HUP0003159A2 - The use of n-monosubstituted-3-oxo-4-aza-5alpha-androst-1-en-17betha-carboxamides for the preparation of pharmaceutical compositions - Google Patents
The use of n-monosubstituted-3-oxo-4-aza-5alpha-androst-1-en-17betha-carboxamides for the preparation of pharmaceutical compositionsInfo
- Publication number
- HUP0003159A2 HUP0003159A2 HU0003159A HUP0003159A HUP0003159A2 HU P0003159 A2 HUP0003159 A2 HU P0003159A2 HU 0003159 A HU0003159 A HU 0003159A HU P0003159 A HUP0003159 A HU P0003159A HU P0003159 A2 HUP0003159 A2 HU P0003159A2
- Authority
- HU
- Hungary
- Prior art keywords
- 17betha
- 5alpha
- androst
- carboxamides
- monosubstituted
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000012261 overproduction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002374 sebum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány (I) általános képletű vegyületek - a képletben R1 és R2egymástól függetlenül hidrogénatomot, hidroxilcsoportot, védetthidroxilcsoportot vagy rövid szénláncú alkoxicsoportot jelent - vagygyógyászatilag elfogadható sóik vagy más származékaik alkalmazásáravonatkozik hajhullás, nőknél rendellenes szőrösség vagyfaggyútúltermelés kezelésére alkalmas gyógyászati készítményekelőállítására, illetve prosztatarák által okozott csontmetasztázismegelőzésére alkalmas gyógyászati készítmények előállítására. ÓThe invention relates to the use of compounds of the general formula (I) - in the formula R1 and R2 independently of each other represent a hydrogen atom, a hydroxyl group, a protected hydroxyl group or a short-chain alkoxy group - or their medicinally acceptable salts or other derivatives for the production of medicinal preparations suitable for the treatment of hair loss, abnormal hairiness or sebum overproduction in women, or for the prevention of bone metastasis caused by prostate cancer for the production of medicinal products. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20313697 | 1997-07-29 | ||
| PCT/JP1998/003337 WO1999006050A1 (en) | 1997-07-29 | 1998-07-27 | Remedial agent for baldness and other diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003159A2 true HUP0003159A2 (en) | 2001-04-28 |
| HUP0003159A3 HUP0003159A3 (en) | 2001-07-30 |
Family
ID=16469018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003159A HUP0003159A3 (en) | 1997-07-29 | 1998-07-27 | The use of n-monosubstituted-3-oxo-4-aza-5alpha-androst-1-en-17betha-carboxamides for the preparation of pharmaceutical compositions |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6380179B1 (en) |
| EP (1) | EP0998930B1 (en) |
| KR (1) | KR20010022066A (en) |
| CN (1) | CN1129433C (en) |
| AT (1) | ATE262337T1 (en) |
| AU (1) | AU733830B2 (en) |
| BR (1) | BR9811293A (en) |
| CA (1) | CA2298851A1 (en) |
| DE (1) | DE69822636T2 (en) |
| DK (1) | DK0998930T3 (en) |
| ES (1) | ES2218840T3 (en) |
| HK (1) | HK1027290A1 (en) |
| HU (1) | HUP0003159A3 (en) |
| ID (1) | ID24566A (en) |
| IL (1) | IL134199A0 (en) |
| NO (1) | NO20000469L (en) |
| NZ (1) | NZ502537A (en) |
| PL (1) | PL338414A1 (en) |
| PT (1) | PT998930E (en) |
| RU (1) | RU2193887C2 (en) |
| TR (1) | TR200000263T2 (en) |
| WO (1) | WO1999006050A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0001441A3 (en) * | 1997-02-26 | 2001-03-28 | Sankyo Company Ltd Chuo Ku | Process for the preparation of pharmaceutical compositions containing 4-aza-androst-1-ene derivatives |
| EP1718333A2 (en) * | 2004-02-02 | 2006-11-08 | Schering Corporation | Methods of modulating cd200 and cd200r |
| US20080108681A1 (en) * | 2006-10-27 | 2008-05-08 | Access Business Group International Llc | Use of allantoin as a pro-collagen synthesis agent in cosmetic compositions |
| EP3871671A3 (en) | 2009-07-29 | 2022-03-09 | Olsen, Elise | Fp receptor antagonists for inhibiting hair growth |
| MX2010012945A (en) * | 2010-11-24 | 2012-05-24 | Fidel Ojeda Gomez | Formulation for controlling and eliminating seborrhea and alopecia on the scalp. |
