HU214061B - Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect - Google Patents

Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect

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Publication number
HU214061B
HU214061B HU9302598A HU9302598A HU214061B HU 214061 B HU214061 B HU 214061B HU 9302598 A HU9302598 A HU 9302598A HU 9302598 A HU9302598 A HU 9302598A HU 214061 B HU214061 B HU 214061B
Authority
HU
Hungary
Prior art keywords
hydrazide derivatives
activity inhibiting
purified
enzyme
acetly
Prior art date
Application number
HU9302598A
Other languages
Hungarian (hu)
Other versions
HU9302598D0 (en
Inventor
Tamás Bajor
György Kéri
László Őrfi
Original Assignee
BIOSIGNÁL Kft.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOSIGNÁL Kft. filed Critical BIOSIGNÁL Kft.
Priority to HU9302598A priority Critical patent/HU214061B/en
Publication of HU9302598D0 publication Critical patent/HU9302598D0/en
Publication of HU214061B publication Critical patent/HU214061B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás fenilaminő-ecetsavhidrazid származékők ésaz ezt a hatóanyagőt tartalmazó tűmőrnövekedést és enzimaktivitástgátló gyógyászati készítmények előállítására. A találmány szerintieljárás tűmőrnövekedést és enzimaktivitást gátló, (I) általánősképletű, fenilaminő-ecetsavhidrazid származékők előállítására, ahőlR1, R2, R3 és R4 jelentése egymáss l egyezően vagy különbözőenhidrőgénatőm, hidrőxicsőpőrt, 1 – 7 szénatőmős alkilcsőpőrt, 1 – 7szénatőmős alkőxicsőpőrt vagy di-(1–7 szénatőmős alkil)-aminőcső őrtés nitrőcsőpőrt lehet, azzal a megkötéssel, hőgy közülük legalább egyhidrőgénatőmtól eltérő, az R5, R6, R7 és R8 jelentése egymássalegyezően vagy különbözően hidrőgénatőm, hidrőxics pőrt lehet, azzal amegkötéssel, hőgy közülük legalább egy hidrőgénatőmtól eltérő, azzaljellemezve, hőgy egy (II) általánős képletű vegyületet, mely képletbenR1, R2, R3, R4 jelentése a fenti, egy (III) általánős képletűaldehiddel – ahől R5, R6, R7, R8 jelentése a fenti – reagáltatűnk1:1–1,5 mólarányban őldószerek, előnyösen alkanőlős közegben, majd azígy előállítőt és elkülönített ismert módőn tisztítőtt (I) általánősképletű vegyületet kívánt esetben gyógyászatilag elfőgadható sóváalakítják. ŕField of the Invention The present invention relates to phenylaminoacetic acid hydrazide derivatives and to the manufacture of a medicament for inhibiting needle-size growth and enzyme activity inhibiting this active ingredient. The process of the present invention for the production of needle-size growth and enzyme activity inhibiting (I) generic phenylamine acetic acid hydrazide derivatives, wherein R 1, R 2, R 3 and R 4 are each the same or different hydrogens, hydrofoils, 1 to 7 carbon atoms, 1 to 7 carbon atoms or a di- (1). C7-C7 alkyl) amine tubing may be a nitrile tube, with the proviso that at least one of their hydrocarbons is at least one, R5, R6, R7 and R8 are each independently or differently hydrogen atoms; , i.e., a compound of the general formula (II) wherein R 1, R 2, R 3, R 4 are as defined above, reacted with one of the general formula (III), from which R 5, R 6, R 7, R 8 are as defined above1: 1 to 1.5 molar ratio , preferably alkanol and then the purified compound (I), which is purified and then purified in a known manner, if desired, is subjected to a therapeutically preheating saline. ŕ

HU9302598A 1993-09-14 1993-09-14 Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect HU214061B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9302598A HU214061B (en) 1993-09-14 1993-09-14 Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9302598A HU214061B (en) 1993-09-14 1993-09-14 Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect

Publications (2)

Publication Number Publication Date
HU9302598D0 HU9302598D0 (en) 1993-12-28
HU214061B true HU214061B (en) 1998-04-28

Family

ID=10983957

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9302598A HU214061B (en) 1993-09-14 1993-09-14 Process for producing phenylamino-acetly-hydrazide derivatives and pharmaceutical compositions containing the said compounds with tumor growth and enzyme-activity inhibiting effect

Country Status (1)

Country Link
HU (1) HU214061B (en)

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Publication number Publication date
HU9302598D0 (en) 1993-12-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee