HUP0001701A2 - Babesia vaccine - Google Patents
Babesia vaccineInfo
- Publication number
- HUP0001701A2 HUP0001701A2 HU0001701A HUP0001701A HUP0001701A2 HU P0001701 A2 HUP0001701 A2 HU P0001701A2 HU 0001701 A HU0001701 A HU 0001701A HU P0001701 A HUP0001701 A HU P0001701A HU P0001701 A2 HUP0001701 A2 HU P0001701A2
- Authority
- HU
- Hungary
- Prior art keywords
- divergens
- protein
- detecting
- iii
- fragment
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000223836 Babesia Species 0.000 title 1
- 201000008680 babesiosis Diseases 0.000 title 1
- 241001455947 Babesia divergens Species 0.000 abstract 7
- 239000012634 fragment Substances 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 238000009007 Diagnostic Kit Methods 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 241000699694 Gerbillinae Species 0.000 abstract 1
- 102000005720 Glutathione transferase Human genes 0.000 abstract 1
- 108010070675 Glutathione transferase Proteins 0.000 abstract 1
- 241001644525 Nastus productus Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000008348 humoral response Effects 0.000 abstract 1
- 238000001114 immunoprecipitation Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Nucleic acid (I) encodes a protein (II) of the 37 kD protein family or its immunogenic fragment of Babesia divergens . Independent claims are also included for the following: (1) nucleic acid (Ia) encoding a protein of the 37 kD family able to bind monoclonal antibody F42F8; (2) recombinant DNA molecule (Ib) comprises (I) or (Ia) plus expression control elements; (3) live recombinant carrier microorganism (III) containing (I), (Ia) or (Ib); (4) host cell (IV) containing (I), (Ia), (Ib) or (III); (5) vaccine (A) for protecting cattle against infection by B. divergens, or its symptoms, containing: (a) at least one (II), or its immunogenic fragments and a carrier; (b) (I), (Ia), (Ib), (III) or (IV); or (c) antibody (Ab) against (II); (6) preparing (A); (7) diagnostic kit for detecting antibodies (Ab1) against B. divergens containing a purified (II) or its fragment containing an antigenic determinant; (8) diagnostic kit for detecting B. divergens containing (Ab); (9) detecting (Ab1) by incubating serum with (II) or its antigenic fragment; and (10) detecting B. divergens by incubating serum with (Ab). ACTIVITY : Antiprotozoal. No supporting data is given. MECHANISM OF ACTION : Vaccine. Gerbils were injected subcutaneously, twice, with 5 mu g of a fusion of glutathione-S-transferase and a B. divergens 37 kD protein, formulated with QuilA adjuvant. Three weeks after the second injection, the animals were challenged with 10 6> erythrocytes parasitized with the homologous B. divergens strain Rouen. Immunoprecipitation showed that all animals had produced a strong humoral response.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201322 | 1999-04-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0001701D0 HU0001701D0 (en) | 2000-07-28 |
| HUP0001701A2 true HUP0001701A2 (en) | 2002-06-29 |
| HUP0001701A3 HUP0001701A3 (en) | 2005-05-30 |
Family
ID=8240157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001701A HUP0001701A3 (en) | 1999-04-29 | 2000-04-28 | Babesia vaccine |
Country Status (2)
| Country | Link |
|---|---|
| HU (1) | HUP0001701A3 (en) |
| NO (1) | NO327859B1 (en) |
-
2000
- 2000-04-28 HU HU0001701A patent/HUP0001701A3/en unknown
- 2000-04-28 NO NO20002213A patent/NO327859B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20002213D0 (en) | 2000-04-28 |
| HUP0001701A3 (en) | 2005-05-30 |
| HU0001701D0 (en) | 2000-07-28 |
| NO327859B1 (en) | 2009-10-05 |
| NO20002213L (en) | 2000-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7968695B2 (en) | Nucleic acids encoding recombinant 56 and 82 kDa antigens from gametocytes of Eimeria maxima and their uses | |
| EA007409B1 (en) | Streptococcus antigen polypeptides, methods of producing and use thereof | |
| CA2371714A1 (en) | Streptococcus pneumoniae proteins and vaccines | |
| US4842999A (en) | Canine heartworm vaccine and diagnostic test | |
| JP2009542196A (en) | Small Streptococcus pyogenes antigens and their use | |
| WO2001079274B1 (en) | Tuberculosis antigens and methods of use thereof | |
| JP2002512800A5 (en) | ||
| CA2217522A1 (en) | Isolated frpb nucleic acid molecule and vaccine | |
| CA2411949A1 (en) | Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof | |
| RU2555530C2 (en) | METHOD OF IDENTIFYING POLYPEPTIDES AND PROTEINS OF H.parasuis | |
| AU2002316558A1 (en) | Nucleic acids encoding recombinant 56 and 82 kDa antigens from gametocytes of Eimeria maxima and their uses | |
| Hillyer | Comparison of purified 12 kDa and recombinant 15 kDa Fasciola hepatica antigens related to a Schistosoma mansoni fatty acid binding protein | |
| CN106692963B (en) | Combined vaccine for preventing staphylococcus aureus infection and tetanus | |
| US20230277638A1 (en) | Southern cattle tick vaccine product | |
| Goswami et al. | Molecular Cloning ofClostridium perfringensEpsilon-Toxin Gene and Its High Level Expression inE. coli | |
| JP2011103893A (en) | Recombinant haemophilus influenzae adhesin protein | |
| CA2411919A1 (en) | Immunization of dairy cattle with chimeric gapc protein against streptococcus infection | |
| HUP0001701A2 (en) | Babesia vaccine | |
| CA2475821A1 (en) | Group b streptococcus antigens | |
| CA2365196A1 (en) | Chlamydia antigens and corresponding dna fragments and uses thereof | |
| Hung et al. | Antibody production in Japanese eels, Anguilla japonica Temminck & Schlegel | |
| EP0726314A1 (en) | FIMBRILLIN PROTEIN OF $i(PORPHYROMONAS GINGIVALIS) | |
| US6193971B1 (en) | Dictyocaulus viviparus antigen for diagnosing lungworm infestation and for vaccination | |
| JP2656521B2 (en) | Production and use of feline leukemia virus antigen | |
| CA2008808A1 (en) | Vaccine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: INTERVET INTERNATIONAL B.V., NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |