HK99096A - The use of vanilloids for the manufacture of a medicament for treating herpes simplex infections - Google Patents
The use of vanilloids for the manufacture of a medicament for treating herpes simplex infectionsInfo
- Publication number
- HK99096A HK99096A HK99096A HK99096A HK99096A HK 99096 A HK99096 A HK 99096A HK 99096 A HK99096 A HK 99096A HK 99096 A HK99096 A HK 99096A HK 99096 A HK99096 A HK 99096A
- Authority
- HK
- Hong Kong
- Prior art keywords
- moiety
- alkyl
- substituted
- carbon atoms
- unsubstituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
The present invention provides methods of treating or preventing herpes simplex infections in humans and lower animals by treatment with natural and synthetic vanilloid compounds, and the pharmaceutically-acceptable salts and amides thereof, having the general structure: <CHEM> n = 0 or 1; the -W-X- moiety is selected from -C(O)NH-, -C(S)NH-, -S(0)2NH-, -NHC(O)O-, -NHC(S)O-, -NHC(O)NH-, -NHC(S)NH-, -C(O)O-, -C(O)S- and -C(O)N(R)-, wherein either available bond of the -W-X-moiety may be bonded to the -R moiety, with the other bond being attached to the benzyl carbon atom, or directly attached to the benzene ring; the -R<1> moiety is selected from hydrogen, hydroxy, alkyl esters of hydroxy having from about 1 to about 5 carbon atoms, alkyl having from about 1 to about 5 carbon atoms, and alkoxy having from about 1 to about 5 carbon atoms; the -Z moiety is selected from hydrogen, hydroxy and methoxy; the -Y- moiety is selected from -O-, -S-, -NH-, -OC(O)-, -OSO3=- and -OPO3=-; the -V moiety is selected from hydrogen, short chain alkyl, and -CR<2>2-CR<2>2-NH2; the -R<2> moieties are each independently selected from hydrogen, halogen, unsubstituted or substituted alkyl having from about 1 to about 6 carbon atoms, substituted or unsubstituted aryl, and carboxylate, or two -R<2> moieties are covalently bonded to form a substituted or unsubstituted alkyl or heteroalkyl ring having from about 3 to about 8 atoms in the ring including from 0 to about 3 heteroatoms; and the -R moiety is a C2-C24 alkyl moiety which may be straight, branched or cyclic chain and may be saturated, monounsaturated, or polyunsaturated, substituted or unsubstituted, or two -R moieties are covalently bonded to form a substituted or unsubstituted alkyl ring having from about 2 to about 14 carbon atoms in the ring.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20832188A | 1988-06-17 | 1988-06-17 | |
US35875189A | 1989-06-02 | 1989-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK99096A true HK99096A (en) | 1996-06-14 |
Family
ID=26903095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK99096A HK99096A (en) | 1988-06-17 | 1996-06-06 | The use of vanilloids for the manufacture of a medicament for treating herpes simplex infections |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0347000B1 (en) |
JP (1) | JP2874896B2 (en) |
KR (1) | KR0159086B1 (en) |
AT (1) | ATE113205T1 (en) |
CA (1) | CA1337117C (en) |
DE (1) | DE68918991T2 (en) |
HK (1) | HK99096A (en) |
IE (1) | IE63871B1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5461075A (en) * | 1988-06-17 | 1995-10-24 | The Procter & Gamble Company | Use of vanilloids for the prevention of lesions due to herpes simplex infections |
US5403868A (en) * | 1988-12-23 | 1995-04-04 | Sandoz Ltd. | Capsaicin derivatives |
AU9073691A (en) * | 1990-11-27 | 1992-06-25 | Procter & Gamble Company, The | Combinations of vanilloid compounds and nucleoside antiviral compounds for treatment of herpes infections |
AU9079491A (en) * | 1990-11-27 | 1992-06-25 | Procter & Gamble Company, The | Combinations of vanilloid compounds and phosphonate antiviral compounds for treatment of herpes infections |
GB9713484D0 (en) * | 1997-06-27 | 1997-09-03 | Smithkline Beecham Plc | Neuroprotective vanilloid compounds |
PE20030417A1 (en) | 2001-09-13 | 2003-08-06 | Smithkline Beecham Plc | DERIVATIVES OF UREA AS ANTAGONISTS OF THE VAINILLOID RECEPTOR |
EP2033953A1 (en) | 2002-02-15 | 2009-03-11 | Glaxo Group Limited | Vanilloid receptor modulators |
JP4931128B2 (en) | 2003-04-10 | 2012-05-16 | ニューロジェシックス, インコーポレイテッド | Methods and compositions for administration of TRPV1 agonists |
GB0319150D0 (en) | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
WO2012045729A1 (en) | 2010-10-05 | 2012-04-12 | Glaxo Group Limited | Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists |
WO2012072512A1 (en) | 2010-11-29 | 2012-06-07 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists |
JP2014510768A (en) | 2011-04-11 | 2014-05-01 | グラクソ グループ リミテッド | N-cyclobutylimidazopyridine methylamine as a TRPV1 antagonist |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4313958A (en) * | 1980-10-24 | 1982-02-02 | The Procter & Gamble Company | Method of producing analgesia |
US4536404A (en) * | 1983-06-16 | 1985-08-20 | Dermatological Enterprises, Ltd. | Method and composition for treating post-herpetic neuralgia |
US4599342A (en) * | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
GB2178031B (en) * | 1985-06-10 | 1989-07-26 | Procter & Gamble | Phenylacetic acid amides having anti-inflammatory and analgesic activity |
ES2061624T3 (en) * | 1987-03-09 | 1994-12-16 | Procter & Gamble | FENILIC COMPOUNDS REPLACED WITH AMINO-ETHYL IN BETA POSITION, AND ANTI-INFLAMMATORY OR ANALGESIC COMPOSITIONS THAT CONTAIN THEM. |
-
1989
- 1989-06-13 DE DE68918991T patent/DE68918991T2/en not_active Expired - Fee Related
- 1989-06-13 EP EP89201543A patent/EP0347000B1/en not_active Expired - Lifetime
- 1989-06-13 AT AT89201543T patent/ATE113205T1/en not_active IP Right Cessation
- 1989-06-15 CA CA000602878A patent/CA1337117C/en not_active Expired - Fee Related
- 1989-06-16 IE IE196589A patent/IE63871B1/en unknown
- 1989-06-17 JP JP1155566A patent/JP2874896B2/en not_active Expired - Lifetime
- 1989-06-17 KR KR1019890008365A patent/KR0159086B1/en not_active IP Right Cessation
-
1996
- 1996-06-06 HK HK99096A patent/HK99096A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH02104520A (en) | 1990-04-17 |
EP0347000B1 (en) | 1994-10-26 |
KR0159086B1 (en) | 1998-12-01 |
EP0347000A2 (en) | 1989-12-20 |
CA1337117C (en) | 1995-09-26 |
IE891965L (en) | 1989-12-17 |
ATE113205T1 (en) | 1994-11-15 |
JP2874896B2 (en) | 1999-03-24 |
DE68918991T2 (en) | 1995-04-27 |
KR910000137A (en) | 1991-01-29 |
EP0347000A3 (en) | 1992-02-26 |
DE68918991D1 (en) | 1994-12-01 |
IE63871B1 (en) | 1995-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |