HUP0300689A2 - Method and compositions for treating an inflammatory disease - Google Patents

Method and compositions for treating an inflammatory disease

Info

Publication number
HUP0300689A2
HUP0300689A2 HU0300689A HUP0300689A HUP0300689A2 HU P0300689 A2 HUP0300689 A2 HU P0300689A2 HU 0300689 A HU0300689 A HU 0300689A HU P0300689 A HUP0300689 A HU P0300689A HU P0300689 A2 HUP0300689 A2 HU P0300689A2
Authority
HU
Hungary
Prior art keywords
compositions
treating
inflammatory disease
inhibitors
inflammatory
Prior art date
Application number
HU0300689A
Other languages
Hungarian (hu)
Inventor
James M. Kanagy
Elizabeth T. Keating
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP0300689A2 publication Critical patent/HUP0300689A2/en
Publication of HUP0300689A3 publication Critical patent/HUP0300689A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány gyulladásos betegségek kezelésére szolgáló kompozíciókra,illetve eljárásokra vonatkozik, ahol foszfodiészteráz-4 (PDE4)inhibitorokat, például cisz-4-ciano-4-[3-(ciklopentil-oxi)-4-metoxi-fenil]-1-ciklohexánkarbonsavat prosztaglandinszintézis-inhibitorokkal,például nemszteroid gyulladásellenes hatóanyagokkal (NSAID-kel) együttalkalmaznak. ÓThe invention relates to compositions for the treatment of inflammatory diseases, as well as to methods where phosphodiesterase-4 (PDE4) inhibitors, for example cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-cyclohexanecarboxylic acid, are used for prostaglandin synthesis -inhibitors, such as non-steroidal anti-inflammatory drugs (NSAIDs). HE

HU0300689A 2000-02-08 2001-02-08 Method and compositions for treating an inflammatory disease HUP0300689A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18087900P 2000-02-08 2000-02-08
PCT/US2001/003972 WO2001058441A1 (en) 2000-02-08 2001-02-08 Method and compositions for treating an inflammatory disease

Publications (2)

Publication Number Publication Date
HUP0300689A2 true HUP0300689A2 (en) 2003-07-28
HUP0300689A3 HUP0300689A3 (en) 2003-09-29

Family

ID=22662062

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300689A HUP0300689A3 (en) 2000-02-08 2001-02-08 Method and compositions for treating an inflammatory disease

Country Status (16)

Country Link
EP (1) EP1253919A4 (en)
JP (1) JP2003522142A (en)
KR (1) KR20020073577A (en)
CN (1) CN1398181A (en)
AU (1) AU7205701A (en)
BR (1) BR0108087A (en)
CA (1) CA2398184A1 (en)
CZ (1) CZ20022682A3 (en)
HK (1) HK1051319A1 (en)
HU (1) HUP0300689A3 (en)
IL (1) IL150963A0 (en)
MX (1) MXPA02007688A (en)
NO (1) NO20023737L (en)
PL (1) PL356447A1 (en)
WO (1) WO2001058441A1 (en)
ZA (1) ZA200206252B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338971B2 (en) * 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
IL160271A0 (en) * 2001-09-19 2004-07-25 Altana Pharma Ag Pharmaceutical compositions containing pde4-inhibitors and nsaid
US20040259863A1 (en) * 2001-10-31 2004-12-23 Hans-Michael Eggenweiler Type 4 phosphodiesterase inhibitors and uses thereof
WO2004098605A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Pharmaceutical composition comprising a pde4 inhibitor and il-1 trap
WO2005020926A2 (en) * 2003-08-28 2005-03-10 Pharmacia Corporation Treatment or prevention of vascular disorders with cox-2 inhibitors in combination with cyclic amp-specific phosphodiesterase inhibitors
JP2012519160A (en) * 2009-02-27 2012-08-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Combination drug containing PDE4 inhibitor and NSAID
JP2012519159A (en) * 2009-02-27 2012-08-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Combination drug containing PDE4 inhibitor and NSAID
EP2593452B1 (en) 2010-07-14 2017-01-18 Novartis AG Ip receptor agonist heterocyclic compounds
CN104053659B (en) 2012-01-13 2016-11-09 诺华股份有限公司 For treating the pyroles condensed as IP receptor stimulating agent of pulmonary hypertension (PAH) and associated conditions
EP2956455B1 (en) 2013-02-13 2017-05-17 Novartis AG Ip receptor agonist heterocyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061779A (en) * 1973-09-11 1977-12-06 Beecham Group Limited Naphthalene derivatives having anti-inflammatory activity
GB9108128D0 (en) * 1991-04-15 1991-06-05 Zambeletti Spa L Novel formulation
SK279958B6 (en) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Compounds exhibiting anti-allergic and anti-inflammatory properties, pharmaceutical composition them containing and their use
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
FR2753706B1 (en) * 1996-09-20 1998-10-30 NOVEL N-SUBSTITUTED CYCLIC AMINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
EP1253919A4 (en) 2007-03-14
IL150963A0 (en) 2003-02-12
BR0108087A (en) 2002-10-29
CZ20022682A3 (en) 2003-09-17
HK1051319A1 (en) 2003-08-01
KR20020073577A (en) 2002-09-27
ZA200206252B (en) 2003-08-26
HUP0300689A3 (en) 2003-09-29
JP2003522142A (en) 2003-07-22
CA2398184A1 (en) 2001-08-16
NO20023737D0 (en) 2002-08-07
NO20023737L (en) 2002-09-27
CN1398181A (en) 2003-02-19
PL356447A1 (en) 2004-06-28
WO2001058441A1 (en) 2001-08-16
EP1253919A1 (en) 2002-11-06
MXPA02007688A (en) 2002-12-13
AU7205701A (en) 2001-08-20

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees