HUP0105289A2 - Calpain activators - Google Patents
Calpain activatorsInfo
- Publication number
- HUP0105289A2 HUP0105289A2 HU0105289A HUP0105289A HUP0105289A2 HU P0105289 A2 HUP0105289 A2 HU P0105289A2 HU 0105289 A HU0105289 A HU 0105289A HU P0105289 A HUP0105289 A HU P0105289A HU P0105289 A2 HUP0105289 A2 HU P0105289A2
- Authority
- HU
- Hungary
- Prior art keywords
- calpain
- peptides
- activators
- subject
- calpastatin
- Prior art date
Links
- 102000007590 Calpain Human genes 0.000 title abstract 2
- 108010032088 Calpain Proteins 0.000 title abstract 2
- 239000012190 activator Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102100035037 Calpastatin Human genes 0.000 abstract 1
- 206010070834 Sensitisation Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 108010090633 calpain activator Proteins 0.000 abstract 1
- 108010044208 calpastatin Proteins 0.000 abstract 1
- ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008313 sensitization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgyát a kalpasztatin négy (gátló) doménjének A és Cszubdoménje bármelyikének szekvenciájából származó izolált kalpain-aktivátor peptidek és azok bármilyen funkcionális homológjai vagyvariánsai képezik. Szintén a találmány tárgyát képezik peptidekgyógyászati alkalmazásra. A találmány tárgyát képezik továbbákészítmények, reagenskészletek és kutatási eszközök, amelyek apeptideket tartalmazzák, valamint eljárások kalpain aktiválásáraés/vagy érzékenyítésre. ÓThe subject of the invention is isolated calpain-activator peptides derived from the sequence of any of the four (inhibitory) domains A and C of calpastatin and any functional homologues or variants thereof. Also subject to the invention are peptides for medical use. The invention also includes compositions, reagent kits and research tools containing the peptides, as well as methods for calpain activation and/or sensitization. HE
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105289A HUP0105289A2 (en) | 2001-12-10 | 2001-12-10 | Calpain activators |
| PCT/HU2002/000140 WO2003050141A2 (en) | 2001-12-10 | 2002-12-10 | Calpain activators |
| AU2002348941A AU2002348941A1 (en) | 2001-12-10 | 2002-12-10 | Calpain activators |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105289A HUP0105289A2 (en) | 2001-12-10 | 2001-12-10 | Calpain activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU0105289D0 HU0105289D0 (en) | 2002-02-28 |
| HUP0105289A2 true HUP0105289A2 (en) | 2003-06-28 |
Family
ID=89979978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105289A HUP0105289A2 (en) | 2001-12-10 | 2001-12-10 | Calpain activators |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002348941A1 (en) |
| HU (1) | HUP0105289A2 (en) |
| WO (1) | WO2003050141A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1632245A1 (en) * | 2004-09-02 | 2006-03-08 | Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus | ICA512 couples insulin secretion and gene expression in Beta-cells |
| WO2010115745A2 (en) * | 2009-03-30 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarkers, methods and kits for the diagnosis of rheumatoid arthritis |
-
2001
- 2001-12-10 HU HU0105289A patent/HUP0105289A2/en unknown
-
2002
- 2002-12-10 WO PCT/HU2002/000140 patent/WO2003050141A2/en not_active Application Discontinuation
- 2002-12-10 AU AU2002348941A patent/AU2002348941A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002348941A1 (en) | 2003-06-23 |
| AU2002348941A8 (en) | 2003-06-23 |
| HU0105289D0 (en) | 2002-02-28 |
| WO2003050141B1 (en) | 2004-02-12 |
| WO2003050141A2 (en) | 2003-06-19 |
| WO2003050141A3 (en) | 2003-12-11 |
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