HU197656B - Rodenticidal mass bait - Google Patents

Abstract

Rodent killer compsns. for use in blocks of bait contain: 0.001-1.0 wt.% anticoagulant 1,3-indan-dione deriv. and/or 4-hydroxycoumarin as paraffin soluble amine salt as active ingredient, 50-85 wt.% paraffin opt. with additives, 8-45 wt.% rough, fibrous or granular vegetable matter, minerals and/or material of animal origin unsuitable for human consumption, and not more than 10 wt.% known additives. - The components are mixed to give a liq. slurry, this is poured into small moulds which will form the outer skin of the final bait blocks, the filled moulds are covered before solidification of the slurry using covers opt. fitted with handles.

Description

FIELD OF THE INVENTION The present invention relates to solid, waterproof rodenticide bait blocks.

It is known that the control of harmful rodents in wet or wet conditions is difficult because conventional granular or powdered rodenticides quickly lose their original consistency and effectiveness due to moisture. It is also known that these difficulties can be partially overcome by the use of water-repellent vehicles.

No. 153,590. According to French patent specification, stearic acid is used as a water repellant carrier. In the preparation of the baits, the active ingredient is mixed with melted stearic acid (warfarin), the edible component (wheat flour, oatmeal or rice) and rodents, and then the melt is poured into a trough.

A similar solution for making rodenticide baits is described in U.S. Patent Nos. 74 to 21,069. Japanese Patent Specification. The baits described herein contain 0.1 parts by weight of the hydroxycoumarin derivative, 25 parts by weight of paraffin, 5 parts by weight of Japanese wax, 60 parts by weight of vegetable material and 9.7 parts by weight of glucose.

No. 178,667. Hungarian Patent Specification for Animal Fats, Vegetable Oils and / or Mineral Fats, and 1.5—

It discloses pressurized mixtures of 7.5% by weight of the active ingredient containing cereal seeds or other plant parts (e.g., beet or celery slices) as nutrients for rodents.

No. 80-62001. Japanese Patent Laid-Open Publication discloses tablet baits containing 15 parts by weight of active ingredient, 10 parts by weight of paraffin, 50 parts by weight of vegetable fiber, 55 parts by weight of bread and 10 parts by weight of sugar.

One of the most common drawbacks of the bait described in the cited publications is that the mass is soft, pasty and does not satisfy the needs of rodents.

This disadvantage can be found in T / 129 577. According to the published Hungarian patent application, it is eliminated by incorporating the rodenticide and the nutrient for rodents into a polymer or copolymer mass. In the preparation of bulk baits, the aqueous dispersion of the monomer (s) is mixed with the active ingredient, the nutrient and other excipients (such as flavoring, appetizing, coloring, etc.), molded into a flowable mass, and polymerization is initiated and after it has been carried out, the mass is dried and cut. Although this method can produce harder baits than those quoted above, it has the disadvantage that it is more complicated and energy intensive than other methods. A further disadvantage is that the resulting product swells significantly in water, thus decomposing relatively quickly in a humid environment and losing its effectiveness.

A common disadvantage of all known solutions is that the rodenticide is not dissolved but more or less finely dispersed; since the rodenticides used are not soluble or only slightly soluble in the water-repellent carrier, so that the distribution of the active ingredient in the formulations is uneven, which may result in accidental under- or overdose and insufficient absorption. Therefore, the safety of the rodenticides of islert formulations is usually not guaranteed. Extremely high content of active ingredients is usually required for the preparation of guaranteed effective preparations, which in turn greatly increases the environmental hazard of the preparation.

A further disadvantage is that the known formulations provide valuable substances such as cereals, fish, meat or bone meal, oil cakes, dried vegetables or fruits, etc., as nutrients suitable for rodents and for animal feed. They contain. The use of nutrients suitable for nutritional purposes significantly increases the cost of bait production, but at the same time makes the bait attractive to farmed animals (eg chickens, fur animals, etc.), further reducing the environmental safety of the preparation.

Finally, it is a disadvantage that current technologies use rodenticide baits to produce a single block of horseradish and to produce ready-to-use dosage units that can be placed directly in the rodents' migration area or location. These subsequent unit dose preparation procedures are costly and present an increased risk to the health of the operator.

