Claims (4)
1. Spoj s formulom (I):
naznačen time što:
predstavlja aromatski prsten pri čemu V je C,
R neovisno predstavlja vodikov atom, halogeni atom ili skupinu koja se bira između skupine -CN, hidroksilne skupine, skupine -COOR1, skupine (C1-C3)fluoroalkil, skupine (C1-C3)fluoroalkoksi, skupine -NO2, skupine -NR1R2, skupine (C1-C4)alkoksi, fenoksi skupine i skupine (C1-C3)alkil, navedeni alkil je po izboru mono-supstituiran s hidroksilnom skupinom,
R1 i R2 su neovisno vodikov atom ili skupina (C1-C3)alkil,
n je 1, 2 ili 3,
n' je 1 ili 2,
R' je vodikov atom, halogeni atom ili skupinu koja se bira između skupine (C1-C3)alkil, skupine -COOR1, skupine -NO2, skupine -NR1R2, morfolinil skupine ili morfolino skupine, skupine N-metilpiperazinil, skupine (C1-C3)fluoroalkil, skupine (C1-C4)alkoksi i skupine -CN,
R" je vodikov atom ili skupina (C1-C4)alkil,
Z je N, V je C, Y je N, X je C, T je C, U je C i W je C,
ili bilo koja od njegovih farmaceutski prihvatljivih soli,
za upotrebu kao sredstvo za prevenciju, inhibiranje ili liječenje raka.1. Compound with formula (I):
characterized by:
represents an aromatic ring where V is C,
R independently represents a hydrogen atom, a halogen atom or a group selected from the group -CN, hydroxyl group, group -COOR1, group (C1-C3)fluoroalkyl, group (C1-C3)fluoroalkoxy, group -NO2, group -NR1R2, group (C1-C4)Alkoxy, phenoxy groups and (C1-C3)alkyl groups, said alkyl is optionally mono-substituted with a hydroxyl group,
R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group,
n is 1, 2 or 3,
n' is 1 or 2,
R' is a hydrogen atom, a halogen atom or a group selected from the (C1-C3)alkyl group, the -COOR1 group, the -NO2 group, the -NR1R2 group, the morpholinyl group or the morpholino group, the N-methylpiperazinyl group, the (C1-C3 )fluoroalkyl, (C1-C4) alkoxy groups and -CN groups,
R" is a hydrogen atom or a (C1-C4)alkyl group,
Z is N, V is C, Y is N, X is C, T is C, U is C and W is C,
or any of its pharmaceutically acceptable salts,
for use as an agent for the prevention, inhibition or treatment of cancer.
2. Spoj s formulom (I) prema patentnom zahtjevu 1, za upotrebu kao sredstvo za prevenciju, inhibiranje ili liječenje raka, koji je s formulom (Ia)
naznačen time što:
R neovisno predstavlja vodikov atom, halogeni atom ili skupinu koja se bira između skupine (C1-C3)alkil, skupine -CN, hidroksilne skupine, skupine -COOR1, skupine (C1-C3)fluoroalkil, skupine -NO2, skupine -NR1R2 i skupine (C1-C3)alkoksi,
R" je kako je definirano u zahtjevu 1 i povoljno je vodikov atom,
n je kako je definirano u zahtjevu 1 i povoljno je 1,
n' je kako je definirano u zahtjevu 1 i povoljno je 1,
R' je vodikov atom, halogeni atom ili skupinu koja se bira između skupine (C1-C3)alkil, skupine -NO2, skupine (C1-C3)alkoksi i skupine -NR1R2,
R1 i R2 su vodikov atom ili skupina (C1-C3)alkil,
ili jedna od njegovih farmaceutski prihvatljivih soli.2. A compound of formula (I) according to claim 1, for use as an agent for preventing, inhibiting or treating cancer, which is of formula (Ia)
characterized by:
R independently represents a hydrogen atom, a halogen atom or a group selected from the group (C1-C3)alkyl, the group -CN, the hydroxyl group, the group -COOR1, the group (C1-C3)fluoroalkyl, the group -NO2, the group -NR1R2 and the group (C1-C3)Alkoxy,
R" is as defined in claim 1 and is preferably a hydrogen atom,
n is as defined in claim 1 and is preferably 1,
n' is as defined in claim 1 and is preferably 1,
R' is a hydrogen atom, a halogen atom or a group selected from the group (C1-C3)alkyl, the group -NO2, the group (C1-C3)alkoxy and the group -NR1R2,
R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group,
or one of its pharmaceutically acceptable salts.
3. Spoj s formulom (I) prema bilo kojem od prethodnih patentnih zahtjeva, za upotrebu kao sredstvo za prevenciju, inhibiranje ili liječenje raka, koji je s formulom (Ia)
naznačen time što:
R neovisno predstavlja vodikov atom, halogeni atom ili skupinu koja se bira između skupine (C1-C3)alkil, skupine -CN, skupine -COOR1 i skupine (C1-C3)fluoroalkil,
R1 je vodikov atom ili skupina (C1-C3)alkil,
R" je kako je definirano u zahtjevu 1 i poželjnije je vodikov atom,
n je kako je definirano u zahtjevu 1 i poželjnije je 1,
n' je kako je definirano u zahtjevu 1,
R' je vodikov atom, halogeni atom ili skupina (C1-C3)alkil,
ili jedna od njegovih farmaceutski prihvatljivih soli.3. A compound of formula (I) according to any of the preceding claims, for use as an agent for preventing, inhibiting or treating cancer, which is of formula (Ia)
characterized by:
R independently represents a hydrogen atom, a halogen atom or a group selected from the group (C1-C3)alkyl, the group -CN, the group -COOR1 and the group (C1-C3)fluoroalkyl,
R1 is a hydrogen atom or a (C1-C3)alkyl group,
R" is as defined in claim 1 and is more preferably a hydrogen atom,
n is as defined in claim 1 and is preferably 1,
n' is as defined in claim 1,
R' is a hydrogen atom, a halogen atom or a (C1-C3)alkyl group,
or one of its pharmaceutically acceptable salts.
4. Spoj naznačen time što je odabran iz niza koji čine:
- (1) (8-Kloro-kinolin-2-il)-piridin-2-il-amin
- (2) 2-(Kinolin-2-ilamino)-izonikotinska kiselina
- (3) (4-Metil-piridin-2-il)-kinolin-2-il-amin
- (4) Piridin-2-il-kinolin-2-il-amin
- (5) 2-(8-Kloro-kinolin-2-ilamino)-izonikotinska kiselina
- (6) (8-Kloro-kinolin-2-il)-(4-metil-piridin-2-il)-amin
- (7) 6-(Kinolin-2-ilamino)-nikotinonitril
- (17) N-(6-metilpiridin-2-il)kinolin-2-amin
- (18) 8-kloro-N-(6-metilpiridin-2-il)kinolin-2-amin
- (19) 4-metil-N-(piridin-2-il)kinolin-2-amin
- (20) 4-metil-N-(4-metilpiridin-2-il)kinolin-2-amin
- (21) 3-metil-N-(4-metilpiridin-2-il)kinolin-2-amin
- (22) 3-metil-N-(piridin-2-il)kinolin-2-amin
- (23) 6-((4-metilkinolin-2-il)amino)nikotinonitril
- (24) 6-((3-metilkinolin-2-il)amino)nikotinonitril
- (25) 6-kloro-N-(4-metilpiridin-2-il)kinolin-2-amin
- (26) 6-kloro-N-(6-metilpiridin-2-il)kinolin-2-amin
- (27) 4-metil-N-(5-nitropiridin-2-il)kinolin-2-amin
- (28) N-(3-nitropiridin-2-il)kinolin-2-amin
- (29) 8-kloro-N-(3-nitropiridin-2-il)kinolin-2-amin
- (30) 2-((4-metilkinolin-2-il)amino)nikotinonitril
- (31) N-(3-metilpiridin-2-il)kinolin-2-amin
- (32) N-(5-metilpiridin-2-il)kinolin-2-amin
- (33) 2-(kinolin-2-ilamino)izonikotinonitril
- (34) N-(5-(trifluorometil)piridin-2-il)kinolin-2-amin
- (35) 8-kloro-N-(3-metilpiridin-2-il)kinolin-2-amin
- (36) 8-kloro-N-(5-metilpiridin-2-il)kinolin-2-amin
- (37) 8-kloro-N-(5-(trifluorometil)piridin-2-il)kinolin-2-amin
- (38) N-(3-methoksipiridin-2-il)kinolin-2-amin
- (39) N-(5-nitropiridin-2-il)kinolin-2-amin
- (40) 6-((8-klorokinolin-2-il)amino)nikotinonitril
- (41) N-(5-fluoropiridin-2-il)kinolin-2-amin
- (42) N-(6-(trifluorometil)piridin-2-il)kinolin-2-amin
- (43) 8-kloro-N-(5-fluoropiridin-2-il)kinolin-2-amin
- (44) 2-((8-klorokinolin-2-il)amino)nikotinska kiselina
