HU201247B - Composition containing stqbilized hydrogen peroxide for cleaning, blood removing and disinfecting surgical instruments and devices - Google Patents

Abstract

SUMMARY OF THE INVENTION The present invention relates to a disinfectant detergent composition having a high wettability, stabilized hydrogen peroxide comprising 20 parts by weight of an alkylphenol polyglycol ether of formula (I) and / or (II), and / or an alkyl polyglycol ether of formula (I) wherein R1 is C 6 -C 18 alkylene. n is 6-12, in formula II, R2 is C8-C20 alkyl, or a mixture thereof, n 'is 2 to 8, and 0.1 to 20 parts by weight of Compound (I) and / or (II). - 3 parts by weight of a dialkylsulfosuccinate-Na salt of formula (III): wherein R 3 is C 6 -C 12 alkyl, contains 1-4 parts by weight of an alkyl polyglycol ether phthalate of formula (IV): R 4 is C 6 -C 18 alkyl or a mixture thereof, n " and 2 to 8, 8 to 12 parts by weight of hydrogen peroxide and, if desired, 1 to 20 weight percent viscosity modifier, preferably ethyl alcohol, complexing agent, preferably ethylenediamine tetraacetic acid disodium salt, passive additive, preferably phosphoric acid, purified instrument surface R2- (0CH2 - CH2) rf-OH 0 II H2C - C - 0 - R3 I / 0 - R3 h2c - c IO3Na '0 - (0CH2 - CH2) rf - 0 - Rz, C - OH 0 Scope of the description: W page, 4 formulas ( IV) EN 201 247 B -1-

Description

BACKGROUND OF THE INVENTION The present invention relates to a detergent composition having a stabilized hydrogen peroxide disinfectant, having a high wetting ability, suitable for the pre-sterilization, disinfection and cleaning of medical hand instruments and devices.

Prior to sterilization, the following technological procedures must be followed:

- rinsing - disinfection - soaking - mechanical cleaning and bleeding - drying

Instruments and devices that have been pre-treated and disinfected by the above procedure are then sterilized. The sterile condition, as it is known, means a higher hygienic quality condition than the disinfected condition, however, the achievement of the sterile microbiological state depends crucially on the preventive disinfection! operation efficiency.

It is an object of the present invention to provide a hydrogen peroxide detergent composition which is capable of performing a single sterilization, decontamination and disinfection of medical instruments prior to sterilization.

In solving the object of the invention, basically two aspects had to be considered:

- the preparation of a formulation containing a stable surfactant with a good cleaning effect, which does not decompose hydrogen peroxide, which is an essential active ingredient, from production to use; - the provision of a formulation containing hydrogen peroxide which provides complete and high-quality cleaning of special medical equipment.

In order to meet the latter criterion, it was important to take into account the fact that the equipment to be cleaned, such as needles, scissors, chisels, vascular pliers, demolition tools, tweezers, hooks, hooks, etc. devices with complex articulated surfaces, in which the efficiency of cleaning and disinfection depends fundamentally on penetration of the slots used, often in very narrow gaps, ie their extremely intensive wetting capacity. In the requirements for disinfectants and detergents, he emphasizes the importance of the wetting effect in the treatment of medical instruments and devices Russel, A.D-Hugo, W.B-Ayliffe, G.A.J. Also in his work Principles and Practice of Disinfection, Preservation and Sterilization (Blackwell Scientific Publication, Oxford, 1982).

The object of the present invention is based on the basic literature that the stabilization of the hydrogen peroxide is enhanced by the ethoxylates of the nonionic surfactants, i.e. stable in the composition of H2O2 ethoxylate detergents which are otherwise prone to degradation in aqueous media. An example of this is European Patent Application 195 195, where 55 wt% 27.5% hydrogen peroxide is used in the detergent composition for dishwashing purposes at 20 wt% fatty alcohol ethoxylate. A suitable composition of a non-ionic surfactant of the hydrogen peroxide and ethoxylate type for textile cleaning is disclosed in U.S. Patent 4,331,618. No. 218,631. The GDR patent discloses a stable composition based on alkylphenol-polyglycolterterter and hydrogen peroxide for disinfectant cleaning of flat, smooth surfaces. Japanese Patent Laid-Open No. 59-120,700 discloses a composition comprising an alkyl polyglycol ether detergent composition besides hydrogen peroxide and a complexing agent for cleaning greasy oily surfaces.

On the basis of the foregoing, a detergent composition containing alkyl and / or alkyl alkylaryl ethoxylates as detergent and hydrogen peroxide as a desensitizing agent is known. However, a major disadvantage of the present invention is that non-ionic surfactants, such as ethoxylate surfactants, have very low wetting properties, such as complex, articulated surface-mounted instruments, e.g. needles, tweezers, etc. They are unsuitable for wetting or, at the same time, for purifying them by antifungal treatment because they are unable to deliver the active ingredient inside narrow gaps or small diameter surfaces due to their low wetting capacity.

This property of ethoxylate-type surfactants is discussed in detail in Schönfeldt, N., (1976), Grenzflachenaktive Athylenoxid Adduct, Stuttgart, Wissenschaftliche Verlaggesellschaft.

Experiments with hydrogen peroxide-ethylone oxide adducts in aqueous media supported the results of theoretical publications. The results of experiments using various aqueous media ethoxylates-hydrogen peroxide compositions have shown that these compositions are not suitable for the purpose of the present invention due to improper wetting action.

To accomplish the object of the present invention, the above hydrogen peroxide-ethylene oxide adduct composition requires the use of a third component having a rapid wetting effect which not only enhances the effectiveness of the disinfectant and detergent but also the rapid wetting of narrow gaps, needles properties. As a result of the experiments carried out, it was found that dialkylsulfosuccinate Na salts are the most suitable for this purpose.

It is known in surfactant chemistry that the dialkyl sulfosuccinate Na salts of defined molecular structure have outstandingly effective wetting activity (Juhász, É-Lelkesné-Erős, M: Surface-active Materials Pocket Book, Technical Publisher, Budapest 1979). In terms of molecular structure, the optimum wetting effect is for dialkyl sulfosuccinates characterized by a C8 alkyl group.

-3HU 201 247 Β

Various aqueous media for commercially available fast-wet phthalate products contain the dioctylsulfosuccinate Na salt. Such products include Aerosol OT (Cyanamid Co, New Jersey, USA), SBS-Netzer (Barlocher A.G. - USG), 5 Spolion-8 (Slovnaft-CsSzK) and Solovet (United Chemicals - Budapest). In our attempts to solve the object of the invention, for reasons of convenience, the above-mentioned domestic product Solovet, a 25 wt% aqueous solution of its dioctylsulfosuccinate Na salt, was used.

Numerous experiments have demonstrated that the triple system of alkyl or alkyl-arylethoxylate-dialkylsulfosuccinate-Na-salt-hydrogen peroxide is capable of addressing the ₁₅ objectives of the present invention, both in terms of antimicrobial activity, antifouling and cleansing effects. However, it is a serious problem that the dioctyl- ₂ θ sulfosuccinate Na salt (Solovet) in this ternary system very rapidly degrades, inactivates, the hydrogen peroxide in the composition. This is not surprising given the chemical properties of hydrogen peroxide. It is known that hydrogen peroxide is strongly decomposed in the presence of cyanogenated Na ⁺ ions in an alkaline medium. Nevertheless etoxilátum - Solovei - (detergency, clamping and, bactericidal, virucidal, fungicidal) ³⁰ can not give off any other detailed above, preferred characteristics of a complex of hydrogen peroxide ternary system.

In our studies of the present invention, the basic aim was to stabilize hydrogen peroxide ^{35 in} the ethoxylate-Solovet-hydrogen peroxide triple system to prevent its degradation.

There are numerous references in the patent literature to the effect that hydrogen peroxide can be stabilized by additives in various surfactant compositions. Thus, ⁴⁰ in U.S. Pat. No. 899,620. Soviet Patent discloses a degreasing and cleaning composition hidrogónperoxidot wherein in addition to the nonionic and amphoteric surfactants are aliphatic or aromatic amines ⁴⁵ has a stabilizing. The effect of fatty acid on the stabilization of hydrogen peroxide is described in U.S. Patent No. 4,510,018. U.S. Pat. Because of their toxic activity, amines are not suitable for the purpose of the present invention. For similar reasons, no. nor is the solution according to Japanese Patent No. 6,400,125, wherein stabilization of hydrogen peroxide is provided by carbonates of heavy metals. The authors of US Patent No. 1,183,473, for a similar purpose, suggest the highly 55 toxic oxalic acid, while U.S. Patent No. 4,133,869. U.S. Pat.