| RU2477155C2 (en) * | 2011-04-27 | 2013-03-10 | Закрытое акционерное общество "Патент-Фарм" | Method of treating androgenetic alopecia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571817A (en) | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
| US5516768A (en) | 1990-03-16 | 1996-05-14 | Smithkline Beecham Corporation | Uncompetitive inhibition of steroid and 5α-reductose |
| IE76452B1 (en) * | 1990-10-29 | 1997-10-22 | Sankyo Co | Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use |
| JP3030152B2 (en) * | 1992-02-03 | 2000-04-10 | 三共株式会社 | 4-azasteroid compounds |
| TW382595B (en) | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
| JPH0873492A (en) * | 1994-06-28 | 1996-03-19 | Sankyo Co Ltd | Azasteroids |
| US5635197A (en) | 1995-03-21 | 1997-06-03 | Eli Lilly And Company | Treatment and prevention of prostatic cancer metastasis |
| US5629007A (en) | 1995-03-21 | 1997-05-13 | Eli Lilly And Company | Method of preventing prostatic cancer development |
| AU7078296A (en) | 1995-09-27 | 1997-04-17 | Merck & Co., Inc. | Method of preventing androgenetic alopecia with 5-alpha reductase inhibitors |
| CZ289856B6 (en) * | 1996-02-05 | 2002-04-17 | Sankyo Company Limited | Pharmaceutical preparation based on 5{alpha}-reductase inhibitor |
| US6093722A (en) | 1997-02-26 | 2000-07-25 | Sankyo Company, Limited | Method for treating prostate cancer |
| HUP0001441A3 (en) * | 1997-02-26 | 2001-03-28 | Sankyo Company Ltd Chuo Ku | Process for the preparation of pharmaceutical compositions containing 4-aza-androst-1-ene derivatives |
-
1998
- 1998-07-27 IL IL13419998A patent/IL134199A0/en unknown
- 1998-07-27 CN CN98809366A patent/CN1129433C/en not_active Expired - Fee Related
- 1998-07-27 AU AU83585/98A patent/AU733830B2/en not_active Ceased
- 1998-07-27 TR TR2000/00263T patent/TR200000263T2/en unknown
- 1998-07-27 NZ NZ502537A patent/NZ502537A/en unknown
- 1998-07-27 HU HU0003159A patent/HUP0003159A3/en unknown
- 1998-07-27 RU RU2000102642/14A patent/RU2193887C2/en not_active IP Right Cessation
- 1998-07-27 AT AT98933945T patent/ATE262337T1/en not_active IP Right Cessation
- 1998-07-27 EP EP98933945A patent/EP0998930B1/en not_active Expired - Lifetime
- 1998-07-27 PL PL98338414A patent/PL338414A1/en unknown
- 1998-07-27 ID IDW20000167A patent/ID24566A/en unknown
- 1998-07-27 DE DE69822636T patent/DE69822636T2/en not_active Expired - Fee Related
- 1998-07-27 CA CA002298851A patent/CA2298851A1/en not_active Abandoned
- 1998-07-27 PT PT98933945T patent/PT998930E/en unknown
- 1998-07-27 KR KR1020007000635A patent/KR20010022066A/en not_active Application Discontinuation
- 1998-07-27 ES ES98933945T patent/ES2218840T3/en not_active Expired - Lifetime
- 1998-07-27 DK DK98933945T patent/DK0998930T3/en active
- 1998-07-27 WO PCT/JP1998/003337 patent/WO1999006050A1/en not_active Application Discontinuation
- 1998-07-27 BR BR9811293-7A patent/BR9811293A/en not_active IP Right Cessation
-
2000
- 2000-01-28 US US09/493,488 patent/US6380179B1/en not_active Expired - Fee Related
- 2000-01-28 NO NO20000469A patent/NO20000469L/en not_active Application Discontinuation
- 2000-10-10 HK HK00106422A patent/HK1027290A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ID24566A (en) | 2000-07-27 |
| HK1027290A1 (en) | 2001-01-12 |
| PL338414A1 (en) | 2000-11-06 |
| EP0998930B1 (en) | 2004-03-24 |
| BR9811293A (en) | 2000-08-29 |
| DE69822636D1 (en) | 2004-04-29 |
| AU8358598A (en) | 1999-02-22 |
| KR20010022066A (en) | 2001-03-15 |
| NO20000469D0 (en) | 2000-01-28 |
| DK0998930T3 (en) | 2004-04-26 |
| CN1129433C (en) | 2003-12-03 |
| PT998930E (en) | 2004-05-31 |
| NZ502537A (en) | 2002-11-26 |
| RU2193887C2 (en) | 2002-12-10 |
| EP0998930A4 (en) | 2002-06-12 |
| IL134199A0 (en) | 2001-04-30 |
| CN1271285A (en) | 2000-10-25 |
| US6380179B1 (en) | 2002-04-30 |
| CA2298851A1 (en) | 1999-02-11 |
| TR200000263T2 (en) | 2000-09-21 |
| AU733830B2 (en) | 2001-05-24 |
| NO20000469L (en) | 2000-03-28 |
| WO1999006050A1 (en) | 1999-02-11 |
| ATE262337T1 (en) | 2004-04-15 |
| EP0998930A1 (en) | 2000-05-10 |
| ES2218840T3 (en) | 2004-11-16 |
| HUP0003159A3 (en) | 2001-07-30 |
| DE69822636T2 (en) | 2005-01-05 |
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