- (45) 4-metil-N-(6-metilpiridin-2-il)kinolin-2-amin
- (46) 3-metil-N-(6-metilpiridin-2-il)kinolin-2-amin
- (47) 5-cijano-2-(kinolin-2-ilamino)piridin-1-ium klorid
- (48) 2-((8-klorokinolin-2-il)amino)-4-metilpiridin-1-ium klorid
- (49) 8-kloro-N-(4-etilpiridin-2-il)kinolin-2-amin
- (50) 8-kloro-N-(6-etilpiridin-2-il)kinolin-2-amin
- (51) 8-kloro-N-(4,6-dimetilpiridin-2-il)kinolin-2-amin
- (52) 6-((8-klorokinolin-2-il)amino)-2-metilnikotinonitril
- (53) 8-kloro-N-(4-kloropiridin-2-il)kinolin-2-amin
- (54) 8-metil-N-(4-metilpiridin-2-il)kinolin-2-amin
- (55) N-(5-bromo-4-metilpiridin-2-il)-8-klorokinolin-2-amin
- (56) 8-kloro-N-(3-etil-6-metilpiridin-2-il)kinolin-2-amin
- (57) 8-fluoro-N-(4-metilpiridin-2-il)kinolin-2-amin
- (58) 8-bromo-N-(4-metilpiridin-2-il)kinolin-2-amin
- (59) metil 6-(kinolin-2-ilamino)nikotinat
- (60) metil 6-[(8-klorokinolin-2-il)amino]piridin-3-karboksilat
- (61) metil 6-[(3-metilkinolin-2-il)amino]piridin-3-karboksilat
- (62) metil 2-[(8-klorokinolin-2-il)amino]piridin-3-karboksilat
- (63) 8-methoksi-N-(4-metilpiridin-2-il)kinolin-2-amin
- (64) N-(4-metilpiridin-2-il)-5-nitrokinolin-2-amin
- (65) 2-N-(4-metilpiridin-2-il)kinolin-2,8-diamin
- (66) N-(4-metilpiridin-2-il)-5-aminokinolin-2-amin
- (67) metil 6-[(4-metilkinolin-2-il)amino]piridin-3-karboksilat
- (68) 8-kloro-N-[4-(trifluorometil)piridin-2-il]kinolin-2-amin
- (69) 2-[(8-klorokinolin-2-il)amino]piridin-3-ol
- (70) 8-kloro-N-[6-(trifluorometil)piridin-2-il]kinolin-2-amin
- (71) 6-kloro-N-(5-fluoropiridin-2-il)kinolin-2-amin
- (72) N-(6-etilpiridin-2-il)-3-metilkinolin-2-amin
- (73) N-(5-fluoropiridin-2-il)-3-metilkinolin-2-amin
- (74) 3-metil-N-[5-(trifluorometil)piridin-2-il]kinolin-2-amin
- (150) N-(4-metilpiridin-2-il)-8-nitrokinolin-2-amin
- (151) 6-kloro-N-(6-etilpiridin-2-il)kinolin-2-amin
- (152) 6-kloro-N-(5-metilpiridin-2-il)kinolin-2-amin
- (153) 6-kloro-N-[5-(trifluorometil)piridin-2-il]kinolin-2-amin
- (154) N2-(8-klorokinolin-2-il)-4-metilpiridin-2,3-diamin
- i njihove farmaceutski prihvatljive soli,
za upotrebu kao sredstvo za prevenciju, inhibiranje ili liječenje raka.4. A compound characterized by the fact that it is selected from the series consisting of:
- (1) (8-Chloro-quinolin-2-yl)-pyridin-2-yl-amine
- (2) 2-(Quinolin-2-ylamino)-isonicotinic acid
- (3) (4-Methyl-pyridin-2-yl)-quinolin-2-yl-amine
- (4) Pyridin-2-yl-quinolin-2-yl-amine
- (5) 2-(8-Chloro-quinolin-2-ylamino)-isonicotinic acid
- (6) (8-Chloro-quinolin-2-yl)-(4-methyl-pyridin-2-yl)-amine
- (7) 6-(Quinolin-2-ylamino)-nicotinonitrile
- (17) N-(6-methylpyridin-2-yl)quinolin-2-amine
- (18) 8-chloro-N-(6-methylpyridin-2-yl)quinolin-2-amine
- (19) 4-methyl-N-(pyridin-2-yl)quinolin-2-amine
- (20) 4-methyl-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (21) 3-methyl-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (22) 3-methyl-N-(pyridin-2-yl)quinolin-2-amine
- (23) 6-((4-methylquinolin-2-yl)amino)nicotinonitrile
- (24) 6-((3-methylquinolin-2-yl)amino)nicotinonitrile
- (25) 6-chloro-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (26) 6-chloro-N-(6-methylpyridin-2-yl)quinolin-2-amine
- (27) 4-methyl-N-(5-nitropyridin-2-yl)quinolin-2-amine
- (28) N-(3-nitropyridin-2-yl)quinolin-2-amine
