HUP0203463A2 - Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents - Google Patents

Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents

Info

Publication number
HUP0203463A2
HUP0203463A2 HU0203463A HUP0203463A HUP0203463A2 HU P0203463 A2 HUP0203463 A2 HU P0203463A2 HU 0203463 A HU0203463 A HU 0203463A HU P0203463 A HUP0203463 A HU P0203463A HU P0203463 A2 HUP0203463 A2 HU P0203463A2
Authority
HU
Hungary
Prior art keywords
aziridino
production
derivatives
compounds
hydroxyiminomethyl
Prior art date
Application number
HU0203463A
Other languages
Hungarian (hu)
Inventor
Viktor Adrianov
Ilona Domracheva
Ivars Kalvins
Iveta Kanepe
Irina Shestakova
Original Assignee
Analyticon Discovery Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Analyticon Discovery Gmbh filed Critical Analyticon Discovery Gmbh
Publication of HUP0203463A2 publication Critical patent/HUP0203463A2/en
Publication of HUP0203463A3 publication Critical patent/HUP0203463A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A jelen találmány tárgyát képezik azok az (I) általános képletű 1-aziridino-l-hidroxi-imino-metil-származékok, ahol a képletben Rjelentése tetszés szerinti szerves gyök, amely elhelyezkedéséttekintve a két aziridinoxim csoporthoz kovalens módon kapcsolódik, R1és R2 csoportok jelentése egymástól függetlenül hidrogénatom vagy a -CH3, -CH2H5, -CN, -COOH, -COOCH3, -COOC2H5, -CONH2 vagy -C6H5csoportok valamelyike, és n értéke 2. A találmány tárgyát képeziktovábbá magukat a vegyületeket, továbbá a vegyületeket tartalmazógyógyszerkészítmények előállítására szolgáló eljárások. Az (I)általános képletű vegyületek tumorellenes hatásúak. ÓThe subject of the present invention are those 1-aziridino-l-hydroxyimino-methyl derivatives of the general formula (I), where R in the formula is any organic radical, which is covalently linked to the two aziridinoxime groups depending on their position, R1 and R2 have the meanings of each other is independently a hydrogen atom or one of the groups -CH3, -CH2H5, -CN, -COOH, -COOCH3, -COOC2H5, -CONH2 or -C6H5, and the value of n is 2. The subject of the invention is further the compounds themselves, as well as methods for the production of pharmaceutical preparations containing the compounds. The compounds of general formula (I) have an antitumor effect. HE

HU0203463A 1999-09-24 2000-09-22 Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents HUP0203463A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947440A DE19947440A1 (en) 1999-09-24 1999-09-24 1-Aziridino-1-hydroxyiminomethyl derivatives, process for their preparation and medicaments containing these compounds
PCT/DE2000/003441 WO2001021585A2 (en) 1999-09-24 2000-09-22 Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents

Publications (2)

Publication Number Publication Date
HUP0203463A2 true HUP0203463A2 (en) 2003-02-28
HUP0203463A3 HUP0203463A3 (en) 2003-11-28

Family

ID=7924241

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203463A HUP0203463A3 (en) 1999-09-24 2000-09-22 Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents

Country Status (12)

Country Link
US (1) US7078418B1 (en)
EP (1) EP1220838B1 (en)
JP (1) JP4860865B2 (en)
AT (1) ATE486847T1 (en)
AU (1) AU1991801A (en)
CZ (1) CZ303316B6 (en)
DE (3) DE19947440A1 (en)
ES (1) ES2355058T3 (en)
HU (1) HUP0203463A3 (en)
PL (1) PL204282B1 (en)
RU (1) RU2264397C2 (en)
WO (1) WO2001021585A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628619A (en) * 2015-02-02 2015-05-20 东力（南通）化工有限公司 Method for preparing cell growth inhibitor anticancer drug leacadin and relative derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617398A (en) * 1982-04-12 1986-10-14 The Research Foundation Of State University Of New York Phosphoaziridine compounds useful for treatment of tumors
NL8301626A (en) * 1983-05-06 1984-12-03 Rijksuniversiteit AZIRIDINE DERIVATIVE OF A TETRAMIC CYCLOCHLOROPHOSPHOSPHENE COMPOUND, PROCESS FOR THE PREPARATION THEREOF, AND A AZIRIDINE DERIVATIVE DERIVED BY SUBSTITUTION OF THE CHLOROUS ATOMS OF THE TETRAMERIC CHLOROPHOSPHAZENE.
US4806531A (en) * 1986-02-20 1989-02-21 Yale University 2,3-bis(aziridinyl)-1,4-naphthoquinone sulfonate derivatives having antineoplastic activity
US5612329A (en) * 1995-06-05 1997-03-18 University Of Maryland At Baltimore Diaziridinylpolyamine anti-cancer agents

