HUP0200583A2 - A process for the preparation of aziridinyl epothilones from oxiranyl epothilones - Google Patents
A process for the preparation of aziridinyl epothilones from oxiranyl epothilonesInfo
- Publication number
- HUP0200583A2 HUP0200583A2 HU0200583A HUP0200583A HUP0200583A2 HU P0200583 A2 HUP0200583 A2 HU P0200583A2 HU 0200583 A HU0200583 A HU 0200583A HU P0200583 A HUP0200583 A HU P0200583A HU P0200583 A2 HUP0200583 A2 HU P0200583A2
- Authority
- HU
- Hungary
- Prior art keywords
- epothilones
- preparation
- aziridinyl
- oxiranyl
- oxiranyl epothilones
- Prior art date
Links
- -1 aziridinyl epothilones Chemical class 0.000 title 2
- 229930013356 epothilone Natural products 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12693699P | 1999-03-29 | 1999-03-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0200583A2 true HUP0200583A2 (en) | 2002-06-29 |
| HUP0200583A3 HUP0200583A3 (en) | 2004-07-28 |
Family
ID=22427457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0200583A HUP0200583A3 (en) | 1999-03-29 | 2000-03-20 | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1165067A4 (en) |
| JP (1) | JP2002540154A (en) |
| KR (1) | KR20020005639A (en) |
| AU (1) | AU4017400A (en) |
| CA (1) | CA2368658A1 (en) |
| HU (1) | HUP0200583A3 (en) |
| IL (1) | IL144590A0 (en) |
| MX (1) | MXPA01009709A (en) |
| WO (1) | WO2000057874A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0977563B1 (en) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| ATE452896T1 (en) | 2002-03-12 | 2010-01-15 | Bristol Myers Squibb Co | C3-CYANOEPOTHILONE DERIVATIVES |
| EP1674098A1 (en) * | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water |
| EP2065054A1 (en) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Combinations comprising a prostaglandin and uses thereof |
| DE102007059752A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Functionalized solid polymer nanoparticles containing epothilones |
| EP2070521A1 (en) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Surface-modified nanoparticles |
| EP2210584A1 (en) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer |
| MX2012013100A (en) | 2010-05-18 | 2013-01-22 | Cerulean Pharma Inc | Compositions and methods for treatment of autoimmune and other diseases. |
| US9717803B2 (en) | 2011-12-23 | 2017-08-01 | Innate Pharma | Enzymatic conjugation of polypeptides |
| WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
| WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| US10611824B2 (en) | 2013-03-15 | 2020-04-07 | Innate Pharma | Solid phase TGase-mediated conjugation of antibodies |
| US10071169B2 (en) | 2013-06-20 | 2018-09-11 | Innate Pharma | Enzymatic conjugation of polypeptides |
| KR20160042871A (en) | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | Enzymatic conjugation of polypeptides |
| WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59609305D1 (en) * | 1995-11-17 | 2002-07-11 | Biotechnolog Forschung Gmbh | Epothilone derivatives and their production |
| US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
-
2000
- 2000-03-20 HU HU0200583A patent/HUP0200583A3/en unknown
- 2000-03-20 CA CA002368658A patent/CA2368658A1/en not_active Abandoned
- 2000-03-20 KR KR1020017012398A patent/KR20020005639A/en not_active Application Discontinuation
- 2000-03-20 AU AU40174/00A patent/AU4017400A/en not_active Abandoned
- 2000-03-20 IL IL14459000A patent/IL144590A0/en unknown
- 2000-03-20 WO PCT/US2000/007426 patent/WO2000057874A1/en active Search and Examination
- 2000-03-20 MX MXPA01009709A patent/MXPA01009709A/en unknown
- 2000-03-20 JP JP2000607625A patent/JP2002540154A/en active Pending
- 2000-03-20 EP EP00919495A patent/EP1165067A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002540154A (en) | 2002-11-26 |
| EP1165067A4 (en) | 2002-06-26 |
| IL144590A0 (en) | 2002-05-23 |
| HUP0200583A3 (en) | 2004-07-28 |
| EP1165067A1 (en) | 2002-01-02 |
| WO2000057874A1 (en) | 2000-10-05 |
| CA2368658A1 (en) | 2000-10-05 |
| KR20020005639A (en) | 2002-01-17 |
| MXPA01009709A (en) | 2002-05-14 |
| AU4017400A (en) | 2000-10-16 |
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