HU9301325D0 - Aryl-acetamides as well as method for producing said compounds - Google Patents

Aryl-acetamides as well as method for producing said compounds

Info

Publication number
HU9301325D0
HU9301325D0 HU9301325A HU9301325A HU9301325D0 HU 9301325 D0 HU9301325 D0 HU 9301325D0 HU 9301325 A HU9301325 A HU 9301325A HU 9301325 A HU9301325 A HU 9301325A HU 9301325 D0 HU9301325 D0 HU 9301325D0
Authority
HU
Hungary
Prior art keywords
acetamides
aryl
compounds
producing
well
Prior art date
Application number
HU9301325A
Other languages
Hungarian (hu)
Other versions
HU214578B (en
HUT70172A (en
Inventor
Rudolf Gottschlich
Karl-August Ackermann
Helmut Pruecher
Christoph Seyfried
Hartmut Greiner
Gerd Bartoszyk
Frank Mauler
Manfred Stohrer
Andrew Barber
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HU9301325D0 publication Critical patent/HU9301325D0/en
Publication of HUT70172A publication Critical patent/HUT70172A/en
Publication of HU214578B publication Critical patent/HU214578B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Novel arylacetamides of the formula I <IMAGE> in which Q, R<1>, R<2> and R<3> have the meaning indicated in Patent Claim 1 exhibit analgesic and neuroprotective properties and bind with high affinity to kappa receptors.
HU9301325A 1992-05-09 1993-05-07 Process for producing aryl-acetamides, pharmaceutical compositions comprising them and method for producing thereof HU214578B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4215213A DE4215213A1 (en) 1992-05-09 1992-05-09 Arylacetamide

Publications (3)

Publication Number Publication Date
HU9301325D0 true HU9301325D0 (en) 1993-09-28
HUT70172A HUT70172A (en) 1995-09-28
HU214578B HU214578B (en) 1998-04-28

Family

ID=6458428

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9301325A HU214578B (en) 1992-05-09 1993-05-07 Process for producing aryl-acetamides, pharmaceutical compositions comprising them and method for producing thereof

Country Status (22)

Country Link
US (1) US5532266A (en)
EP (1) EP0569802B1 (en)
JP (1) JP3210771B2 (en)
KR (1) KR100241637B1 (en)
CN (1) CN1041087C (en)
AT (1) ATE168368T1 (en)
AU (1) AU662051B2 (en)
BR (1) BR1100581A (en)
CA (1) CA2095797C (en)
CZ (1) CZ289961B6 (en)
DE (2) DE4215213A1 (en)
DK (1) DK0569802T3 (en)
ES (1) ES2121030T3 (en)
HK (1) HK1011990A1 (en)
HU (1) HU214578B (en)
NO (1) NO179789C (en)
PL (1) PL173779B1 (en)
RU (1) RU2125041C1 (en)
SK (1) SK282646B6 (en)
TW (1) TW372961B (en)
UA (1) UA32543C2 (en)
ZA (1) ZA933222B (en)

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US5137571A (en) * 1990-06-05 1992-08-11 Rohm And Haas Company Method for improving thickeners for aqueous systems
DE4407047A1 (en) * 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
WO1996006078A1 (en) * 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists
DE19523502A1 (en) * 1995-06-28 1997-01-02 Merck Patent Gmbh Kappa opiate agonists for inflammatory bowel diseases
DE19531464A1 (en) * 1995-08-26 1997-02-27 Merck Patent Gmbh N-methyl-N - [(1S -) - 1-phenyl-2 - ((3S) -3-hydroxypyrrolidin 1-yl -) - ethyl] -2,2-diphenyl-acetamide
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
AU3172397A (en) * 1996-06-05 1998-01-05 Novartis Ag Anti-neurodegeneratively effective xanthene derivatives
MXPA99011298A (en) * 1997-07-14 2004-10-28 Adolor Corp Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith.
DE19827633A1 (en) * 1998-04-20 1999-10-21 Merck Patent Gmbh Production of N-methyl-N-(1-phenyl-2-(3-hydroxypyrrolidino)ethyl)-2,2-diphenylacetamide enantiomers, e.g. with antiinflammatory, analgesic and diuretic activity
DE10116978A1 (en) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa opiate agonists for the treatment of diseases of the bladder
AU2007207867B2 (en) * 2001-04-05 2009-09-24 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of bladder diseases
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
CA2486000A1 (en) 2002-05-17 2003-11-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (en) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivatives of asimadolin with covalently bound acids
US6852713B2 (en) * 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
CA2544245A1 (en) * 2003-10-30 2005-05-26 Tioga Pharmaceuticals, Inc. Use of selective opiate receptor modulators in the treatment of neuropathy
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
ATE399164T1 (en) * 2004-03-12 2008-07-15 Lilly Co Eli ANTAGONISTS OF THE OPIOID RECEPTOR
EP2561870A1 (en) 2007-03-30 2013-02-27 Tioga Pharmaceuticals, Inc. Kappa-Opiate Agonists For The Treatment Of Diarrhea-Predominant and Alternating Irritable Bowel Syndrome
WO2011062052A1 (en) * 2009-11-18 2011-05-26 日本ゼオン株式会社 Fluorene compound, stabilizer containing the fluorene compound, and composition
CN103664727A (en) * 2013-12-19 2014-03-26 无锡万全医药技术有限公司 Technology for preparing 1-[(3s)-3-hydroxypyrrolidine-1-base]-(2s)-2-methylamino-2-phenylethane with one-pot method
CN103772257A (en) * 2013-12-31 2014-05-07 无锡万全医药技术有限公司 Method for preparing 2-((3s)-3-hydroxy pyrrolidine-1-yl)-(1s)-1-phenethyl carbamate
CN109641884B (en) 2016-08-18 2024-01-02 维达克制药有限公司 Piperazine derivatives, pharmaceutical compositions thereof, and methods of use thereof
ES2906979T3 (en) 2016-12-21 2022-04-21 Tioga Pharmaceuticals Inc Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

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US4192883A (en) * 1976-04-09 1980-03-11 Pierre Fabre, S.A. Amides of pyrrolidinoethylamine which can be used in lung therapy
FR2421891A1 (en) * 1977-10-17 1979-11-02 Fabre Sa Pierre Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
JPH02138254A (en) * 1988-02-23 1990-05-28 Glaxo Group Ltd Heterocyclic derivative
DE4034785A1 (en) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1- (2-arylethyl) pyrrolidine
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DE3916663A1 (en) * 1989-05-23 1990-11-29 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-ACYL-SULPHONAMIDES AND CYANAMIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
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Also Published As

Publication number Publication date
CN1079219A (en) 1993-12-08
PL173779B1 (en) 1998-04-30
BR1100581A (en) 2000-08-01
NO179789B (en) 1996-09-09
CA2095797A1 (en) 1993-11-10
SK282646B6 (en) 2002-10-08
NO179789C (en) 1996-12-18
NO931681L (en) 1993-11-10
NO931681D0 (en) 1993-05-07
CA2095797C (en) 2007-09-18
HK1011990A1 (en) 1999-07-23
KR100241637B1 (en) 2000-03-02
CZ289961B6 (en) 2002-05-15
ES2121030T3 (en) 1998-11-16
JPH0649022A (en) 1994-02-22
HU214578B (en) 1998-04-28
CN1041087C (en) 1998-12-09
EP0569802B1 (en) 1998-07-15
JP3210771B2 (en) 2001-09-17
HUT70172A (en) 1995-09-28
PL298845A1 (en) 1994-01-10
US5532266A (en) 1996-07-02
SK46893A3 (en) 1994-04-06
KR930023340A (en) 1993-12-18
RU2125041C1 (en) 1999-01-20
DK0569802T3 (en) 1999-04-19
UA32543C2 (en) 2001-02-15
TW372961B (en) 1999-11-01
AU662051B2 (en) 1995-08-17
CZ82393A3 (en) 1994-02-16
AU3834193A (en) 1993-11-11
ATE168368T1 (en) 1998-08-15
DE4215213A1 (en) 1993-11-11
ZA933222B (en) 1993-12-08
DE59308763D1 (en) 1998-08-20
EP0569802A1 (en) 1993-11-18

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: TIOGA PHARMACEUTICALS, INC., US

Free format text: FORMER OWNER(S): MERCK PATENT GMBH., DE