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Publication of HN2009000012ApublicationCriticalpatent/HN2009000012A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Medicinal Preparation
(AREA)
Abstract
ESTA INVENCION SE REFIERE A COMPOSICIONES FARMACEUTICAS SOLIDAS,EN PARTICULAR ANTICOPCEPTIVOS ORALES, QUE COMPRENDEN UN PROGESTAGENO, TAL COMO DROSPIRENONA; UN ESTROGENO, TAL COMO ETILNILESTRADIOL; UN ACIDO TETRAHIDROFOLICO O UNA DE SUS SALES ADECUADAS PARA USO FARMACEUTICO, TAL COMO 5-METIL-(6S)-TETRAHIDROFOLATO DE CALCIO; Y POR O MENOS UN EXCIPIENTE O VEHICULO ADECUADO PARA USO FARMACEUTICO. LAS COMPOSICIONES DE LA INVENCION PROPORCIONAN BUENA ESTABILIDAD DEL ACIDO TETRAHIDROFOLICO DURANTE EL ALMACENAMIENTO ASEGURANDO NO OBSTANTE UNA LIBERACION RAPIDA Y CONFIABLE DEL ESTROGENO Y DEL PROGESTAGENO PRESENTES EN LA COMPOSICION.THIS INVENTION REFERS TO SOLID PHARMACEUTICAL COMPOSITIONS, IN PARTICULAR ORAL ANTICOPCEPTIVES, THAT UNDERSTAND A PROGESTAGEN, AS DROSPIRENONE; A STROGEN, SUCH AS ETHYLESTRADIOL; A TETRAHYDROPHOLIC ACID OR ONE OF ITS SUITS SUITABLE FOR PHARMACEUTICAL USE, SUCH AS 5-METHYL- (6S) -THE CALCIUM TETRAHYDROPHOLATE; AND FOR OR LESS A SUITABLE EXCIPIENT OR VEHICLE FOR PHARMACEUTICAL USE. THE COMPOSITIONS OF THE INVENTION PROVIDE GOOD STABILITY OF THE TETRAHYDROPHOLIC ACID DURING STORAGE, INSURING NON-OBTAINING A QUICK AND RELIABLE RELEASE OF THE STROGEN AND OF THE PROGESTAGEN PRESENT IN THE COMPOSITION.
HN2009000012A2006-07-062009-01-06
PHARMACEUTICAL COMPOSITION CONTAINING A TETRAHYDROPHOLIC ACID
HN2009000012A
(en)
Compounds derived from 4-benzylamino-1-carboxyacyl-pyridine, cetp inhibitors; pharmaceutical composition comprising them; pharmaceutical combination; and use in the treatment of metabolic, atherosclerosis and cardiovascular diseases, among others.
COMPOUNDS DERIVED FROM PIRROLOPIRIMIDINA, INHIBITORS OF CIANASA JAK3; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF REPLACEMENT OF TRANSPLANTS, AUTOIMMUN DISEASES
Compounds derived from carboxycyclopropyl- (bis-phenyl-oxamides); pharmaceutical composition containing them; process for the preparation of the compositions and the use of the compounds in the treatment of diabetes and cancer disorders among other diseases.