HRP20191258T1 - Stable, protracted glp-1/glucagon receptor co-agonists for medical use - Google Patents

Stable, protracted glp-1/glucagon receptor co-agonists for medical use Download PDF

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HRP20191258T1
HRP20191258T1 HRP20191258TT HRP20191258T HRP20191258T1 HR P20191258 T1 HRP20191258 T1 HR P20191258T1 HR P20191258T T HRP20191258T T HR P20191258TT HR P20191258 T HRP20191258 T HR P20191258T HR P20191258 T1 HRP20191258 T1 HR P20191258T1
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amino
carboxy
butanoyl
ethoxy
leu10
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HRP20191258TT
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Ulrich Sensfuss
Thomas Kruse
Jesper F. Lau
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Novo Nordisk A/S
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Priority claimed from PCT/EP2014/058084 external-priority patent/WO2014170496A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
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  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (23)

1. Glukagonski derivat, naznačen time što sadrži aminokiselinski slijed Formule I (koji odgovara SEQ ID NO:4 i SEQ ID NO:5): His-X2-X3-Gly-Thr-Phe-Thr-Ser-Asp-X10-Ser-X12-Tir-Leu-X15-X16-X17-X18-Ala-X20-X21-Phe-Val-X24-Trp-Leu-X27-X28-X29-X30 [I], gdje X2 predstavlja Aib, Acb ili Acpr; X3 predstavlja Gln ili His; X10 predstavlja Leu; X12 predstavlja Lys ili Arg; X15 predstavlja Asp ili Glu; X16 predstavlja Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val ili Lys; X17 predstavlja Arg ili Lys; X18 predstavlja Arg, Ala ili Lys; X20 predstavlja Gln, Arg, Glu, Aib ili Lys; X21 predstavlja Asp, Glu, Ser, ili Lys; X24 predstavlja Gln, Ala, Arg, Glu, Aib ili Lys; X27 predstavlja Met, Leu ili Val; X28 predstavlja Asn, Ser, Thr, Gln, Ala, Gly, Glu ili Lys; X29 predstavlja Thr,Gly, Ser, Gln, Ala, Glu ili Lys; X30 predstavlja Lys, ili je X30 odsutan; gdje navedeni aminokiselinski slijed sadrži lizinski ostatak na jednom ili više položaja 12, 16, 17, 18, 20, 21, 24, 28, 29 i/ili 30; i gdje navedeni glukagonski derivat sadrži supstituent koji sadrži lipofilni ostatak i najmanje tri negativno nabijena ostatka, gdje je jedan od navedenih negativnoh nabijenih ostataka udaljen od navedenog lipofilnog ostatka, te gdje je navedeni supstituent vezan na položaju epsilon u lizinskom ostatku na jednom od aminokiselinskih položaja 16, 17, 18, 20, 21, 24, 28, 29 ili 30; i gdje je navedeni glukagonski derivat C-terminalni amid; ili njegova farmaceutski prihvatljiva sol ili predlijek.1. Glucagon derivative, characterized in that it contains the amino acid sequence of Formula I (corresponding to SEQ ID NO:4 and SEQ ID NO:5): His-X2-X3-Gly-Thr-Phe-Thr-Ser-Asp-X10-Ser-X12-Tyr-Leu-X15-X16-X17-X18-Ala-X20-X21-Phe-Val-X24-Trp- Leu-X27-X28-X29-X30 [I], where X2 represents Aib, Acb or Acpr; X3 represents Gln or His; X10 represents Leo; X12 represents Lys or Arg; X15 represents Asp or Glu; X16 represents Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys; X17 represents Arg or Lys; X18 represents Arg, Ala or Lys; X20 represents Gln, Arg, Glu, Aib or Lys; X21 represents Asp, Glu, Ser, or Lys; X24 represents Gln, Ala, Arg, Glu, Aib or Lys; X27 represents Met, Lea or Val; X28 represents Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys; X29 represents Thr, Gly, Ser, Gln, Ala, Glu or Lys; X30 represents Lys, or X30 is absent; where said amino acid sequence contains a lysine residue at one or more positions 12, 16, 17, 18, 20, 21, 24, 28, 29 and/or 30; and where said glucagon derivative contains a substituent containing a lipophilic residue and at least three negatively charged residues, where one of said negatively charged residues is distant from said lipophilic residue, and where said substituent is attached to the epsilon position in the lysine residue at one of the amino acid positions 16, 17, 18, 20, 21, 24, 28, 29 or 30; and wherein said glucagon derivative is the C-terminal amide; or a pharmaceutically acceptable salt or prodrug thereof. 2. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je navedeni glukagonski derivat agonist glukagonski receptor i agonist receptora GLP-1.2. A glucagon derivative according to claim 1, characterized in that said glucagon derivative is a glucagon receptor agonist and GLP-1 receptor agonist. 