HUP0105291A2 - Pharmaceutical compositions for the treatment of indigestion and related diseases - Google Patents
Pharmaceutical compositions for the treatment of indigestion and related diseasesInfo
- Publication number
- HUP0105291A2 HUP0105291A2 HU0105291A HUP0105291A HUP0105291A2 HU P0105291 A2 HUP0105291 A2 HU P0105291A2 HU 0105291 A HU0105291 A HU 0105291A HU P0105291 A HUP0105291 A HU P0105291A HU P0105291 A2 HUP0105291 A2 HU P0105291A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- fat
- improving
- gastrointestinal
- activity
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 201000006549 dyspepsia Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 abstract 4
- 208000024891 symptom Diseases 0.000 abstract 3
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 abstract 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 230000029087 digestion Effects 0.000 abstract 2
- 230000002496 gastric effect Effects 0.000 abstract 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract 2
- 235000005875 quercetin Nutrition 0.000 abstract 2
- 229960001285 quercetin Drugs 0.000 abstract 2
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 abstract 2
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 2
- 229960001661 ursodiol Drugs 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 210000000013 bile duct Anatomy 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 235000013373 food additive Nutrition 0.000 abstract 1
- 239000002778 food additive Substances 0.000 abstract 1
- 235000012041 food component Nutrition 0.000 abstract 1
- 239000005428 food component Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A composition comprising a bile acid and a bioflavonoid component has synergistic activity for treating or preventing gastrointestinal diseases and diseases of the liver and bile duct, and improving digestion and absorption of fat soluble food components and food additives. An independent claim is also included for use of the composition for enhancing the function of the digestive system, treating or preventing diseases associated with damaged digestion or absorption of fat-soluble food, also improving the eye and premenstrual symptoms, and improving topical activity of fat soluble substances. ACTIVITY : Antiinflammatory; Gastrointestinal; Gynecological; Opthalmological. A study was carried out in 48 patients affected by either non ulcer dyspepsia, biliary dyskinesis or irritable bowel syndrome. 24 Patients with unrestricted fat diet received only 150 mg ursodeoxycholic acid (group A) and 24 received only bioflavonoid (300 mg quercetin) (group B), for 3 months. After one month wash out, both groups received ursodeoxycholic acid + quercetin (group C) for 3 months. The overall (psychosomatic) condition and subjective symptoms were compared to the results of a control group. Gastrointestinal symptoms were evaluated using a grading system. The overall condition improved in 67 % of cases in group A, 45 % in group B and 89 % in group C. MECHANISM OF ACTION : None given.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105291A HUP0105291A2 (en) | 2001-12-11 | 2001-12-11 | Pharmaceutical compositions for the treatment of indigestion and related diseases |
| US10/450,359 US20040038952A1 (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treatment of digestive disorders and associated diseases |
| AU2002216301A AU2002216301A1 (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treatment of digestive disorders and associated diseases |
| JP2002549265A JP2004515532A (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treating digestive disorders and related diseases |
| EP01270334A EP1408982A1 (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treatment of digestive disorders and associated diseases |
| CA002445091A CA2445091A1 (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treatment of digestive disorders and associated diseases |
| PCT/HU2001/000123 WO2002047694A1 (en) | 2000-12-13 | 2001-12-13 | Pharmaceutical compositions for treatment of digestive disorders and associated diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105291A HUP0105291A2 (en) | 2001-12-11 | 2001-12-11 | Pharmaceutical compositions for the treatment of indigestion and related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU0105291D0 HU0105291D0 (en) | 2002-02-28 |
| HUP0105291A2 true HUP0105291A2 (en) | 2002-08-28 |
Family
ID=89979980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105291A HUP0105291A2 (en) | 2000-12-13 | 2001-12-11 | Pharmaceutical compositions for the treatment of indigestion and related diseases |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP0105291A2 (en) |
-
2001
- 2001-12-11 HU HU0105291A patent/HUP0105291A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU0105291D0 (en) | 2002-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |