HU9302983D0 - Quinoline-derivatives - Google Patents

Quinoline-derivatives

Info

Publication number
HU9302983D0
HU9302983D0 HU9302983A HU9302983A HU9302983D0 HU 9302983 D0 HU9302983 D0 HU 9302983D0 HU 9302983 A HU9302983 A HU 9302983A HU 9302983 A HU9302983 A HU 9302983A HU 9302983 D0 HU9302983 D0 HU 9302983D0
Authority
HU
Hungary
Prior art keywords
quinoline
derivatives
Prior art date
Application number
HU9302983A
Other versions
HUT67349A (en
Inventor
Masaaki Matsuo
Kiyoshi Tsuji
Katsuya Nakamura
Glen Spears
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB919108547A priority Critical patent/GB9108547D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of HU9302983D0 publication Critical patent/HU9302983D0/en
Publication of HUT67349A publication Critical patent/HUT67349A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
HU9302983A 1991-04-22 1992-04-21 Quinoline derivatives, pharmaceutical composition comprising them and their preparation HUT67349A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB919108547A GB9108547D0 (en) 1991-04-22 1991-04-22 Quinoline derivatives

Publications (2)

Publication Number Publication Date
HU9302983D0 true HU9302983D0 (en) 1994-01-28
HUT67349A HUT67349A (en) 1995-03-28

Family

ID=10693693

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9302983A HUT67349A (en) 1991-04-22 1992-04-21 Quinoline derivatives, pharmaceutical composition comprising them and their preparation

Country Status (8)