Without further reference to the patents, it will be appreciated that known hydrogen peroxide stabilization methods and solutions are not applicable to hydrogen peroxide detergent compositions for use in medical and patient care devices and devices. A further difficulty was that the extensive literature search did not find a composition suitable for purification which contained hydrogen peroxide and dloctylsulfosuccinate-Na salt simultaneously.

The basic objective of the present invention was to stabilize the hydrogen peroxide used in the composition suitable for the above-mentioned problem by using a solution or additive that satisfies the needs of medical and health care, thus it does not react with other components of the composition. and does not damage the treated surfaces in any other way. In addition, it has been kept in mind that the H2O2 stabilizer used should not be indifferent in its purifying or antifoaming effect and should not reduce the effectiveness of the detergent composition. For this purpose, acidic surfactants have been considered both theoretically and practically.

In our research on synthetic detergents, we have concluded that in the alkyl and / or alkylarylethylethoxylate dioctylsulfosuccinate hydrogen peroxide triple system underlying the invention, the decomposition of hydrogen peroxide can be practically prevented, the ratio of hydrogen peroxide can be stabilized The acidic acid ester of the alkylethoxyl phthalate of formula III is added. It has been discovered that in the presence of alkyl and / or alkylarylethyletoxylate and dioctylsulfosuccinate (Solovet) surfactants, hydrogen peroxide remains stable when a certain proportion of the acidic semisester of the alkyl ethoxyphthalate of formula IV is present.

It has also been found that the moisturizing effect of the fast wetting dioctyl sulfosuccinate in the composition is further enhanced by component (IV), otherwise intended to stabilize H2O2, thereby significantly improving the overall cleaning, dehydrating and disinfecting efficacy of the composition. The above two findings are surprising, since they do not exhibit any advantageous properties of the other alkyl phthalate acid semester esters having the structure similar to the other alkyl ethoxyl phthalate acid esters of formula (IV) in terms of hydrogen peroxide stabilization or enhancement of wettability. That is, only those acidic phthalate esters in which the ester-bonded group is an alkyl ethoxylate, i.e., ethoxylated fatty alcohol, are preferred for both stabilization of hydrogen peroxide and enhancement of wetting ability.

The purifying functional alkylethylethoxylate or alkylethoxylate of the composition according to the invention, which are represented by the general formulas (I) and (II) below, may alternatively be substituted in a certain proportion, that is to say, any one may be used alone in the composition.

Without the appreciable influence of the complex effect of the composition of formula (I) and (II), nonionic surfactants of the ethoxylate type can be used in any proportion within the limits of the application concentration. The present invention is thus soluble in aqueous media. is a detergent composition having a stabilized hydrogen peroxide solution with a disinfectant, antiseptic, virucidal and fungicidal action, and which is capable of decontamination and general cleaning of medical instruments and devices in addition to the effects listed above.

The composition is characterized in that it contains 20 parts by weight of an alkylphenol polyglycol ether of formula (I) and / or an alkylpolyglycol ether of formula (II), alone or in any ratio, wherein R 1 is a C 6-18 alkylene group, n is from 6 to 12, R _{2 in the} formula (II) is a C 8-20 alkyl group or a mixture thereof, and R ₁ is from 2 to 8, based on 20 parts by weight of the compound of the formula I and / or II, Contains 1-3 parts by weight of a dialkyl sulfosuccinate Na salt of formula III wherein R 3 is a C 6-12 alkyl group, and contains 1-4 parts by weight of an acidic ester of an alkyl ethyl ethoxylate of formula IV wherein R 4 is 6-18 C 1 -C 4 alkyl or a mixture thereof, and n is from 2 to 8. The alkylpolyglycol ether of formula (II) and the phthalic acid semester of formula (IV) are not necessarily uniform in terms of the number of carbon atoms of the alkyl radicals R ₂ and R 4, respectively. containing several R ₂ and R 4 alkyl groups in the range of atomic numbers.

The antimicrobial and desiccant component of the composition of the invention is 8 to 12 parts by weight of hydrogen peroxide, based on the active ingredient, in the form of a commercially available aqueous solution.

