HUP0202237A2 - Amine-modified pseudomycin compounds, pharmaceutical composition comprising thereof and their use - Google Patents
Amine-modified pseudomycin compounds, pharmaceutical composition comprising thereof and their useInfo
- Publication number
- HUP0202237A2 HUP0202237A2 HU0202237A HUP0202237A HUP0202237A2 HU P0202237 A2 HUP0202237 A2 HU P0202237A2 HU 0202237 A HU0202237 A HU 0202237A HU P0202237 A HUP0202237 A HU P0202237A HU P0202237 A2 HUP0202237 A2 HU P0202237A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- amine
- alkyl
- pharmaceutical composition
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 phenyl- Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
A találmány tárgyát az (I) általános képletű vegyületek, amelyeknél azáltalános képletben R jelentése szubsztituált alkil-, karboxamido-,fenil-, amelyben bifenil-, trifenil-, 2-hidroxi-(2-4 szénatomosalkil)fenil-, piridilcsoport, vagy -(CH2)-NRm-(13-18 szénatomosalkil)-csoport, ahol Rm jelentése hidrogénatom, metilcsoport vagy -C(O)CH3 csoport; R1 jelentése egymástól függetlenül formil-,acilalkil-acilalkilamin-, acil-azaalkil-, aciloxialkén, aciloxiaril-,vagy valamely acilmetilén-karbamát, ahol az általános képletben az R1szubsztituensek legalább egyike hidrogénatomtól eltérő; R2 és R3jelentése egymástól függetlenül alkoxi- vagy alkilaminocsoport,illetve ezen vegyületek gyógyászatilag elfogadható sói és szolvátjaiképezik. Szintén a találmány tárgyát képezi ezen vegyületekalkalmazása gombafertőzések elleni gyógyszerkészítményekelőállításánál, az ezen vegyületeket tartalmazó gyógyszerkészítmények,illetve eljárás állatok gombafertőzéseinek kezelésére. ÓThe subject of the invention is the compounds of general formula (I), in which R in the formula is substituted alkyl-, carboxamido-, phenyl-, in which biphenyl-, triphenyl-, 2-hydroxy-(2-4 carbon atom alkyl)phenyl-, pyridyl group, or - (CH2)-NRm-(C13-18 alkyl) where Rm is hydrogen, methyl or -C(O)CH3; R1 independently means formyl, acylalkyl-acylalkylamine, acyl-azaalkyl, acyloxyalkene, acyloxyaryl, or an acylmethylene carbamate, where at least one of the R1 substituents in the general formula is different from a hydrogen atom; The meaning of R2 and R3 independently of each other is an alkoxy or alkylamino group, or the pharmaceutically acceptable salts and solvates of these compounds. Also the subject of the invention is the use of these compounds in the production of pharmaceutical preparations against fungal infections, the pharmaceutical preparations containing these compounds, and a method for the treatment of fungal infections in animals. HE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14383999P | 1999-07-15 | 1999-07-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0202237A2 true HUP0202237A2 (en) | 2002-11-28 |
| HUP0202237A3 HUP0202237A3 (en) | 2002-12-28 |
Family
ID=22505899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202237A HUP0202237A3 (en) | 1999-07-15 | 2000-06-08 | Amine-modified pseudomycin compounds, pharmaceutical composition comprising thereof and their use |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1198472A1 (en) |
| JP (1) | JP2003505398A (en) |
| CN (1) | CN1361790A (en) |
| AU (1) | AU5453100A (en) |
| BR (1) | BR0013168A (en) |
| CA (1) | CA2379317A1 (en) |
| EA (1) | EA200200163A1 (en) |
| HU (1) | HUP0202237A3 (en) |
| MX (1) | MXPA02000320A (en) |
| NO (1) | NO20020194L (en) |
| WO (1) | WO2001005816A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576298A (en) * | 1992-11-30 | 1996-11-19 | Research And Development Institute, Inc. At Montana State University | Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity |
-
2000
- 2000-06-08 JP JP2001511473A patent/JP2003505398A/en not_active Withdrawn
- 2000-06-08 BR BR0013168-7A patent/BR0013168A/en not_active Application Discontinuation
- 2000-06-08 EA EA200200163A patent/EA200200163A1/en unknown
- 2000-06-08 CA CA002379317A patent/CA2379317A1/en not_active Abandoned
- 2000-06-08 CN CN00810326A patent/CN1361790A/en active Pending
- 2000-06-08 AU AU54531/00A patent/AU5453100A/en not_active Abandoned
- 2000-06-08 WO PCT/US2000/015019 patent/WO2001005816A1/en not_active Application Discontinuation
- 2000-06-08 EP EP00939447A patent/EP1198472A1/en not_active Withdrawn
- 2000-06-08 HU HU0202237A patent/HUP0202237A3/en unknown
- 2000-06-08 MX MXPA02000320A patent/MXPA02000320A/en not_active Application Discontinuation
-
2002
- 2002-01-14 NO NO20020194A patent/NO20020194L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1361790A (en) | 2002-07-31 |
| AU5453100A (en) | 2001-02-05 |
| EA200200163A1 (en) | 2002-06-27 |
| WO2001005816A1 (en) | 2001-01-25 |
| JP2003505398A (en) | 2003-02-12 |
| EP1198472A1 (en) | 2002-04-24 |
| NO20020194D0 (en) | 2002-01-14 |
| HUP0202237A3 (en) | 2002-12-28 |
| CA2379317A1 (en) | 2001-01-25 |
| BR0013168A (en) | 2002-04-02 |
| MXPA02000320A (en) | 2002-06-21 |
| NO20020194L (en) | 2002-03-14 |
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