HRP20161011T1 - Aryl dihydropyridinones and piperidinones as mgat2 inhibitors - Google Patents

Aryl dihydropyridinones and piperidinones as mgat2 inhibitors Download PDF

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HRP20161011T1
HRP20161011T1 HRP20161011TT HRP20161011T HRP20161011T1 HR P20161011 T1 HRP20161011 T1 HR P20161011T1 HR P20161011T T HRP20161011T T HR P20161011TT HR P20161011 T HRP20161011 T HR P20161011T HR P20161011 T1 HRP20161011 T1 HR P20161011T1
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Croatia
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HRP20161011TT
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Croatian (hr)
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Huji Turdi
Jon J. Hangeland
Michael R. Lawrence
Dong Cheng
Saleem Ahmad
Wei Meng
Robert Paul Brigance
Pratik Devasthale
Guohua Zhao
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Bristol-Myers Squibb Company
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Publication of HRP20161011T1 publication Critical patent/HRP20161011T1/en

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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Claims (35)

1. Spoj formule (I): [image] ili njegov stereoizomer, tautomer, farmaceutski prihvatljiva sol ili solvat, u kojem: --- označava jednogubu ili dvogubu vezu; x i y oba mogu biti jednoguba veza; kada je x dvoguba veza, tada je y jednoguba veza i R4 i R16 su odsutni; kada je y dvoguba veza, tada je x jednoguba veza i R5 i R16 su odsutni; R1 je nezavisno izabran iz grupe koja se sastoji od: -CONH(C4-18 alkil), -CONHC2-8 haloalkil, -CONH(CH2)1-8Ph, -CONHCH2COC2-8 alkil, -(CH2)m-(C3-10 karbociklus supstituiran sa 0-2 Rb i 0-2 Rg), -(CH2)m-(5-do 6-člani heteroaril koji sadrži: atome ugljika i 1-4 heteroatoma izabrana od N, NRe, O i S; pri čemu je navedeni heteroaril supstituiran sa 0-1 Rb i 0-2 Rg), i C1-12 ugljikovodični lanac supstituiran sa 0-3 Ra; pri čemu navedeni ugljikovodični lanac može biti linearan ili razgranat, zasićen ili nezasićen; R2 je nezavisno izabran iz grupe koja se sastoji od: C1-4 alkil, C3-4 cikloalkil i C1-4 haloalkil; R3 je nezavisno izabran iz grupe koja se sastoji od: H, F, Cl, C1-4 alkil i CN; R4 i R5 nezavisno su izabrani iz grupe koja se sastoji od: H, F, Cl i C1-4 alkil; kada je x jednoguba veza, R3 i R4 mogu biti kombinirani sa atomom ugljika za koji su vezani tako da formiraju 3- do 6-člani karbociklus; R6 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil, NO2, Rc, -(CH2)n-(X)t(CH2)mRc, NH2, -CONH(C1-6 alkil), -NHCOX1SO2Rj, -NHCOCH2PO(OEt)2, -NHCOCORj, -NHCOCH(OH)Rj, -NHCOCH2CORj, -NHCONHRj i -OCONRfRj; X je nezavisno izabran iz grupe koja se sastoji od: O, S, NH, CONH i NHCO; X1 je nezavisno C1-4 ugljikovodični lanac izborno supstituiran sa C1-4 alkil ili C3-4 cikloalkil; kada je y jednoguba veza, R5 i R6 mogu biti kombinirani sa atomom ugljika za koji su vezani tako da formiraju 3- do 6-člani karbociklus; R11, R12, R13, R14 i R15 nezavisno su izabrani iz grupe koja se sastoji od: H, halo, C1-4 alkil supstituiran sa 0-2 Ri, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, -(CH2)m –C3-6 cikloalkil, CN, NRfRj, ORj, SRj, NHCO2(C1-4 alkil), NHSO2(C1-4 alkil) i 4- do 6-člani heterociklus koji sadrži: atome ugljika i 1-4 heteroatoma izabrana od N, NRe, O i S; alternativno, R11 i R12, zajedno sa atomima ugljika za koje su vezani, kombiniraju se tako da formiraju 5- do 6-člani karbociklični prsten ili 5- do 6-člani heterociklični prsten koji sadrži: atome ugljika i 1-3 heteroatoma izabrana od N, NRe, O i S; alternativno, R12 i R13, zajedno sa atomima ugljika za koje su vezani, kombiniraju se tako da formiraju 5- do 6-člani karbociklični prsten ili 5- do 6-člani heterociklični prsten koji sadrži: atome ugljika i 1-3 heteroatoma izabrana od N, NRe, O i S; R16 je nezavisno izabran iz grupe koja se sastoji od: H i C1-4 alkil; Ra je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, OH, C1-6 alkoksi, C1-6 haloalkil, C1-6 haloalkoksi, N(C1-4 alkil)2, -(CH2)n-(X)t-(CH2)mRc i -(CH2)n-(CH2O)m-(CH2)nRf; Rb je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, OH, C1-10 alkil, C1-10 alkoksi, C1-10 haloalkil, C1-10 haloalkoksi, C1-10 alkiltio, C1-10 haloalkiltio, N(C1-4 alkil)2, -CONH(CH2)4-20H, -O(CH2)sO(C1-6 alkil), Rc, -(CH2)n-(X)t(CH2)mRc i -(CH2)n-(CH2O)m-(CH2)nRf; Rc je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: C3-6 cikloalkila supstituiranog sa 0-2 Rd, C3-6 cikloalkenila supstituiranog sa 0-2 Rd, -(CH2)m-(fenila supstituiranog sa 0-3 Rd) i 5- do 6-članog heterociklusa koji sadrži: atome ugljika i 1-4 heteroatoma izabranih od N, NRe, O i S; pri čemu je navedeni heterociklus supstituiran sa 0-2 Rd; Rd je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, OH, CN, NO2, C1-4 alkil, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, tetrazolil, OBn i fenil supstituiranog sa 0-2 Rh; Re je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: H, C1-8 alkil, C1-8 haloalkil, benzil izborno supstituiranog sa C1-4 alkoksi, CO(C1-4 alkil) i COBn; Rf je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: H i C1-4 alkil; Rg, Rh i Ri su, u svakom slučaju, nezavisno izabrani iz grupe koja se sastoji od: halo, C1-4 alkil, C1-4 alkoksi, C1-4 haloalkil i C1-4 haloalkoksi; RJ je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: C1-4 alkil, C3-4 cikloalkil i fenil; n, u svakom slučaju, je nezavisno 0 ili 1; m, u svakom slučaju, je nezavisno 0, 1, 2, 3 ili 4 s, u svakom slučaju, je nezavisno 1, 2 ili 3; i t, u svakom slučaju, je nezavisno 0 ili 1; uz uvjet da je slijedeći spoj isključen: [image] 1. Compound of formula (I): [image] or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate thereof, in which: --- indicates a single-ply or double-ply bond; x and y can both be single bonds; when x is a double bond, then y is a single bond and R4 and R16 are absent; when y is a double bond, then x is a single bond and R5 and R16 are absent; R1 is independently selected from the group consisting of: -CONH(C4-18 alkyl), -CONHC2-8 haloalkyl, -CONH(CH2)1-8Ph, -CONHCH2COC2-8 alkyl, -(CH2)m-(C3- 10 carbocycle substituted with 0-2 Rb and 0-2 Rg), -(CH2)m-(5- to 6-membered heteroaryl containing: carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S; at wherein said heteroaryl is substituted with 0-1 Rb and 0-2 Rg), and the C1-12 hydrocarbon chain is substituted with 0-3 Ra; wherein said hydrocarbon chain can be linear or branched, saturated or unsaturated; R 2 is independently selected from the group consisting of: C 1-4 alkyl, C 3-4 cycloalkyl and C 1-4 haloalkyl; R 3 is independently selected from the group consisting of: H, F, Cl, C 1-4 alkyl and CN; R 4 and R 5 are independently selected from the group consisting of: H, F, Cl and C 1-4 alkyl; when x is a single bond, R 3 and R 4 may be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle; R6 is independently selected from the group consisting of: H, halo, C1-4 alkyl, NO2, Rc, -(CH2)n-(X)t(CH2)mRc, NH2, -CONH(C1-6 alkyl), -NHCOX1SO2Rj, -NHCOCH2PO(OEt)2, -NHCOCORj, -NHCOCH(OH)Rj, -NHCOCH2CORj, -NHCONHRj and -OCONRfRj; X is independently selected from the group consisting of: O, S, NH, CONH and NHCO; X1 is independently a C1-4 hydrocarbon chain optionally substituted with C1-4 alkyl or C3-4 cycloalkyl; when y is a single bond, R5 and R6 may be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle; R11, R12, R13, R14 and R15 are independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-2 Ri, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, - (CH2)m –C3-6 cycloalkyl, CN, NRfRj, ORj, SRj, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl) and a 4- to 6-membered heterocycle containing: carbon atoms and 1-4 a heteroatom selected from N, NRe, O and S; alternatively, R11 and R12, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring containing: carbon atoms and 1-3 heteroatoms selected from N , NRe, O and S; alternatively, R12 and R13, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring containing: carbon atoms and 1-3 heteroatoms selected from N , NRe, O and S; R 16 is independently selected from the group consisting of: H and C 1-4 alkyl; Ra is, in each case, independently selected from the group consisting of: halo, OH, C1-6 Alkoxy, C1-6 Haloalkyl, C1-6 HaloAlkoxy, N(C1-4 alkyl)2, -(CH2)n- (X)t-(CH2)mRc and -(CH2)n-(CH2O)m-(CH2)nRf; Rb is, in each case, independently selected from the group consisting of: halo, OH, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C1-10 haloalkoxy, C1-10 alkylthio, C1-10 haloalkylthio, N(C1-4 alkyl)2, -CONH(CH2)4-20H, -O(CH2)sO(C1-6 alkyl), Rc, -(CH2)n-(X)t(CH2)mRc and -( CH2)n-(CH2O)m-(CH2)nRf; Rc is, in each case, independently selected from the group consisting of: C3-6 cycloalkyl substituted with 0-2 Rd, C3-6 cycloalkenyl substituted with 0-2 Rd, -(CH2)m-(phenyl substituted with 0- 3 Rd) and a 5- to 6-membered heterocycle containing: carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S; wherein said heterocycle is substituted with 0-2 Rd; Rd is, in each case, independently selected from the group consisting of: halo, OH, CN, NO2, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, tetrazolyl, OBn and phenyl substituted with 0-2 Rh; Re is, in each case, independently selected from the group consisting of: H, C1-8 alkyl, C1-8 haloalkyl, benzyl optionally substituted with C1-4 alkoxy, CO(C1-4 alkyl) and COBn; R f is, in each case, independently selected from the group consisting of: H and C 1-4 alkyl; Rg, Rh and Ri are, in each case, independently selected from the group consisting of: halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl and C1-4 haloalkoxy; RJ is, in each case, independently selected from the group consisting of: C1-4 alkyl, C3-4 cycloalkyl and phenyl; n, in each case, is independently 0 or 1; m, in each case, is independently 0, 1, 2, 3, or 4 s, in each case, is independently 1, 2 or 3; and t, in each case, is independently 0 or 1; provided that the following connection is excluded: [image] 2. Spoj prema patentnom zahtjevu 1, u kojem: R1 je nezavisno izabran iz grupe koja se sastoji od: -CONHC4-18 alkil, -CONH(CH2)1-8 Ph, C1-12 alkil supstituiran sa 0-2 Ra, C1-12 alkenil supstituiran sa 0-2 Ra, C1-12 alkinil supstituiran sa 0-2 Ra, -(CH2)m-(fenil supstituiran sa 0-1 Rb i 0-2 Rg), -(CH2)m-(C3-6 cikloalkil supstituiran sa 0-1 Rb) i -(CH2)m-(5- do 6-člani heteroaril supstituiran sa 0-1 Rb i 0-2 Rg), pri čemu je navedeni heteroaril izabran od: piridil, oksazolil, tiazolil i [image] 2. Compound according to patent claim 1, in which: R1 is