HUP0104509A3 - Angiogenesis inhibiting nitroaryl-derivatives process for their preparation and their use - Google Patents
Angiogenesis inhibiting nitroaryl-derivatives process for their preparation and their useInfo
- Publication number
- HUP0104509A3 HUP0104509A3 HU0104509A HUP0104509A HUP0104509A3 HU P0104509 A3 HUP0104509 A3 HU P0104509A3 HU 0104509 A HU0104509 A HU 0104509A HU P0104509 A HUP0104509 A HU P0104509A HU P0104509 A3 HUP0104509 A3 HU P0104509A3
- Authority
- HU
- Hungary
- Prior art keywords
- nitroaryl
- preparation
- angiogenesis inhibiting
- derivatives process
- derivatives
- Prior art date
Links
- 230000033115 angiogenesis Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11088598A | 1998-07-06 | 1998-07-06 | |
| PCT/US1999/015252 WO2000001383A1 (en) | 1998-07-06 | 1999-07-06 | Angiogenesis inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104509A2 HUP0104509A2 (en) | 2002-04-29 |
| HUP0104509A3 true HUP0104509A3 (en) | 2002-05-28 |
Family
ID=22335452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104509A HUP0104509A3 (en) | 1998-07-06 | 1999-07-06 | Angiogenesis inhibiting nitroaryl-derivatives process for their preparation and their use |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1094812A4 (en) |
| JP (1) | JP2002519377A (en) |
| KR (1) | KR20010079497A (en) |
| CN (1) | CN1308534A (en) |
| AU (1) | AU4862599A (en) |
| BR (1) | BR9911885A (en) |
| CA (1) | CA2336774A1 (en) |
| HU (1) | HUP0104509A3 (en) |
| ID (1) | ID28125A (en) |
| NO (1) | NO20010085L (en) |
| PL (1) | PL345574A1 (en) |
| SK (1) | SK242001A3 (en) |
| WO (1) | WO2000001383A1 (en) |
| ZA (1) | ZA200007405B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
| US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| WO2003079442A1 (en) | 2002-03-20 | 2003-09-25 | Koninklijke Philips Electronics N.V. | Active matrix electroluminescent display devices, and their manufacture |
| EP1694349B1 (en) * | 2003-12-03 | 2013-10-09 | The Scripps Research Institute | Integrin alpha ii beta3 specific antibodies and peptides |
| EP3381460A4 (en) * | 2015-11-26 | 2019-07-17 | Daiwa Pharmaceutical Co., Ltd | Angiogenesis inhibitor |
| CN109535035A (en) * | 2019-01-08 | 2019-03-29 | 吉尔生化（上海）有限公司 | A kind of preparation method of the N- benzyloxycarbonyl group -3- amino-alanine tert-butyl ester |
| CN113773260B (en) * | 2021-08-26 | 2023-09-22 | 华南师范大学 | Covalent-like organic material and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0664792B1 (en) * | 1992-10-14 | 2000-01-05 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
| CA2150550A1 (en) * | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
| CA2190870A1 (en) * | 1994-05-27 | 1995-12-07 | George D. Hartman | Compounds for inhibiting osteoclast-mediated bone resorption |
| JP2000508319A (en) * | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αvβ3 antagonist |
-
1999
- 1999-07-06 AU AU48625/99A patent/AU4862599A/en not_active Abandoned
- 1999-07-06 KR KR1020017000144A patent/KR20010079497A/en not_active Application Discontinuation
- 1999-07-06 CN CN99808280A patent/CN1308534A/en active Pending
- 1999-07-06 PL PL99345574A patent/PL345574A1/en not_active Application Discontinuation
- 1999-07-06 BR BR9911885-8A patent/BR9911885A/en not_active Application Discontinuation
- 1999-07-06 EP EP99932289A patent/EP1094812A4/en not_active Withdrawn
- 1999-07-06 CA CA002336774A patent/CA2336774A1/en not_active Abandoned
- 1999-07-06 ID IDW20010172A patent/ID28125A/en unknown
- 1999-07-06 SK SK24-2001A patent/SK242001A3/en unknown
- 1999-07-06 WO PCT/US1999/015252 patent/WO2000001383A1/en not_active Application Discontinuation
- 1999-07-06 HU HU0104509A patent/HUP0104509A3/en unknown
- 1999-07-06 JP JP2000557829A patent/JP2002519377A/en active Pending
-
2000
- 2000-12-12 ZA ZA200007405A patent/ZA200007405B/en unknown
-
2001
- 2001-01-05 NO NO20010085A patent/NO20010085L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104509A2 (en) | 2002-04-29 |
| CN1308534A (en) | 2001-08-15 |
| ID28125A (en) | 2001-05-03 |
| SK242001A3 (en) | 2001-10-08 |
| KR20010079497A (en) | 2001-08-22 |
| EP1094812A4 (en) | 2003-04-16 |
| AU4862599A (en) | 2000-01-24 |
| ZA200007405B (en) | 2001-09-21 |
| NO20010085L (en) | 2001-03-05 |
| NO20010085D0 (en) | 2001-01-05 |
| WO2000001383A1 (en) | 2000-01-13 |
| CA2336774A1 (en) | 2000-01-13 |
| BR9911885A (en) | 2001-03-27 |
| PL345574A1 (en) | 2001-12-17 |
| EP1094812A1 (en) | 2001-05-02 |
| JP2002519377A (en) | 2002-07-02 |
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