HUP0004967A2 - New crystalline form of nestorone and process for the preparation thereof - Google Patents

New crystalline form of nestorone and process for the preparation thereof

Info

Publication number
HUP0004967A2
HUP0004967A2 HU0004967A HUP0004967A HUP0004967A2 HU P0004967 A2 HUP0004967 A2 HU P0004967A2 HU 0004967 A HU0004967 A HU 0004967A HU P0004967 A HUP0004967 A HU P0004967A HU P0004967 A2 HUP0004967 A2 HU P0004967A2
Authority
HU
Hungary
Prior art keywords
nesztoron
water
allotrope
active
allotrop
Prior art date
Application number
HU0004967A
Other languages
Hungarian (hu)
Inventor
Lajosne Dr Dancsi
Hegedues Bela Dr
Dora Bauer
Janos Csoergei
Csaba Molnar
Laszlone Pechy
Dr Nezdei Magdolna Hasznosne
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU0004967A priority Critical patent/HUP0004967A2/en
Publication of HU0004967D0 publication Critical patent/HU0004967D0/hu
Publication of HUP0004967A2 publication Critical patent/HUP0004967A2/en

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  • Medicinal Preparation (AREA)

Abstract

A novel crystal allotrope of 16-methylene-17-hydroxy-19-norpregn-4-en-3,20-dione-17-acetate (NESZTORON) is prepared as follows, e.g.: (i) at least 99% active NESZTORON of any morphology is dissolved in an organic solvent which is completely or partially miscible with water, for crystallisation; and (ii) the 'B' allotrope of NESZTORON is precipitated out using 0.1-5 times the volume of water. A novel crystal allotrop of 16-methylene-17-hydroxy-19-norpregn-4-en-3,20-dione-17-acetate (NESZTORON) is prepared as follows: (i) at least 99% active NESZTORON of any morphology is dissolved in an organic solvent which is completely or partially miscible with water, for crystallisation; (ii) the 'B' allotrop of NESZTORON is precipitated out using 0.1-5 times volume of water; and (iii) crystals are separated and optionally washed and dried. This novel 'B' allotrope of NESZTORON is formulated into solid or semi-liquid medicinal preparations that contain and release an even distribution of active matter in a given time period. Formulations find intravaginal applications, and in transdermal creams, gels, and plasters.
HU0004967A 2000-12-18 2000-12-18 New crystalline form of nestorone and process for the preparation thereof HUP0004967A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU0004967A HUP0004967A2 (en) 2000-12-18 2000-12-18 New crystalline form of nestorone and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0004967A HUP0004967A2 (en) 2000-12-18 2000-12-18 New crystalline form of nestorone and process for the preparation thereof

Publications (2)

Publication Number Publication Date
HU0004967D0 HU0004967D0 (en) 2001-02-28
HUP0004967A2 true HUP0004967A2 (en) 2002-09-28

Family

ID=89978862

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004967A HUP0004967A2 (en) 2000-12-18 2000-12-18 New crystalline form of nestorone and process for the preparation thereof

Country Status (1)

Country Link
HU (1) HUP0004967A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10632066B1 (en) 2019-02-01 2020-04-28 The Population Council, Inc. Method of providing birth control
WO2020257544A1 (en) 2019-06-21 2020-12-24 The Population Council, Inc. System for providing birth control
WO2022236045A1 (en) 2021-05-07 2022-11-10 The Population Council, Inc. Methods of providing birth control
US11529308B2 (en) 2019-06-21 2022-12-20 The Population Council, Inc. System for providing birth control

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10632066B1 (en) 2019-02-01 2020-04-28 The Population Council, Inc. Method of providing birth control
US10765628B2 (en) 2019-02-01 2020-09-08 The Population Council, Inc. Method of providing birth control
US10780047B2 (en) 2019-02-01 2020-09-22 The Population Council, Inc. Method of providing birth control
WO2020257544A1 (en) 2019-06-21 2020-12-24 The Population Council, Inc. System for providing birth control
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
US10925882B2 (en) 2019-06-21 2021-02-23 The Population Council, Inc. System for providing birth control
US10940157B2 (en) 2019-06-21 2021-03-09 The Population Council, Inc. System for providing birth control
US11529308B2 (en) 2019-06-21 2022-12-20 The Population Council, Inc. System for providing birth control
WO2022236045A1 (en) 2021-05-07 2022-11-10 The Population Council, Inc. Methods of providing birth control

Also Published As

Publication number Publication date
HU0004967D0 (en) 2001-02-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished