HUP0202938A2 - N-aryl-2-sulfonamidobenzamides as phosphate transport inhibitors and pharmaceutical compositions containing them - Google Patents
N-aryl-2-sulfonamidobenzamides as phosphate transport inhibitors and pharmaceutical compositions containing themInfo
- Publication number
- HUP0202938A2 HUP0202938A2 HU0202938A HUP0202938A HUP0202938A2 HU P0202938 A2 HUP0202938 A2 HU P0202938A2 HU 0202938 A HU0202938 A HU 0202938A HU P0202938 A HUP0202938 A HU P0202938A HU P0202938 A2 HUP0202938 A2 HU P0202938A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- aryl
- amino
- carbamoyl
- substituted
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 carboxy- Chemical class 0.000 abstract 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 4
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 229930192474 thiophene Natural products 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
Abstract
A találmány a nátriumfüggő foszfáttranszport inhibitorkéntalkalmazható (I) általános képletű vegyületekre vonatkozik, amelyekképletében R1 és R2 jelentése egymástól függetlenül hidrogénatom,alkil-, alkenil-, aralkil-, acil-, aril-karbonil-, halogén-alkil-,aril-, heteroarilcsoport, halogénatom, karboxi-, alkoxi-karbonil-,karbamoil-, alkil-karbamoil-, aril-karbamoil-, ciano-, alkoxi-,hidroxi-, fenil-azo-, amino-, nitro-, alkil-amino-, aril-amino-,aralkil-amino-, acil-amino-, (aril-karbonil)-amino-, alkil-tio-,aralkil-tio-, aril-tio-, alkil-szulfinil-, aril-szulfinil-, aralkil-szulfinil-, alkil-szulfonil-, aril-szulfonil-, aralkil- szulfonil-,szulfamoil-, (aril-szulfonil)-amino- vagy (alkil-szulfonil)- amino-csoport; vagy R1 és/vagy R2 az általa szubsztituált gyűrűvelbenzotiofént, naftalint, kinolint vagy izokinolint alkotó kondenzáltgyűrűt jelent; vagy (R1)n és/vagy (R2)m és az általa szubsztituáltgyűrű egy a következők közül kiválasztott heterociklust jelent:tiofén, furán, piridin, pirimidin és pirazin, valamintbenzoanalógjaik; és R3 jelentése alkil-, halogén-alkil-csoport, R1csoporttal szubsztituált arilcsoport vagy R1 csoporttal szubsztituáltaralkilcsoport, illetve egy R1 csoporttal szubsztituált heterociklusoscsoport, amely heterociklusos csoport a következő vegyületekbőlszármazik: tiofén, furán, piridin, pirimidin, pirazin, imidazol éstiazol, valamint benzoanalógjaik. A találmány kiterjed az (I)általános képletű vegyületeket tartalmazó gyógyszerkészítményekre,melyeket krónikus veseelégtelenség és urémiás csontbetegség kezelésérehasználnak. ÓThe invention relates to compounds of general formula (I) that can be used as sodium-dependent phosphate transport inhibitors, in which R1 and R2 are independently hydrogen atom, alkyl, alkenyl, aralkyl, acyl, arylcarbonyl, haloalkyl, aryl, heteroaryl, halogen atom, carboxy-, alkoxy-carbonyl-, carbamoyl-, alkyl-carbamoyl-, aryl-carbamoyl-, cyano-, alkoxy-, hydroxy-, phenylazo-, amino-, nitro-, alkylamino-, aryl- amino-, aralkylamino-, acylamino-, (arylcarbonyl)amino-, alkylthio-, aralkylthio-, arylthio-, alkylsulfinyl-, arylsulfinyl-, aralkylsulfinyl -, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, sulfamoyl, (arylsulfonyl)amino or (alkylsulfonyl)amino; or R1 and/or R2 represents a fused ring forming benzothiophene, naphthalene, quinoline or isoquinoline with the ring substituted by it; or (R1)n and/or (R2)m and the ring substituted by it represents a heterocycle selected from the following: thiophene, furan, pyridine, pyrimidine and pyrazine and their benzoanalogues; and R3 is an alkyl group, a haloalkyl group, an aryl group substituted with R1 group or a paraalkyl group substituted with R1 group, or a heterocyclic group substituted with R1 group, which heterocyclic group is derived from the following compounds: thiophene, furan, pyridine, pyrimidine, pyrazine, imidazole and thiazole, and their benzo analogues. The invention covers pharmaceutical preparations containing compounds of general formula (I), which are used for the treatment of chronic kidney failure and uremic bone disease. HE
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14464699P | 1999-07-20 | 1999-07-20 | |
PCT/US2000/019616 WO2001005398A1 (en) | 1999-07-20 | 2000-07-19 | Phosphate transport inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0202938A2 true HUP0202938A2 (en) | 2003-01-28 |
HUP0202938A3 HUP0202938A3 (en) | 2006-07-28 |
Family
ID=22509500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0202938A HUP0202938A3 (en) | 1999-07-20 | 2000-07-19 | N-aryl-2-sulfonamidobenzamides as phosphate transport inhibitors and pharmaceutical compositions containing them |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1202729A1 (en) |
JP (1) | JP2003504403A (en) |
KR (1) | KR20020015382A (en) |
CN (1) | CN1361687A (en) |
AR (1) | AR030911A1 (en) |
AU (1) | AU6354300A (en) |
BR (1) | BR0012568A (en) |
CA (1) | CA2379657A1 (en) |
CO (1) | CO5190714A1 (en) |
CZ (1) | CZ2002204A3 (en) |
HU (1) | HUP0202938A3 (en) |
IL (1) | IL147697A0 (en) |
MX (1) | MXPA02000753A (en) |
NO (1) | NO20020278D0 (en) |
NZ (1) | NZ516619A (en) |
PL (1) | PL353741A1 (en) |
TR (1) | TR200200112T2 (en) |
WO (1) | WO2001005398A1 (en) |
ZA (1) | ZA200200464B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020093983A (en) * | 2000-05-12 | 2002-12-16 | 스미스클라인 비참 코포레이션 | Phosphate Transport Inhibitors |
GB2378179A (en) * | 2001-08-03 | 2003-02-05 | Pantherix Ltd | Aromatic sulfonamides and their use in treating bacterial diseases |
AUPR738301A0 (en) * | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
WO2006047302A1 (en) | 2004-10-21 | 2006-05-04 | Transtech Pharma, Inc. | Bissulfonamide compounds as agonists of galr1, compositions, and methods of use |
WO2006077901A1 (en) * | 2005-01-20 | 2006-07-27 | Shionogi & Co., Ltd. | Ctgf expression inhibitor |
CN102137669A (en) * | 2008-06-03 | 2011-07-27 | 弗雷森纽斯医疗护理德国有限责任公司 | Pharmaceutical compositions comprising gamma secretase modulators |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
KR101766619B1 (en) | 2008-12-31 | 2017-08-08 | 알데릭스, 인코포레이티드 | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US8664425B2 (en) * | 2010-02-02 | 2014-03-04 | Honeywell International Inc. | Bluegreen fluorescent compounds |
JP5827326B2 (en) * | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
JP5827327B2 (en) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
JP5827328B2 (en) * | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
JP5823514B2 (en) * | 2010-07-07 | 2015-11-25 | アーデリクス,インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
EP2822935B1 (en) | 2011-11-17 | 2019-05-15 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
KR102138390B1 (en) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | Compounds and methods for inhibiting nhe-mediaded antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
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CN103183623A (en) * | 2013-03-12 | 2013-07-03 | 中国医学科学院医药生物技术研究所 | A group of benzene sulfonamido benzamide derivatives, and preparation and application thereof |
EP2983667B1 (en) | 2013-04-12 | 2019-03-20 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
CN105395532B (en) * | 2015-11-25 | 2017-11-14 | 中国医学科学院医药生物技术研究所 | Application of the 2 benzene sulfonamido benzamide compounds in liver injury protection and liver fibrosis preventing and treating |
JP6713051B2 (en) | 2016-08-30 | 2020-06-24 | 日本曹達株式会社 | Sulfonylaminobenzamide compounds and pest control agents |
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Publication number | Priority date | Publication date | Assignee | Title |
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IL86462A (en) * | 1987-05-29 | 1992-12-01 | Fujisawa Pharmaceutical Co | Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same |
US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
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2000
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- 2000-07-18 CO CO00053928A patent/CO5190714A1/en not_active Application Discontinuation
- 2000-07-19 KR KR1020027000801A patent/KR20020015382A/en not_active Application Discontinuation
- 2000-07-19 CZ CZ2002204A patent/CZ2002204A3/en unknown
- 2000-07-19 WO PCT/US2000/019616 patent/WO2001005398A1/en active IP Right Grant
- 2000-07-19 EP EP00950437A patent/EP1202729A1/en not_active Withdrawn
- 2000-07-19 AU AU63543/00A patent/AU6354300A/en not_active Abandoned
- 2000-07-19 MX MXPA02000753A patent/MXPA02000753A/en unknown
- 2000-07-19 CA CA002379657A patent/CA2379657A1/en not_active Abandoned
- 2000-07-19 CN CN00810644A patent/CN1361687A/en active Pending
- 2000-07-19 PL PL00353741A patent/PL353741A1/en not_active Application Discontinuation
- 2000-07-19 IL IL14769700A patent/IL147697A0/en unknown
- 2000-07-19 JP JP2001510455A patent/JP2003504403A/en not_active Withdrawn
- 2000-07-19 BR BR0012568-7A patent/BR0012568A/en not_active Application Discontinuation
- 2000-07-19 TR TR2002/00112T patent/TR200200112T2/en unknown
- 2000-07-19 NZ NZ516619A patent/NZ516619A/en unknown
- 2000-07-19 HU HU0202938A patent/HUP0202938A3/en unknown
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2002
- 2002-01-18 NO NO20020278A patent/NO20020278D0/en not_active Application Discontinuation
- 2002-01-18 ZA ZA200200464A patent/ZA200200464B/en unknown
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HUP0202938A3 (en) | 2006-07-28 |
PL353741A1 (en) | 2003-12-01 |
KR20020015382A (en) | 2002-02-27 |
MXPA02000753A (en) | 2002-07-22 |
NO20020278L (en) | 2002-01-18 |
NZ516619A (en) | 2004-02-27 |
CN1361687A (en) | 2002-07-31 |
BR0012568A (en) | 2002-04-30 |
AU6354300A (en) | 2001-02-05 |
JP2003504403A (en) | 2003-02-04 |
CO5190714A1 (en) | 2002-08-29 |
IL147697A0 (en) | 2002-08-14 |
CZ2002204A3 (en) | 2002-11-13 |
ZA200200464B (en) | 2003-04-30 |
AR030911A1 (en) | 2003-09-03 |
NO20020278D0 (en) | 2002-01-18 |
CA2379657A1 (en) | 2001-01-25 |
WO2001005398A1 (en) | 2001-01-25 |
EP1202729A1 (en) | 2002-05-08 |
TR200200112T2 (en) | 2002-05-21 |
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