HRP20161011T1 - Aryl dihydropyridinones and piperidinones as mgat2 inhibitors - Google Patents

Aryl dihydropyridinones and piperidinones as mgat2 inhibitors

Info

Publication number
HRP20161011T1
HRP20161011T1 HRP20161011TT HRP20161011T HRP20161011T1 HR P20161011 T1 HRP20161011 T1 HR P20161011T1 HR P20161011T T HRP20161011T T HR P20161011TT HR P20161011 T HRP20161011 T HR P20161011T HR P20161011 T1 HRP20161011 T1 HR P20161011T1
Authority
HR
Croatia
Prior art keywords
piperidinones
mgat2 inhibitors
dihydropyridinones
aryl
aryl dihydropyridinones
Prior art date
Application number
HRP20161011TT
Other languages
Croatian (hr)
Inventor
Huji Turdi
Jon J. Hangeland
Michael R. Lawrence
Dong Cheng
Saleem Ahmad
Wei Meng
Robert Paul Brigance
Pratik Devasthale
Guohua Zhao
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201161566039P priority Critical
Priority to US13/688,584 priority patent/US8791091B2/en
Priority to EP12821212.3A priority patent/EP2785693B1/en
Priority to PCT/US2012/067173 priority patent/WO2013082345A1/en
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HRP20161011T1 publication Critical patent/HRP20161011T1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
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HRP20161011TT 2011-12-02 2016-08-11 Aryl dihydropyridinones and piperidinones as mgat2 inhibitors HRP20161011T1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US201161566039P true 2011-12-02 2011-12-02
US13/688,584 US8791091B2 (en) 2011-12-02 2012-11-29 Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
EP12821212.3A EP2785693B1 (en) 2011-12-02 2012-11-30 Aryl dihydropyridinones and piperidinones as mgat2 inhibitors
PCT/US2012/067173 WO2013082345A1 (en) 2011-12-02 2012-11-30 Aryl dihydropyridinone and piperidinone as mgat2 inhibitors

Publications (1)

Publication Number Publication Date
HRP20161011T1 true HRP20161011T1 (en) 2016-10-07

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HRP20161011TT HRP20161011T1 (en) 2011-12-02 2016-08-11 Aryl dihydropyridinones and piperidinones as mgat2 inhibitors

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US (6) US8791091B2 (en)
EP (2) EP3053912B1 (en)
JP (2) JP5806417B2 (en)
KR (2) KR20160120797A (en)
CN (2) CN104080768B (en)
AR (1) AR090041A1 (en)
AU (1) AU2012345863B2 (en)
BR (1) BR112014013228A2 (en)
CA (1) CA2857689C (en)
CL (1) CL2014001437A1 (en)
CO (1) CO6990718A2 (en)
CY (1) CY1118128T1 (en)
DK (1) DK2785693T3 (en)
EA (1) EA026367B1 (en)
ES (2) ES2699905T3 (en)
HK (1) HK1197231A1 (en)
HR (1) HRP20161011T1 (en)
HU (1) HUE030547T2 (en)
IL (1) IL232727A (en)
IN (1) IN2014CN03803A (en)
MA (1) MA35753B1 (en)
MX (1) MX355988B (en)
NZ (1) NZ626751A (en)
PE (1) PE20141307A1 (en)
PH (1) PH12014501162A1 (en)
PL (1) PL2785693T3 (en)
PT (1) PT2785693T (en)
RS (1) RS54985B1 (en)
SG (2) SG11201402389PA (en)
SI (1) SI2785693T1 (en)
SM (1) SMT201600272B (en)
TN (1) TN2014000238A1 (en)
TW (1) TWI636044B (en)
WO (1) WO2013082345A1 (en)
ZA (1) ZA201404867B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
CA2891569A1 (en) 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
JP6322203B2 (en) 2012-11-16 2018-05-09 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Dihydropyrazole GPR40 modulator
EP2925726B1 (en) 2012-11-16 2016-10-26 Bristol-Myers Squibb Company Dihydropyrazole gpr40 modulators
AU2013344605A1 (en) 2012-11-16 2015-07-02 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
WO2014085528A1 (en) 2012-11-29 2014-06-05 Merck Patent Gmbh Azaquinazoline carboxamide derivatives
EA201592268A1 (en) * 2013-05-29 2016-04-29 Бристол-Майерс Сквибб Компани Dihydropyridinone inhibitors mgat2
RS58740B1 (en) * 2014-03-07 2019-06-28 Squibb Bristol Myers Co Tetrazolone-substituted dihydropyridinone mgat2 inhibitors
EA201691600A1 (en) 2014-03-07 2017-01-30 Бристол-Маерс Сквибб Компани Dihydropyridinous inhibitors mgat2 for use in the treatment of metabolic disorders
WO2015191681A2 (en) 2014-06-11 2015-12-17 Bristol-Myers Squibb Company Substituted pyridinones as mgat2 inhibitors
KR101750392B1 (en) * 2014-12-03 2017-06-26 한국도로공사 Guide rail equipment for bridge inspection and the bridge inspection equipment
WO2017069224A1 (en) * 2015-10-22 2017-04-27 塩野義製薬株式会社 Spiro heterocyclic derivative having mgat2-inhibiting activity
JPWO2017110841A1 (en) * 2015-12-21 2018-10-11 塩野義製薬株式会社 Non-aromatic heterocyclic derivatives having MGAT2 inhibitory activity
WO2018235785A1 (en) * 2017-06-20 2018-12-27 塩野義製薬株式会社 Dihydropyridone derivative having mgat2 inhibitory activity
TW201908313A (en) 2017-07-14 2019-03-01 日商鹽野義製藥股份有限公司 Mgat2 condensed ring derivative having the activity of inhibiting
CN107759498A (en) * 2017-11-08 2018-03-06 南京大学 Antitumoral compounds, preparation method and its usage

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073838A (en) * 1963-01-15 Derivatives of hydkogenateb pyridones
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
AR051202A1 (en) 2004-09-20 2006-12-27 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as inhibitors of stearoyl coa desaturase-
CA2610484A1 (en) * 2005-06-22 2007-01-04 Biocryst Pharmaceuticals, Inc. Methods for the preparation of 9-deazapurine derivatives
WO2008038768A1 (en) * 2006-09-28 2008-04-03 Dainippon Sumitomo Pharma Co., Ltd. Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the compound
US8232447B2 (en) 2007-01-31 2012-07-31 Msd K.K. Animal having modification in MGAT2 gene
JP2012518597A (en) 2009-02-23 2012-08-16 Msd株式会社 Pyrimidin-4 (3H) -one derivative
WO2012124744A1 (en) 2011-03-14 2012-09-20 大正製薬株式会社 Nitrogen-containing condensed heterocyclic compound
US8791091B2 (en) * 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
RS58740B1 (en) 2014-03-07 2019-06-28 Squibb Bristol Myers Co Tetrazolone-substituted dihydropyridinone mgat2 inhibitors
EA201691600A1 (en) 2014-03-07 2017-01-30 Бристол-Маерс Сквибб Компани Dihydropyridinous inhibitors mgat2 for use in the treatment of metabolic disorders

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