HUE042907T2 - Szfingozin 1 típusú inhibitorok és eljárás azok elõállítására és alkalmazásaik - Google Patents
Szfingozin 1 típusú inhibitorok és eljárás azok elõállítására és alkalmazásaikInfo
- Publication number
- HUE042907T2 HUE042907T2 HUE10757646A HUE10757646A HUE042907T2 HU E042907 T2 HUE042907 T2 HU E042907T2 HU E10757646 A HUE10757646 A HU E10757646A HU E10757646 A HUE10757646 A HU E10757646A HU E042907 T2 HUE042907 T2 HU E042907T2
- Authority
- HU
- Hungary
- Prior art keywords
- inhibitors
- making
- methods
- same
- sphingosine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/584,131 US8314151B2 (en) | 2008-04-29 | 2009-08-31 | Sphingosine kinase type 1 inhibitors, and processes for using same |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE042907T2 true HUE042907T2 (hu) | 2019-07-29 |
Family
ID=43030496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE10757646A HUE042907T2 (hu) | 2009-08-31 | 2010-08-31 | Szfingozin 1 típusú inhibitorok és eljárás azok elõállítására és alkalmazásaik |
Country Status (9)
Country | Link |
---|---|
US (8) | US8314151B2 (hu) |
EP (2) | EP2496225B1 (hu) |
CA (1) | CA2793090C (hu) |
DK (1) | DK2496225T3 (hu) |
ES (1) | ES2718091T3 (hu) |
HU (1) | HUE042907T2 (hu) |
PL (1) | PL2496225T3 (hu) |
PT (1) | PT2496225T (hu) |
WO (1) | WO2011025545A1 (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8314151B2 (en) | 2008-04-29 | 2012-11-20 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, and processes for using same |
US9250246B2 (en) * | 2011-06-29 | 2016-02-02 | Portland State University | Near-infrared fluorescent dyes with large stokes shifts |
WO2013071061A1 (en) * | 2011-11-11 | 2013-05-16 | The Children's Hospital Of Philadelphia | Compositions and methods for increasing stress resilience |
US10660879B2 (en) | 2017-06-23 | 2020-05-26 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
CA3061201A1 (en) | 2017-06-23 | 2018-12-27 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
US10364211B1 (en) | 2017-10-25 | 2019-07-30 | Enzo Biochem, Inc. | Methods and intermediates for synthesizing SK1-I |
EP4121025A4 (en) | 2020-03-17 | 2024-03-27 | Enzo Biochem Inc | COMPOUNDS MODULATING THE SPHINGOSINE PATHWAY FOR THE TREATMENT OF CORONAVIRUS INFECTION |
GB2617070A (en) * | 2022-03-28 | 2023-10-04 | Jaguar Land Rover Ltd | Vehicle charging control system and method |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2868844A (en) | 1957-01-22 | 1959-01-13 | Ethyl Corp | Selective nitration process |
US3871958A (en) | 1972-03-04 | 1975-03-18 | Ajinomoto Kk | Biological method of producing serine and serinol derivatives |
US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
US5948820A (en) | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
AU5100201A (en) | 2000-04-03 | 2001-10-15 | Sankyo Co | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods ofuse thereof |
US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
WO2004080960A2 (en) * | 2003-03-06 | 2004-09-23 | Neose Technologies Inc. | Methods and compositions for the enzymatic synthesis of gangliosides |
CN106075435A (zh) | 2004-06-04 | 2016-11-09 | 健泰科生物技术公司 | 用于治疗多发性硬化的方法 |
KR20060002290A (ko) * | 2004-07-01 | 2006-01-09 | 주식회사 두산 | 신규 스핑고리피드 유도체 및 그를 함유하는 항암 조성물 |
US8324237B2 (en) * | 2005-05-20 | 2012-12-04 | Smith Charles D | Methods for the treatment and prevention of inflammatory diseases |
RU2447060C2 (ru) | 2005-06-17 | 2012-04-10 | Эпоуджи Биотекнолоджи Корпорейшн | Ингибиторы сфингозинкиназы |
US8148338B2 (en) | 2006-02-22 | 2012-04-03 | Supratek Pharma Inc. | Doxorubicin formulations for anti-cancer use |
US20080145883A1 (en) | 2006-10-09 | 2008-06-19 | Thomas Baumruker | Biomarker in inflammatory diseases |
US8314151B2 (en) * | 2008-04-29 | 2012-11-20 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, and processes for using same |
US8372888B2 (en) * | 2008-04-29 | 2013-02-12 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, compositions and processes for using same |
-
2009
- 2009-08-31 US US12/584,131 patent/US8314151B2/en active Active
-
2010
- 2010-08-31 EP EP10757646.4A patent/EP2496225B1/en active Active
- 2010-08-31 ES ES10757646T patent/ES2718091T3/es active Active
- 2010-08-31 DK DK10757646.4T patent/DK2496225T3/en active
- 2010-08-31 PL PL10757646T patent/PL2496225T3/pl unknown
- 2010-08-31 PT PT10757646T patent/PT2496225T/pt unknown
- 2010-08-31 EP EP18167892.1A patent/EP3417854A1/en active Pending
- 2010-08-31 CA CA2793090A patent/CA2793090C/en active Active
- 2010-08-31 HU HUE10757646A patent/HUE042907T2/hu unknown
- 2010-08-31 WO PCT/US2010/002383 patent/WO2011025545A1/en active Application Filing
-
2012
- 2012-10-11 US US13/649,221 patent/US9388121B2/en active Active
-
2016
- 2016-06-14 US US15/181,826 patent/US9974758B2/en active Active
-
2018
- 2018-04-16 US US15/954,131 patent/US10166204B2/en active Active
- 2018-11-26 US US16/199,337 patent/US10456370B2/en active Active
-
2019
- 2019-09-17 US US16/572,699 patent/US10624863B2/en active Active
-
2020
- 2020-03-10 US US16/813,961 patent/US10945971B2/en active Active
-
2021
- 2021-02-08 US US17/169,662 patent/US11737992B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3417854A1 (en) | 2018-12-26 |
CA2793090C (en) | 2015-03-24 |
US10166204B2 (en) | 2019-01-01 |
US11737992B2 (en) | 2023-08-29 |
ES2718091T3 (es) | 2019-06-27 |
PL2496225T3 (pl) | 2019-09-30 |
US20200197328A1 (en) | 2020-06-25 |
EP2496225B1 (en) | 2019-01-16 |
US10624863B2 (en) | 2020-04-21 |
US20180235907A1 (en) | 2018-08-23 |
WO2011025545A1 (en) | 2011-03-03 |
US20210177776A1 (en) | 2021-06-17 |
US20120237448A9 (en) | 2012-09-20 |
DK2496225T3 (en) | 2019-04-15 |
PT2496225T (pt) | 2019-04-26 |
US20130245321A1 (en) | 2013-09-19 |
US9388121B2 (en) | 2016-07-12 |
EP2496225A1 (en) | 2012-09-12 |
US20190111007A1 (en) | 2019-04-18 |
US10945971B2 (en) | 2021-03-16 |
US20100278741A1 (en) | 2010-11-04 |
US8314151B2 (en) | 2012-11-20 |
US9974758B2 (en) | 2018-05-22 |
US20200069611A1 (en) | 2020-03-05 |
US20160317472A1 (en) | 2016-11-03 |
CA2793090A1 (en) | 2011-03-03 |
US10456370B2 (en) | 2019-10-29 |
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