independently selected from the group consisting of: -CONHC4-18 alkyl, -CONH(CH2)1-8 Ph, C1-12 alkyl substituted with 0-2 Ra, C1-12 alkenyl substituted with 0-2 Ra, C1 -12 alkynyl substituted with 0-2 Ra, -(CH2)m-(phenyl substituted with 0-1 Rb and 0-2 Rg), -(CH2)m-(C3-6 cycloalkyl substituted with 0-1 Rb) and -(CH2)m-(5- to 6-membered heteroaryl substituted with 0-1 Rb and 0-2 Rg), wherein said heteroaryl is selected from: pyridyl, oxazolyl, thiazolyl and [image] 3. Spoj prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, u kojem: R11 i R15 nezavisno su izabrani iz grupe koja se sastoji od: H, C1-4 alkil i halo; R12 i R14 nezavisno su izabrani iz grupe koja se sastoji od: H, halo, C1-4 alkil i C1-4 alkoksi; i R13 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil supstituiran sa 0-1 Ri, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, -(CH2)m-C3-4 cikloalkil, CN, NRfRj, SRj, NHCO2(C1-4 alkil), NHSO2(C1-4 alkil), i 4- do 6-člani heteorciklus koji sadrži: atome ugljika i 1-4 heteroatoma izabrana od N, NRe, O i S.3. Compound according to patent claim 1 or patent claim 2, in which: R 11 and R 15 are independently selected from the group consisting of: H, C 1-4 alkyl and halo; R 12 and R 14 are independently selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 alkoxy; and R13 is independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-1 Ri, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, -(CH2)m-C3-4 cycloalkyl, CN, NRfRj, SRj, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), and a 4- to 6-membered heterocycle containing: carbon atoms and 1-4 heteroatoms selected from N, NRe, O and WITH. 4. Spoj prema bilo kojem od patentnih zahtjeva 1 do 3, pri čemu je spoj formule (II): [image] ili njegov stereoizomer, tautomer, farmaceutski prihvatljiva sol ili solvat.4. A compound according to any one of claims 1 to 3, wherein the compound of formula (II): [image] or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate thereof. 5. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, u kojem: R1 je nezavisno izabran iz grupe koja se sastoji od: C1-6 alkil, C3-6 cikloalkil, -CONHC4-18 alkil, -CONHC2-8 haloalkil, -CONH(CH2)1-8 Ph, -(CH2)m-(fenil supstituiran sa 1 Rb i 0-2 Rg), i 5- do 6-člani heteroaril supstituiran sa 0-1 Rb i 0-2 Rg, pri čemu je navedeni heteroaril izabran od: piridil, oksazolil, tiazolil i [image] R2 je nezavisno izabran iz grupe koja se sastoji od: C1-4 alkil i C1-4 haloalkil; R3 je nezavisno izabran iz grupe koja se sastoji od: H i F; R4 je nezavisno izabran iz grupe koja se sastoji od: H i F; R6 je nezavisno izabran iz grupe koja se sastoji od: NH2, -CONH(C1-6 alkil), Rc, -(CH2)n-(X)t(CH2)mRc, -NHCO(CH2))SO2)(C1-4 alkil), -NHCOCH2PO(OEt)2, -NHCOCO(C1-4 alkil), -NHCOCH(OH)(C1-4 alkil), -NHCOCH2CO(C1-4 alkil), -NHCONH(C1-4 alkil), i -OCONH(C1-4 alkil); R11 i R15 nezavisno su izabrani iz grupe koja se sastoji od: H, C1-4 alkil i halo; R12 i R14 nezavisno su izabrani iz grupe koja se sastoji od: H, halo, C1-4 alkil i C1-4 alkoksi; R13 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil supstituiran sa 0-1 C1-4 alkoksi, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, -(CH2)m-C3-4 cikloalkil, CN, N(C1-4 alkil)2, NHCO2(C1-4 alkil), NHSO2(C1-4 alkil), pirazolil i morfolinil; alternativno, R12 i R13, zajedno sa atomima ugljika za koje su vezani, kombiniraju se tako da formiraju 5- do 6-člani karbociklični prsten ili 5- do 6-člani heterociklični prsten koji sadrži: atome ugljika i 1-3 heteroatoma izabrana od N, NRe, O i S; Rb je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, OH, C1-8 alkil, C1-8 alkoksi, C1-8 haloalkil, C1-10 haloalkoksi, -O(CH2)sO(C1-6 alkil), N(C1-4 alkil)2, -CONH(CH2)6-20H, -(CH2)m(C3-6 cikloalkil), -(CH2)m(C4-6 cikloalkenil), -O(CH2)m(C3-6 cikloalkil), 4-C1-4 alkoksi-Ph, -O(CH2)mPh, morfolinil, piridil, 2-C1-4 alkoksi-piridin-5-il, pirimidinil, pirazinil i -O-pirimidinil; Rg je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, C1-4 alkil, C1-4 alkoksi, C1-4 haloalkil i C1-4 haloalkoksi; m, u svakom slučaju, je nezavisno 0, 1, 2 ili 3; i s, u svakom slučaju, je nezavisno 1, 2 ili 3.5. A compound according to any one of claims 1 to 4, in which: R1 is independently selected from the group consisting of: C1-6 alkyl, C3-6 cycloalkyl, -CONHC4-18 alkyl, -CONHC2-8 haloalkyl, -CONH(CH2)1-8 Ph, -(CH2)m-( phenyl substituted with 1 Rb and 0-2 Rg), and 5- to 6-membered heteroaryl substituted with 0-1 Rb and 0-2 Rg, wherein said heteroaryl is selected from: pyridyl, oxazolyl, thiazolyl and [image] R 2 is independently selected from the group consisting of: C 1-4 alkyl and C 1-4 haloalkyl; R 3 is independently selected from the group consisting of: H and F; R 4 is independently selected from the group consisting of: H and F; R6 is independently selected from the group consisting of: NH2, -CONH(C1-6 alkyl), Rc, -(CH2)n-(X)t(CH2)mRc, -NHCO(CH2))SO2)(C1- 4 alkyl), -NHCOCH2PO(OEt)2, -NHCOCO(C1-4 alkyl), -NHCOCH(OH)(C1-4 alkyl), -NHCOCH2CO(C1-4 alkyl), -NHCONH(C1-4 alkyl), and -OCONH(C1-4 alkyl); R 11 and R 15 are independently selected from the group consisting of: H, C 1-4 alkyl and halo; R 12 and R 14 are independently selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 alkoxy; R13 is independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-1 