HU202749B - Process for producing fodder additive preventing cattle ketosis - Google Patents

Abstract

Field of the Invention The present invention relates to a feed supplement for ketose in cows with high milk production. The composition contains from 20 to 30% by weight of the final product, in a ratio of 0.4% to 1.0: 1-2: 0.41.0% by weight of methinoin and / or methionine metal chelate, 50% by weight of choline. contains lithium and niacin, and the homogenous mixture has a 1-2 mm particle size in a stearic or stearic acid paraffin coating. Scope of the description: 4 pages, without figure EN 202 749 A -1-

Description

FIELD OF THE INVENTION The present invention relates to a feed supplement composition having anti-bovine ketosis activity.

Common metabolic disturbances are ketosis in high-lactation cows at the start of lactation. About 50% of high-yielding cows suffer from ketosis at the start of lactation.

Ketosis is most common in the first 6-8 weeks after calving. This is because the concentration of ketone-like compounds in the blood increases, which is caused by a lack of energy. This is because the animal cannot cover its energy needs from feed and fat is mobilized from fat stores. If ketosis is prolonged, liver fat increases and fatty liver syndrome develops (Schultz, L.M. and Frank, T.J. 1980). As a result, the milk production of the animals is reduced, because of the development of fatty liver syndrome, large dairy cows have to be culled every 4-5 years and therefore the optimal 8-9 year rearing cycle cannot be maintained.

A prerequisite for the prevention and cure of ketosis is a proportionate and balanced diet.

Prevention should aim to support this process of increased fat loss in some way.

The purpose of healing is to restore the carbohydrates and fat that have already been overturned. Fats burn in the "fire" of carbohydrates. An animal suffering from ketosis has low blood sugar levels and a slight decrease in insulin levels. The latter only exacerbates the condition by requiring insulin to pass glucose from the blood into somatic cells where fatty acids are oxidized.

183,673. It is known from the Hungarian patent application No. 3,600,900 to prepare a feed supplement containing amino acids which is protected against microbial amino acid digestive enzymes. The coating may comprise a mixture of gelatin and formaldehyde, C14 fatty acids, high molecular weight esters, waxes, stearic acid, a mixture of stearic acid and paraffin, and other polymers. The amino acid may be lysine, threonine or methionine.

Addition of amino acids such as lysine, threonine and methionine to the feed enhances the utility of other feed amino acids and proteins. The coating of added amino acids is intended to protect the rumen bacterial flora from the feed supplement, i.e., to protect it from biodegradation in the rumen.

173,959. In the Hungarian Patent No. 3,600,900, a rhyolitic meal is prepared, in particular for poultry, by homogenization of choline chloride and optionally with vitamins or trace elements or antibiotics to produce a high concentration of active ingredient in a technically easy to prepare feed supplement. The rhyolite powder may be obsidian, tarstone, pumice or perlite. Among the antibiotics, ardinone or bacitracin are mentioned. The ratio of choline chloride to niacin is 100: 8 (12.5: 1). In addition to niacin, they also use ardinone and bacitracin.

The mechanism or action of choline chloride concentrate used as a feed additive in poultry, especially chicken and turkey breeding is not described. The object of the solution is to increase the stability of known feed additives by using a special carrier.

No. 184,583. Hungarian Patent Application Serial No. 3,600,198 relates to choline chloride and / or to a fat-containing feed additive. The role of choline chloride is to prevent fat deposits in the body of energy-containing fats. The carrier of the treatable choline chloride composition is, according to the patent, dispersed plant material, such as hardwoods, kernels, etc., digested with water at high temperature and pressure, containing lignin and cellulose.

From the above, it can be stated that methionine is used to facilitate the uptake of proteins into the animal body, and choline chloride and niacin are used to reduce fat deposits in the body.

It is an object of the present invention to provide a feed supplement which, when made from readily available components, effectively protects against the development of ketosis in lactating cows during lactation and allows an optimum breeding cycle for breeding animals at constant milk production.

The process of the present invention for the preparation of a feed supplement having anti-bovine ketosis activity is characterized in that 20 to 30% by weight of methionine and / or methionine metal chelate in a ratio of 0.4 to 1.0: 12: 0.4: 1.0 The mixture containing choline chloride and niacin is admixed with a melt of 80-70 tr of stearic acid or a mixture of stearic acid and paraffin at 70-90 ° C and the homogenized mixture is atomized in a known manner and the bulk product has a particle size of 1-2 mm. The methionine metal chelate used is Zn, Mn or Fe chelate.

The use of the feed supplement comprises the daily administration of 20-60 g, preferably 40 g, of feed supplement per animal per animal during the lactation period.

The fatty acid-coated active compound mixture according to the invention has a by-pass effect, i.e., it is only slightly dissolved in the rumen, completely in the inoculum stomach. The combined administration of the three active ingredients has an anti-ketotic effect, stabilizing daily milk yield without reducing the breeding time in the animal due to the development of ketosis.

The preparation and use of the feed additive according to the invention is illustrated in the following examples:

Example 1

In a steam heated mixing vessel, a homogeneous melt of stearic acid is prepared. The melt at 70-90 ° C is pumped into another stirred heated tank. In a dry powder mixer, a mixture of methionine, niacin, choline chloride is prepared in the prescribed ratio. The finished powder mixture is mixed in the second container with the stearic acid melt.

A homogeneous mixture of the active ingredient and stearic acid is placed on a spray drying tower maintained at 70-27 ° C 202749 A 'C. Drying is controlled so that the finished product leaving the tower has a particle size of 70%

in the size range of 1-2 mm. Composition of the manufactured product: 5 DL-methionine 8t% niacin 4t% choline chloride (50%) 131% stearic 751% Example 2 10

The daily ration and nutrient content of the feeds fed in the experiment are shown in Table 1.

The difference between the treatment of the two groups (control - experimental) was that 40 g of the product of Example 1 were administered to the experimental animals 15 times daily.

The assays were carried out using R 1, R 2 and R 2 from Holk frisfer F1 or by crossing it with Holstein Fischer. R3 was constructed with a genetic construct. The average number of lactations in the experimental and control cows, the previous year's lactation production, the distribution of genetic constructs by

See Table 2.

During the experimental period, the animals on average produce 5-6 lactations. months. Examining the date of the last 25 calves (given that not all animals were calved between May and July), we found a normal distribution.

The experiment was not performed on fresh milk needles, because we expected the product to increase milk production in the second half of the lactation, and thus the role of lactation during almost all lactation, and on the other hand, if the product increases daily milk production during this period. , we can achieve a more pronounced effect at the beginning of lactation.

After two weeks of feeding, the milk production of the animals was measured for four weeks. Measurement of the total milk volume in the groups is for information purposes only, but in any case it has followed well the change in milk volume.

After two weeks of feeding, daily milk production and percentage of milk fat were measured individually at week 2 and at the end of week 4 of the experiment.

The results of the experiment are shown in Table 3. At the end of November, there was no difference in milk production between the experimental group (21.31 kg / day, milk fat: 3.60%) and the control group (21.26 kg / day, milk fat: 3.59%) before the start of the experiment. .

At the beginning of December, the difference in milk production between the two groups was 0.91 kg in daily milk production. Cows in the experimental group had higher milk production (19.90 kg / day) than control (18.99 kg / day). The difference in milk fat percentage between the two groups was minimal (experimental: 4.07%; control: 4.02%). At the end of the experiment, the milk production of the experimental animals was 1 kg above the control, with the same percentage of milk fat. (Experimental: 20.31 kg / day, Control: 19.31 kg / day.) Milk fat% for both treatments: 3.93%.

The results of the experiment confirmed the beneficial effect of the preparation on milk production.

A daily dose of 40 g, 1 kg per cow increased the daily milk production by 5-6 lactations. with a lactation capacity of 4,500 kg per month without loss of milk fat.

Table 1

The composition and nutrient content of the feed ration fed in the experiment

dry- 1 kg dry matter fed In the fed portion material NEl Raw Raw Ca P Tak dry Nee Raw Raw Ca P white. fiber mass of material white. fiber g / kg MJ g g g g kg kg kg MJ g g g g

Need

650kgélet-

reservations 43.03 515 48.8 32.5 20 kg milk Meles 62.00 1740 56.0 34.0 Altogether: 105.03 2255 104.8 66.5

corn silage silage Alfalfa- 298.8 6.56 102.4 232.6 4.4 2.7 sensation Wet re- 326.5 5.70 199.7 277.8 16.5 3.7 paszelet 151.9 6.41 114.5 221.2 7.9 1.3 Dairy feed Premixture 875.9 7.99 149.8 47.8 3.8 4.4 and additive 896.3 8.34 133.9 37.0 1.2 4.1 Corpus 868.2 Mineral 6.32 164.1 109.1 1.2 11.5

additional 920.0 TOTAL:

114.1 135.9

20.0 5.9760 39.20 611.9 1390.0 26.3 16.1 10.0 3.2650 18.61 652.0 907.0 53.8 12.1 6.0 .9114 5.84 104.3 201.6 7.2 1.2 5.0 4.3795 34.99 656.0 209.3 16.6 19.3 1.0 .8963 7.48 120.0 33.2 1.1 3.7 1.0 0.862 5.49 142.5 94.7 1.0 10.0

0.1 0.0920

10.5 12.5

16,3884 2286.7 116.5 74.9

111.61 2835.8

-3EN 202749 A

6

Composition of the premixture containing the preparation: Example 1 4.01% maize 40.01% wheat 36.01% bran 20.01% 100.01%

Table 2

Distribution of genetic construction, previous lactation production and average number of lactations in experimental and control groups

Genetic Experimental control construction (Db) (Db) Fi 10 8 Ri 48 48 R2 27 31 Rs 3 1 Altogether: 88 88

Previous lactation production (kg) 4613.7 4514.4 Average lactations number 2.99 3.01

Table 3

Milk production and percentage of milk fat in the experimental and control groups at different completion times

Experimental group n-88 Control group n-88 completion Time Milk kg / day X ± S.D. Teizsír% X ± S.D. Milk kg / day X ± S.D. Milk fat% X ± S November 21.31 ± 2.11 3.60 ± 0.29 21.26 ± 2.20 3.59 ± 0.34 December 2 19.90 ± 3.40 4.07 ± 0.27 18.99 ± 3.47 4.02 ± 0.20 December 16 20.31 ± 3.65 3.93 ± 0.51 19.31 ± 3.70 3.93 ± 0.19

PATENT CLAIMS

Claims (2)

PATENT CLAIMS CLAIMS 1. A process for the preparation of a feed additive for the prevention of bovine ketosis, characterized in that methionine and / or methionine metal chelate is present in a weight ratio of 20-30 tr 0.4-1.0: 1-2: 0.4-1.0. A mixture of -55% choline chloride and niacin is mixed with a melt of 80-70 tr of stearic acid or a mixture of stearic acid and paraffin at 70-90 [deg.] C. and the homogenized mixture is atomized in a known manner and the bulk product is 1-2 mm in size . 2. A process according to claim 1, wherein the methionine metal chelate is Zn, Mn or Fe chelate.