It is an object of the present invention to overcome the above disadvantages.

It has now been discovered that the drawbacks of the uneven distribution of the active ingredients can be completely eliminated by using the rodenticides in the form of their paraffin-soluble amine salts. The paraffin carrier is a soft material that does not satisfy the chewing needs of rodents, according to the literature. Because the paraffin-soluble amine salts of the rodenticides are usually high viscosity oils or low melting solids, it was expected that their melt and solutions with the paraffinic carrier would be unsuitable for soft, waxy rodenticidal purposes. However, it has been found that combining these fluxes or solutions with materials unfit for human or animal consumption, fibrous, coarse or coarse grains, is hard, form-effective, satisfies the rodent's chewing requirements in all respects, but does not entail valuable use for the 2197656 case. environmentally safe preparations.

The present invention thus relates to rodent block bait containing 0.001% by weight of the active ingredient, 1,3-indanedione and / or 4-hydroxycoumarin derivative having anticoagulant activity, and paraffin or doped paraffin as carrier. The rodenticidal bulk baits of the present invention are characterized in that the rodenticidal agent is present in the form of a paraffin-soluble amino salt thereof, as a carrier, 50-85% by weight of paraffin or 8% to 45% by weight of paraffinic additive nutrient. and / or minerals, and up to 10% by weight of known additives and / or auxiliaries commonly used in the preparation of rodenticide block bait.

For example, the rodenticidal bulk baits of the present invention may contain the following anticoagulant rodenticides in the form of paraffin-soluble amino salts:

1,3-indanedione derivatives such as

2- (2,2-dimethylpropionyl) -1,3-indanedione (pindone),

2- (2,2-di-phenylacetyl) -1,3-indanedione (difacinone),

2- (2- (4-chlorophenyl) -2-phenyl-1-acetyl) -1,3-indanedione (chlorophacinone); 4-hydroxycoumarin derivatives such as

3- (1-phenyl-3-isobutyl-butyl) -4-hydroxycoumarin (warfarin),

3- (1- (4-chlorophenyl) -3-oxobutyl) -4-hydroxycoumarin (coumachlor),

3- (1- / 2-furyl-3-oxo-butyl) -4-hydroxy-coumarin (coumfuryl),

4-hydroxy-3- (1,2,3,4-tetrahydro-1-naphthyl) coumarin (coumetralyl),

3-3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl) -4-hydroxycoumarin (difenacoum),

3- (3- / 4'-Bromo-biphenyl-4-yl / -1,2,3,4-tetrahydro-1-naphthyl) -4-hydroxy-coumarin (Brodifacum), and

3- (3- / 4'-Bromo-biphenyl-4-yl / -3-hydroxy-1-phenyl-propyl) -4-hydroxy-coumarin (bromadiolone).

Paraffin-soluble amine salts of the listed compounds include, for example, salts of trioctylamine, di-dodecylamine, tri-dodecylamine, di-tridecylamine, tris-tridecylamine, di-hexadecylamine and di-octadecylamine. They are. The preparation of salts is described in U.S. Patent No. 177,497. Hungarian patent specification.

The bulk baits of the present invention contain paraffin or paraffin as a carrier. The term "doped paraffin" refers to paraffin containing up to 20% by weight of other wax-like paraffin soluble substances (e.g., beeswax, pine resin, montan wax, polyethylene wax, stearin, etc.).

The bulk baits of the present invention may contain, for example, sunflower husk, walnut or hazelnut husk, inedible plant or animal extraction residues, talc, chalk powder, diatomaceous earth, zeolite, or the like as fiber, coarse or coarse grained additives.

In addition, the bulk baits of the invention are additives and / or auxiliaries commonly used in the preparation of such compositions, such as flavorings, aromas. sweeteners, attractants and / or coloring agents (such as fish oil, cocoa butter, sunflower oil, parsley oil, vanillin, natural or artificial sweeteners, wheat germ oil, cheese, smoke or fruit flavors, fat-soluble dyes, etc.).