C1-4 alkoxy, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, -(CH2)m- C3-4 cycloalkyl, CN, N(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), pyrazolyl and morpholinyl; alternatively, R12 and R13, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring containing: carbon atoms and 1-3 heteroatoms selected from N , NRe, O and S; Rb is, in each case, independently selected from the group consisting of: halo, OH, C1-8 alkyl, C1-8 alkoxy, C1-8 haloalkyl, C1-10 haloalkoxy, -O(CH2)sO(C1-6 alkyl), N(C1-4 alkyl)2, -CONH(CH2)6-20H, -(CH2)m(C3-6 cycloalkyl), -(CH2)m(C4-6 cycloalkenyl), -O(CH2) m(C3-6 cycloalkyl), 4-C1-4 alkoxy-Ph, -O(CH2)mPh, morpholinyl, pyridyl, 2-C1-4 alkoxy-pyridin-5-yl, pyrimidinyl, pyrazinyl and -O-pyrimidinyl; R 8 is, in each case, independently selected from the group consisting of: halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl and C 1-4 haloalkoxy; m, in each case, is independently 0, 1, 2 or 3; and s, in each case, is independently 1, 2, or 3. 6. Spoj prema bilo kojem od patentnih zahtjeva 1 do 5, u kojem: R1 je nezavisno izabran iz grupe koja se sastoji od: C1-6 alkil, -CONHC4-18 alkil, -CONH(CH2)1-8Ph, i [image] R6 je nezavisno izabran iz grupe koja se sastoji od: NH2, -CONH(C1-6 alkil), -NHCOCH2PO(OEt)2, -NHCO(CH2)SO2(C1-4 alkil), Rc, ORc, -CONHRc i -NHCORc; R12 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil i C1-4 alkoksi; R13 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil supstituiran sa 0-1 C1-4 alkoksi, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, -(CH2)m-C3-4 cikloalkil, CN, N(C1-4 alkil)2, NHCO2(C1-4 alkil), NHSO2(C1-4 alkil), pirazolil i morfolinil; alternativno, R12 i R13, zajedno sa atomima ugljika za koje su vezani, kombiniraju se tako da formiraju 5- do 6-člani karbociklični prsten ili 5- do 6-člani zasićeni heterociklični prsten koji sadrži: atome ugljika i 1-2 atoma kisika; R14 je nezavisno izabran iz grupe koja se sastoji od: H i C1-4 alkoksi; Rb je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, C1-6 alkil, C1-6 alkoksi, C1-6 haloalkil, C1-10 haloalkoksi, -O(CH2)sO(C1-6 alkil), -CONH(CH2)6-20H, -(CH2)m(C3-6 cikloalkil), -(CH2)m(C4-6 cikloalkenil), -O(CH2)m(C3-6 cikloalkil), fenoksi, benzoksi, morfolinil, 2-C1-4 alkoksi-piridin-5-il, pirimidin-5-il, pirazin-2-il i -O-pirimidinil; i Rc je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: C3-6 cikloalkil supstituiran sa 0-2 Rd, -(CH2)m-(fenil supstituiran sa 0-3 Rd) i heteroaril izabran od: oksazolil, izoksazolil, toazolil, pirazolil, imidazolil, oksadiazolil, triazolil, tetrazolil, piridil i pirazinil; pri čemu je navedeni heteroaril supstituiran sa 0-2 Rd.6. A compound according to any one of claims 1 to 5, in which: R1 is independently selected from the group consisting of: C1-6 alkyl, -CONHC4-18 alkyl, -CONH(CH2)1-8Ph, and [image] R6 is independently selected from the group consisting of: NH2, -CONH(C1-6 alkyl), -NHCOCH2PO(OEt)2, -NHCO(CH2)SO2(C1-4 alkyl), Rc, ORc, -CONHRc and - NHCORc; R 12 is independently selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 alkoxy; R13 is independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-1 C1-4 alkoxy, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, -(CH2)m- C3-4 cycloalkyl, CN, N(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), pyrazolyl and morpholinyl; alternatively, R 12 and R 13 , together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered saturated heterocyclic ring containing: carbon atoms and 1-2 oxygen atoms; R 14 is independently selected from the group consisting of: H and C 1-4 alkoxy; Rb is, in each case, independently selected from the group consisting of: halo, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-10 haloalkoxy, -O(CH2)sO(C1-6 alkyl) , -CONH(CH2)6-20H, -(CH2)m(C3-6 cycloalkyl), -(CH2)m(C4-6 cycloalkenyl), -O(CH2)m(C3-6 cycloalkyl), phenoxy, benzoxy , morpholinyl, 2-C1-4 alkoxy-pyridin-5-yl, pyrimidin-5-yl, pyrazin-2-yl and -O-pyrimidinyl; and Rc is, in each case, independently selected from the group consisting of: C3-6 cycloalkyl substituted with 0-2 Rd, -(CH2)m-(phenyl substituted with 0-3 Rd) and heteroaryl selected from: oxazolyl, isoxazolyl , thazolyl, pyrazolyl, imidazolyl, oxadiazolyl, triazolyl, tetrazolyl, pyridyl and pyrazinyl; wherein said heteroaryl is substituted with 0-2 Rd. 7. Spoj prema bilo kojem od patentnih zahtjeva 1-6, u kojem: R2 je nezavisno izabran iz grupe koja se sastoji od: CF3 i Me; R3 je nezavisno izabran iz grupe koja se sastoji od: H i F; R4 je nezavisno izabran iz grupe koja se sastoji od: H i F; R6 je nezavisno izabran iz grupe koja se sastoji od: NH2, -CONHMe, OPh, -CONH(ciklopropil), -CONH(ciklobutil), -CONH(ciklopentil), -CONH(cikloheksil), -CONHPh, -CONH(4-F-Ph), -CONH(2-Cl-Ph), -CONH(4-Cl-Ph), -CONH(4-Me-Ph), -CONH(4-OH-Ph), -CONH(3-OMe-Ph), -CONH(4-OMe-Ph), -CONH(4-CF3-Ph), -CONH(4-OCF3-Ph), -CONH(1-Me-pirazol-3-il), -CONH(4-(1H-tetrazol-2-il)-Ph), -CONH(4-(2H-tetrazol-5-il)-Ph), -CONH(3-F-4-Me-Ph), -CONH(3-F-4-OMe-Ph), -CONH(CH2)2Ph, -CONH(5-OMe-pirid-2-il), -CONH(6-OMe-pirid-3-il), -CONH(5-OMe-pirazin-2-il), -CONH(6-OMe-piridazin-3-il), NHCO(CH2)SO2Me, -NHCOPh, -NHCO(2-Me-Ph), -NHCO(3-Me-Ph), -NHCO(4-Me-Ph), -NHCO(2-Cl-Ph), -NHCO(3-Cl-Ph), -NHCO(2-Cl-4-F-Ph), -NHCO(2-Cl-5-F-Ph), -NHCO(izoksazol-5-il), -NHCO(3-Me-izoksazol-5-il), -NHCO(4-Me-izoksazol-5-il), -NHCO(3-OMe-izoksazol-5-il), -NHCO(3-Br-izoksazol-5-il), -NHCO(3-(2-Cl-Ph)-izoksazol-5-il), -NHCO(3-(3-F-Ph)-izoksazol-5-il), -NHCO(3-OBn-izoksazol-5-il), 