3. Glukagonski derivat u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što navedeni supstituent ima Formulu II: Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10- [II], gdje Z1 predstavlja strukturu u prema Formuli IIa: , gdje je n u Formula IIa 6-20, a simbol * predstavlja mjesto vezanja na dušik u susjednoj skupini, te gdje su Z2, Z3, Z4, Z5, Z6, Z7, Z8, Z9, Z10 pojedinačno predstavljeni sljedećim aminokiselinama: Glu, γGlu, Gly, Ser, Ala, Thr, Ado ili su odsutni, gdje je prisutno najmanje dva od ostataka Z2 do Z10, gdje je navedeni supstituent vezan na položaju epsilon u Lys Formule I, te gdje Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10 zajedno sadrži najmanje tri negativna naboja.;3. A glucagon derivative according to any of the preceding patent claims, characterized in that said substituent has Formula II: Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10- [II], where Z1 represents the structure u according to Formula IIa: , where n in Formula IIa is 6-20, and the symbol * represents the site of attachment to nitrogen in the neighboring group, and where Z2, Z3, Z4, Z5, Z6, Z7, Z8, Z9, Z10 are individually represented by the following amino acids: Glu, γGlu, Gly, Ser, Ala, Thr, Ado or are absent, where at least two of the residues Z2 to Z10 are present, where said substituent is attached at the epsilon position in Lys of Formula I, and where Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10 together contain at least three negative charges.; 4. Glukagonski derivat u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što navedeni glukagonski derivat sadrži modifikacije 3-15 aminokiselinskih ostataka, poput supstitucija ili adicija, u usporedbi s glukagonom (SEQ ID NO: 1).;4. A glucagon derivative according to any of the previous patent claims, characterized in that said glucagon derivative contains modifications of 3-15 amino acid residues, such as substitutions or additions, compared to glucagon (SEQ ID NO: 1).; 5. Glukagonski derivat u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što navedeni supstituent predstavlja strukturu prema bilo kojoj od sljedećih devet formula (Chem.A do Chem.I), gdje * označuje mjesto vezanja na atom dušika na položaju epsilon u ostatku Lys Formule I: ; ; ; ; ; ; ; ; .5. A glucagon derivative according to any of the preceding patent claims, characterized in that the specified substituent represents a structure according to any of the following nine formulas (Chem.A to Chem.I), where * indicates the site of attachment to the nitrogen atom at the epsilon position in to the remainder of Lys Formula I: ; ; ; ; ; ; ; ; . 6. Glukagonski derivat u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ga se bira iz skupine koju čine: Nε16-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Arg20,Leu27,Ser28]-glukagon amid ; Nε21-(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Lys21,Leu27,Ser28]-glukagon amid ; Nε24-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Lys24,Leu27,Ser28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Leu27,Lys28]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Leu27,Ser28,Lys29]-glukagon amid ; Nα-([Aib2,Leu10,Arg20,Leu27,Ser28]-glukagonil)-N{Epsilon}[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]Lys amid ; Nε16-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Lys17,Glu21,Leu27]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu 10,Lys17,Ala18,Glu21,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Ala18,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε16-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Arg20,Glu21,Leu27]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Thr16,Lys20,Leu27,Ser28,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu16,Lys20,Leu27,Ser28,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Glu20,Leu27,Ser28,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Thr16,Arg24,Leu27,Ser28,Lys29]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Acb2,Leu10,Glu15,Glu16,Arg20,Leu27,Lys28]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Lys17,Ala18,Arg20,Glu21,Ala24,Leu27]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Ala18,Arg20,Glu21,Ala24,Leu27]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,Leu10,Lys16,Arg20,Glu21,Ala24,Leu27]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Ala18,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]-acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε16-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Glu21,Val27,Lys28,Gly29]-glukagon