HU199077B - Process for producing complex composition for treating udder - Google Patents

Abstract

Prepns. for the treatment of udders after milking, contains disinfectants, antiinflammatory cpds., skin nourishing agents, vitamins and generally used veterinary substances. Prepns. may be solutions or ointments depending on their end use.

Description

SUMMARY OF THE INVENTION The present invention relates to a process for the preparation of complex udder care compositions. More particularly, the present invention relates to a process for the preparation of udder care compositions to be applied after the plumage, which compositions have significant antiseptic, skin care and regenerative and anti-inflammatory properties.

According to surveys covering several countries, the proportion of udder cows varies between 17-44% of the total herd (Dr. Horváth Gy .: Control of mastitis, Agricultural Journal, Bp., 1982, p. 15). As a result of mastitis, milk yields decline, milk quality deteriorates, medical costs rise, forced slaughter occurs, healthy stock is endangered, and it puts animal carers at risk. The damage resulting from these is currently estimated at an average of around HUF 1,800 per animal in Hungary (Kováts, J., Control of mastitis, Agroinform, Bp., 1977).

The development of various udder diseases can be attributed to a number of internal and external factors. There are many different causes of external factors, which result in an abnormal condition of the udder. These include mainly hygienic factors such as irregular litter change, increased average germ number, temperature and humidity issues (such as too cold a substrate, deep-bottomed padding or insufficient ventilation), systematic microtrauma, and after-treatment, poor milking technology, lack of regular skin care. In many cases mechanical injuries also occur where the resulting wounds provide a good breeding ground for viral, bacterial or fungal infections.

The uneven, pitted floor and the lack of straw, especially the obstruction of the urine flow, the occasional faecal faeces loosen the skin of the udder and this environment provides optimal conditions for the growth of bacteria and fungi. Secondary pathogens also appear in the loosened or already inflamed skin and may cause inflammation of the necrosis type. In this case, the skin temperature is 2-5 ° C lower than normal, the color turns gray or black and dies in map-like patches, and then becomes parchment-like. Inflammation can also spread to the glandular tissue.

Various microorganisms play an important role in the octane of mastitis, but mastoids without microbes are also known. Bacteria usually enter the udder through the nipple opening from the outside environment. In most cases, Staphylococci and Streptococcus play a major role, but in about 15% of cases Colibacteria, Klebsiella and Corynebacteriun occur. ·,

In large-scale dairy farms, unfavorable housing conditions lead to damage to the udder mechanics, but the effects of milking and udder treatment can cause even greater damage.

Tanned skin and dehydration are known to be prone to skin inflammation q On the one hand, through injury, the udder connective tissue becomes infected and can develop: mastitis acuta gravis, and on the other hand, the injury causes the milk to drop. Withholding milk can lead to mastitis on its own.

One of the most important goals of professional udder preparation (washing and disinfecting) is to get rid of the contaminants from the udder and nipples skin.

The purpose of treating the nipple after milking is to prevent bacteria from entering the nasal passages. The bacteria remaining in the last drop of milk proliferate rapidly and can quickly migrate into the udder canal. In many cases, milk droplets on the tip of the teat are not detectable, but only during the t disinfection operation.

q Frequent warm water washing of the udder dissolves a significant part of the fat content of the udder skin. For this reason, it is advisable to treat the udders occasionally with special uddering ointment at the end of milking. This is especially important in the case of cows entering the milking parlor and in the spring when the mating season begins.

If you do wash the udder with cold water, then the essential thing about milking is big. the use of a stimulus stimulus.

Vacuum fluctuations in the milking cups and milking cartridges can occur when milking machines are used incorrectly, but can also result in blind milking or milking. The former, as well as the choice of milking speed in winter, can mechanically damage the udder. Imperfect expression of the udder is one of the most important predisposing factors to these mastitis.

Nipples should be treated immediately with milk by dipping or spraying with germicidal and cosmetic preparations to reduce the risk of infection of the udder.

It is especially harmful to wash all the cows' toads with a sponge or cloth dipped in the same bucket. The clear purpose of tooth washing is to reduce mgcroscopic and microscopic contamination.

Individual flush milk washings are used, for example disinfectant washings with iodophores (0.5% Iosan-CCT or Incosan-W). Nipple disinfection after milking can also be done with Demost emulsion or similar disinfectant solutions. . In America, after the dairy, 4% is hypo3

HU 199077 Β dipped in chlorite solution or bathed in a vinaigrette seal.

Performed according to known methods. after disinfection, especially in premature and three times advanced individuals, the skin of the nipple is cracked, causing pain in the chin. Repairing this condition during windy, rainy periods was very tiring and costly.

In the absence of skin nourishing and skin regenerating effects, the disinfectants used had to be treated with boron petroleum several times at least once a week in wet periods to prevent dehydration and cracking.

It is an object of the present invention to provide stable, durable udder care compositions which, by treating the udder or teat, prevent the development of various mastitis, the skin of the udder being replaced by a smooth, supple nipple. inhibits the adherence and multiplication of microorganisms and their germs, and has a regenerative, antiseptic, skincare and anti-inflammatory action, that is to say, a product which, when used, can effectively assist in udder biology and milk hygiene.

It has now been found that formulations which simultaneously contain the desired components in a complex formulation, and thus can be applied simultaneously to the udder skin, are best suited to achieve this goal.

The compositions of the present invention can be used in both solution and ointment forms. The solution form is best suited for dipping and spraying applications, while the ointment form is primarily used to rub the nipples.

The compositions of the present invention contain disinfectants, vitamins, skin nourishing agents, Brillant green and other substances commonly used in veterinary formulations.

The budding liquid of the present invention is prepared by making mucilage from methylcellulose distilled water in a manner known per se and adding to the mucilage a solution of 0.6% aluminum in aluminum acetate tartrate, glycerol, made from a nonionic ointment. aqueous emulsion, aetheroleum chamomillae, a solution of Brillant green (viridae nitens, Ph. Hg. VI,) followed by Bradophent (benzyl dodecylbis / 2-hydroxyethyl) ammonium chloride] and finally vitamins. Stirring until homogeneous. Bradophen smert is a disinfectant.

The ointment composition is prepared as described above, except that the weight ratio of the non-ionic emulsifying ointment is increased to about ten and the amount of distilled water is reduced by about one third.

The compositions of the present invention were tested for antibacterial activity using appropriate test microorganisms. The formulations were tested freshly prepared and after two weeks of storage, with no difference between the results. The results suggest that the compositions have a broad spectrum antibacterial activity against the appropriate microorganisms and are capable of inducing germ-poor status of the udder and teat. The assay was performed by applying a known amount of the Example 2.5 formulation to a known amount of bacterial-infected Bouillon agar plate sufficient for severe infection. The results of the microbiological assays are shown in Table 1.

Brillant Green, a coloring agent with 0% anti-inflammatory properties, was added to the formulations. The primary purpose of adding Brillant Green was to check afterwards the actual occurrence of the case. When using formulations without the addition of Brillant Green, we found the surprising result that the efficacy of the formulations was significantly reduced by about one third. BrilQ lute green and ethereal chamomile extract were omitted from the formulations, and the results are shown in Tables 2 and 3.

The ointment and solution 5 of the present invention has also been tested under in vivo conditions. Swab specimens were swabed 4 hours after treatment and subjected to bacteriological examination. For cows kept under clean conditions, the test was negative.

When designing formulas, keep in mind the factors such as «easy handling, the applied material 5 covers the nipples well and seals the nasal passages with a thin film, and is protected from external influences, easy to wash off before the head and cost of treatment better than the materials previously used.

The compositions of the present invention have a superior antiseptic, anti-inflammatory, and skin-protective properties.

-35 EN 199077 Β and have a vitamin content that promotes regeneration.

Regular application of the formulations to a bovine animal is approx. It requires 1000 cm ^ per year to achieve the desired effect.

The following examples are intended to illustrate the present invention without limiting our claims to protection:

glycerol

Bradophen 100 S

Vitamin A

D3

Brillant green chamomile extract distilled water

2.0%

5.0%

4000HU / 1000cm ³ 75000 NB / 1000cm ³ 0.01%

0.05%

84.74%

Example 1

A method for producing a nipple bath liquid

Methyl cellulose distilled water is prepared in a manner known per se, and then added to the mucus is aluminum glycerol solution and an aqueous emulsion of non-ionic ointment (emulsion is prepared using 1 part ointment and 10 parts water), optionally aqueous dye solution, then Bradophen and finally the vitamins. The mixture is stirred until homogeneous. The composition of the nipple bath liquid thus produced is as follows:

Aluminum acetate solution 5.0% Nonionic emulsifying ointment 2.5% Roethyl cellulose 0.7%

Example 2

Process for the production of udder ointment

The preparation is carried out according to the procedure of Example 1 except that the ingredients are used in the amounts indicated below. Ingredients:

aluminum acetate solution nonionic emulsifying ointment methylcellulose glycerol

Bradophen 100 S Vitamin A Vitamin D D Brillant green chamomile extract distilled water

5.0%

28.0%

0.8%

2.0%

5.0%

40000 IU / 1000 cm ³ 75000 IU / 1000 cm ³ 0.01%

0.1%

59.09%

Table I

Microbiological Activity Assay of Example 2

test microorganism Spotting surface Bacteria recorded Quantity of emulsion lubricated (cm ² ) quantity (live germ) 0,03g 0.06 g Pseudomonas seruginosa 012 50 2 x 10 ⁹ bactericidal effect bactericidal effect Escherichia coli 044 50 3 x 10 «> bactericidal effect bactericidal effect Streptococcus agalactiac 80200 50 2 x 10® bactericidal effect bactericidal effect Staphylococcus aureus 420 50 4 x 10 ¹¹ buck tericidal effect bactericidal effect Klebsiella pneumoniae 50 3 x 10 ¹¹ retarded growth bactericidal effect mixed culture 50 4 x 10 ⁹ retarded growth bactericidal effect

-4HU 199077 Β II. spreadsheet

microbiological preparation of Example 2 prepared by omitting trillion t green and camomile extract • examination : sztmikroorganizmuBok Gripping (cm ² ) surface Bacteria applied quantity (live germ) Quantity of emulsion lubricated 0,03g 0.06 g seudomonas aeruginosa 012 50 2 x 10 ⁸ bactericidal effect bactericidal effect scherichia coli 044 50 3 x 10® bactericidal effect bactericidal effect treptococcus agalactiae 0200 50 2 x 10 ' bactericidal effect bactericidal effect itaphylococcus aureus 420 50 4 x 10 '' bactericidal effect bactericidal effect ilebsiella pneumoniae 50 3x10 " retarded growth bactericidal effect depressed culture 50 5 x 10 ⁸ retarded growth bactericidal effect

Table III

Microbiological Activity Test of Example 2 Preparation of Brillant Green Leave

esztmikroorganizmusok Spotting surface Bacteria recorded Quantity of emulsion lubricated (cm ² ) quantity (live germ) 0,03g 0.06 g 'Seudomonas seruginosa 012 50 6 x 10 ⁸ bactericidal effect bactericidal effect Ischerichia coli 044 50 5 x 10® bactericidal effect bactericidal effect Streptococcus agalactiae 10200 50 5 x 10 ' . bactericidal effect bactericidal effect Staphylococcus aureus 420 50 6 x 10 ¹ ° bactericidal effect bactericidal effect ílebsiella pneumoniae 50 5.x10 " retarded growth bactericidal effect depressed culture 50 3 x 10® retarded growth bactericidal effect

Claims (1)

A process for the preparation of complex uddering compositions comprising: 5 the. A mucosa is prepared from 0.5-1.0% methylcellulose in 80-90% distilled water, and a 3.0-7.0% aluminum acetate tartrate solution containing 0.6% aluminum is added. (Ph. Hg. VII.), 1.0-3.0% by weight glycerol and 2.0-3.0% by weight aqueous emulsion of non-ionic ointment, 0.001-0.1% by weight of chamomile extract ether, 0.005- 0.05% Brillant Green (viridae nitens, Ph. Hg. VI), 3.0-8.0% Bradophen 100 St 15 [(benzyldodecylbis) 2-hydroxyethyl (ammonium chloride)] and 30,000-50,000 IU of vitamin A and 60,000-90,000 IU of Ds Vitamin A followed by mixing until homogeneous, or g0 b. A mucosa is prepared from 0.5-1.0% methylcellulose in 50-70% distilled water and then a 3.0-7.0% aluminum acetate tartrate solution containing 0.6% aluminum is added. <Ph. Hg. VII), 1.0-3.0 ₂ 5% glycerol and 20-40% non-ionic ointment aqueous emulsion, 0.01-0.5% ether chamomile train, 0.005-0.05% Brillant green (viridae nitens, Ph. Hg. VI.), 3.0-8.0% Bradophen 100 St 35 - [(benzyldodecylbis) 2-hydroxyethyl (-ammonium chloride)] and 30,000- 50,000 IU of Vitamin A and 60,000-90,000 IU of Vitamin D and mix until homogeneous.