1H-imidazol-1-il, -NHCO(5-Me-1,3,4-oksadiazol-2-il), -NHCO(1-Me-1,2,3-triazol-4-il), -NHCO(6-OMe-pirid-3-il), -NHCO(6-Cl-piridazin-3-il), 5-CF3-1,3,4-oksadiazol-2-il, 1H-tetrazol-1-il, 1H-tetrazol-3-il i 2H-tetrazol-5-il; R11 i R15 nezavisno su izabrani iz grupe koja se sastoji od: H, Me, F i Cl; R12 je nezavisno izabran iz grupe koja se sastoji od: H, F, Cl, Me i OMe; R13 je nezavisno izabran iz grupe koja se sastoji od: H, F, Cl, Br, Me, OMe, OEt, CH2OMe, CF3, CH2CF3, OCHF2, OCF3, CN, N(Me)2, ciklopropil i ciklopropilmetil; alternativno, R12 i R13, zajedno sa atomima ugljika za koje su vezani, kombiniraju se tako da formiraju 5- do 6-člani karbociklični prsten ili 5- do 6-člani zasićeni heterociklični prsten koji sadrži: atome ugljika i 1-2 atoma kisika; R14 je H; Rb je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: n-pentil, metoksi, n-butoksi, i-butoksi, i-pentoksi, -O(CH2)1-6CF3, -O(CH2)1-4CF2CF3, -CONH(CH2)6-20H, ciklopropil, ciklopent-1-en-1-il, cikloheks-1-en-1-il, -O(CH2)2(ciklopentil), fenoksi, benzoksi, pirimidin-5-il, pirazin-2-il i -O-pirimidin-2-il; i Rg je F.7. A compound according to any of claims 1-6, in which: R 2 is independently selected from the group consisting of: CF 3 and Me; R 3 is independently selected from the group consisting of: H and F; R 4 is independently selected from the group consisting of: H and F; R6 is independently selected from the group consisting of: NH2, -CONHMe, OPh, -CONH(cyclopropyl), -CONH(cyclobutyl), -CONH(cyclopentyl), -CONH(cyclohexyl), -CONHPh, -CONH(4- F-Ph), -CONH(2-Cl-Ph), -CONH(4-Cl-Ph), -CONH(4-Me-Ph), -CONH(4-OH-Ph), -CONH(3- OMe-Ph), -CONH(4-OMe-Ph), -CONH(4-CF3-Ph), -CONH(4-OCF3-Ph), -CONH(1-Me-pyrazol-3-yl), - CONH(4-(1H-tetrazol-2-yl)-Ph), -CONH(4-(2H-tetrazol-5-yl)-Ph), -CONH(3-F-4-Me-Ph), - CONH(3-F-4-OMe-Ph), -CONH(CH2)2Ph, -CONH(5-OMe-pyrid-2-yl), -CONH(6-OMe-pyrid-3-yl), -CONH (5-OMe-pyrazin-2-yl), -CONH(6-OMe-pyridazin-3-yl), NHCO(CH2)SO2Me, -NHCOPh, -NHCO(2-Me-Ph), -NHCO(3- Me-Ph), -NHCO(4-Me-Ph), -NHCO(2-Cl-Ph), -NHCO(3-Cl-Ph), -NHCO(2-Cl-4-F-Ph), - NHCO(2-Cl-5-F-Ph), -NHCO(isoxazol-5-yl), -NHCO(3-Me-isoxazol-5-yl), -NHCO(4-Me-isoxazol-5-yl) , -NHCO(3-OMe-isoxazol-5-yl), -NHCO(3-Br-isoxazol-5-yl), -NHCO(3-(2-Cl-Ph)-isoxazol-5-yl), - NHCO(3-(3-F-Ph)-isoxazol-5-yl), -NHCO(3-OBn-isoxazol-5-yl), 1H-imidazol-1-yl, -NHCO(5-Me-1, 3,4-oxadiazol-2-yl), -NHCO(1- Me-1,2,3-triazol-4-yl), -NHCO(6-OMe-pyrid-3-yl), -NHCO(6-Cl-pyridazin-3-yl), 5-CF3-1,3 ,4-oxadiazol-2-yl, 1H-tetrazol-1-yl, 1H-tetrazol-3-yl and 2H-tetrazol-5-yl; R 11 and R 15 are independently selected from the group consisting of: H, Me, F and Cl; R 12 is independently selected from the group consisting of: H, F, Cl, Me and OMe; R13 is independently selected from the group consisting of: H, F, Cl, Br, Me, OMe, OEt, CH2OMe, CF3, CH2CF3, OCHF2, OCF3, CN, N(Me)2, cyclopropyl and cyclopropylmethyl; alternatively, R 12 and R 13 , together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered saturated heterocyclic ring containing: carbon atoms and 1-2 oxygen atoms; R 14 is H; Rb is, in each case, independently selected from the group consisting of: n-pentyl, methoxy, n-butoxy, i-butoxy, i-pentoxy, -O(CH2)1-6CF3, -O(CH2)1- 4CF2CF3, -CONH(CH2)6-20H, cyclopropyl, cyclopent-1-en-1-yl, cyclohex-1-en-1-yl, -O(CH2)2(cyclopentyl), phenoxy, benzoxy, pyrimidine-5 -yl, pyrazin-2-yl and -O-pyrimidin-2-yl; and Rg is F. 8. Spoj prema patentnom zahtjevu 4 ili patentnom zahtjevu 5, u kojem: R1 je [image] R2 je nezavisno izabran od CF3 i CH3; R6 je nezavisno izabran od: Rc, -CONHRc, -NHCORc i -NHCOCH2SO2(C1-4 alkil); Rb je nezavisno izabran od: -O(CH2)1-6CF3, -O(CH2)1-4CF2CF3, -CONH(CH2)6-20H, ciklopent-1-en-1-il, cikloheks-1-en-1-il, -O(CH2)2(ciklopentil), fenoksi, benzoksi, pirimidin-5-il, pirazin-2-il i -O-pirimidin-2-il; Rc je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: -(CH2)m-(fenil supstituiran sa 0-3 Rd), i heteroaril izabran od: oksazolil, izoksazolil, pirazolil, imidazolil, oksadiazolil, triazolil, tetrazolil, piridil i pirazinil; pri čemu je navedeni heteroaril supstituiran sa 0-2 Rd; i Rd je, u svakom slučaju, nezavisno izabran iz grupe koja se sastoji od: halo, OH, CN, C1-4 alkil, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, tetrazolil i OBn.8. Compound according to patent claim 4 or patent claim 5, in which: R1 is [image] R 2 is independently selected from CF 3 and CH 3 ; R6 is independently selected from: Rc, -CONHRc, -NHCORc and -NHCOCH2SO2(C1-4 alkyl); Rb is independently selected from: -O(CH2)1-6CF3, -O(CH2)1-4CF2CF3, -CONH(CH2)6-20H, cyclopent-1-en-1-yl, cyclohex-1-en-1 -yl, -O(CH2)2(cyclopentyl), phenoxy, benzoxy, pyrimidin-5-yl, pyrazin-2-yl and -O-pyrimidin-2-yl; Rc is, in each case, independently selected from the group consisting of: -(CH2)m-(phenyl substituted with 0-3 Rd), and heteroaryl selected from: oxazolyl, isoxazolyl, pyrazolyl, imidazolyl, oxadiazolyl, triazolyl, tetrazolyl , pyridyl and pyrazinyl; wherein said heteroaryl is substituted with 0-2 Rd; and R d is, in each case, independently selected from the group consisting of: halo, OH, CN, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, tetrazolyl and OBn. 9. Spoj prema bilo kojem od patentnih zahtjeva 1-6 ili 8, u kojem: R13 je nezavisno izabran iz grupe koja se sastoji od: H, halo, C1-4 alkil supstituiran sa 0-1 C1-4 alkoksi, C1-4 alkoksi, C1-4 haloalkil, C1-4 haloalkoksi, CN ili C3-4 cikloalkil.9. A compound according to any of claims 1-6 or 8, in which: R 13 is independently selected from the group consisting of: H, halo, C 1-4 alkyl substituted with 0-1 C 1-4 alkoxy, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkyl, CN or C 3-4 cycloalkyl . 10. Spoj prema bilo kojem od patentnih zahtjeva 1-5, 8 ili 9 u kojem: R1 je nezavisno [image] 10. A compound according to any of claims 1-5, 8 or 9 in which: R1 is independent [image] 11. Spoj prema bilo kojem od patentnih zahtjeva 1-10, u kojem: Rb je nezavisno izabran od: -O(CH2)1-6CF3, i -O(CH2)1-4CF2)CF3.11. A compound according to any one of claims 1-10, wherein: Rb is independently selected from: -O(CH2)1-6CF3, and -O(CH2)1-4CF2)CF3. 12. Spoj prema bilo kojem od patentnih zahtjeva 1-5, u kojem: R6 je nezavisno 5-člani dušikov heteroaril.12. A compound according to any one of claims 1-5, wherein: R6 is independently a 5-membered nitrogen heteroaryl. 13. Spoj prema bilo kojem od patentnih zahtjeva 1-12, u kojem: R6 je nezavisno: 1H-imidazol-1-il, 1H-tetrazol-1-il, 1H-tetrazol-3-il ili 2H-tetrazol-5-il.13. A compound according to any one of claims 1-12, in which: R6 is independently: 1H-imidazol-1-yl, 1H-tetrazol-1-yl, 1H-tetrazol-3-yl or 2H-tetrazol-5- or 14. Spoj prema patentnom zahtjevu 1, naznačen time što je spoj izabran od: 3-(1H-Tetrazol-5-il)-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; (S)-3-(1H-Tetrazol-5-il)-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; (R)-3-(1H-Tetrazol-5-il)-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; N-(4-Metoksifenil)-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluoro-metil)-1,2,5,6-tetrahidropiridin-3-karboksamid; (R)-N-(4-Metoksifenil)-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluoro-metil)-1,2,5,6-tetrahidropiridin-3-karboksamid; (S)-N-(4-Metoksifenil)-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluoro-metil)-1,2,5,6-tetrahidropiridin-3-karboksamid; (S)-3-(2H-Tetrazol-5-il)-4-p-tolil-6-(4-(6,6,6-trifluoroheksiloksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; 3-(2-Etil-2H-tetrazol-5-il)-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; 4-p-Tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-3-(5-(trifluorometil)-1,3,4-oksadiazol-2-il)-5 ,6-dihidropiridin-2(1H)-on; 6-Metil-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-N-(4-(trifluorometoksi)-fenil)-1,2,5,6-tetrahidropiridin-3-karboksamid; 3-(2H-Tetrazol-5-il)-4-p-tolil-6-(trifluorometil)-6-(1-(5,5,5-trifluoropentil)-1H-pirazol-4-il)-5,6-dihidropiridin-2(1H)-on; 3-Nitro-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; N-(4-Metoksifenil)-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)piperidin-3-karboksamid; spojevi formule (IIa) [image] u kojima su R1, R2 i R6 supstituenti navedeni u tabeli u daljnjem tekstu, i u kojima R11 do R15 su vodik, osim ukoliko nije drugačije naznačeno u tabeli u daljnjem tekstu: [image] [image] [image] N5-(4-Metoksifenil)-2-metil-6-okso-4-p-tolil-N2-(4,4,4-trifluorobutil)-1,2,3,6-tetrahidropiridin-2,5-dikarboksamid; N-(4-Cijanofenil)-5,5-difluoro-2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-1,2,5,6-tetrahidropiridin-3-karboksamid; (S)-3-Amino-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; (S)-2-Metil-N-(2-okso-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-1,2,5,6-tetrahidropiridin-3-il)benzamid; (S)-3-fenoksi-4-p-tolil-6-(4-(4,4,4-trifluorobutoksi)fenil)-6-(trifluorometil)-5,6-dihidropiridin-2(1H)-on; i spojevi formule (II) [image] u kojima R1, R2, R3, R4 i R6 su susptituenti navedeni u tabeli u daljnjem tekstu, i u kojima R1 do R15 su vodik, osim ukoliko nije drugačije naznačeno u tabeli u daljnjem tekstu: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] ili njegov stereoizomer, tautomer, farmaceutski prihvatljiva sol ili solvat.14. Compound according to claim 1, characterized in that the compound is selected from: 3-(1H-Tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridine-2(1H )-he; (S)-3-(1H-Tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridine -2(1H)-one; (R)-3-(1H-Tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridine -2(1H)-one; N-(4-Methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoro-methyl)-1,2,5,6 -tetrahydropyridine-3-carboxamide; (R)-N-(4-Methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoro-methyl)-1,2 ,5,6-tetrahydropyridine-3-carboxamide; (S)-N-(4-Methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoro-methyl)-1,2 ,5,6-tetrahydropyridine-3-carboxamide; (S)-3-(2H-Tetrazol-5-yl)-4-p-tolyl-6-(4-(6,6,6-trifluorohexyloxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridine -2(1H)-one; 3-(2-Ethyl-2H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridine -2(1H)-one; 4-p-Tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl) -5,6-dihydropyridin-2(1H)-one; 6-Methyl-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-N-(4-(trifluoromethoxy)-phenyl)-1,2,5,6 -tetrahydropyridine-3-carboxamide; 3-(2H-Tetrazol-5-yl)-4-p-tolyl-6-(trifluoromethyl)-6-(1-(5,5,5-trifluoropentyl)-1H-pyrazol-4-yl)-5, 6-dihydropyridin-2(1H)-one; 3-Nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one; N-(4-Methoxyphenyl)-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)piperidine-3-carboxamide; compounds of formula (IIa) [image] in which R1, R2 and R6 are the substituents listed in the table below, i in which R11 to R15 are hydrogen, unless otherwise indicated in the table below: [image] [image] [image] N5-(4-Methoxyphenyl)-2-methyl-6-oxo-4-p-tolyl-N2-(4,4,4-trifluorobutyl)-1,2,3,6-tetrahydropyridine-2,5-dicarboxamide; N-(4-Cyanophenyl)-5,5-difluoro-2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2 ,5,6-tetrahydropyridine-3-carboxamide; (S)-3-Amino-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one; (S)-2-Methyl-N-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5, 6-tetrahydropyridin-3-yl)benzamide; (S)-3-phenoxy-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one; and compounds of formula (II) [image] in which R1, R2, R3, R4 and R6 are the substituents listed in the table below, and in which R1 to R15 are hydrogen, unless otherwise indicated in the table below: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate thereof. 15. Spoj prema patentnom zahtjevu 1, naznačen time što spoj ima slijedeću formulu: [image] ili njegov stereoizomer, tautomer ili farmaceutski prihvatljiva sol ili solvat.15. Compound according to claim 1, characterized in that the compound has the following formula: [image] or a stereoisomer, tautomer, or a pharmaceutically acceptable salt or solvate thereof. 16. Spoj prema patentnom zahtjevu 15, naznačen time što spoj ima slijedeću formulu: [image] ili njegov tautomer ili farmaceutski prihvatljiva sol.16. A compound according to claim 15, characterized in that the compound has the following formula: [image] or a tautomer or a pharmaceutically acceptable salt thereof. 17. Spoj prema patentnom zahtjevu 15, naznačen time što spoj je: [image] 17. Compound according to patent claim 15, characterized in that the compound is: [image] 18. Farmaceutski prihvatljiva sol spoja prema patentnom zahtjevu 15 ili patentnom zahtjevu 16.18. Pharmaceutically acceptable salt of the compound according to patent claim 15 or patent claim 16. 19. Spoj prema patentnom zahtjevu 1, naznačen time što spoj ima slijedeću formulu: [image] ili njegov stereoizomer, tautomer ili farmaceutski prihvatljiva sol.19. Compound according to claim 1, characterized in that the compound has the following formula: [image] or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. 20. Spoj prema patentnom zahtjevu 19, naznačen time što spoj ima slijedeću formulu: [image] ili njegov tautomer ili farmaceutski prihvatljiva sol.20. Compound according to claim 19, characterized in that the compound has the following formula: [image] or a tautomer or a pharmaceutically acceptable salt thereof. 21. Spoj prema patentnom zahtjevu 19, naznačen time što spoj je: [image] 21. Compound according to claim 19, characterized in that the compound is: [image] 22. Spoj prema patentnom zahtjevu 1, naznačen time što spoj ima slijedeću formulu: [image] ili njegov stereoizomer, tautomer ili farmaceutski prihvatljiva sol.22. The compound according to claim 1, characterized in that the compound has the following formula: [image] or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. 23. Spoj prema patentnom zahtjevu 22, naznačen time što spoj ima slijedeću formulu: [image] ili njegov tautomer ili farmaceutski prihvatljiva sol.23. Compound according to claim 22, characterized in that the compound has the following formula: [image] or a tautomer or a pharmaceutically acceptable salt thereof. 24. Spoj prema patentnom zahtjevu 22, naznačen time što spoj je: [image] 24. Compound according to claim 22, characterized in that the compound is: [image] 25. Spoj prema patentnom zahtjevu 1, naznačen time što spoj ima slijedeću formulu: [image] ili njegov stereoizomer, tautomer ili farmaceutski prihvatljiva sol.25. Compound according to claim 1, characterized in that the compound has the following formula: [image] or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. 26. Spoj prema patentnom zahtjevu 25, naznačen time što spoj ima slijedeću formulu: [image] ili njegov tautomer ili farmaceutski prihvatljiva sol.26. Compound according to claim 25, characterized in that the compound has the following formula: [image] or a tautomer or a pharmaceutically acceptable salt thereof. 27. Spoj prema patentnom zahtjevu 25, naznačen time što spoj je: [image] 27. Compound according to patent claim 25, characterized in that the compound is: [image] 28. Spoj prema patentnom zahtjevu 1, naznačen time što spoj ima slijedeću formulu: [image] ili njegov stereoizomer, tautomer ili farmaceutski prihvatljiva sol.28. Compound according to claim 1, characterized in that the compound has the following formula: [image] or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. 29. Spoj prema patentnom zahtjevu 28, naznačen time što spoj ima slijedeću formulu: [image] ili njegov tautomer ili farmaceutski prihvatljiva sol.29. Compound according to claim 28, characterized in that the compound has the following formula: [image] or a tautomer or a pharmaceutically acceptable salt thereof. 30. Spoj prema patentnom zahtjevu 28, naznačen time što spoj je: [image] 30. Compound according to claim 28, characterized in that the compound is: [image] 31. Farmaceutska kompozicija, koja sadrži: farmaceutski prihvatljiv nosač i spoj prema bilo kojem od patentnih zahtjeva 1 do 30, ili njegov stereoizomer, tautomer ili farmaceutski prihvatljivu sol, i izborno jedan ili više dodatnih terapeutskih sredstava.31. Pharmaceutical composition, which contains: a pharmaceutically acceptable carrier and a compound according to any of claims 1 to 30, or its stereoisomer, tautomer or pharmaceutically acceptable salt, and optionally one or more additional therapeutic agents. 32. Farmaceutska kompozicija prema patentnom zahtjevu 31, koja dalje sadrži jedno ili više drugih pogodnih terapeutskih sredstava izabranih od: anti-dijabetičkih sredstava, anti-hiperglikemijskih sredstava, anti-hiperinsulinemijskih sredstava, anti-retinopatskih sredstava, anti-neuropatskih sredstava, anti-nefropatijski sredstava, anti-aterosklerotičnih sredstava, anti-ishemijskih sredstava, anti-hipertenzivnih sredstava, sredstava protiv debljine, anti-dislipidemijskih sredstava, anti-hiperlipidemijskih sredstava, anti-hipertrigliceridemijskih sredstava, anti-hiperkolesterolemijskih sredstava, anti-restenotičnih sredstava, sredstava za snižavanje lipida, anorektičkih sredstava i supresanata apetita.32. Pharmaceutical composition according to patent claim 31, which further contains one or more other suitable therapeutic agents selected from: anti-diabetic agents, anti-hyperglycemic agents, anti-hyperinsulinemic agents, anti-retinopathic agents, anti-neuropathic agents, anti-nephropathic agents, anti-atherosclerotic agents, anti-ischemic agents, anti-hypertensive agents, anti-obesity agents, anti-dyslipidemic agents, anti-hyperlipidemic agents, anti-hypertriglyceridemic agents, anti-hypercholesterolemic agents, anti-restenotic agents, lipid-lowering agents , anorectic agents and appetite suppressants. 33. Farmaceutska kompozicija prema patentnom zahtjevu 31, koja dalje sadrži jedno ili više drugih pogodnih terapeutskih sredstava izabranih od: inhibitora dipeptidil peptidaze-IV, inhibitora transportera 2 natrij glukoze i inhibitora 11b-HSD-1.33. Pharmaceutical composition according to patent claim 31, which further contains one or more other suitable therapeutic agents selected from: dipeptidyl peptidase-IV inhibitors, sodium glucose transporter 2 inhibitors and 11b-HSD-1 inhibitors. 34. Spoj prema bilo kojem od patentnih zahtjeva 1-30, ili njegov stereoizomer, tautomer, farmaceutski prihvatljiva sol ili solvat, ili kompozicija prema bilo kojem od patentnih zahtjeva 18-20, za uporabu u terapiji, izborno istovremeno, odvojeno ili uzastopno sa jednim ili više dodatnih terapeutskih sredstava.34. A compound according to any of claims 1-30, or its stereoisomer, tautomer, pharmaceutically acceptable salt or solvate, or a composition according to any of claims 18-20, for use in therapy, optionally simultaneously, separately or sequentially with one or more additional therapeutic agents. 35. Spoj prema bilo kojem od patentnih zahtjeva 1 do 30, ili njegov stereoizomer, tautomer, farmaceutski prihvatljiva sol ili solvat, ili kompozicija prema bilo kojem od patentnih zahtjeva 18-20, za uporabu u prevenciji, modulaciji ili liječenju dijabetesa, hiperglikemije, smanjene tolerancije glukoze, gestacionog dijebetsa, insulinske rezistencije, hiperinsulinemije, bolesti nealkoholne masne jetre (NAFLD) uključujući nealkoholni steatohepatitis (NASH), retinopatije, neuropatije, nefropatije, odloženog zarastanja rana, ateroskleroze i njenih sekvela, abnormalne srčane funkcije, ishemije miokarda, moždanog udara, metaboličkog sindroma, povišenog krvnog tlaka, debljine, dislipidemije, dislipidemije, hiperlipidemije, hipertrigliceridemije, hiperholesterolemije, niskog niova lipoproteina visoke gustoće (HDL), visoke razine lipoproteina niske gustoće (LDL), ne-srčane ishemije, poremećaja lipida i glaukoma, izborno za uporabu istovremeno, odvojeno ili uzastopno s jednim ili više dodatnih terapeutskih sredstava.35. A compound according to any of claims 1 to 30, or its stereoisomer, tautomer, pharmaceutically acceptable salt or solvate, or a composition according to any of claims 18-20, for use in the prevention, modulation or treatment of diabetes, hyperglycemia, reduced glucose tolerance, gestational diabetes, insulin resistance, hyperinsulinemia, nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH), retinopathy, neuropathy, nephropathy, delayed wound healing, atherosclerosis and its sequelae, abnormal heart function, myocardial ischemia, stroke, metabolic syndrome, elevated blood pressure, obesity, dyslipidemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low high-density lipoprotein (HDL), high low-density lipoprotein (LDL), non-cardiac ischemia, lipid disorders, and glaucoma, optional for use simultaneously, separately or consecutively with one or more additional te therapeutic agents.
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JP6449919B2 (en) 2014-03-07 2019-01-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors

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