amid ; Nε16-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Lys16,Glu21,Leu27]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Arg20,Glu21,Ala24,Leu27,Lys28]-glukagon amid ; Nε16-[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Lys16,Arg20,Glu21,Ala24,Leu27,Ser28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]-[Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Acb2,His3,Leu10,Glu15,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Aib2,His3,Leu10,Glu15,Arg20,Leu27,Lys28]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acpr2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Aib16,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Leu16,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]acetil]-[Aib2,Leu10,Leu16,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib2,Leu10,Glu15,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib2,Leu10,Ala16,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Arg12,Ala16,Arg20,Leu27,Lys28]-glukagon amid ; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Acb2,Leu10,Glu15,Leu27,Lys28]-glukagon amid ; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib2,Leu10,Arg12,Ala16,Leu27,Lys28]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Ala16,Arg20,Leu27,Lys29]-glukagon amid ; Nε29-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Ala16,Arg20,Leu27,Ser28,Lys29]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid ; i Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]-glukagon amid . 6. A glucagon derivative according to any of the preceding patent claims, characterized in that it is selected from the group consisting of: Nε16-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[ 2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy ]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Arg20,Leu27,Ser28]-glucagon amide ; Nε21-(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)- 4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Lys21,Leu27,Ser28 ]-glucagon amide; Nε24-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Lys24,Leu27, Ser28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Leu27,Lys28] - glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Leu27,Ser28, Lys29]-glucagon amide; Nα-([Aib2,Leu10,Arg20,Leu27,Ser28]-glucagonyl)-N{Epsilon}[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[ 2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl] amino]butanoyl]amino]butanoyl]Lys amide ; Nε16-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Lys17,Glu21, Leu27]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu 10,Lys17,Ala18,Glu21 ,Leu27,Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Ala18,Arg20,Glu21, Leu27,Lys29]-glucagon amide; Nε16-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Arg20,Glu21, Leu27]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Thr16,Lys20,Leu27, Ser28,Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Glu21,Leu27, Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu16,Lys20,Leu27, Ser28,Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Glu20,Leu27, Ser28,Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Thr16,Arg24,Leu27, Ser28,Lys29]-glucagon amide; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Acb2,Leu10,Glu15,Glu16,Arg20,Leu27,Lys28]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Lys17,Ala18, Arg20,Glu21,Ala24,Leu27]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Ala18,Arg20, Glu21,Ala24,Leu27]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Arg20,Glu21, Ala24,Leu27]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20, Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Ala18, Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]-acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Leu16,Lys17,Arg20 ,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,His3,Leu10,Glu15,Lys17, Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε16-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[(4S)-4-carboxy-4-[[( 4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Glu21,Val27,Lys28, Gly29]-glucagon amide; Nε16-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[(4S)-4-carboxy-4-[[( 4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Lys16,Glu21,Leu27]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,His3,Leu10,Glu15,Arg20, Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,His3,Leu10,Glu15,Arg20, Glu21,Ala24,Leu27,Lys28]-glucagon