In addition to the above, if desired, without modifying the basic function of the composition of the invention, ethyl alcohol which improves the disinfectant effect but substantially modifies the viscosity, hardener, e.g. a surface-gloss excipient such as citric acid, fumaric acid, salicylic acid, and fragrances and colorants in a proportion of from 1 to 20, preferably at least 10% by weight.

The antimicrobial disinfectant and general cleansing composition of the present invention may be prepared by mixing the components or preparing an aqueous solution of the composition. Preferably, the ethoxylate type component (s) is weighed first, followed by weighing of the wetting dialkyl sulfosuccinate followed by the acidic semisester of the alkyl ethoxylate phthalate to provide a stabilizing effect, and then the hydrogen peroxide is added. At the end of the manufacturing process, the auxiliaries not critical to the basic effect are weighed in any order. Because of the high viscosity of the alkyl and / or alkylaryl ethoxylates, the concentrated active ingredient composition is preferably formulated as an aqueous solution having a total water content (including water content of the aqueous H ₂ O ₂ solution) of 35-75% by weight, preferably 40-60% by weight. .

The invention is illustrated by the following examples.

Example 1

Mixing In an enamelled container, while stirring, 445 liters of water are added and the temperature set at 20-30 ° C. Subsequently, 80 kg of 10-degree nonylphenol polyglycol cholesterol with 120 kg of C10-C18 saturated alkyl groups (having an average number of words 16.2) and 4 ethoxy groups were dissolved in water and 15 kg of a 25% w / w aqueous solution (active ingredient: 3.75). kg) of dioctylsulfosuccinate Na salt (Solovet) followed by a stabilizer of hydrogen peroxide which is 25 kg (100% concentration) of alkylpolyglycolphthalate, which is characterized by the presence of alkylpolyglycol ethers having an average carbon number 16.2) and contains 4 ethoxy groups. Subsequently, 285 kg of 35 wt% hydrogen peroxide, 50 liters l.o., were added to the system. and 6 kg of citric acid and 4 kg of phosphoric acid. After continuous mixing, a slightly yellow, translucent, viscous, water-like composition is obtained which, besides its antimicrobial action, is suitable for intensive and rapid blood removal of medical devices.

Measurements were made to express a numerical comparative evaluation of the germicidal activity of the composition of the invention. During the measurements, the composition according to Example 1, 30% hydrogen peroxide (Hydrogenium peroxidatum concentratum, Ph.Hg. VII), according to the pharmacopoeial quality standards and currently used for hemodialysis in health practice (Company for Oil and Detergents, Budapest). The blood solubilizing effects of an agent containing a proteolytic enzyme were compared.

Test substances were prepared in volumes of 1, 2, 3, 4 and 5% by volume, and the blood solubility was determined as a function of concentration. For the composition of the invention and for solutions of hydrogen peroxide, blood solubility tests were performed in 20 ° C solution using a 30 minute exposure time, while in the case of Haemopon, the current product specification was 5

-5HF 201 247 Β (Dr. Pecho, Z-Dr. Milassin, M: Sterilization Information, Budapest 1985, p. 45), the temperature of the solution used was 60 ° C and the exposure time was 90 minutes. Blood solubility was determined according to the requirements of standard MSZ-033181. The use of Gregersen's reagent for the detection of trace amounts of undissolved blood is very sensitive.

The results are summarized in Table 1.

Table 1

Test preparation (1 L solution) Concentration of preparation in 1 L solution (volume ° / o) H2O2 equivalent concentration in 1 L solution (w / w) Dissolved blood volume exp. time: 30 p temperature: 20 'C (Ml) 1 0.12 15 The composition of Example 1 2 0.25 30 3 0.36 45 4 0.50 60 5 0.60 75

Hydrogen peroxide (Ph.Hg.VII) pharmacopoeia quality 1 2 3 4 5 0.3 0.6 1.0 1.3 1.7 2 4 5 10 15 Concentrate of preparation enzyme Concentration Dissolved blood volume Haemopon in 1 L solution 1 L solution exp. time: 90 p (Wt ° / o) (crowd%) temperature: 60 ° C (ml) 1 0.02 0.05 2 0.04 0.1 3 0.06 0.2

