HRP20201574T1 - Supstituirani nikotinimidni inhibitori btk, njihova priprava i upotreba u liječenju raka, upale i autoimunih bolesti - Google Patents
Supstituirani nikotinimidni inhibitori btk, njihova priprava i upotreba u liječenju raka, upale i autoimunih bolesti Download PDFInfo
- Publication number
- HRP20201574T1 HRP20201574T1 HRP20201574TT HRP20201574T HRP20201574T1 HR P20201574 T1 HRP20201574 T1 HR P20201574T1 HR P20201574T T HRP20201574T T HR P20201574TT HR P20201574 T HRP20201574 T HR P20201574T HR P20201574 T1 HRP20201574 T1 HR P20201574T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- nicotinamide
- phenoxyphenyl
- acryloylpiperazin
- cancer
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title claims 2
- 206010028980 Neoplasm Diseases 0.000 title claims 2
- 201000011510 cancer Diseases 0.000 title claims 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- MZPVEMOYADUARK-UHFFFAOYSA-N 2-(4-phenoxyphenyl)-6-(1-prop-2-enoylpiperidin-4-yl)pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=C(C2CCN(CC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 MZPVEMOYADUARK-UHFFFAOYSA-N 0.000 claims 1
- HKODXZQCALAKRP-RMKNXTFCSA-N CN(C/C=C/C(=O)N1CCN(CC1)C1=NC(=C(C(=O)N)C=C1)C1=CC=C(C=C1)OC1=CC=CC=C1)C Chemical compound CN(C/C=C/C(=O)N1CCN(CC1)C1=NC(=C(C(=O)N)C=C1)C1=CC=C(C=C1)OC1=CC=CC=C1)C HKODXZQCALAKRP-RMKNXTFCSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- FVFNTQTXHXLUCG-UHFFFAOYSA-N NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C FVFNTQTXHXLUCG-UHFFFAOYSA-N 0.000 claims 1
- RXLBSUXDQSYOQK-UHFFFAOYSA-N NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C RXLBSUXDQSYOQK-UHFFFAOYSA-N 0.000 claims 1
- ALCPIQJGNIFEEW-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(F)cc2)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(F)cc2)cc1)N1CCN(CC1)C(=O)C=C ALCPIQJGNIFEEW-UHFFFAOYSA-N 0.000 claims 1
- FOVPGEGKCVVOCG-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(cc2)C#N)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(cc2)C#N)cc1)N1CCN(CC1)C(=O)C=C FOVPGEGKCVVOCG-UHFFFAOYSA-N 0.000 claims 1
- YSLHZFWPYAMITN-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2cccc(F)c2)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2cccc(F)c2)cc1)N1CCN(CC1)C(=O)C=C YSLHZFWPYAMITN-UHFFFAOYSA-N 0.000 claims 1
- HSJHKGOOSPVBOE-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)c(F)c1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)c(F)c1)N1CCN(CC1)C(=O)C=C HSJHKGOOSPVBOE-UHFFFAOYSA-N 0.000 claims 1
- YRXXJFYRLCXWSW-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C YRXXJFYRLCXWSW-UHFFFAOYSA-N 0.000 claims 1
- FFOQNEVDIRMUML-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C FFOQNEVDIRMUML-UHFFFAOYSA-N 0.000 claims 1
- AUZUWAWZXHHHRK-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)S(=O)(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)S(=O)(=O)C=C AUZUWAWZXHHHRK-UHFFFAOYSA-N 0.000 claims 1
- QTBYHUSOXPOMAU-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C QTBYHUSOXPOMAU-UHFFFAOYSA-N 0.000 claims 1
- TVVGIVUDWNGTBO-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)S(=O)(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)S(=O)(=O)C=C TVVGIVUDWNGTBO-UHFFFAOYSA-N 0.000 claims 1
- VGYWZKPHSUBBSA-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1F)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1F)N1CCN(CC1)C(=O)C=C VGYWZKPHSUBBSA-UHFFFAOYSA-N 0.000 claims 1
- LQTWOAKAPZKRHG-UHFFFAOYSA-N NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2F)cc1)N1CCN(CC1)C(=O)C=C Chemical compound NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2F)cc1)N1CCN(CC1)C(=O)C=C LQTWOAKAPZKRHG-UHFFFAOYSA-N 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (4)
1. Spoj, naznačen time što ga se bira iz skupine koju čine:
6-(1-akriloilpiperidin-4-il)-2-(4-fenoksifenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(4-fenoksifenil)nikotinamid;
[image]
6-(1-akriloilpirolidin-3-il)-2-(4-fenoksifenil)nikotinamid;
[image]
6-(1-akriloilpiperidin-3-il)-2-(4-fenoksifenil)nikotinamid;
[image]
(E)-6-(4-(4-(dimetilamino)but-2-enoil)piperazin-1-il)-2-(4-fenoksifenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(4-(4-cijanofenoksi)fenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(4-(3-fluorfenoksi)fenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(3-fluor-4-fenoksifenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(4-(4-fluorfenoksi)fenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(4-(2-fluorfenoksi)fenil)nikotinamid;
[image]
6-(4-akriloilpiperazin-1-il)-2-(2-fluor-4-fenoksifenil)nikotinamid;
[image]
5-(1-akriloilpiperidin-4-il)-4′-fenoksibifenil-2-karboksamid;
[image]
5-(4-akriloilpiperazin-1-il)-4′-fenoksibifenil-2-karboksamid;
[image]
2-(4-fenoksifenil)-6-(4-(vinilsulfonil)piperazin-1-il)nikotinamid;
[image]
2-(4-fenoksifenil)-6-(1-(vinilsulfonil)piperidin-4-il)nikotinamid;
[image]
ili njihove farmaceutski prihvatljive soli.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
ili
[image]
.
3. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s bilo kojim od patentnog zahtjeva 1 ili patentnim zahtjevom 2, ili njegovu farmaceutski prihvatljivu sol.
4. Farmaceutski pripravak namijenjen upotrebi u liječenju raka, kronične upale, ili autoimune bolesti kod sisavca, naznačen time što sadrži spoj u skladu s bilo kojim od patentnog zahtjeva 1 ili patentnog zahtjeva 2, ili njegovu farmaceutski prihvatljivu sol.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361884958P | 2013-09-30 | 2013-09-30 | |
CN201310485048 | 2013-10-16 | ||
EP14848083.3A EP3052476B1 (en) | 2013-09-30 | 2014-09-29 | Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
PCT/US2014/058084 WO2015048662A2 (en) | 2013-09-30 | 2014-09-29 | Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201574T1 true HRP20201574T1 (hr) | 2020-12-11 |
Family
ID=72422342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201574TT HRP20201574T1 (hr) | 2013-09-30 | 2020-10-05 | Supstituirani nikotinimidni inhibitori btk, njihova priprava i upotreba u liječenju raka, upale i autoimunih bolesti |
Country Status (6)
Country | Link |
---|---|
DK (1) | DK3052476T3 (hr) |
ES (1) | ES2822586T3 (hr) |
HR (1) | HRP20201574T1 (hr) |
HU (1) | HUE050771T2 (hr) |
LT (1) | LT3052476T (hr) |
PT (1) | PT3052476T (hr) |
-
2014
- 2014-09-29 ES ES14848083T patent/ES2822586T3/es active Active
- 2014-09-29 DK DK14848083.3T patent/DK3052476T3/da active
- 2014-09-29 HU HUE14848083A patent/HUE050771T2/hu unknown
- 2014-09-29 PT PT148480833T patent/PT3052476T/pt unknown
- 2014-09-29 LT LTEP14848083.3T patent/LT3052476T/lt unknown
-
2020
- 2020-10-05 HR HRP20201574TT patent/HRP20201574T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
DK3052476T3 (da) | 2020-09-14 |
NZ718073A (en) | 2021-04-30 |
ES2822586T3 (es) | 2021-05-04 |
LT3052476T (lt) | 2020-10-26 |
PT3052476T (pt) | 2020-10-09 |
HUE050771T2 (hu) | 2021-01-28 |
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