- (29) 8-chloro-N-(3-nitropyridin-2-yl)quinolin-2-amine
- (30) 2-((4-methylquinolin-2-yl)amino)nicotinonitrile
- (31) N-(3-methylpyridin-2-yl)quinolin-2-amine
- (32) N-(5-methylpyridin-2-yl)quinolin-2-amine
- (33) 2-(quinolin-2-ylamino)isonicotinonitrile
- (34) N-(5-(trifluoromethyl)pyridin-2-yl)quinolin-2-amine
- (35) 8-chloro-N-(3-methylpyridin-2-yl)quinolin-2-amine
- (36) 8-chloro-N-(5-methylpyridin-2-yl)quinolin-2-amine
- (37) 8-chloro-N-(5-(trifluoromethyl)pyridin-2-yl)quinolin-2-amine
- (38) N-(3-methoxypyridin-2-yl)quinolin-2-amine
- (39) N-(5-nitropyridin-2-yl)quinolin-2-amine
- (40) 6-((8-chloroquinolin-2-yl)amino)nicotinonitrile
- (41) N-(5-fluoropyridin-2-yl)quinolin-2-amine
- (42) N-(6-(trifluoromethyl)pyridin-2-yl)quinolin-2-amine
- (43) 8-chloro-N-(5-fluoropyridin-2-yl)quinolin-2-amine
- (44) 2-((8-chloroquinolin-2-yl)amino)nicotinic acid
- (45) 4-methyl-N-(6-methylpyridin-2-yl)quinolin-2-amine
- (46) 3-methyl-N-(6-methylpyridin-2-yl)quinolin-2-amine
- (47) 5-cyano-2-(quinolin-2-ylamino)pyridin-1-ium chloride
- (48) 2-((8-chloroquinolin-2-yl)amino)-4-methylpyridin-1-ium chloride
- (49) 8-chloro-N-(4-ethylpyridin-2-yl)quinolin-2-amine
- (50) 8-chloro-N-(6-ethylpyridin-2-yl)quinolin-2-amine
- (51) 8-chloro-N-(4,6-dimethylpyridin-2-yl)quinolin-2-amine
- (52) 6-((8-chloroquinolin-2-yl)amino)-2-methylnicotinonitrile
- (53) 8-chloro-N-(4-chloropyridin-2-yl)quinolin-2-amine
- (54) 8-methyl-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (55) N-(5-bromo-4-methylpyridin-2-yl)-8-chloroquinolin-2-amine
- (56) 8-chloro-N-(3-ethyl-6-methylpyridin-2-yl)quinolin-2-amine
- (57) 8-fluoro-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (58) 8-bromo-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (59) methyl 6-(quinolin-2-ylamino)nicotinate
- (60) methyl 6-[(8-chloroquinolin-2-yl)amino]pyridine-3-carboxylate
- (61) methyl 6-[(3-methylquinolin-2-yl)amino]pyridine-3-carboxylate
- (62) methyl 2-[(8-chloroquinolin-2-yl)amino]pyridine-3-carboxylate
- (63) 8-methoxy-N-(4-methylpyridin-2-yl)quinolin-2-amine
- (64) N-(4-methylpyridin-2-yl)-5-nitroquinolin-2-amine
- (65) 2-N-(4-methylpyridin-2-yl)quinolin-2,8-diamine
- (66) N-(4-methylpyridin-2-yl)-5-aminoquinolin-2-amine
- (67) methyl 6-[(4-methylquinolin-2-yl)amino]pyridine-3-carboxylate
- (68) 8-chloro-N-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine
- (69) 2-[(8-chloroquinolin-2-yl)amino]pyridin-3-ol
- (70) 8-chloro-N-[6-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine
- (71) 6-chloro-N-(5-fluoropyridin-2-yl)quinolin-2-amine
- (72) N-(6-ethylpyridin-2-yl)-3-methylquinolin-2-amine
- (73) N-(5-fluoropyridin-2-yl)-3-methylquinolin-2-amine
- (74) 3-methyl-N-[5-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine
- (150) N-(4-methylpyridin-2-yl)-8-nitroquinolin-2-amine
- (151) 6-chloro-N-(6-ethylpyridin-2-yl)quinolin-2-amine
- (152) 6-chloro-N-(5-methylpyridin-2-yl)quinolin-2-amine
- (153) 6-chloro-N-[5-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine
- (154) N2-(8-chloroquinolin-2-yl)-4-methylpyridin-2,3-diamine
- and their pharmaceutically acceptable salts,
for use as an agent for the prevention, inhibition or treatment of cancer.