Country Link
EP (1) EP0639182A1 (en)
JP (1) JPH06506925A (en)
AU (1) AU656576B2 (en)
CA (1) CA2108971A1 (en)
GB (1) GB9108547D0 (en)
HU (1) HUT67349A (en)
MX (1) MX9201823A (en)
WO (1) WO1992018483A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311562D0 (en) * 1993-06-04 1993-07-21 Fujisawa Pharmaceutical Co Heterocyclic derivatives
GB9404378D0 (en) * 1994-03-07 1994-04-20 Fujisawa Pharmaceutical Co Quinoline derivatives
GB2290786A (en) * 1994-06-30 1996-01-10 Fujisawa Pharmaceutical Co Quinoline derivatives
US6165799A (en) * 1996-12-10 2000-12-26 Heska Corporation Detection of anti-Fc.sub.ε R autoantibodies in asthmatics
DE69826034T2 (en) 1997-12-03 2005-09-08 Taisho Pharmaceutical Co., Ltd. 1,2-dihydro-2-oxoquinoline derivatives
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
SE9801474D0 (en) * 1998-04-27 1998-04-27 Active Biotech Ab quinoline Derivatives
US6121287A (en) * 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives
SE9802550D0 (en) * 1998-07-15 1998-07-15 Active Biotech Ab quinoline derivatives
SE9802549D0 (en) * 1998-07-15 1998-07-15 Active Biotech Ab quinoline derivatives
US6133285A (en) 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
JP2000044560A (en) * 1998-07-31 2000-02-15 Kyorin Pharmaceut Co Ltd Benzoquinolizine derivative and its production
JP2000044561A (en) * 1998-07-31 2000-02-15 Kyorin Pharmaceut Co Ltd Pyrroloquinoline derivative and its production
NZ512883A (en) 1999-01-08 2003-03-28 Japan Tobacco Inc 2-oxoquinoline compounds and medicinal uses thereof
DE60034240T2 (en) * 1999-10-25 2007-12-20 Active Biotech Ab Drugs for the treatment of malignant tumors
PL199781B1 (en) 1999-10-25 2008-10-31 Active Biotech Ab Drugs for the treatment of malignant tumours
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
DE60140456D1 (en) 2000-09-01 2009-12-24 Novartis Vaccines & Diagnostic Aza heterocyclic derivatives and their therapeutic use
DK1650203T3 (en) 2000-09-11 2008-06-02 Novartis Vaccines & Diagnostic Quinolinone derivatives as tyrosine kinase inhibitors
US7642278B2 (en) 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
US6822097B1 (en) 2002-02-07 2004-11-23 Amgen, Inc. Compounds and methods of uses
AUPS058102A0 (en) 2002-02-15 2002-03-14 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds
BR0313743A (en) 2002-08-23 2005-07-05 Chiron Corp quinolinones benzimidazole and uses these
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
KR20050075005A (en) 2002-11-13 2005-07-19 카이론 코포레이션 Methods of treating cancer and related methods
CA2520124A1 (en) * 2003-03-28 2004-10-14 Chiron Corporation Use of benzazole compounds for immunopotentiation
CA2538960C (en) 2003-09-17 2013-03-19 Sumitomo Chemical Company, Limited Cinnamoyl compound and use of the same
WO2005028441A1 (en) 2003-09-17 2005-03-31 Sumitomo Chemical Company, Limited Cinnamoyl derivatives and use thereof
CA2543820C (en) 2003-11-07 2012-07-10 Chiron Corporation Methods for synthesizing quinolinone compounds
EP1718306A2 (en) 2004-02-20 2006-11-08 Chiron Corporation Modulation of inflammatory and metastatic processes
HUE036512T2 (en) 2004-06-24 2018-07-30 Vertex Pharma Modulators of ATP-binding cassette transporters
MX2007002238A (en) * 2004-08-23 2007-04-20 Hoffmann La Roche Heterocyclic antiviral compounds.
ES2525670T3 (en) 2005-01-27 2014-12-29 Novartis Ag Treatment of metastatic tumors
WO2006093339A1 (en) 2005-03-02 2006-09-08 Sumitomo Chemical Company, Limited Use of cinnamoyl compound
CA2608171C (en) 2005-05-13 2014-02-04 Novartis Ag Use of quinolinone compounds for treating drug resistant cancers
US8222413B2 (en) 2005-05-17 2012-07-17 Novartis Ag Methods for synthesizing heterocyclic compounds
KR101368519B1 (en) 2005-05-23 2014-02-27 노파르티스 아게 Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
BRPI0619370A2 (en) 2005-11-29 2011-09-27 Novartis Ag quinolinone formulations
EP1993360B1 (en) 2005-12-28 2017-02-08 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
BRPI1011506A8 (en) 2009-03-20 2016-07-05 Vertex Pharma process for manufacturing cystic fibrosis transmembrane conductance regulator modulators
CN102267984B (en) * 2010-06-04 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 4-hydroxyquinoline-3-amide derivatives, preparation method thereof and purposes thereof
CA2813711A1 (en) * 2010-10-14 2012-04-19 Immunahr Ab 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators.
MX2013005954A (en) * 2010-11-28 2013-07-29 Mapi Pharma Ltd Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium.
CN102146068A (en) * 2011-01-20 2011-08-10 南开大学 3-benzoyl-4-hydroxycoumarin derivatives and analogues thereof and application thereof in weeding aspect
RU2692779C2 (en) 2012-02-27 2019-06-27 Вертекс Фармасьютикалз Инкорпорейтед Pharmaceutical composition and introduction thereof
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH473807A (en) * 1966-10-20 1969-06-15 Ciba Geigy A process for preparing new 4-hydroxy-quinolines
FR2443467B1 (en) * 1978-12-08 1981-08-14 Roussel Uclaf
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
FR2585356B1 (en) * 1985-07-25 1987-10-23 Roussel Uclaf Novel 4-substituted quinoline carboxylic oh acid 2 by two hydroxyl functions optionally etherified or esterified, their processes of preparation, the novel intermediates obtained, their application as medicines and compositions containing them
SE8902076D0 (en) * 1989-06-09 1989-06-09 Pharmacia Ab Derivatives of quinoline-3-carboxanilide

Also Published As

Publication number Publication date
AU656576B2 (en) 1995-02-09
WO1992018483A1 (en) 1992-10-29
MX9201823A (en) 1992-10-01
AU1548792A (en) 1992-11-17
EP0639182A1 (en) 1995-02-22
GB9108547D0 (en) 1991-06-05
JPH06506925A (en) 1994-08-04
HUT67349A (en) 1995-03-28
CA2108971A1 (en) 1992-10-23

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Legal Events

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DFD9 Temporary prot. cancelled due to non-payment of fee