From the data in the table it is striking that the composition according to the invention has a very high blood solubility. Based on the measured data, two significant findings can be made:

a) 5 liters / volume of the composition according to the invention, containing 0.6% by weight of active H2O2, is capable of dissolving 5 times the volume of blood as the same volume of 5% by volume of a pharmaceutical grade hydrogen peroxide solution containing o almost triple (1.7% by weight). This fact proves that the detergent composition of the composition of the invention significantly increases the blood solubility of hydrogen peroxide in terms of blood solubility.

b) The 5% v / v composition of the invention is capable of dissolving nearly 200 times the amount of blood as the same concentration and amount of Haemopon solution, which is also based on a detergent composition, contains elevated protein degrading enzymes and is currently used in medical

Example 2

The procedure of Example 1 was followed, except that to 370 liters 330 kg of hydrogen peroxide solution of 30 wt .45 ° C were added, followed by 60 kg of alkylphenol polyglycolol ether having an alkylene group of 6, an ethoxylation degree of 6, the alkyl group of the weighed 140 kg alkylpolyglycol ether has a carbon number of 8 and a degree of ethoxy50 of 2.

The metered amount of hydrogen peroxide stabilizer employed is 25 kg, except that an alkyl polyglycolphthalate acidic semester ester is used wherein the ester bonded alkyl polyglycol ether is characterized by a C 6 alkyl group having an ethoxylation degree of 2. All other weighed components in terms of quantity and composition, as in Example 1. The viscosity fluid, which is substantially the same as Example 1, has the same viscosity as the product of Example 1 and has the same H2O2 content as Example ⁶⁵ .

HU 201 247 Β

Examining the bacteriostatic activity of the preparation, both the mode of execution and its evaluation were performed according to the "Richtlinien für die Prüfung und Bewertung Chemischer Desinfektionsverfahren" (Gustav Flscher Verlag, Stuttgart, New York, 5,1981). The results are summarized in Table 2.

Table 2

Tesztbakterium name Concentrations required for inhibition of reproduction 10 Example 2 conc. (crowd%) active - H2O2 Conc. (microwave oven- g / ml) 15 Staphylococcus aureus 0.03 29.7 20 Escherichia coli HNCMB 3301 0.05 49.5 Pseudomonas aeruginosa HNCMB 170001 0.25 247.5 25 Salmonella typhi HNCMB 15005 0.06 59.4 Proteus vulgaris HNCMB 60001 0:02 19.8 ΟΛ

For in vitro studies, 18-hour bouillon cultures of bacterial subculture 3 were used. The results indicate that a bacteriostatic effect of the composition of the present invention, without linking to detail-free comparative results _35, has a very low threshold value is extremely pronounced.

Example 3 40

The procedure of Example 1 is followed, except that 100 kg of alkylphenol polyglycol is added to 370 liters of water, the alkylene group has a word number of 18, an ethoxylation degree of 12, a measured 100 kg of alkylpolyglycol ether has a word number of 20. In the system, 25 kg of the alkyl polyglycol terephthalate acidic semester, which is characterized in that the alkyl polyglycol cholesterol in the ester bond is 50 to 18 and has an ethoxylation degree of 8, is dissolved in the system. .

Liquids having a similar viscosity to those of Examples 1 and 2 with slightly higher viscosities are obtained. The bactericld activity of the formulation was measured in the absence or presence of pro-active substances for the test bacteria, according to the method of θθ as set forth in the literature reference of Example 2.

1% bovin albumin was used as a bactericidal inhibitor. The measured results are summarized in Table 3. 65

Table 3

Bacteria test name Exposure time (minutes) required for bactericidal action is a protective substance without the presence in Staphylococcus areUS HNCMB 110003 3 13 Escherichia coli HNCMB 33001 5 13 Pseudomonas aeruginosa HNCMB 170001 10 18 Salmonella typhi HNCMB 15005 7 15 Proteus vulgaris HNCMB 60001 3 13

The exposure time of the bactericidal activity measured for the composition of the present invention, without reference to comparative results, is very prominent.

Example 4 (Comparative Example)

All of the procedures of Example 1 were followed except that alkyl polyglycolphthalate, a stabilizer for hydrogen peroxide, was not added to the system of the invention. All other components are present in the composition in the amount and quality of Example 1. The compositions of Examples 1 and 4 were subjected to 12 months of storage stability studies at 20 ° C. Storage was carried out in a black polyethylene bottle and the amount of active hydrogen peroxide present in the composition, calculated as a percentage by weight, was continuously measured by iodometry and is summarized in Table 4.

Table 4

Active H2O2 concentration (% w / w)

Time of sampling Example 1 is an invention of With H2O2 stabilizer content Example 4 is a stabilizer for H2O2 according to the invention without 1 day after production 9.83 9.61 1 month later 9.77 7.11 Two months later 9.64 5.32 3 months later 9.58 3.17 In 6 months 9.31 3.05 In 9 months 9.12 2.92 12 months from now 8.97 2.61

From the data in the table it is striking that the alkyl polyglycol terephthalate used in the composition according to the invention

-711

201 H2O2 stabilizer according to the invention proves to be very effective. Typically, after 12 months of storage, 91% of the stabilized hydrogen peroxide remains active, whereas in a composition of the same composition but not containing the H2O2 stabilizer of the invention, the active hydrogen peroxide content decreased by only 27% of the original. Since the anti-microbial activity and antimicrobial activity shown in the previous embodiments are essentially based on the active H2O2 content, the values of the respective effects are also closely related to the active H2O2 content present in the composition. Detailed discussion of relevant measurement results is omitted due to their evidentiary nature.

Example 5 (Comparative Example)

The procedure of Example 1 is followed except that the dioctylsulfosuccinate (Solovet), which is used as a rapid wetting component in the composition of the invention, is not used in the system. All other components are present in the composition in the amount and quality of Example 1. The wetting action of the two compositions was performed according to DIN 53901, since, as stated above, the wetting action is crucial for both the blood solubilizing and the antimicrobial activity. The principle of measurement is to place a raw cotton fiber on the surface of a solution of the test substance at the required concentration and measure the time needed for the fiber to immerse in the liquid. Immersion is measured in seconds. The lower this number, the better the wetting effect of the test substance. In the comparative studies, the composition of Example 5, which did not contain the instant wetting component (Solovet), was compared with the corresponding effect of the composition of Example 4, which did not contain the acidic semester of alkyl polyglycolphthalate used as H2O2 stabilizer, but Solovet and the composition of Example 3 containing both H2O2 stabilizer and Solovet. The formulations were prepared at concentrations of 2 g / l, 5 g / l and 10 g / l and the wetting effect was measured. The results are summarized in Table 5.

_5. table_

Wetting effect measurement results (sec)

Concentrations g / l 5 g / l 10 g / l

example composition 8.3 6.1 4.0 example composition 3.8 2.7 2.1 example composition 3.2 2.7 2Ό

From the data in the table, two important conclusions can be drawn.

a) The highly moisturizing effect of the composition according to the invention is markedly enhanced by the content of dioctylsulfosuccinate in the composition.

b) Alkyl polyglycol terephthalate used as a H2O2 stabilizer in addition to dioctyl sulfosuccinate improves the wetting effect, if only to a small extent.

The above findings were also supported by the practical cleaning procedures carried out.

During purification experiments, 100-100 blood heavily soiled injection needles were cleaned by soaking and evaluated using Gregersen's reagent according to MSZ 31-81. The cleaning conditions are also set out in the above standard.

After purification with the composition of Example 5, the color reaction was positive for 14 needles, meaning that purification had to be repeated.

When the formulations of Examples 4 and 3 were used under the same conditions, 2 and 3 needles, respectively, showed a positive color reaction, which is an effective purification according to the standard.

The results clearly underline the principle that the wetting ability of the agent used is of particular importance when cleaning or treating medical devices, instruments, characterized by narrow gaps and openings.

Apart from the numerical demonstration of general cleaning, germination and antimicrobial effects, further examples of the preparation and possible composition of the composition of the present invention are provided.

Example 6

In the mixing apparatus of Example 1, the following substances are weighed in the following order, with continuous mixing:

800 liters of water, dodecylphenol-polyglycol ether with 8 degrees of ethoxylation, 25% aqueous solution of 45% dodecylsulfosuccinate Na salt (content: 9 kg), 35 kg of alkyl polyglycol ether phthalate (100% active ingredient) in which The alkyl polyglycol ether in the ester bond has a carbon number of 10 and a degree of ethoxylation of 6.395 kg of 30% technical hydrogen peroxide solution, 80 liters of ethyl alcohol, 10 kg of citric acid, 10 kg of disodium salt of ethylenediaminetetraacetic acid and 10 kg of phosphoric acid. Slightly yellowish, translucent, approx. 1500 kg of a composition is obtained which is substantially the same as the compositions of the above-described embodiments in terms of general cleansing, antifungal and antimicrobial activity.

Example 7

The following materials are weighed into the apparatus of Example 1 with continuous mixing:

445 liters of water, 190 kg of alkyl polyglycol ether having a carbon number of 16 and an ethoxylation degree of 6.30 kg of 25% aqueous solution of dodecylsulfosuccinate-Naso (content: 7.5 kg), 20 kg of alkyl polyglycol ether / sour half-ester (100% active ingredient) in which the alkyl polyglycol ether in the ester bond is carbon-813

EN 201 247 Β atomic number 12, degree of ethoxylation 4, 285 kg 35% hydrogen peroxide solution, 40 liters ethyl alcohol, 5 kg fumaric acid and 5 kg salicylic acid. With similar properties to those mentioned in the previous examples, they have substantially the same functional properties in ca. 1000 kg of liquid are obtained.

Example 8

In each case, following the procedure of Example 7, weigh the following materials with continuous mixing:

920 liters of water, 200 kg of dodecylphenol polyglycol ether of Example 6, 50 kg of an alkyl polyglycol of Example 7, 25% aqueous solution of 8 kg of dialkyl sulfosuccinate sodium salt of Example 7 (active ingredient: 2 kg), 17 kg of the alkyl polyglycol ether phthalate acid semester of Example 7, 265 kg of 30% hydrogen peroxide solution, 1 liter of ethyl alcohol, 8 kg of salicylic acid, 4 kg of citric acid, 8 kg of phosphoric acid. 20

Approx. 1500 kg of liquid are obtained.

Example 9 25

In the apparatus of Example 8, using the same procedure as in Example 8, all of the following materials were charged with stirring:

915 liters of water, 150 kg of dodecylphenol polyglycol ether according to Example 6, 50 kg of alkyl polyglycol ether according to Example 7, 60% aqueous solution of 45 kg of dihexylsulfosuccinate sodium salt (active ingredient: 27 kg), kg Example 7 alkyl-polyglycol ether phthalate acid semester,

280 kg 35% hydrogen peroxide, 20 liters 35 ethyl alcohol, 6 kg salicylic acid, 6 kg citric acid, 8 kg phosphoric acid.

Essentially, 1500 kg of liquid having the same properties as the preceding embodiments are obtained. 40

Example 10

In each case, as in Example 9, the following materials were weighed into the mixing apparatus fixed therein: 45

967 liters of water, 150 kg of dodecylphenol polyglycol ether of Example 6, 50 kg of alkyl polyglycol ether of Example 7, 45 kg of a 60% aqueous solution of dihexylsulfosuccinate Na salt (active ingredient: 27 kg), 20 kg 7. Alkyl polyglycol ether phthalate, acidic folate ester of Example 1, 228 kg 35% hydrogen peroxide, 20 L ethyl alcohol, 8 kg salicylic acid, 7 kg citric acid, 5 kg phosphoric acid.

1500 kg of liquid having similar properties to those obtained in the preceding embodiments are obtained.

Claims (1)

A composition containing stabilized hydrogen peroxide for general cleaning, decontamination and disinfection of medical instruments and devices, characterized in that: Contains 20 parts by weight of an alkylphenol polyglycol ether of formula (I) and / or (II) and / or an alkyl polyglycol ether of formula (I) wherein R 1 is C 6 -C 18 alkylene, n is 6 to 12, wherein R 2 is C 8 -C 20 alkyl or a mixture thereof, n 'is 2 to 8, and 20 parts by weight of the compound of formula (I) and / or (II) Containing from 0.1 to 3 parts by weight of a dialkyl sulfosuccinate Na salt of the formula (III) wherein R3 is a C 6 -C 12 alkyl group, 1 to 4 parts by weight of an acidic semester of an alkyl polyglycol ether phthalate of formula IV wherein R4 is a C 6-18 alkyl group or a mixture thereof and n is 2 to 8, 8-12 parts by weight of hydrogen peroxide and, if desired 1 to 20 parts by weight of a viscosity modifier, preferably ethyl alcohol, a complexing agent, preferably an ethylenediaminetetraacetic acid disodium salt, a passive additive, preferably phosphoric acid, an auxiliary agent, preferably citric acid, salicylic acid and fumaric acid. 1 page drawing with formulas