Also Published As

Publication number Publication date
ATE486847T1 (en) 2010-11-15
US7078418B1 (en) 2006-07-18
EP1220838B1 (en) 2010-11-03
DE10082858D2 (en) 2002-02-28
JP4860865B2 (en) 2012-01-25
CZ20021351A3 (en) 2002-07-17
WO2001021585A3 (en) 2001-10-11
PL353863A1 (en) 2003-12-01
PL204282B1 (en) 2009-12-31
HUP0203463A3 (en) 2003-11-28
DE19947440A1 (en) 2001-04-05
CZ303316B6 (en) 2012-08-01
JP2003509489A (en) 2003-03-11
WO2001021585A2 (en) 2001-03-29
ES2355058T3 (en) 2011-03-22
DE50016022D1 (en) 2010-12-16
RU2264397C2 (en) 2005-11-20
AU1991801A (en) 2001-04-24
EP1220838A2 (en) 2002-07-10

Similar Documents

Publication Publication Date Title
CY1106383T1 (en) NOVEL DIPHENYLAZETIDINONES, THE PROCESS FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING THEIR COMPOUNDS AND THEIR USE IN THE TREATMENT OF LIPID METABOLISM DISORDERS
FI942075A (en) Tetrazole derivatives of bile acid derivatives, process for their preparation and use of these compounds as medicaments
HUP0303756A2 (en) 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands and process for their preparation and pharmaceutical compositions containing them
NO304793B1 (en) nor- bile acid derivatives, and their use in the manufacture of drug
HUP0401982A2 (en) Indolizine derivates, process for their preparation and pharmaceutical compositions containing the compounds
HUP0402507A2 (en) Novel n(phenylsulfonyl)glycine derivatives, their use and pharmaceutical compositions containing them
YU59001A (en) 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use
CY1106890T1 (en) PRODUCTS OF ACRIDIN AND USE AS MEDICINES
DE60204452D1 (en) [1,5] pyridine derivatives
HUP0300080A2 (en) Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor xa activity and pharmaceutical compositions containing them
HUP0402489A2 (en) 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine
FI946073A0 (en) Vitamin D series, 20-modified derivatives, process for the preparation of such derivatives, intermediates used in the process, pharmaceutical preparations containing said derivatives and the use of derivatives for the preparation of medicaments
YU56302A (en) 8,8a-dihydro-indeno/1,2-d/thiazol-derivatives, substituted in position 8a, a method for their production and their use as medicaments, e.g.anorectic agents
HUP9802762A2 (en) Diphenylmethylene piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
NO179834C (en) Substituted cyclohexane derivatives and use of the compounds for the manufacture of drugs
HUP9802121A2 (en) Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP0102714A2 (en) Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same
TR28332A (en) Arilasetic acid derivatives.
IL166057A0 (en) Urea-substituted and urethane-substituted acylureas methods for the production thereof and their useas medicaments
CY1112050T1 (en) NEW 2-HOLOGENIFIED PRODUCTS OF 5-0- DESESOAMINYLYLTRONOLIDE A, THEIR PROCEDURE AND THEIR APPLICATION AS MEDICINES
HUP0203463A2 (en) Bis(1-aziridino-1-hydroxyiminomethyl)-derivatives, method for the production thereof and use thereof as anti-tumoral agents
HUP0301553A2 (en) Pharmaceutical compositions and their use for treating neurological disorders
MX9203928A (en) MONKEY AND BIS ALKYLAMINO-ANTHRACICLINES AND PROCEDURE FOR ITS PREPARATION.
HUP0303319A2 (en) 9a-n[n'-(phanylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycina and of 5-o-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide a, process for their preparation and pharmaceutical compositions containing them
ATE296295T1 (en) POLYCYCLIC THIAZOLE SYSTEMS AND THEIR USE AS ANORECTIC DRUGS

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished