HUP0002977A2 - Directed cytolysis of target cells, agents and compositions causing cytolysis, and compounds that can be used to produce the agents - Google Patents
Directed cytolysis of target cells, agents and compositions causing cytolysis, and compounds that can be used to produce the agentsInfo
- Publication number
- HUP0002977A2 HUP0002977A2 HU0002977A HUP0002977A HUP0002977A2 HU P0002977 A2 HUP0002977 A2 HU P0002977A2 HU 0002977 A HU0002977 A HU 0002977A HU P0002977 A HUP0002977 A HU P0002977A HU P0002977 A2 HUP0002977 A2 HU P0002977A2
- Authority
- HU
- Hungary
- Prior art keywords
- sag
- agents
- cytolysis
- target cells
- superantigen
- Prior art date
Links
- 206010057248 Cell death Diseases 0.000 title 2
- 230000009089 cytolysis Effects 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 abstract 10
- 231100000617 superantigen Toxicity 0.000 abstract 3
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Abstract
Target cells (A) are inactivated in presence of T cells by contacting both cell types with a superantigen (Sag) in presence of an immune modulator (IM). The new feature is that at least one of SAg and IM is present as a conjugate between a 'free' superantigen and a component (T) that targets the conjugate to (A). Also new are: (1) Sag conjugates of formula (T)x(Sag)y(IM)z (I), Sag, IM (not a superantigen) and T are linked via organic linkers, same or different, x, y and z are integers typically 0-10, provided that y and at least one of x and z must be greater than zero; (2) targeted IM conjugates of formula (T)x(Sag)y(IM')z (V), IM' = IM in which affinity for lymphocyte receptors or rate of internalisation when bound to this receptor has been reduced, e.g. by mutation; here z and at least one of x and y must be greater than zero; (3) DNA (II) encoding an Sag and an IM, especially interleukin-2 (IL-2), that is not an Sag.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704170A SE9704170D0 (en) | 1997-11-14 | 1997-11-14 | Directed cytolysis of target cells, agents and compositions causing cytolysis, and compounds that can be used to produce the agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002977A2 true HUP0002977A2 (en) | 2000-12-28 |
| HUP0002977A3 HUP0002977A3 (en) | 2003-03-28 |
Family
ID=20408979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002977A HUP0002977A3 (en) | 1997-11-14 | 1998-07-02 | Directed cytolysis of target cells, agents and compositions causing cytolysis, and compounds that can be used to produce the agents |
Country Status (2)
| Country | Link |
|---|---|
| HU (1) | HUP0002977A3 (en) |
| SE (1) | SE9704170D0 (en) |
-
1997
- 1997-11-14 SE SE9704170A patent/SE9704170D0/en unknown
-
1998
- 1998-07-02 HU HU0002977A patent/HUP0002977A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002977A3 (en) | 2003-03-28 |
| SE9704170D0 (en) | 1997-11-14 |
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