HUP0105205A2 - Pharmaceutical composition containing metformin and a hydroxylamine derivative - Google Patents
Pharmaceutical composition containing metformin and a hydroxylamine derivativeInfo
- Publication number
- HUP0105205A2 HUP0105205A2 HU0105205A HUP0105205A HUP0105205A2 HU P0105205 A2 HUP0105205 A2 HU P0105205A2 HU 0105205 A HU0105205 A HU 0105205A HU P0105205 A HUP0105205 A HU P0105205A HU P0105205 A2 HUP0105205 A2 HU P0105205A2
- Authority
- HU
- Hungary
- Prior art keywords
- propoxy
- group
- chloride
- benzimidoyl chloride
- alk
- Prior art date
Links
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003105 metformin Drugs 0.000 title abstract 2
- 150000002443 hydroxylamines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- -1 2 -chloro-N-[2-(morpholin-4-yl)-ethoxy]-benzimidoyl chloride Chemical compound 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- IAHMNSCQDXESII-UHFFFAOYSA-N benzenecarboximidoyl chloride Chemical compound ClC(=N)C1=CC=CC=C1 IAHMNSCQDXESII-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- WFPFEBXJYWAZGV-UHFFFAOYSA-N n-[3-(4-methylpiperazin-1-yl)propoxy]pyridine-3-carboximidoyl chloride Chemical compound C1CN(C)CCN1CCCON=C(Cl)C1=CC=CN=C1 WFPFEBXJYWAZGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya orális gyógyászati kompozíció diabetes mellituskezelésére, amely hatóanyagként metformin (N,N-dimetilimido-dikarbonimid diamid) vagy annak egy savaddiciós sója és egy (I)általános képletű vegyület, ahol Ar jelentése piridil-, tienil-,fenil-, halogénfenil- vagy nitrofenilcsoport, X jelentése halogénatom,n értéke nulla vagy 1, Z jelentése metiléncsoport, oxigénatom vagyAlk-N= csoport, ahol Alk jelentése 1-4 szénatomos alkilcsoport, Yjelentése hidrogénatom vagy hidroxilcsoport, vagy annak egysavaddiciós sója kombinációját tartalmazza. Ugyancsak a találmánytárgya 3-nitro-N-[3-(piperidin-1-il)-propoxi]-benzimidoil-klorid, N-[2-hidroxi-3-piperidin-l-il)-propoxi]-benzimidoil-klorid, N-[3-(4-metil-piperazin-1-il)propoxi]-piridin-3-karboximidoil-klorid, 3-klór-N-[3-(piperedin-1-il)-propoxi]-benzimidoilklorid és 2-klór-N-[2-(morfolin-4-il)-etoxi]-benzimidoil-klorid, valamint e vegyületeksavaddiciós sóinak alkalmazása diabetes mellitus kezelésérehasználható orális gyógyászati készítmények előállítására. ÓThe subject of the invention is an oral medicinal composition for the treatment of diabetes mellitus, the active ingredient of which is metformin (N,N-dimethylimido-dicarbonimide diamide) or an acid addition salt thereof and a compound of general formula (I), where Ar is pyridyl-, thienyl-, phenyl-, halophenyl- or nitrophenyl group, X is a halogen atom, n is zero or 1, Z is a methylene group, an oxygen atom or an Alk-N= group, where Alk is an alkyl group with 1 to 4 carbon atoms, Y is a hydrogen atom or a hydroxyl group, or a combination of its monoacid addition salt. The subject of the invention is also 3-nitro-N-[3-(piperidin-1-yl)-propoxy]-benzimidoyl chloride, N-[2-hydroxy-3-piperidin-1-yl)-propoxy]-benzimidoyl chloride, N-[3-(4-methylpiperazin-1-yl)propoxy]pyridine-3-carboximidoyl chloride, 3-chloro-N-[3-(piperedin-1-yl)propoxy]benzimidoyl chloride and 2 -chloro-N-[2-(morpholin-4-yl)-ethoxy]-benzimidoyl chloride, as well as the use of acid addition salts of these compounds for the production of oral medicinal preparations for the treatment of diabetes mellitus. HE
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105205A HUP0105205A2 (en) | 2001-11-29 | 2001-11-29 | Pharmaceutical composition containing metformin and a hydroxylamine derivative |
| PCT/HU2002/000132 WO2003045387A1 (en) | 2001-11-29 | 2002-11-28 | Pharmaceutical composition with combined active agents containing metformin and a hydroxylamine derivative |
| AU2002347402A AU2002347402A1 (en) | 2001-11-29 | 2002-11-28 | Pharmaceutical composition with combined active agents containing metformin and a hydroxylamine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105205A HUP0105205A2 (en) | 2001-11-29 | 2001-11-29 | Pharmaceutical composition containing metformin and a hydroxylamine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU0105205D0 HU0105205D0 (en) | 2002-01-28 |
| HUP0105205A2 true HUP0105205A2 (en) | 2003-08-28 |
Family
ID=89979939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105205A HUP0105205A2 (en) | 2001-11-29 | 2001-11-29 | Pharmaceutical composition containing metformin and a hydroxylamine derivative |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002347402A1 (en) |
| HU (1) | HUP0105205A2 (en) |
| WO (1) | WO2003045387A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804309B (en) * | 2012-11-09 | 2019-08-02 | 广州喜鹊医药有限公司 | A kind of chlorine oxime compound and preparation method thereof and the application in pharmacy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU222994B1 (en) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hydroxylamine derivatives and use thereof in the preparation of a pharmaceutical compositions for enhancing of molecular chaperon production of cells |
-
2001
- 2001-11-29 HU HU0105205A patent/HUP0105205A2/en unknown
-
2002
- 2002-11-28 AU AU2002347402A patent/AU2002347402A1/en not_active Abandoned
- 2002-11-28 WO PCT/HU2002/000132 patent/WO2003045387A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002347402A1 (en) | 2003-06-10 |
| HU0105205D0 (en) | 2002-01-28 |
| WO2003045387A1 (en) | 2003-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |