HUP0202388A2 - Method and composition for regulating gut motility and food intake and the novel activ ingredients - Google Patents
Method and composition for regulating gut motility and food intake and the novel activ ingredientsInfo
- Publication number
- HUP0202388A2 HUP0202388A2 HU0202388A HUP0202388A HUP0202388A2 HU P0202388 A2 HUP0202388 A2 HU P0202388A2 HU 0202388 A HU0202388 A HU 0202388A HU P0202388 A HUP0202388 A HU P0202388A HU P0202388 A2 HUP0202388 A2 HU P0202388A2
- Authority
- HU
- Hungary
- Prior art keywords
- tricothecin
- epoxy
- composition
- acetoxy
- hydroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000037406 food intake Effects 0.000 title abstract 2
- 235000012631 food intake Nutrition 0.000 title abstract 2
- 230000010243 gut motility Effects 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- LINOMUASTDIRTM-QGRHZQQGSA-N deoxynivalenol Chemical compound C([C@@]12[C@@]3(C[C@@H](O)[C@H]1O[C@@H]1C=C(C([C@@H](O)[C@@]13CO)=O)C)C)O2 LINOMUASTDIRTM-QGRHZQQGSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- LINOMUASTDIRTM-UHFFFAOYSA-N vomitoxin hydrate Natural products OCC12C(O)C(=O)C(C)=CC1OC1C(O)CC2(C)C11CO1 LINOMUASTDIRTM-UHFFFAOYSA-N 0.000 abstract 2
- RANGFOQREJPKIH-UHFFFAOYSA-N 3,15-diacetyl deoxynivalenol Natural products CC(=O)OCC12C(O)C(=O)C(C)=CC1OC1C(OC(C)=O)CC2(C)C11CO1 RANGFOQREJPKIH-UHFFFAOYSA-N 0.000 abstract 1
- ADFIQZBYNGPCGY-HTJQZXIKSA-N 3-acetyldeoxynivalenol Chemical compound C([C@]12[C@]3(C)C[C@H]([C@H]2O[C@H]2[C@@]3([C@H](O)C(=O)C(C)=C2)CO)OC(=O)C)O1 ADFIQZBYNGPCGY-HTJQZXIKSA-N 0.000 abstract 1
- IDGRYIRJIFKTAN-UHFFFAOYSA-N 3-acetyldeoxynivalenol Natural products CC(=O)OCC12C(O)C(=O)C(C)=CC1OC1C(O)CC2(C)C11CO1 IDGRYIRJIFKTAN-UHFFFAOYSA-N 0.000 abstract 1
- ADFIQZBYNGPCGY-UHFFFAOYSA-N Acetyldeoxynivalenol Natural products C1=C(C)C(=O)C(O)C2(CO)C1OC1C(OC(=O)C)CC2(C)C21CO2 ADFIQZBYNGPCGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- UKOTXHQERFPCBU-YQPARWETSA-N Nivalenol Chemical compound C([C@]12[C@@]3([C@H](O)[C@@H](O)[C@H]1O[C@@H]1C=C(C([C@@H](O)[C@@]13CO)=O)C)C)O2 UKOTXHQERFPCBU-YQPARWETSA-N 0.000 abstract 1
- ITCSWEBPTQLQKN-UHFFFAOYSA-N Nivalenol Natural products CC1=CC2OC3C(O)C(O)C(C2(CO)CC1=O)C34CO4 ITCSWEBPTQLQKN-UHFFFAOYSA-N 0.000 abstract 1
- PIHGROVBUUNPDW-UHFFFAOYSA-N Nivalenol-diacetat Natural products CC(=O)OCC12C(O)C(=O)C(C)=CC1OC1C(O)C(OC(C)=O)C2(C)C11CO1 PIHGROVBUUNPDW-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- LJWZOKOFCBPNAG-UHFFFAOYSA-N Trichothecin Natural products CC=CC(=O)OC1CC2OC3C=C(C)C(=O)CC3(C)C1(C)C21CO1 LJWZOKOFCBPNAG-UHFFFAOYSA-N 0.000 abstract 1
- BURHPZJXARNGQY-UHFFFAOYSA-N Trichothecolone Natural products CC12CC(=O)C(C)=CC1OC1CC(O)C2(C)C11CO1 BURHPZJXARNGQY-UHFFFAOYSA-N 0.000 abstract 1
- RANGFOQREJPKIH-CHPZEFIJSA-N [(1R,2R,3S,7R,9R,10R,12S)-10-acetyloxy-3-hydroxy-1,5-dimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate Chemical compound C([C@@]12[C@]3(C)C[C@H]([C@H]1O[C@@H]1C=C(C)C(=O)[C@@H](O)[C@@]13COC(=O)C)OC(C)=O)O2 RANGFOQREJPKIH-CHPZEFIJSA-N 0.000 abstract 1