Block bait compositions as defined above are conveniently marketed in safe unit dosage forms. These can be prepared as follows to form a homogeneous melt of the active ingredient and carrier, add fibrous, coarse or coarse vegetable, animal and / or mineral materials, as well as any excipients and / or excipients that may be used, the slurry, the molds are covered with a closure member prior to the solidification of the slurry and, if desired, a handle (e.g. a piece of string or wire) is inserted into the closure member before the slurry solidifies.

Once the slurry has solidified, the closure member and, if applicable, the handle mounted on the closure member will be firmly attached to the rigid block bait. Suitably, the closure may be a cardboard cut / aluminum foil plate with an inscription and / or mark indicating the toxicity of the composition. The shape of the outer casing of the dosage unit may conveniently be formed from aluminum foil.

In use, the outer casing of the dosage unit is removed and the dosage unit is placed, where appropriate with the aid of a handle on the closure, in the rodents' abode or path (fences, trees, beams, etc.). By locking the bait blocks in a particular position using a handle (e.g. fencing), the composition can be prevented from being exposed to natural forces, e.g. storm) is swept away or taken away by animals.

Note that a sheet provided with a handle as a closure member can also be used.

The main advantages of the array bait according to the invention are:

- the bulk baits contain the active ingredient in a completely homogeneous distribution so that safety overdosage of the active ingredient is unnecessary, which in addition to saving the active ingredient has a significant environmental benefit;

- the preparation does not require the use of valuable nutrients;

-3197656 - the composition is compact, does not swell in water. does not dissolve due to rain or flood;

The preparation of dosage units is extremely simple as there is no need for compression equipment or for subsequent cutting or packaging;

- the irreversible closure of the dosage unit and the warning label placed on the unit increase the safety of the product. The present invention will be described in more detail in the following examples without limiting the scope of the invention.

Example 1

400 g of solid paraffin and 30 g of s. thearin was melted, 15 g of x-maize germ oil, 1 g of Sudan R and G coloring agent and 0.42 g of difacinone trioctylamine salt (= 0.2 g of difacinone) were added to the melt, followed by 150 g of extracted vermouth turmeric, 40 g ground nut shells and 30 g powdered sugar are added. The homogenized slurry is filled into molten cone-shaped aluminum foil molds. In one form approx. 50 g of slurry was poured. After filling, the still hot molten slurry is covered with cardboard discs, and wire bent hooks are inserted into the cardboard discs.

In use, the aluminum foil cover is ripped off the dosage units and the dosage units are secured with hooks.

Example 2

Block baits having the following composition were prepared as described in Example 1:

Shelled sunflower Zeolite 33% by weight 10 Cod liver oil Sudan Long color G 5 1 Chlorfacinone (tri-octylamine- salt form) 0,003 Paraffin ad 100

4 (1

Example 3

Block bait having the following composition was prepared as described in Example 1: Sunflower peel 33% by weight

Fish oil 5

Sudan Power G color 1

Chlorfacinone (0.01 "in the form of its di-dodecylamine salt)

Paraffin ad 100

Example 4

Block bait having the following composition was prepared as described in Example 1: Sunflower peel 33% by weight

Silica sweetener (manufactured by Szilasmenti Mgtsz) 1

Saccharin Amine Salt 2 ”

Coumatetralyl (in the form of its di-dodecylamine salt) 0.01 "

Paraffin ad 100 "

Example 5

Block baits having the following composition were prepared as described in Example 1:

IC

Shelled sunflower

Eggshell powder Saccharin-amine salt Chlorphacinone (as tris-dodecylamine salt) Paraffin ad% 13 '

0.1 "

100

Example 6

Block baits having the following composition were prepared as described in Example 1:

Shelled sunflower 33% by weight Corn Germ Oil 5 Chlorfacinone (di-dodecyl- in the form of an amine salt) 0.5 " Paraffin ad 100

Example 7

Block bait having the following composition was prepared as described in Example 1: Sunflower peel 33% by weight

Sunflower oil 5

Warfarin (as tri-octylamine salt) 0.1

Paraffin ad 100

Example 8

Block bait having the following composition was prepared as described in Example 1: Sunflower peel 33% by weight

Eggshell powder 5

Silica sweetener (manufactured by Szilasmenti Mgtsz) 1 "

Chlorfacinone (as tris trisodecylamine salt) 0.03

Paraffin ad 100

5C

Example 9

Block baits having the following composition were prepared as described in Example 1:

