HUP0203318A2 - Transdermal therapeutic systems with improved stability and a method for the production thereof - Google Patents

Transdermal therapeutic systems with improved stability and a method for the production thereof

Info

Publication number
HUP0203318A2
HUP0203318A2 HU0203318A HUP0203318A HUP0203318A2 HU P0203318 A2 HUP0203318 A2 HU P0203318A2 HU 0203318 A HU0203318 A HU 0203318A HU P0203318 A HUP0203318 A HU P0203318A HU P0203318 A2 HUP0203318 A2 HU P0203318A2
Authority
HU
Hungary
Prior art keywords
excipients
transdermal therapeutic
ttr
active ingredient
production
Prior art date
Application number
HU0203318A
Other languages
Hungarian (hu)
Inventor
Walter Müller
Original Assignee
Lts Lohmann Therapie-Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26007565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0203318(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10054713A external-priority patent/DE10054713C2/en
Application filed by Lts Lohmann Therapie-Systeme Ag filed Critical Lts Lohmann Therapie-Systeme Ag
Publication of HUP0203318A2 publication Critical patent/HUP0203318A2/en
Publication of HUP0203318A3 publication Critical patent/HUP0203318A3/en
Publication of HU228822B1 publication Critical patent/HU228822B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Abstract

A találmány tárgya transzdermális terápiás rendszer (TTR), amelyben abenne lévő, hidroperoxidos oxidációra érzékeny hatóanyag oxidációsbomlási termékeinek tárolás közbeni képződése csökkent, és amelyben ahatóanyaggal érintkező segédanyagok a TTR receptúrája adtarészarányukkal súlyozott peroxidszámának összege legfeljebb 20. Arendszert úgy állítják elő, hogy a) a segédanyagokat úgy választjákki, hogy a TTR receptúrája adta részarányukkal súlyozottperoxidszámának összege legfeljebb 20, vagy b) hidroperoxidtartalmúsegédanyagokat rövid szénláncú alkoholban oldanak és az oldathozszervetlen szulfit vagy hidrogénszulfit vizes oldatát adják, adottesetben a kivált termékeket elkülönítik, majd az a) szerintmegválasztott vagy a b) szerint kezelt segédanyagokból és legalább egyhatóanyagból ismert módon transzdermális terápiás rendszert állítanakelő. ÓThe subject of the invention is a transdermal therapeutic system (TTR), in which the formation of oxidation decomposition products of the active ingredient sensitive to hydroperoxide oxidation is reduced during storage, and in which the peroxide value of excipients in contact with the active ingredient, weighted by their data fraction of the TTR formula, is at most 20. The system is produced in such a way that a) the excipients they are selected in such a way that the total of the peroxide number weighted by their proportion given by the TTR recipe is at most 20, or b) hydroperoxide-containing excipients are dissolved in short-chain alcohol and an aqueous solution of inorganic sulfite or hydrogen sulfite is added to the solution, if necessary, the precipitated products are separated, and then from the excipients selected according to a) or treated according to b) and establishing a transdermal therapeutic system from at least one active ingredient in a known manner. HE

HU0203318A 1999-11-29 2000-11-24 Transdermal therapeutic systems with improved stability and a method for the production thereof HU228822B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19957401 1999-11-29
DE10054713A DE10054713C2 (en) 1999-11-29 2000-11-04 Transdermal therapeutic systems with improved stability and a method for their production
PCT/EP2000/011692 WO2001039753A1 (en) 1999-11-29 2000-11-24 Transdermal therapeutic systems with improved stability and a method for the production thereof

Publications (3)

Publication Number Publication Date
HUP0203318A2 true HUP0203318A2 (en) 2003-02-28
HUP0203318A3 HUP0203318A3 (en) 2004-06-28
HU228822B1 HU228822B1 (en) 2013-05-28

Family

ID=26007565

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203318A HU228822B1 (en) 1999-11-29 2000-11-24 Transdermal therapeutic systems with improved stability and a method for the production thereof

Country Status (21)

Country Link
US (1) US6699498B1 (en)
EP (1) EP1233763B1 (en)
JP (1) JP5753645B2 (en)
CN (1) CN1195506C (en)
AR (1) AR026621A1 (en)
AT (1) ATE245972T1 (en)
AU (1) AU779523B2 (en)
BR (1) BRPI0015939B8 (en)
CA (1) CA2396686C (en)
CZ (1) CZ295031B6 (en)
DK (1) DK1233763T3 (en)
ES (1) ES2204732T3 (en)
HU (1) HU228822B1 (en)
IL (1) IL149812A0 (en)
MX (1) MXPA02005292A (en)
NZ (1) NZ519069A (en)
PL (1) PL198323B1 (en)
PT (1) PT1233763E (en)
RU (1) RU2266735C2 (en)
TW (1) TWI272108B (en)
WO (1) WO2001039753A1 (en)

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DE19814084B4 (en) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's syndrome and process for its preparation
DE10043321B4 (en) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Use of a transdermal therapeutic system for the treatment of Parkinson's disease, for the treatment and prevention of premenstrual syndrome and for lactation inhibition
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
DE10053397A1 (en) * 2000-10-20 2002-05-02 Schering Ag Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases
DE10064453A1 (en) * 2000-12-16 2002-07-04 Schering Ag Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20060263419A1 (en) * 2002-03-12 2006-11-23 Hans-Michael Wolff Transdermal therapeutic system for Parkinson's Disease
US20060216336A1 (en) * 2002-05-07 2006-09-28 Hans-Michael Wolff Transdermal therapeutic system for Parkinson's Disease
DE10224612A1 (en) * 2002-06-04 2003-12-24 Lohmann Therapie Syst Lts Active substance-containing film-like preparations with improved chemical stability, and process for their preparation
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (en) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Hot-melt TTS for the administration of rotigotine and process for its preparation, and use of rotigotine in the manufacture of a hot-melt TTS
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
DE60204229T2 (en) * 2002-12-02 2006-02-02 Schwarz Pharma Ag Administration of rotigotine for the treatment of Parkinson's disease by iontophoresis
DE10261696A1 (en) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Device for the transdermal administration of rotigotine base
TW200514582A (en) * 2003-10-31 2005-05-01 Hisamitsu Pharmaceutical Co Transdermal preparation and method for reducing side effect in pergolide therapy
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
US8563031B2 (en) * 2010-05-27 2013-10-22 Absize, Inc. Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith
DE102017104026A1 (en) 2017-02-27 2018-08-30 Lts Lohmann Therapie-Systeme Ag Nicotine containing transparent transdermal therapeutic system
WO2020250840A1 (en) * 2019-06-14 2020-12-17 久光製薬株式会社 Rotigotine-containing patch

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Also Published As

Publication number Publication date
US6699498B1 (en) 2004-03-02
RU2266735C2 (en) 2005-12-27
RU2002118325A (en) 2004-02-20
CA2396686A1 (en) 2001-06-07
ES2204732T3 (en) 2004-05-01
HUP0203318A3 (en) 2004-06-28
ATE245972T1 (en) 2003-08-15
MXPA02005292A (en) 2002-12-11
BR0015939A (en) 2002-08-20
PL355606A1 (en) 2004-05-04
PT1233763E (en) 2003-11-28
JP2003515554A (en) 2003-05-07
BRPI0015939B8 (en) 2021-05-25
AR026621A1 (en) 2003-02-19
NZ519069A (en) 2004-06-25
PL198323B1 (en) 2008-06-30
CN1195506C (en) 2005-04-06
EP1233763B1 (en) 2003-07-30
IL149812A0 (en) 2002-11-10
EP1233763A1 (en) 2002-08-28
CZ295031B6 (en) 2005-05-18
DK1233763T3 (en) 2003-10-20
WO2001039753A1 (en) 2001-06-07
TWI272108B (en) 2007-02-01
HU228822B1 (en) 2013-05-28
AU779523B2 (en) 2005-01-27
CN1402633A (en) 2003-03-12
JP5753645B2 (en) 2015-07-22
AU2162301A (en) 2001-06-12
CZ20021867A3 (en) 2002-11-13
BR0015939B1 (en) 2013-10-08
CA2396686C (en) 2008-07-08

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