HUP0104302A2 - Inhibition of the formation of vascular hyperpermeability - Google Patents

Inhibition of the formation of vascular hyperpermeability

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Publication number
HUP0104302A2
HUP0104302A2 HU0104302A HUP0104302A HUP0104302A2 HU P0104302 A2 HUP0104302 A2 HU P0104302A2 HU 0104302 A HU0104302 A HU 0104302A HU P0104302 A HUP0104302 A HU P0104302A HU P0104302 A2 HUP0104302 A2 HU P0104302A2
Authority
HU
Hungary
Prior art keywords
tyrosine kinase
vascular hyperpermeability
formation
vascular
inhibition
Prior art date
Application number
HU0104302A
Other languages
Hungarian (hu)
Inventor
Lee D. Arnold
Peter F. Bousquet
Original Assignee
Knoll Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Gmbh filed Critical Knoll Gmbh
Publication of HUP0104302A2 publication Critical patent/HUP0104302A2/en
Publication of HUP0104302A3 publication Critical patent/HUP0104302A3/en

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

A vaszkuláris hiperpermeabilitás számos olyan élettani történésbevezetője, amelyek gyakran káros hatással vannak a szervezetre. Azilyen történések közé tartoznak az ödémaképződés, a diapedezis, azérbelhártyán át zajló cserefolyamatok zavara, az extravazáció, abeszűrődések és izzadmányok, a kötőszövet közötti lerakódások (gyakrana sztróma abnormális proliferációjával társulva) és a vaszkulárishipotenzió. A vaszkuláris hiperpermeabilitás és az azt követőtörténések megakadályozhatók egy olyan vegyület beadásával, amely aVEGF tirozin-kináz-receptor (amely KDR tirozin-kináz néven is ismert)enzimaktivitását gátolja. Az előnyös vegyületek szelektíven gátolják aKDR tirozin-kináz működését, de nem gátolják az Flt-1 tirozin-kinázt,ami egy másik VEGF tirozin-kináz-receptor. ÓVascular hyperpermeability is an introduction to many physiological events that often have a harmful effect on the body. Such events include the formation of edema, diapedesis, disruption of exchange processes across the acetabular membrane, extravasation, fluid secretions and sweats, deposits between the connective tissue (often associated with abnormal proliferation of the stroma) and vascular hypertension. Vascular hyperpermeability and its sequelae can be prevented by administration of a compound that inhibits the enzyme activity of the VEGF receptor tyrosine kinase (also known as KDR tyrosine kinase). Preferred compounds selectively inhibit KDR tyrosine kinase, but do not inhibit Flt-1 tyrosine kinase, another VEGF tyrosine kinase receptor. HE

HU0104302A 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability HUP0104302A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10746298P 1998-11-06 1998-11-06
PCT/US1999/025903 WO2000027414A2 (en) 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability

Publications (2)

Publication Number Publication Date
HUP0104302A2 true HUP0104302A2 (en) 2002-03-28
HUP0104302A3 HUP0104302A3 (en) 2002-11-28

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ID=22316735

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104302A HUP0104302A3 (en) 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability

Country Status (19)

Country Link
EP (1) EP1126842A2 (en)
JP (1) JP2002529421A (en)
KR (1) KR20010080952A (en)
CN (1) CN1342077A (en)
AR (1) AR023912A1 (en)
AU (1) AU1908000A (en)
BG (1) BG105476A (en)
BR (1) BR9915139A (en)
CA (1) CA2347916A1 (en)
CO (1) CO5150183A1 (en)
CZ (1) CZ20011564A3 (en)
HU (1) HUP0104302A3 (en)
ID (1) ID29063A (en)
IL (1) IL142583A0 (en)
NO (1) NO20012218L (en)
PL (1) PL348163A1 (en)
SK (1) SK5052001A3 (en)
TR (1) TR200102278T2 (en)
WO (1) WO2000027414A2 (en)

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Publication number Publication date
KR20010080952A (en) 2001-08-25
HUP0104302A3 (en) 2002-11-28
NO20012218D0 (en) 2001-05-04
CN1342077A (en) 2002-03-27
BG105476A (en) 2002-02-28
CO5150183A1 (en) 2002-04-29
NO20012218L (en) 2001-06-18
WO2000027414A3 (en) 2000-09-08
WO2000027414A2 (en) 2000-05-18
TR200102278T2 (en) 2001-12-21
ID29063A (en) 2001-07-26
PL348163A1 (en) 2002-05-06
SK5052001A3 (en) 2002-10-08
BR9915139A (en) 2001-08-07
JP2002529421A (en) 2002-09-10
IL142583A0 (en) 2002-03-10
CZ20011564A3 (en) 2002-04-17
CA2347916A1 (en) 2000-05-18
AR023912A1 (en) 2002-09-04
EP1126842A2 (en) 2001-08-29
AU1908000A (en) 2000-05-29

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