2020-01-08 | Antev Limited | A lyophilization process and a teverelix-tfa lyophilizate obtained thereby |
CN114249800B (en) * | 2020-09-22 | 2024-07-26 | 深圳市星银医药有限公司 | Preparation method of pamoic acid polypeptide drug |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4431635A (en) * | 1979-06-13 | 1984-02-14 | Coy David Howard | LH-RH Antagonists |
EP0041286B1 (en) * | 1980-06-02 | 1984-08-15 | Andrew Victor Schally | Lh-rh antagonists |
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
DE4305225A1 (en) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | New manufacturing process for Cetrorelix lyophilisate |
CA2123144A1 (en) * | 1993-05-10 | 1994-11-11 | David Bodmer | Stabilisation of pharmacologically active compounds in sustained release compositions |
DE4342092B4 (en) * | 1993-12-09 | 2007-01-11 | Zentaris Gmbh | Long-acting suspension for injection and method of preparation |
CA2178592C (en) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Long-acting injection suspensions and a process for their preparation |
US6054432A (en) * | 1996-09-12 | 2000-04-25 | Asta Medica Aktiengesellschaft | Means for treating prostate hypertrophy and prostate cancer |
SK10272000A3 (en) * | 1998-01-16 | 2001-01-18 | Takeda Chemical Industries, Ltd. | Sustained release compositions, process for producing the same and utilization thereof |
-
2000
- 2000-08-17 DE DE10040700A patent/DE10040700A1/en not_active Withdrawn
-
2001
- 2001-08-09 CZ CZ2003688A patent/CZ2003688A3/en unknown
- 2001-08-09 MX MXPA03001448A patent/MXPA03001448A/en active IP Right Grant
- 2001-08-09 WO PCT/EP2001/009219 patent/WO2002014347A2/en active IP Right Grant
- 2001-08-09 CN CNB018142192A patent/CN1187369C/en not_active Expired - Fee Related
- 2001-08-09 DK DK01978273T patent/DK1309607T3/en active
- 2001-08-09 PL PL359495A patent/PL204496B1/en not_active IP Right Cessation
- 2001-08-09 ES ES01978273T patent/ES2230371T3/en not_active Expired - Lifetime
- 2001-08-09 NZ NZ524023A patent/NZ524023A/en unknown
- 2001-08-09 RU RU2003107560/04A patent/RU2266296C2/en not_active IP Right Cessation
- 2001-08-09 HU HU0300738A patent/HUP0300738A3/en unknown
- 2001-08-09 SI SI200130237T patent/SI1309607T1/en unknown
- 2001-08-09 SK SK303-2003A patent/SK3032003A3/en not_active Application Discontinuation
- 2001-08-09 AU AU1043902A patent/AU1043902A/en active Pending
- 2001-08-09 IL IL15415001A patent/IL154150A0/en not_active IP Right Cessation
- 2001-08-09 AU AU2002210439A patent/AU2002210439B2/en not_active Ceased
- 2001-08-09 BR BR0113296-2A patent/BR0113296A/en not_active IP Right Cessation
- 2001-08-09 PT PT01978273T patent/PT1309607E/en unknown
- 2001-08-09 JP JP2002519484A patent/JP2004506647A/en active Pending
- 2001-08-09 AT AT01978273T patent/ATE280779T1/en not_active IP Right Cessation
- 2001-08-09 EE EEP200300065A patent/EE200300065A/en unknown
- 2001-08-09 EP EP01978273A patent/EP1309607B1/en not_active Expired - Lifetime
- 2001-08-09 DE DE50104316T patent/DE50104316D1/en not_active Expired - Lifetime
- 2001-08-16 AR ARP010103935A patent/AR030371A1/en active IP Right Grant
- 2001-08-17 TW TW090120293A patent/TWI236910B/en active
- 2001-08-22 CA CA002355573A patent/CA2355573A1/en not_active Abandoned
- 2001-08-24 US US09/939,532 patent/US6780972B2/en not_active Expired - Fee Related
- 2001-09-08 UA UA2003032260A patent/UA74005C2/en unknown
-
2003
- 2003-01-29 ZA ZA200300777A patent/ZA200300777B/en unknown
- 2003-02-07 NO NO20030618A patent/NO20030618L/en unknown
- 2003-03-06 BG BG107612A patent/BG107612A/en unknown
-
2004
- 2004-02-13 HK HK04101030A patent/HK1058366A1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: ZENTARIS GMBH, DE Free format text: FORMER OWNER(S): ZENTARIS AG, DE; ZENTARIS GMBH, DE |
|
FD9A | Lapse of provisional protection due to non-payment of fees |