- BIEMSLKEYQTVRH-KLOHDQKESA-N [(1R,2S,3S,7R,9R,10R)-10-hydroxy-2-(hydroxymethyl)-1,5-dimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-3-yl] acetate Chemical compound C12([C@@]3(C[C@@H](O)[C@H]2O[C@@H]2C=C(C)C(=O)[C@H]([C@]32CO)OC(=O)C)C)CO1 BIEMSLKEYQTVRH-KLOHDQKESA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PIHGROVBUUNPDW-SUWHGTQISA-N diacetylnivalenol Chemical compound CC1([C@H](OC(C)=O)[C@@H](O)[C@H]2O[C@@H]3C=C(C)C(=O)[C@@H](O)[C@@]31COC(=O)C)C21CO1 PIHGROVBUUNPDW-SUWHGTQISA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XGCUCFKWVIWWNW-CAYGJDLQSA-N fusarenone x Chemical compound C([C@@]12[C@@]3(C)[C@@]4(CO)[C@H](O)C(=O)C(C)=C[C@H]4O[C@@H]1[C@H](O)[C@H]3OC(=O)C)O2 XGCUCFKWVIWWNW-CAYGJDLQSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000008991 intestinal motility Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229930013292 trichothecene Natural products 0.000 abstract 1
- 150000003327 trichothecene derivatives Chemical class 0.000 abstract 1
- 125000000210 trichothecene group Chemical group [H][C@]12O[C@]3([H])[C@H]([*])[C@@H]([*])[C@@](C)(C33CO3)C1(C[*])C([*])C([*])C(C)=C2 0.000 abstract 1
- LJWZOKOFCBPNAG-HULHSAFCSA-N trichothecin Chemical compound C([C@@]12[C@@]3(C)[C@@]4(C)CC(=O)C(C)=C[C@H]4O[C@@H]1C[C@H]3OC(=O)\C=C/C)O2 LJWZOKOFCBPNAG-HULHSAFCSA-N 0.000 abstract 1
- BURHPZJXARNGQY-LACSLYJWSA-N trichothecolone Chemical compound C([C@@]12[C@@]3([C@H](O)C[C@H]1O[C@@H]1C=C(C(C[C@@]13C)=O)C)C)O2 BURHPZJXARNGQY-LACSLYJWSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány szerinti készítmény és eljárás alkalmazható elhízáskezelésére vagy a tápláléktömeg növelésére. A táplálékbevitelszabályozására szolgáló előnyös hatóanyag a tricothecén vagy annakszármazékai. A találmány tárgya továbbá gyógyászati készítménytápláltsági módozatú bélmozgási aktivitás kiváltására, amely (a)nivalenol, 4-dezoxi-nivalenol (DON), trichothecolon, trichothecin, 3-acetil-dezoxinivalenol, 7-acetil-dezoxinivalenol, 3,15-diacetil-dezoxinivalenol, 4-acetil-nivalenol, 4,15-diacetil-nivalenol, 3-hidroxi-12,13-epoxi-9-tricothecin-8-on-7,15-karbonát (C), 3-acetoxi-12,13-epoxi-9-tricothecin-8-on-7,15-karbonát (D), 3-acetoxi-7,15-benzilidén-12,13-epoxi-9-tricothecin-8-on (E), 3-hidroxi-7,15-benzilidén-12,13-epoxi-9-tricothecin-8-on (F), 3-hidroxi-7,15-izopropilidin-12,13-epoxi-9-tricothecin-8-on (A), 3-acetoxi-7,15-izopropilidin-12,13-epoxi-9-tricothecin-8-on (B), vagy ezekkombinációi közül választott hatóanyagot és (b) egy gyógyászatilagelfogadható vivőanyagot tartalmaz. A találmány vonatkozik, továbbá azeljárásokban és készítményben hatóanyagként alkalmazhatótricothecénszármazékok közül az új vegyületekre is, ezeket azelőzőkben A,B,C,D,E és F betűvel jelölték. ÓThe composition and method according to the invention can be used to treat obesity or to increase food weight. The preferred active ingredient for controlling food intake is trichothecene or its derivatives. The subject of the invention is also a medicinal preparation for inducing intestinal motility activity in the form of nutrition, which contains (a)nivalenol, 4-deoxynivalenol (DON), trichothecolon, trichothecin, 3-acetyldeoxynivalenol, 7-acetyldeoxynivalenol, 3,15-diacetyldeoxynivalenol, 4-acetyl nivalenol, 4,15-diacetyl nivalenol, 3-hydroxy-12,13-epoxy-9-tricothecin-8-one-7,15-carbonate (C), 3-acetoxy-12,13-epoxy -9-tricothecin-8-one-7,15-carbonate (D), 3-acetoxy-7,15-benzylidene-12,13-epoxy-9-tricothecin-8-one (E), 3-hydroxy-7 ,15-benzylidene-12,13-epoxy-9-tricothecin-8-one (F), 3-hydroxy-7,15-isopropylidin-12,13-epoxy-9-tricothecin-8-one (A), 3 -acetoxy-7,15-isopropylidin-12,13-epoxy-9-tricothecin-8-one (B), or a combination thereof, contains an active ingredient and (b) a pharmaceutically acceptable carrier. The invention also applies to the new compounds among the trichothecene derivatives that can be used as active ingredients in the methods and preparations, and these were previously designated by the letters A, B, C, D, E and F. HE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14305499P | 1999-07-06 | 1999-07-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0202388A2 true HUP0202388A2 (en) | 2002-11-28 |
| HUP0202388A3 HUP0202388A3 (en) | 2004-03-01 |
Family
ID=22502402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202388A HUP0202388A3 (en) | 1999-07-06 | 2000-07-06 | Method and composition for regulating gut motility and food intake and the novel activ ingredients |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1196164A2 (en) |
| JP (1) | JP2003507472A (en) |
| CN (1) | CN1370066A (en) |
| AU (1) | AU763751B2 (en) |
| BR (1) | BR0012246A (en) |
| CA (1) | CA2374358A1 (en) |
| CZ (1) | CZ200213A3 (en) |
| HU (1) | HUP0202388A3 (en) |
| IL (1) | IL147312A0 (en) |
| MX (1) | MXPA02000014A (en) |
| NO (1) | NO20020038L (en) |
| PL (1) | PL353593A1 (en) |
| WO (1) | WO2001001968A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20031906A3 (en) * | 2001-01-11 | 2003-11-12 | Enpharma L. P. | Novel multi-ring organic compounds for regulating gut motility and food intake |
| AU2003246490A1 (en) * | 2002-07-18 | 2004-02-09 | Tony Durst | A multi-ring regulator of gut motility and food intake |
| CN101248791B (en) * | 2008-04-14 | 2010-04-14 | 中国科学院南海海洋研究所 | Applications of using macrocyclic single-terminal Spp compound as plants bactericidal agent |
| UA118339C2 (en) * | 2012-09-03 | 2019-01-10 | Біогайа Аб | A method for selection of agents influencing intestinal motility disorders and pain |
| KR101971860B1 (en) * | 2016-01-25 | 2019-04-26 | 부산대학교 산학협력단 | Method for controlling expression of poly immunoglobulin receptor protein by ribosome inactivation |
| KR102006917B1 (en) * | 2016-06-01 | 2019-08-02 | 부산대학교 산학협력단 | Pharmaceutical composition comprising ribosome-binding agent for preventing or treating low density lipoprotein-related disease |
-
2000
- 2000-07-06 CN CN00811624A patent/CN1370066A/en active Pending
- 2000-07-06 AU AU59568/00A patent/AU763751B2/en not_active Ceased
- 2000-07-06 BR BR0012246-7A patent/BR0012246A/en not_active IP Right Cessation
- 2000-07-06 CZ CZ200213A patent/CZ200213A3/en unknown
- 2000-07-06 IL IL14731200A patent/IL147312A0/en unknown
- 2000-07-06 PL PL00353593A patent/PL353593A1/en unknown
- 2000-07-06 JP JP2001518668A patent/JP2003507472A/en active Pending
- 2000-07-06 MX MXPA02000014A patent/MXPA02000014A/en unknown
- 2000-07-06 EP EP00945476A patent/EP1196164A2/en not_active Withdrawn
- 2000-07-06 CA CA002374358A patent/CA2374358A1/en not_active Abandoned
- 2000-07-06 HU HU0202388A patent/HUP0202388A3/en unknown
- 2000-07-06 WO PCT/CA2000/000790 patent/WO2001001968A2/en not_active Application Discontinuation
-
2002
- 2002-01-04 NO NO20020038A patent/NO20020038L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1370066A (en) | 2002-09-18 |
| AU763751B2 (en) | 2003-07-31 |
| NO20020038D0 (en) | 2002-01-04 |
| NO20020038L (en) | 2002-02-27 |
| PL353593A1 (en) | 2003-12-01 |
| WO2001001968A2 (en) | 2001-01-11 |
| HUP0202388A3 (en) | 2004-03-01 |
| JP2003507472A (en) | 2003-02-25 |
| WO2001001968A3 (en) | 2001-09-27 |
| IL147312A0 (en) | 2002-08-14 |
| AU5956800A (en) | 2001-01-22 |
| CZ200213A3 (en) | 2002-08-14 |
| EP1196164A2 (en) | 2002-04-17 |
| CA2374358A1 (en) | 2001-01-11 |
| MXPA02000014A (en) | 2003-07-21 |
| BR0012246A (en) | 2002-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |