HRP20070053A2 - Method for the separation of intermediates which may be used for the preparation of escitalopram - Google Patents
Method for the separation of intermediates which may be used for the preparation of escitalopramInfo
- Publication number
- HRP20070053A2 HRP20070053A2 HR20070053A HRP20070053A HRP20070053A2 HR P20070053 A2 HRP20070053 A2 HR P20070053A2 HR 20070053 A HR20070053 A HR 20070053A HR P20070053 A HRP20070053 A HR P20070053A HR P20070053 A2 HRP20070053 A2 HR P20070053A2
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- intermediates
- escitalopram
- separation
- formula
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title 1
- 229960004341 escitalopram Drugs 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 150000002009 diols Chemical class 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Predstavljeni izum se odnosi na novu metodu pripremanja diol posrednika s formulom (II) i/ili suprotnim enantiomerom aciliranog diola s formulom (IV), korisno za pripravak escitaloprema koji uključuje selektivnu enzimatsku acilaciju ili deacilacijuThe present invention relates to a novel method of preparing diol intermediates of formula (II) and / or the opposite enantiomer of acylated diol of formula (IV), useful for the preparation of escitaloprem comprising selective enzymatic acylation or deacylation
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20070053A HRPK20070053B3 (en) | 2007-02-14 | 2007-02-14 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20070053A HRPK20070053B3 (en) | 2007-02-14 | 2007-02-14 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20070053A2 true HRP20070053A2 (en) | 2008-09-30 |
HRPK20070053B3 HRPK20070053B3 (en) | 2009-11-30 |
Family
ID=39776245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20070053A HRPK20070053B3 (en) | 2007-02-14 | 2007-02-14 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Country Status (1)
Country | Link |
---|---|
HR (1) | HRPK20070053B3 (en) |
-
2007
- 2007-02-14 HR HR20070053A patent/HRPK20070053B3/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HRPK20070053B3 (en) | 2009-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
AKOB | Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent) | ||
PKB1 | Consensual patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20140103 Year of fee payment: 8 |
|
PBKO | Lapse due to non-payment of renewal fee for consensual patent |
Effective date: 20150214 |