Zeolite 10 crowd% stearic 10 1 i Saccharin salt 1 icing sugar 3 Sudan Long color G 1 Chlorfacinone (di-hexadecyl- in the form of an amine salt) 0.2 J J Paraffin ad 100 > 1

Example 10

Nutrition studies in rodents

Studies have been conducted to determine how rodents consume bulk bait according to the invention. In order to ensure that differences in the amount and quality of the active ingredient, which leads to a reasonably different mortality, are not interfered with, the use of the vehicle in studies 2-9 is not impaired. Formulations other than the active ingredient (i.e., pure carrier compositions) which were otherwise in the same composition as those described in Example 1B were tested. Exam-4197656 gala were performed on groups of 8 to 8 wild-type rats. Prior to the start of the experiment, the rats were fasted for 24 hours; during this time, the rats could drink water of their choice. The rats were then placed in cages and the cages were filled with 1 to 1 unit dose of bait per animal and 100-100 g of wheat-corn mixture per animal. At intervals, the remainder of the array bait was weighed. Since the animals were completely depleted of the block bait in all experiments within 24 hours, a further 1 to 1 unit dose of block bait per animal was added to the cages after 24 hours and observation was continued for a further 2 days. During this time, we did not have to replenish the wheat-corn mixture for animals, as it remained in the cages on the last day of the study.

The results are reported in Table I below

The serial number of the example 4 o'clock It's 12 hours stale mass 24 hours after salads, 48 hours and you 72 hours Second 15 40 100 70 100 Third 15 80 100 100 - 4th 0 20 100 86 100 5th Ű 20 100 90 100 6 β . 20 100 - 100 - 7th 40 100 - 100 - S. 5 30 100 65 100 9th 5 40 100 62 100

The data in Table I show that the animals, although not containing the valuable nutrients, were not averse to the choice of carrier material for the bulk baits, and the bulk baits met their chewing needs.

As the data in Table I indicate that animals were particularly keen to use the composition of Examples 3, 6 and 7 from the bait block tested, a further series of experiments were conducted to determine the extent to which the formulations replaced the rat diet.

Experiments were performed on mixed-weight wild rats weighing 250-400 g. The animals were exposed for 24 hours before the start of the experiments

Fasted for 4q; during this time the animals were free to consume water. The animals were then placed in cages and 100-100 g of block bait and 100-100 g of wheat-corn mixture were added to each cage. After 24 and 48 hours, the bait blocks, as well

The amount consumed was determined by measuring the residue of a5 a-wheat-corn mixture. The wheat-corn mixture was then removed from the cages, the bulk bait

However, the remainder of 5Q was replaced and the animals were observed for another day. The results are shown in Table II. in Table.

II. spreadsheet

The serial number of the example 24 TCS Running out hour B / K ztott 48 TC 3 food, hour B / K e 72 hours TCS 6th 1 18 5 12 6 Third 1 19 6 11 7 7th 2 18 17 12 24

-5197656

II. It can be concluded from the data of Table 1 that the animals were at ca. Get used to 24 hours! after the period, increasing quantities of bulk baits were consumed. It is particularly noteworthy that, despite having a better choice, the animals of the formulation of Example 7 consumed nearly 50% more than the wheat-corn mixture. After the withdrawal of the wheat-corn mixture, the animals continued to consume bulk bait; in the formulation of Example 7, the bulk baits were taken in an amount corresponding to their total daily nutrient requirements.

II. Table Tes refers to Bait Bait, B / K Wheat / Maize Mixture.

Claims (1)

Patent Claim Point Rodent blocking baits containing, as active ingredient, 0.001 to 1% by weight of an anti-coagulant 1,3-indanedione derivative and / or a 4-hydroxycoumarin derivative and containing paraffin or doped paraffin as the carrier, characterized in that the active ingredient is obtained in paraffinic soluble amine salt , and based on the total weight of the composition 50 to 85% by weight of paraffin or paraffinic additives, 8 to 45% by weight of material of plant, mineral and / or animal origin, unfit for human or animal consumption, of fibrous, filamentous or coarse grains and up to 10% by weight of known sweeteners and / or flavoring substances commonly used in rodent block formulations contains dyes.