HUP0202032A2 - Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump - Google Patents

Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump

Info

Publication number
HUP0202032A2
HUP0202032A2 HU0202032A HUP0202032A HUP0202032A2 HU P0202032 A2 HUP0202032 A2 HU P0202032A2 HU 0202032 A HU0202032 A HU 0202032A HU P0202032 A HUP0202032 A HU P0202032A HU P0202032 A2 HUP0202032 A2 HU P0202032A2
Authority
HU
Hungary
Prior art keywords
nanoemulsion
intake
mucous membrane
throogh
spray
Prior art date
Application number
HU0202032A
Other languages
Hungarian (hu)
Inventor
D. Endre Radics
Original Assignee
D. Endre Radics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by D. Endre Radics filed Critical D. Endre Radics
Priority to HU0202032A priority Critical patent/HUP0202032A2/en
Publication of HU0202032D0 publication Critical patent/HU0202032D0/hu
Priority to AU2003244885A priority patent/AU2003244885A1/en
Priority to PCT/HU2003/000049 priority patent/WO2004000274A1/en
Publication of HUP0202032A2 publication Critical patent/HUP0202032A2/en
Priority to GBGB0500594.7A priority patent/GB0500594D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Jelen találmány a bioaktív anyagok (étrendkiegészítők, gyógyszerek ésgyógyhatású anyagok) összetételeit, formáját és emberi szervezetbevaló bevitelük új módszerét írja le. A találmány a nanoemulziókhatóanyagszállító rendszerként való alkalmazásának, valamint aszájüreg nyálkahártyáján keresztüli felszívódás módszerénekkombinációja. A nanoemulzió egyaránt tartalmaz vízben és zsírbanoldódó bioaktív anyagokat, melyek a hagyományos emulgeálószerek nélkülis stabil oldatot alkotnak. A heterogén oldat zsír- ésvízrészecskéinek két fázisra való szétválását tisztán természetesfoszfolipidek hozzáadása akadályozza meg. Az átlagban 0,00005- 0,0001mm átmérőjű részecskékből álló nanoemulzió mechanikus sprayszórófejenkeresztül kifújva kerül be a szájüregbe, majd a száj nyálkahártyájánfelszívódva jut be a véráramba és hasznosul a szervezetben. ÓThe present invention describes the composition, form and new method of their intake into the human body of bioactive substances (dietary supplements, drugs and medicinal substances). The invention is a combination of the use of nanoemulsion as an active agent delivery system and the method of absorption through the oral mucosa. The nanoemulsion contains both water- and fat-soluble bioactive substances, which form a stable solution without traditional emulsifiers. The separation of the fat and water particles of the heterogeneous solution into two phases is prevented by the addition of purely natural phospholipids. The nanoemulsion, consisting of particles with an average diameter of 0.00005-0.0001 mm, is blown into the oral cavity through a mechanical spray nozzle, then absorbed by the mucous membrane of the mouth, enters the bloodstream and is used in the body. HE

HU0202032A 2002-06-19 2002-06-19 Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump HUP0202032A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HU0202032A HUP0202032A2 (en) 2002-06-19 2002-06-19 Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump
AU2003244885A AU2003244885A1 (en) 2002-06-19 2003-06-18 Oral delivery of biological active agents in a nanoemulsion formulation to the human body
PCT/HU2003/000049 WO2004000274A1 (en) 2002-06-19 2003-06-18 Oral delivery of biological active agents in a nanoemulsion formulation to the human body
GBGB0500594.7A GB0500594D0 (en) 2002-06-19 2005-01-12 Oral delivery of biological active agents in a nanoemulsion formulation to the human body

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0202032A HUP0202032A2 (en) 2002-06-19 2002-06-19 Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump

Publications (2)

Publication Number Publication Date
HU0202032D0 HU0202032D0 (en) 2002-08-28
HUP0202032A2 true HUP0202032A2 (en) 2004-10-28

Family

ID=89980533

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202032A HUP0202032A2 (en) 2002-06-19 2002-06-19 Bioactive materials in nanoemulsion form for intake to human organ throogh the mucous membrane of mouth cavity by spray of mechanic pump

Country Status (4)

Country Link
AU (1) AU2003244885A1 (en)
GB (1) GB0500594D0 (en)
HU (1) HUP0202032A2 (en)
WO (1) WO2004000274A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3988168B1 (en) * 2006-04-07 2007-10-10 伸司 嶋田 Composition having brain cell activity effect by ginkgo biloba leaf nanoparticle
JP5459939B2 (en) * 2006-06-09 2014-04-02 富士フイルム株式会社 Carotenoid-containing emulsion composition, method for producing the same, food containing the same, and cosmetics
CN101759727B (en) * 2009-09-30 2013-03-27 钱娟 Nano-scale pine bark extract and preparation method thereof
EP2512648B1 (en) * 2009-12-15 2018-01-24 Emultec S.r.L. Nanoemulsion, method for its preparation and use
US9468626B2 (en) 2014-03-13 2016-10-18 Chiesi Farmaceutici S.P.A. Melatonin-based formulations for parenteral administration

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525341A (en) * 1984-04-09 1985-06-25 Mayor Pharmaceutical Laboratories, Inc. Method of administering vitamins
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5891465A (en) * 1996-05-14 1999-04-06 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth
FR2788007B1 (en) * 1999-01-05 2001-02-09 Oreal NANOEMULSION BASED ON BLOCK COPOLYMERS OF ETHYLENE OXIDE AND PROPYLENE OXIDE, AND ITS USES IN THE COSMETIC, DERMATOLOGICAL AND / OR OPHTHALMOLOGICAL FIELDS
FR2804016B1 (en) * 2000-01-21 2006-07-28 Oreal NANEMULSION CONTAINING AMPHIPHILIC LIPIDS AND PEG ESTER AND USES THEREOF
FR2804014B1 (en) * 2000-01-21 2002-10-18 Oreal NANOEMULSION BASED ON AMPHIPHILIC LIPIDS AND CATIONIC POLYMERS AND USES
JP4549625B2 (en) * 2002-01-05 2010-09-22 株式會社アモーレパシフィック Finely emulsified particles containing ginseng saponin metabolites as active ingredients, a method for producing the same, and a cosmetic composition for preventing skin aging containing the same

Also Published As

Publication number Publication date
HU0202032D0 (en) 2002-08-28
AU2003244885A1 (en) 2004-01-06
GB0500594D0 (en) 2005-02-16
WO2004000274A1 (en) 2003-12-31

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees