Claims (19)
1. Polimerni hidrogel za upotrebu kao lijek, naznačen time da spomenuti polimerni hidrogel sadrži hidrofilni polimer unakrsno povezan sa polikarboksilnom kiselinom odabranom od C4-C12-dikarboksilnih kiselina, trikarboksilnih kiselina i tetrakarboksilnih kiselina.1. A polymeric hydrogel for use as a medicine, characterized in that said polymeric hydrogel contains a hydrophilic polymer cross-linked with a polycarboxylic acid selected from C4-C12-dicarboxylic acids, tricarboxylic acids and tetracarboxylic acids.
2. Polimerni hidrogel za upotrebu u smanjenju unosa kalorija u subjektu kojem je to potrebno, naznačen time da spomenuti polimerni hidrogel sadrži hidrofilni polimer unakrsno povezan sa polikarboksilnom kiselinom odabranom od C4-C12-dikarboksilnih kiselina, trikarboksilnih kiselina i tetrakarboksilnih kiselina.2. A polymer hydrogel for use in reducing calorie intake in a subject in need thereof, characterized in that said polymer hydrogel contains a hydrophilic polymer cross-linked with a polycarboxylic acid selected from C4-C12-dicarboxylic acids, tricarboxylic acids and tetracarboxylic acids.
3. Upotreba polimernog hidrogela u proizvodnji lijeka za smanjenje unosa kalorija u subjektu kojem je to potrebno, naznačena time da spomenuti polimerni hidrogel sadrži hidrofilni polimer unakrsno povezan sa polikarboksilnom kiselinom odabranom od C4-C12-dikarboksilnih kiselina, trikarboksilnih kiselina i tetrakarboksilnih kiselina.3. The use of a polymer hydrogel in the production of a drug to reduce calorie intake in a subject who needs it, characterized in that said polymer hydrogel contains a hydrophilic polymer cross-linked with a polycarboxylic acid selected from C4-C12-dicarboxylic acids, tricarboxylic acids and tetracarboxylic acids.
4. Polimerni hidrogel za upotrebu prema zahtjevu 2 naznačen time da spomenuti polimerni hidrogel je za upotrebu u tretiranju gojaznosti.4. Polymer hydrogel for use according to claim 2, characterized in that said polymer hydrogel is for use in obesity treatment.
5. Upotreba polimernog hidrogela prema zahtjevu 3 naznačena time da spomenuti lijek je za tretiranje gojaznosti.5. Use of polymer hydrogel according to claim 3, characterized in that said drug is for treating obesity.
6. Polimerni hidrogel za upotrebu prema bilo kojem od zahtjeva 1, 2 ili 4, naznačen time da polikarboksilna kiselina je odabrana iz skupine koja se sastoji od malonske kiseline, jabučne kiseline, maleinske kiseline, sukcinske kiseline, glutarne kiseline, adipinske kiseline, pimelinske kiseline, suberinske kiseline, azelainske kiseline, limunske kiseline, ftalne kiseline, o-ftalne kiseline, trikarboksilne kiseline, piromelitne kiseline, 2,3,3',4'-bifeniltetrakarboksilne kiseline, 3,3',4,4'-tetrakarboksidifeniletera, 2,3',3,4'-tetrakarboksidifeniletera, 3,3',4,4'-benzofenoetetrakarboksilne kiseline, 2,3,6,7-tetrakarboksinaftalena, 1,4,5,7-tetrakarboksinaftalena, 1,4,5,6-tetrakarboksinaftalena, 3,3',4,4'-tetrakarboksidifenilmetana, 2,2-bis(3,4-dikarboksifenil)propana, butantetrakarboksilne kiseline i ciklopentanetetrakarboksilne kiseline.6. Polymeric hydrogel for use according to any one of claims 1, 2 or 4, characterized in that the polycarboxylic acid is selected from the group consisting of malonic acid, malic acid, maleic acid, succinic acid, glutaric acid, adipic acid, pimelic acid , suberic acid, azelaic acid, citric acid, phthalic acid, o-phthalic acid, tricarboxylic acid, pyromellitic acid, 2,3,3',4'-biphenyltetracarboxylic acid, 3,3',4,4'-tetracarboxydiphenylether, 2 ,3',3,4'-tetracarboxydiphenylether, 3,3',4,4'-benzophenonetetracarboxylic acid, 2,3,6,7-tetracarboxynaphthalene, 1,4,5,7-tetracarboxynaphthalene, 1,4,5, 6-tetracarboxynaphthalene, 3,3',4,4'-tetracarboxydiphenylmethane, 2,2-bis(3,4-dicarboxyphenyl)propane, butanetetracarboxylic acid and cyclopentanetetracarboxylic acid.
7. Polimerni hidrogel za upotrebu prema bilo kojem od zahtjeva 1, 2, 4 ili 6 naznačen time da hidrofilni polimer je polisaharid, pri čemu je hidrofilni polimer opcionalno odabran od:
a) skupine koja se sastoji od C1-C6-alkilceluloza, hidroksi-C1-C6-alkilceluloza, hidroksi-C1-C6-alkil-C1-C6-alkilceluloza, karboksimetilceluloza, škrobova, supstituiranih dekstrana, glikozaminoglikana i poliuronskih kiselina; ili njihovih soli; ili
b) skupine koja se sastoji od metilceluloze, etilceluloze, n-propilceluloze, hidroksietilceluloze, hidroksi-n-propilceluloze, hidroksi-n-butilceluloze, hidroksipropilmetilceluloze, etilhidroksietilceluloze, karboksimetilceluloze, kukuruznog škroba, hidroksipropil škroba, karboksimetilškroba, dekstran sulfata, dekstran fosfata, dietilaminodekstrana, heparina, hijaluronana, kondroitina, kondroitin sulfata, heparan sulfata, poliglukuronske kiseline, polimanuronske kiseline, poligalakturonske kiseline i poliarabinske kiseline.7. Polymeric hydrogel for use according to any one of claims 1, 2, 4 or 6 characterized in that the hydrophilic polymer is a polysaccharide, wherein the hydrophilic polymer is optionally selected from:
a) a group consisting of C1-C6-alkylcelluloses, hydroxy-C1-C6-alkylcelluloses, hydroxy-C1-C6-alkyl-C1-C6-alkylcelluloses, carboxymethylcelluloses, starches, substituted dextrans, glycosaminoglycans and polyuronic acids; or their salts; or
b) a group consisting of methylcellulose, ethylcellulose, n-propylcellulose, hydroxyethylcellulose, hydroxy-n-propylcellulose, hydroxy-n-butylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, carboxymethylcellulose, corn starch, hydroxypropyl starch, carboxymethyl starch, dextran sulfate, dextran phosphate, diethylaminodextran , heparin, hyaluronan, chondroitin, chondroitin sulfate, heparan sulfate, polyglucuronic acid, polymannuronic acid, polygalacturonic acid and polyarabic acid.
8. Polimerni hidrogel za upotrebu prema bilo kojem od zahtjeva 1, 2, 4, 6 ili 7 naznačen time da hidrofilni polimer je ionski polimer, pri čemu je ionski polimer opcionalno odabran iz skupine koja se sastoji od alginata, dekstran sulfata, karboksimetilceluloze, karboksimetilškroba, hijaluronske kiseline, poliglukuronske kiseline, polimanuronske kiseline, poligalakturonske kiseline, poliarabinske kiseline, krondroitin sulfata, dekstran fosfata, kitosana i dimetilaminodekstrana, ili njihovih soli.8. Polymeric hydrogel for use according to any one of claims 1, 2, 4, 6 or 7, characterized in that the hydrophilic polymer is an ionic polymer, wherein the ionic polymer is optionally selected from the group consisting of alginate, dextran sulfate, carboxymethylcellulose, carboxymethylstarch , hyaluronic acid, polyglucuronic acid, polymannuronic acid, polygalacturonic acid, polyarabic acid, chrondroitin sulfate, dextran phosphate, chitosan and dimethylaminodextran, or their salts.
9. Polimerni hidrogel za upotrebu prema bilo kojem od zahtjeva 1, 2, 4, 6, 7 ili 8 naznačen time da polikarboksilna kiselina je limunska kiselina.9. Polymeric hydrogel for use according to any one of claims 1, 2, 4, 6, 7 or 8, characterized in that the polycarboxylic acid is citric acid.
10. Polimerni hidrogel za upotrebu prema zahtjevu 9, naznačen time da hidrofilni polimer je karboksimetilceluloza ili njena sol, pri čemu omjer masa limunske kiseline prema karboksimetilcelulozi je opcionalno 1% do 5%.10. Polymeric hydrogel for use according to claim 9, characterized in that the hydrophilic polymer is carboxymethylcellulose or its salt, wherein the mass ratio of citric acid to carboxymethylcellulose is optionally 1% to 5%.
11. Polimerni hidrogel za upotrebu prema bilo kojem od zahtjeva 8 do 10 naznačen time da polimerni hidrogel nadalje sadrži neionski polimer, pri čemu neionski polimer je opcionalno odabran od:
a) skupine koja se sastoji od polialilalkohola, polivinilalkohola, škrobova, alkilceluloza, hidroksi-C1-C6-alkilceluloza, hidroksi-C1-C6-alkil-C1-C6-alkilceluloza i supstituiranih alkilceluloza; ili
b) skupine koja se sastoji od kukuruznog škroba, hidroksipropilškroba, C1-C6-alkilceluloza, hidroksietilceluloza, hidroksi-n-propilceluloza, hidroksi-n-butilceluloza, hidroksipropilmetilceluloza i etilhidroksietilceluloza, pri čemu, opcionalno, ionski polimer je karboksimetilceluloza, ili njena sol, polikarboksilna kiselina je limunska kiselina te neionski polimer je hidroksietilceluloza.11. Polymeric hydrogel for use according to any one of claims 8 to 10, characterized in that the polymer hydrogel further contains a nonionic polymer, wherein the nonionic polymer is optionally selected from:
a) group consisting of polyallyl alcohol, polyvinyl alcohol, starches, alkylcelluloses, hydroxy-C1-C6-alkylcelluloses, hydroxy-C1-C6-alkyl-C1-C6-alkylcelluloses and substituted alkylcelluloses; or
b) a group consisting of corn starch, hydroxypropyl starch, C1-C6-alkylcellulose, hydroxyethylcellulose, hydroxy-n-propylcellulose, hydroxy-n-butylcellulose, hydroxypropylmethylcellulose and ethylhydroxyethylcellulose, wherein, optionally, the ionic polymer is carboxymethylcellulose, or its salt, polycarboxylic acid is citric acid and nonionic polymer is hydroxyethyl cellulose.
12. Polimerni hidrogel za upotrebu prema zahtjevu 1 ili 2, naznačen time da polimerni hidrogel je karboksimetilceluloza, ili njena sol, unakrsno povezana sa limunskom kiselinom.12. Polymer hydrogel for use according to claim 1 or 2, characterized in that the polymer hydrogel is carboxymethylcellulose, or its salt, cross-linked with citric acid.
13. Upotreba polimernog hidrogela prema zahtjevu 3 ili zahtjevu 5, naznačena time da polikarboksilna kiselina je odabrana iz skupine koja se sastoji od malonske kiseline, jabučne kiseline, maleinske kiseline, sukcinske kiseline, glutarne kiseline, adipinske kiseline, pimelinske kiseline, suberinske kiseline, azelainske kiseline, sebacinske kiseline, ftalne kiseline, o-ftalne kiseline, izoftalne kiseline, m-ftalne kiseline, tereftalne kiseline, limunske kiseline, izolimunske kiseline, aconitinske kiseline, propan-1,2,3-trikarboksilne kiseline, piromelitne kiseline, 2,3,3',4'-bifeniltetrakarboksilne kiseline, 3,3',4,4'-tetrakarboksidifeniletera, 2,3',3,4'-tetrakarboksidifeniletera, 3,3',4,4'-benzofenoetetrakarboksilne kiseline, 2,3,6,7-tetrakarboksinaftalena, 1,4,5,7-tetrakarboksinaftalena, 1,4,5,6-tetrakarboksinaftalena, 3,3',4,4'-tetrakarboksidifenilmetana, 2,2-bis(3,4-dikarboksifenil)propana, butantetrakarboksilne kiseline i ciklopentanetetrakarboksilne kiseline.13. Use of a polymer hydrogel according to claim 3 or claim 5, characterized in that the polycarboxylic acid is selected from the group consisting of malonic acid, malic acid, maleic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid acids, sebacic acids, phthalic acids, o-phthalic acids, isophthalic acids, m-phthalic acids, terephthalic acids, citric acids, isolimonic acids, aconitic acids, propane-1,2,3-tricarboxylic acids, pyromellitic acids, 2,3 ,3',4'-biphenyltetracarboxylic acid, 3,3',4,4'-tetracarboxydiphenylether, 2,3',3,4'-tetracarboxydiphenylether, 3,3',4,4'-benzophenonetetracarboxylic acid, 2,3 ,6,7-tetracarboxynaphthalene, 1,4,5,7-tetracarboxynaphthalene, 1,4,5,6-tetracarboxynaphthalene, 3,3',4,4'-tetracarboxydiphenylmethane, 2,2-bis(3,4-dicarboxyphenyl )propane, butanetetracarboxylic acid and cyclopentanetetracarboxylic acid.
14. Upotreba polimernog hidrogela prema bilo kojem od zahtjeva 3, 5 ili 13 naznačena time da hidrofilni polimer je polisaharid, pri čemu hidrofilni polimer je opcionalno odabran od:
a) skupine koja se sastoji od C1-C6-alkilceluloza, hidroksi-C1-C6-alkilceluloza, hidroksi-C1-C6-alkil-C1-C6-alkilceluloza, karboksimetilceluloza, škrobova, supstituiranih dekstrana, glikozaminoglikana i poliuronskih kiselina; ili njihovih soli; ili
b) skupine koja se sastoji od metilceluloze, etilceluloze, n-propilceluloze, hidroksietilceluloze, hidroksi-n-propilceluloze, hidroksi-n-butilceluloze, hidroksipropilmetilceluloze, etilhidroksietilceluloze, karboksimetilceluloze, kukuruznog škroba, hidroksipropil škroba, karboksimetilškroba, dekstran sulfata, dekstran fosfata, dietilaminodekstrana, heparina, hijaluronana, kondroitina, kondroitin sulfata, heparan sulfata, poliglukuronske kiseline, polimanuronske kiseline, poligalakturonske kiseline i poliarabinske kiseline.14. The use of a polymer hydrogel according to any one of claims 3, 5 or 13, characterized in that the hydrophilic polymer is a polysaccharide, wherein the hydrophilic polymer is optionally selected from:
a) a group consisting of C1-C6-alkylcelluloses, hydroxy-C1-C6-alkylcelluloses, hydroxy-C1-C6-alkyl-C1-C6-alkylcelluloses, carboxymethylcelluloses, starches, substituted dextrans, glycosaminoglycans and polyuronic acids; or their salts; or
b) a group consisting of methylcellulose, ethylcellulose, n-propylcellulose, hydroxyethylcellulose, hydroxy-n-propylcellulose, hydroxy-n-butylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, carboxymethylcellulose, corn starch, hydroxypropyl starch, carboxymethyl starch, dextran sulfate, dextran phosphate, diethylaminodextran , heparin, hyaluronan, chondroitin, chondroitin sulfate, heparan sulfate, polyglucuronic acid, polymannuronic acid, polygalacturonic acid and polyarabic acid.
15. Upotreba polimernog hidrogela prema bilo kojem od zahtjeva 3, 5, 13 ili 14 naznačena time da hidrofilni polimer je ionski polimer, pri čemu ionski polimer je opcionalno odabran iz skupine koja se sastoji od alginata, dekstran sulfata, karboksimetilceluloze, karboksimetilškroba, hijaluronske kiseline, poliglukuronske kiseline, polimanuronske kiseline, poligalakturonske kiseline, poliarabinske kiseline, krondroitin sulfata, dekstran fosfata, kitosana i dimetilaminodekstrana, ili njihovih soli.15. The use of a polymer hydrogel according to any one of claims 3, 5, 13 or 14, characterized in that the hydrophilic polymer is an ionic polymer, wherein the ionic polymer is optionally selected from the group consisting of alginate, dextran sulfate, carboxymethylcellulose, carboxymethylstarch, hyaluronic acid , polyglucuronic acid, polymannuronic acid, polygalacturonic acid, polyarabic acid, chrondroitin sulfate, dextran phosphate, chitosan and dimethylaminodextran, or their salts.
16. Upotreba polimernog hidrogela prema bilo kojem od zahtjeva 3, 5, 13, 14 ili 15 naznačena time da polikarboksilna kiselina je limunska kiselina.16. Use of a polymer hydrogel according to any one of claims 3, 5, 13, 14 or 15, characterized in that the polycarboxylic acid is citric acid.
17. Upotreba polimernog hidrogela prema zahtjevu 16, naznačena time da hidrofilni polimer je karboksimetilceluloza ili njena sol, pri čemu omjer masa limunske kiseline u odnosu na karboksimetilcelulozu je opcionalno 1% do 5%.17. Use of a polymer hydrogel according to claim 16, characterized in that the hydrophilic polymer is carboxymethylcellulose or its salt, wherein the mass ratio of citric acid to carboxymethylcellulose is optionally 1% to 5%.
18. Upotreba polimernog hidrogela prema bilo kojem od zahtjeva 15 do 17 naznačena time da polimerni hidrogel nadalje sadrži neionski polimer, pri čemu neionski polimer je opcionalno odabran od:
a) skupine koja se sastoji od polialilalkohola, polivinilalkohola, škrobova, alkilceluloza, hidroksi-C1-C6-alkilceluloza, hidroksi-C1-C6-alkil-C1-C6-alkilceluloza i supstituiranih alkilceluloza; ili
b) skupine koja se sastoji od kukuruznog škroba, hidroksipropilškroba, C1-C6-alkilceluloza, hidroksietilceluloza, hidroksi-n-propilceluloza, hidroksi-n-butilceluloza, hidroksipropilmetilceluloza i etilhidroksietilceluloza, pri čemu, opcionalno, ionski polimer je karboksimetilceluloza, ili njena sol, polikarboksilna kiselina je limunska kiselina te neionski polimer je hidroksietilceluloza.18. The use of a polymer hydrogel according to any one of claims 15 to 17, characterized in that the polymer hydrogel further contains a nonionic polymer, wherein the nonionic polymer is optionally selected from:
a) group consisting of polyallyl alcohol, polyvinyl alcohol, starches, alkylcelluloses, hydroxy-C1-C6-alkylcelluloses, hydroxy-C1-C6-alkyl-C1-C6-alkylcelluloses and substituted alkylcelluloses; or
b) a group consisting of corn starch, hydroxypropyl starch, C1-C6-alkylcellulose, hydroxyethylcellulose, hydroxy-n-propylcellulose, hydroxy-n-butylcellulose, hydroxypropylmethylcellulose and ethylhydroxyethylcellulose, wherein, optionally, the ionic polymer is carboxymethylcellulose, or its salt, polycarboxylic acid is citric acid and nonionic polymer is hydroxyethyl cellulose.
19. Upotreba polimernog hidrogela prema zahtjevu 3, naznačena time da polimerni hidrogel je karboksimetilceluloza, ili njena sol, unakrsno povezana sa limunskom kiselinom.19. Use of a polymer hydrogel according to claim 3, characterized in that the polymer hydrogel is carboxymethylcellulose, or its salt, cross-linked with citric acid.