amide; Nε16-[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]-[Aib2,His3,Leu10,Glu15,Lys16, Arg20,Glu21,Ala24,Leu27,Ser28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,His3,Leu10,Glu15,Arg20, Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino] butanoyl]-[Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Acb2,His3,Leu10,Glu15,Leu27,Lys28]-glucagon amide; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Aib2,His3,Leu10,Glu15,Arg20,Leu27,Lys28]-glucagon amide ; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[(4S)-4-carboxy-4-(17- carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys29]-glucagon amide ; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[(4S)-4-carboxy-4-(17- carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys29]-glucagon amide ; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[(4S)-4-carboxy-4-(17- carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino] butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]-[Aib2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Ala16,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Leu16,Arg20,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[2-[[(2S)-2-[[(4S)-4-carboxy-4-[ [(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[ Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acpr2,Leu10,Glu15,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Aib16,Arg20,Glu21, Leu27,Lys28]-glucagon amide; Nε28(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2 -[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]- 3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S) -2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino ]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Leu16,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S) -2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino ]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]-[Aib2,Leu10,Leu16,Arg20, Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Arg20,Glu21,Leu27, Lys28]-glucagon amide; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]-[Aib2,Leu10,Glu15,Arg20,Leu27, Lys28]-glucagon amide; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]-[Aib2,Leu10,Ala16,Arg20,Leu27, Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl] amino]butanoyl]-[Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino] butanoyl]-[Aib2,Leu10,Arg12,Ala16,Arg20,Leu27,Lys28]-glucagon amide; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]-[Acb2,Leu10,Glu15,Leu27,Lys28] - glucagon amide; Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]-[Aib2,Leu10,Arg12,Ala16,Leu27, Lys28]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Ala16,Arg20,Leu27, Lys29]-glucagon amide; Nε29-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[[2-[2-[2-[[(4S) -4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Ala16,Arg20,Leu27, Ser28,Lys29]-glucagon amide; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S) -2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino ]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S) -2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino ]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide ; and Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S )-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl] amino]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]-glucagon amide . 7. Glukagonski derivat u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Arg20,Leu27,Lys28]-glukagon amid: .7. A glucagon derivative according to any of the preceding patent claims, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[ 2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl] amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Leu16,Arg20,Leu27,Lys28]-glucagon amide: . 8. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid: .8. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2- [[(2S)-4-carboxy-2-[[(2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl ]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]- glucagon amide: . 9. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Glu15,Arg20, Glu21,Leu27,Lys28]-glukagon amid: .9. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[ 2-[[2-[2-[2-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl ]amino]butanoyl]-[Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]-glucagon amide: . 10. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glukagon amid: .10. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[ 2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy ]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]-glucagon amide: . 11. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib2,Leu10,Ala16,Arg20,Leu27,Lys28]-glukagon amid: .11. A glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[2-[2-[2-[[2-[2-[2-[[(4S)-4-carboxy-4- [[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy ]ethoxy]acetyl]-[Aib2,Leu10,Ala16,Arg20,Leu27,Lys28]-glucagon amide: . 12. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]-glukagon amid: .12. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[ 2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy ]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]-glucagon amide: . 13. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]amino]butanoil]amino]butanoil]-[Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]-glukagon amid: .13. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[ 2-[[2-[2-[2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl]amino]butanoyl]amino]ethoxy ]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]-[Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]-glucagon amide: . 14. Glukagonski derivat u skladu s patentnim zahtjevom 1, naznačen time što je glukagonski derivat Nε28-[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-[[(2S)-2-[[(2S)-4-karboksi-2-[[(2S)-2-[[(4S)-4-karboksi-4-[[(4S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]-3-hidroksipropanoil]amino]butanoil]amino]butanoil]-[Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]-glukagon amid: .14. Glucagon derivative according to claim 1, characterized in that the glucagon derivative is Nε28-[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(2S)-2- [[(2S)-4-carboxy-2-[[(2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butanoyl ]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]butanoyl]-[Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]- glucagon amide: . 15. Međuprodukt, naznačen time što je u obliku glukagonskog peptida koji sadrži C-terminalni amid i bilo koju od sljedećih modifikacija u usporedbi s glukagonom (SEQ ID NO: 1): a) [Aib2,Leu10,Lys16,Arg20,Leu27,Ser28]; b) [Aib2,Leu10,Arg20,Lys21,Leu27,Ser28]; c) [Aib2,Leu10,Arg20,Lys24,Leu27,Ser28]; d) [Aib2,Leu10,Arg20,Leu27,Lys28]; e) [Aib2,Leu10,Arg20,Leu27,Ser28,Lys29]; f) [Aib2,Leu10,Arg20,Leu27,Ser28]; g) [Aib2,Leu10,Lys16,Lys17,Glu21,Leu27]; h) [Aib2,Leu10,Lys17,Ala18,Glu21,Leu27,Lys29]; i) [Aib2,Leu10,Ala18,Arg20,Glu21,Leu27,Lys29]; j) [Aib2,Leu10,Lys16,Arg20,Glu21,Leu27]; k) [Aib2,Leu10,Thr16,Lys20,Leu27,Ser28,Lys29]; I) [Aib2,Leu10,Arg20,Glu21,Leu27,Lys29]; m) [Aib2,Leu 10,Glu16,Lys20,Leu27,Ser28,Lys29]; n) [Aib2,Leu10,Lys16,Glu20,Leu27,Ser28,Lys29]; o) [Aib2,Leu10,Thr16,Arg24,Leu27,Ser28,Lys29]; p) [Acb2,Leu10,Glu15,Glu16,Arg20,Leu27,Lys28]; q) [Aib2,Leu10,Lys16,Lys17,Ala18,Arg20,Glu21,Ala24,Leu27]; r) [Aib2,Leu10,Lys16,Ala18,Arg20,Glu21,Ala24,Leu27]; s) [Aib2,Leu10,Lys16,Arg20,Glu21,Ala24,Leu27]; t) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; u) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]; v) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; w) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; x) [Aib2,Leu10,Glu15,Lys17,Ala18,Arg20,Glu21,Leu27,Lys28]; y) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; z) [Aib2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; æ) [Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; ø) [Aib2,Leu10,Lys16,Glu21,Val27,Lys28,Gly29]; å) [Aib2,Leu10,Lys16,Glu21,Leu27]; aa) [Aib2,His3,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ee) [Aib2,His3,Leu10,Glu15,Arg20,Glu21,Ala24,Leu27,Lys28]; cc) [Aib2,His3,Leu10,Glu15,Lys16,Arg20,Glu21,Ala24,Leu27,Ser28]; dd) [Aib2,His3,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ee) [Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; ii) [Acb2,His3,Leu10,Glu15,Leu27,Lys28]; gg) [Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28] kk) [Aib2,His3,Leu10,Glu15,Arg20,Leu27,Lys28]; ii) [Aib2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys29]; jj) [Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys29]; kk) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]; II) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; mm) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; nn) [Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys28]; oo) [Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; pp) [Acb2,Leu10,Leu 16,Arg20,Leu27,Lys28]; qq) [Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]; rr) [Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; ss) [Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; tt) [Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]; uu) [Acpr2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; vv) [Aib2,Leu10,Aib16,Arg20,Glu21,Leu27,Lys28]; ww) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; xx) [Aib2,Leu10,Leu16,Leu27,Lys28]; yy) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; zz) [Aib2,Leu10,Leu16,Arg20,Leu27,Lys28]; ææ) [Aib2,Leu10,Arg20,Glu21,Leu27,Lys28]; øø) [Aib2,Leu10,Glu15,Arg20,Leu27,Lys28]; åå) [Aib2,Leu10,Ala16,Arg20,Leu27,Lys28]; aaa) [Acb2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]; bbb) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ccc) [Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ddd) [Aib2,Leu10,Arg12,Ala16,Arg20,Leu27,Lys28]; eee) [Acb2,Leu10,Glu15,Leu27,Lys28]; fff) [Aib2,Leu10,Arg12,Ala16,Leu27,Lys28]; ggg) [Aib2,Leu10,Ala16,Arg20,Leu27,Lys29]; hhh) [Aib2,Leu10,Ala16,Arg20,Leu27,Ser28,Lys29]; iii) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; jjj) [Aib2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]; kkk) [Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; ili lll) [Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]; ili njegove farmaceutski prihvatljive soli, amida ili estera.15. An intermediate, characterized in that it is in the form of a glucagon peptide containing a C-terminal amide and any of the following modifications compared to glucagon (SEQ ID NO: 1): a) [Aib2,Leu10,Lys16,Arg20,Leu27,Ser28]; b) [Aib2,Leu10,Arg20,Lys21,Leu27,Ser28]; c) [Aib2,Leu10,Arg20,Lys24,Leu27,Ser28]; d) [Aib2,Leu10,Arg20,Leu27,Lys28]; e) [Aib2,Leu10,Arg20,Leu27,Ser28,Lys29]; f) [Aib2,Leu10,Arg20,Leu27,Ser28]; d) [Aib2,Leu10,Lys16,Lys17,Glu21,Leu27]; h) [Aib2,Leu10,Lys17,Ala18,Glu21,Leu27,Lys29]; i) [Aib2,Leu10,Ala18,Arg20,Glu21,Leu27,Lys29]; j) [Aib2, Leu10, Lys16, Arg20, Glu21, Leu27]; k) [Aib2,Leu10,Thr16,Lys20,Leu27,Ser28,Lys29]; I) [Aib2,Leu10,Arg20,Glu21,Leu27,Lys29]; m) [Aib2, Leu 10, Glu16, Lys20, Leu27, Ser28, Lys29]; n) [Aib2,Leu10,Lys16,Glu20,Leu27,Ser28,Lys29]; o) [Aib2,Leu10,Thr16,Arg24,Leu27,Ser28,Lys29]; p) [Acb2,Leu10,Glu15,Glu16,Arg20,Leu27,Lys28]; q) [Aib2,Leu10,Lys16,Lys17,Ala18,Arg20,Glu21,Ala24,Leu27]; r) [Aib2, Leu10, Lys16, Ala18, Arg20, Glu21, Ala24, Leu27]; s) [Aib2,Leu10,Lys16,Arg20,Glu21,Ala24,Leu27]; t) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; u) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]; v) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; w) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; x) [Aib2,Leu10,Glu15,Lys17,Ala18,Arg20,Glu21,Leu27,Lys28]; y) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; z) [Aib2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; æ) [Aib2, His3, Leu10, Glu15, Lys17, Arg20, Glu21, Leu27, Lys28]; ø) [Aib2,Leu10,Lys16,Glu21,Val27,Lys28,Gly29]; å) [Aib2,Leu10,Lys16,Glu21,Leu27]; aa) [Aib2, His3, Leu10, Glu15, Arg20, Glu21, Leu27, Lys28]; ee) [Aib2,His3,Leu10,Glu15,Arg20,Glu21,Ala24,Leu27,Lys28]; cc) [Aib2,His3,Leu10,Glu15,Lys16,Arg20,Glu21,Ala24,Leu27,Ser28]; dd) [Aib2, His3, Leu10, Glu15, Arg20, Glu21, Leu27, Lys28]; ee) [Aib2,His3,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; ii) [Acb2, His3, Leu10, Glu15, Leu27, Lys28]; gg) [Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28] kk) [Aib2,His3,Leu10,Glu15,Arg20,Leu27,Lys28]; ii) [Aib2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys29]; jj) [Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys29]; kk) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys29]; II) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; mm) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; nn) [Aib2,Leu10,Ala16,Arg20,Glu21,Leu27,Lys28]; oo) [Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; pp) [Acb2,Leu10,Leu 16,Arg20,Leu27,Lys28]; qq) [Acb2,Leu10,Arg12,Leu16,Arg20,Leu27,Lys28]; rr) [Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; ss) [Acb2,Leu10,Leu16,Lys17,Arg20,Glu21,Leu27,Lys28]; tt) [Acb2,Leu10,Leu16,Arg20,Glu21,Leu27,Lys28]; uu) [Acpr2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; vv) [Aib2,Leu10,Aib16,Arg20,Glu21,Leu27,Lys28]; ww) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; xx) [Aib2,Leu10,Leu16,Leu27,Lys28]; yy) [Aib2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; zz) [Aib2,Leu10,Leu16,Arg20,Leu27,Lys28]; ææ) [Aib2,Leu10,Arg20,Glu21,Leu27,Lys28]; øø) [Aib2,Leu10,Glu15,Arg20,Leu27,Lys28]; åå) [Aib2,Leu10,Ala16,Arg20,Leu27,Lys28]; aaa) [Acb2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]; bbb) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ccc) [Acb2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; ddd) [Aib2,Leu10,Arg12,Ala16,Arg20,Leu27,Lys28]; eee) [Acb2,Leu10,Glu15,Leu27,Lys28]; fff) [Aib2,Leu10,Arg12,Ala16,Leu27,Lys28]; ggg) [Aib2,Leu10,Ala16,Arg20,Leu27,Lys29]; hhh) [Aib2,Leu10,Ala16,Arg20,Leu27,Ser28,Lys29]; iii) [Aib2,Leu10,Glu15,Arg20,Glu21,Leu27,Lys28]; jjj) [Aib2,Leu10,Arg12,Glu15,Arg20,Glu21,Leu27,Lys28]; kkk) [Acb2,Leu10,Glu15,Lys17,Arg20,Glu21,Leu27,Lys28]; or III) [Aib2,Leu10,Glu15,Lys17,Arg20,Ser21,Leu27,Lys28]; or pharmaceutically acceptable salts, amides or esters thereof. 16. Glukagonski derivat u skladu s bilo kojim od patentnih zahtjeva 1-14, naznačen time što je u kombinaciji sa spojem GLP-1 ili s inzulinskim spojem.16. A glucagon derivative according to any of claims 1-14, characterized in that it is combined with a GLP-1 compound or an insulin compound. 17. Glukagonski derivat u skladu s patentnim zahtjevom 16, naznačen time što se spoj GLP-1 bira iz skupine koju čine: N-epsilon26-((S)-4-karboksi-4-heksadekanoilaminobutiril)[Arg34]GLP-1-(7-37) ; i N-epsilon26-[2-(2-{2-[2-(2-{2-[(S)-4-karboksi-4-(17-karboksiheptadekanoilamino)butirilamino]etoksi}etoksi)acetilamino]etoksi}etoksi)acetil][Aib8,Arg34]GLP-1-(7-37): ; i njihove farmaceutski prihvatljive soli, amidi, alkili ili esteri.17. Glucagon derivative according to claim 16, characterized in that the GLP-1 compound is selected from the group consisting of: N-epsilon26-((S)-4-carboxy-4-hexadecanoylaminobutyryl)[Arg34]GLP-1-(7-37) ; and N-epsilon26-[2-(2-{2-[2-(2-{2-[(S)-4-carboxy-4-(17-carboxyheptadecanoylamino)butyrylamino]ethoxy}ethoxy)acetylamino]ethoxy}ethoxy) acetyl][Aib8,Arg34]GLP-1-(7-37): ; and their pharmaceutically acceptable salts, amides, alkyls or esters. 18. Glukagonski derivat u skladu s patentnim zahtjevom 16 ili 17, naznačen time što je inzulinski spoj: N-epsilon-B29-[(S)-4-karboksi-4-(15-karboksipentadekanoilamino)butiril] dezB30 ljudski inzulin .18. A glucagon derivative according to claim 16 or 17, characterized in that the insulin compound is: N-epsilon-B29-[(S)-4-carboxy-4-(15-carboxypentadecanoylamino)butyryl] desB30 human insulin . 19. Farmaceutski pripravak, naznačen time što sadrži glukagonski derivat u skladu s bilo kojim od patentnih zahtjeva 1-14 ili 16-18 i izborno jednu ili više farmaceutski prihvatljivih pomoćnh tvari.19. Pharmaceutical preparation, characterized in that it contains a glucagon derivative according to any of claims 1-14 or 16-18 and optionally one or more pharmaceutically acceptable excipients. 20. Glukagonski derivat u skladu s bilo kojim od patentnih zahtjeva 1-14, izborno u kombinaciji s jednim ili više dodatnih terapijski aktivnih spojeva, naznačen time što je namijenjen upotrebi u medicini.20. Glucagon derivative according to any one of patent claims 1-14, optionally in combination with one or more additional therapeutically active compounds, indicated by the fact that it is intended for use in medicine. 21. Glukagonski derivat u skladu s patentnim zahtjevom 20, naznačen time što je namijenjen upotrebi u liječenju pretilosti i/ili smanjivanju telesne težine.21. Glucagon derivative according to patent claim 20, characterized in that it is intended for use in the treatment of obesity and/or weight reduction. 22. Glukagonski derivat u skladu s patentnim zahtjevom 20, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju hiperglikemije, dijabetesa tip 2, poremećene tolerancije glukoze i/ili dijabetesa tip 1.22. A glucagon derivative according to claim 20, characterized in that it is intended for use in the treatment or prevention of hyperglycemia, type 2 diabetes, impaired glucose tolerance and/or type 1 diabetes. 23. Upotreba glukagonskog derivata u skladu s patentnim zahtjevom 20, naznačena time što je glukagonski derivat namijenjen sprječavanju prekomjerne težine, i/ili kod neterapijske indikacije za smanjivanje telesne težine.23. Use of a glucagon derivative in accordance with patent claim 20, characterized in that the glucagon derivative is intended to prevent excess weight, and/or in a non-therapeutic indication for reducing body weight.
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