HK1248123A1 - 用於治療膿毒症的半通道胞外域特異性藥劑 - Google Patents

用於治療膿毒症的半通道胞外域特異性藥劑

Info

Publication number
HK1248123A1
HK1248123A1 HK18107698.0A HK18107698A HK1248123A1 HK 1248123 A1 HK1248123 A1 HK 1248123A1 HK 18107698 A HK18107698 A HK 18107698A HK 1248123 A1 HK1248123 A1 HK 1248123A1
Authority
HK
Hong Kong
Prior art keywords
domain specific
specific agents
treating sepsis
hemichannel
extracellular
Prior art date
Application number
HK18107698.0A
Other languages
English (en)
Inventor
王海潮
李威
凱文‧J‧翠西
王平
Original Assignee
范斯坦醫藥研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 范斯坦醫藥研究院 filed Critical 范斯坦醫藥研究院
Publication of HK1248123A1 publication Critical patent/HK1248123A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
HK18107698.0A 2015-08-06 2018-06-14 用於治療膿毒症的半通道胞外域特異性藥劑 HK1248123A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562201759P 2015-08-06 2015-08-06
PCT/US2016/045284 WO2017023997A1 (en) 2015-08-06 2016-08-03 Hemichannel extracellular-domain specific agents for treating sepsis

Publications (1)

Publication Number Publication Date
HK1248123A1 true HK1248123A1 (zh) 2018-10-12

Family

ID=57943626

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107698.0A HK1248123A1 (zh) 2015-08-06 2018-06-14 用於治療膿毒症的半通道胞外域特異性藥劑

Country Status (8)

Country Link
US (2) US10548949B2 (zh)
EP (1) EP3331545B1 (zh)
JP (1) JP6845219B2 (zh)
CN (1) CN108025036A (zh)
AU (1) AU2016302235A1 (zh)
CA (1) CA2994943C (zh)
HK (1) HK1248123A1 (zh)
WO (1) WO2017023997A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10314883B2 (en) 2015-02-13 2019-06-11 University Of Virginia Patent Foundation Compositions and methods for regulating blood pressure
WO2017019952A1 (en) * 2015-07-29 2017-02-02 University Of Virginia Patent Foundation Compositions and methods for regulating leukocyte adhesion
CN107469071B (zh) * 2017-09-29 2021-01-26 河南大学 Connexin模拟肽在制备预防或治疗急性肺损伤药物中的应用
CN109938870A (zh) * 2019-03-20 2019-06-28 复旦大学附属华山医院 一种大鼠重症脑出血合并脓毒症复合模型的建立方法及其应用
WO2023034110A1 (en) * 2021-08-31 2023-03-09 The Feinstein Institutes For Medical Research Choline acetyltransferase as a therapy for endotoxemia, sepsis, colitis and inflammatory diseases
WO2023143513A1 (zh) * 2022-01-26 2023-08-03 羽晓瑜 一种多肽化合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003238441A (ja) 2002-02-08 2003-08-27 英行 ▲高▼野 血管新生抑制剤
EP2662088A3 (en) * 2005-02-03 2014-02-19 Coda Therapeutics Limited Anti-connexin compounds and uses thereof
JP2015515282A (ja) * 2012-04-25 2015-05-28 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント 創傷治癒および組織修復のための組成物および方法
US9657109B2 (en) 2012-11-02 2017-05-23 Wisconsin Alumni Research Foundation Compositions and methods for the treatment of systemic inflammatory response syndromes

Also Published As

Publication number Publication date
JP6845219B2 (ja) 2021-03-17
US10548949B2 (en) 2020-02-04
CA2994943A1 (en) 2017-02-09
US20190008921A1 (en) 2019-01-10
CA2994943C (en) 2021-10-12
EP3331545A4 (en) 2019-03-06
AU2016302235A1 (en) 2018-03-08
JP2018522056A (ja) 2018-08-09
CN108025036A (zh) 2018-05-11
US20200206310A1 (en) 2020-07-02
US11083777B2 (en) 2021-08-10
WO2017023997A1 (en) 2017-02-09
EP3331545B1 (en) 2021-03-10
EP3331545A1 (en) 2018-06-13

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