HU172798B - Sposob poluchenija timozina al'fa-1 - Google Patents

Sposob poluchenija timozina al'fa-1

Info

Publication number
HU172798B
HU172798B HU77HO00002021A HUHO002021A HU172798B HU 172798 B HU172798 B HU 172798B HU 77HO00002021 A HU77HO00002021 A HU 77HO00002021A HU HO002021 A HUHO002021 A HU HO002021A HU 172798 B HU172798 B HU 172798B
Authority
HU
Hungary
Prior art keywords
thimozine
alpha
producing
thimozine alpha
producing thimozine
Prior art date
Application number
HU77HO00002021A
Other languages
English (en)
Inventor
Allan L Goldstein
Teresa L K Low
Chun-Yen Lai
Su-Sun Wang
Original Assignee
Hoffmann La Roche
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Univ Texas filed Critical Hoffmann La Roche
Publication of HU172798B publication Critical patent/HU172798B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU77HO00002021A 1976-10-28 1977-10-26 Sposob poluchenija timozina al'fa-1 HU172798B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73663876A 1976-10-28 1976-10-28

Publications (1)

Publication Number Publication Date
HU172798B true HU172798B (hu) 1978-12-28

Family

ID=24960663

Family Applications (1)

Application Number Title Priority Date Filing Date
HU77HO00002021A HU172798B (hu) 1976-10-28 1977-10-26 Sposob poluchenija timozina al'fa-1

Country Status (4)

Country Link
US (1) US4079127A (hu)
BE (1) BE860169A (hu)
HU (1) HU172798B (hu)
ZA (1) ZA775976B (hu)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
US4680276A (en) * 1977-05-25 1987-07-14 Institut National De La Sante Et De La Recherche Medicale Metal polypeptides
US4264571A (en) * 1979-01-22 1981-04-28 George Washington University Radioimmunoassay of thymosin α1
US4297276A (en) * 1979-03-23 1981-10-27 Hoffman-La Roche Inc. Thymosin beta 3 and beta 4
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
EP0033384B1 (de) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente
EP0035454A3 (en) * 1980-02-28 1982-03-03 Genentech, Inc. Desacetylthymosin alpha 1, its process of preparation and its use
US4361673A (en) * 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
SE448605B (sv) * 1980-10-27 1987-03-09 Vtoroi Mo G Med I Imen Terapeutiskt preparat for reglering av t-immunsystemet och forfarande for framstellning derav
JPS57110196A (en) * 1980-10-30 1982-07-08 Hoffmann La Roche Preparation of thimocin alpha 1
US4444757A (en) * 1981-11-16 1984-04-24 Research Corporation Use of thymosin as an anti-diabetes and anti-hypertensive disease agent
US4388234A (en) * 1981-12-28 1983-06-14 Hoffmann-La Roche Inc. Peptide isolation
DE3230151A1 (de) * 1982-08-13 1984-02-16 Hoechst Ag, 6230 Frankfurt Neues polypeptid mit wirkung auf das immunsystem, verfahren zu seiner isolierung und reinigung, seine verwendung, dieses enthaltende mittel sowie seine spaltprodukte, deren verwendung und diese enthaltende mittel
US4504415A (en) * 1983-04-04 1985-03-12 Hoffman-La Roche Inc. Synthesis of thymosin α1 and desacetyl thymosin α1
US4517119A (en) * 1983-04-04 1985-05-14 Hoffmann-La Roche Inc. Synthesis of thymosin α1
US4543340A (en) * 1983-04-07 1985-09-24 George Washington University Radioimmunoassay of thymosin β4
US4614731A (en) * 1983-09-15 1986-09-30 Hoffmann-La Roche Inc. Peptide having immunopotentiating activity similar to thymosin alpha1
US4621135A (en) * 1983-12-08 1986-11-04 Yeda Research & Development Company, Ltd. Novel THF compositions
US4983387A (en) * 1986-05-19 1991-01-08 Viral Technologies Inc. HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus
US4777239A (en) * 1986-07-10 1988-10-11 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic peptides of human papilloma virus
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
JPH06506918A (ja) * 1991-02-04 1994-08-04 ジヨージ・ワシントン・ユニバーシテイ インターロイキン−１の産生を促進しそして年令−関連性免疫応答を調整するペプチドｍｂ−４
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
US5308833A (en) * 1992-02-06 1994-05-03 Sciclone Pharmaceuticals Method for treating hepatitis B carriers with minimal disease
EP0728010A4 (en) * 1992-02-06 1997-10-01 Sciclone Pharmaceuticals METHOD FOR TREATING HEPATITIS B CARRIERS WITH A MINOR DISEASE
CN1058500C (zh) * 1993-02-03 2000-11-15 施塞克龙药品公司 胸腺素α－1衍生物
WO1994020063A2 (en) * 1993-03-04 1994-09-15 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US6200952B1 (en) 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
TW252045B (hu) * 1993-10-07 1995-07-21 Allan L Goldstein
WO1995009647A1 (en) * 1993-10-07 1995-04-13 The George Washington University Medical Center METHOD OF TREATING SEPTIC SHOCK USING THYMOSIN-α¿1?
WO1995012405A1 (en) * 1993-11-05 1995-05-11 Alpha 1 Biomedicals, Inc. Method and composition for treatment of patients having decompensated liver disease
US6262230B1 (en) 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1
JP3853384B2 (ja) * 1994-09-09 2006-12-06 株式会社三菱化学ヤトロン 抗サイモシンα１モノクローナル抗体産生ハイブリドーマ
US5632983A (en) 1994-11-17 1997-05-27 University Of South Florida Method for treating secondary immunodeficiency
AU6164898A (en) * 1997-02-18 1998-09-08 Sciclone Pharmaceuticals, Inc. Use of thymosin alpha 1 for the manufacture of a medicament for promoting stem cell development
US6977072B2 (en) 2000-10-27 2005-12-20 Irx Therapeutics, Inc. Vaccine immunotherapy for immune suppressed patients
US20070154399A1 (en) * 2000-10-27 2007-07-05 Hadden John W Immunotherapy for immune suppressed patients
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
KR100902197B1 (ko) * 2001-10-26 2009-06-11 로드아일랜드하스피틀 티모신에 의한 유전적 면역화 증대
UA78726C2 (en) * 2001-11-01 2007-04-25 Sciclone Pharmaceuticals Inc Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
UA77999C2 (en) * 2001-12-10 2007-02-15 Thymosin-alpha 1 for treatment of malignant glioblastoma
CA2506893A1 (en) 2002-11-25 2004-06-10 Sciclone Pharmaceuticals, Inc. Methods of protecting against radiation damage using alpha thymosin
US8207294B2 (en) 2003-03-28 2012-06-26 Sciclone Pharmaceuticals, Inc. Treatment of Aspergillus infections with alpha thymosin peptides
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
CN1822850A (zh) * 2003-07-18 2006-08-23 雷根内克斯生物制药有限公司 由放射线照射引起的损伤的治疗或预防
WO2005115341A2 (en) * 2004-05-27 2005-12-08 Advanced Bionutrition Corporation Microparticles for oral delivery
ITRM20060583A1 (it) * 2006-10-27 2008-04-28 Francesco Bistoni Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie
DK2234642T3 (en) 2007-11-28 2018-01-08 Irx Therapeutics Inc PROCEDURE FOR INCREASING AN IMMUNOLOGICAL EFFECT
CN102458470B (zh) * 2009-05-08 2016-01-20 赛生制药有限公司 作为疫苗增强剂的α胸腺素肽
JP5797190B2 (ja) 2009-05-15 2015-10-21 アイ アール エックス セーラピューティクス， インコーポレイテッド ワクチン免疫療法
CN103097543A (zh) 2009-12-08 2013-05-08 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法
US20130296223A1 (en) 2012-03-30 2013-11-07 Sciclone Pharmaceuticals, Inc. Use of thymosin alpha for the treatment of sepsis
GB201621732D0 (en) * 2016-12-20 2017-02-01 Agricultural Research Council A multi-epitope dna vaccine for heartwater

Also Published As

Publication number Publication date
ZA775976B (en) 1978-06-28
BE860169A (fr) 1978-04-27
US4079127A (en) 1978-03-14

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628