HK1248070A1 - Heterocyclic compounds as kinase inhbitors - Google Patents

Heterocyclic compounds as kinase inhbitors

Info

Publication number
HK1248070A1
HK1248070A1 HK18107657.9A HK18107657A HK1248070A1 HK 1248070 A1 HK1248070 A1 HK 1248070A1 HK 18107657 A HK18107657 A HK 18107657A HK 1248070 A1 HK1248070 A1 HK 1248070A1
Authority
HK
Hong Kong
Prior art keywords
heterocyclic compounds
kinase inhbitors
inhbitors
kinase
heterocyclic
Prior art date
Application number
HK18107657.9A
Other languages
Chinese (zh)
Inventor
T‧王
S‧蓋特利
Original Assignee
轉化藥物開發有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 轉化藥物開發有限責任公司 filed Critical 轉化藥物開發有限責任公司
Publication of HK1248070A1 publication Critical patent/HK1248070A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK18107657.9A 2015-05-18 2018-06-13 Heterocyclic compounds as kinase inhbitors HK1248070A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163369P 2015-05-18 2015-05-18
US201562203070P 2015-08-10 2015-08-10
PCT/US2016/033111 WO2016187324A1 (en) 2015-05-18 2016-05-18 Heterocyclic compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1248070A1 true HK1248070A1 (en) 2018-10-12

Family

ID=57320732

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107657.9A HK1248070A1 (en) 2015-05-18 2018-06-13 Heterocyclic compounds as kinase inhbitors

Country Status (9)

Country Link
US (3) US10392402B2 (en)
EP (1) EP3297437A4 (en)
JP (1) JP2018515623A (en)
CN (1) CN107835637A (en)
AU (1) AU2016264220A1 (en)
CA (1) CA3024113A1 (en)
HK (1) HK1248070A1 (en)
IL (1) IL255750A (en)
WO (1) WO2016187324A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210069016A1 (en) * 2008-11-13 2021-03-11 Gholam A. Peyman Neurodegenerative Disorder Treatment Method
EP3105210B1 (en) 2014-02-11 2019-01-30 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as midh1 inhibitors
PE20170143A1 (en) 2014-02-11 2017-03-19 Bayer Pharma AG BENZIMIDAZOLE-2-AMINES AS MIDH1 INHIBITORS
AU2016264220A1 (en) * 2015-05-18 2018-01-04 Translational Drug Development Llc Heterocyclic compounds as kinase inhibitors
AU2020273376C1 (en) * 2016-10-24 2024-02-29 Translational Drug Development, Llc Amide compounds as kinase inhibitors, compositions and methods of treatment
JP2020502066A (en) * 2016-11-21 2020-01-23 トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー Heterocyclic compounds as kinase inhibitors
WO2020142745A1 (en) * 2019-01-04 2020-07-09 Translational Drug Development, Llc Methods of treating graft versus host disease and neoplastic disease with amide compounds
WO2019210008A1 (en) * 2018-04-24 2019-10-31 Translational Drug Development, Llc Amide compounds as kinase inhibitors, compositions and methods of treatment
CN114728926A (en) * 2019-11-15 2022-07-08 武汉朗来科技发展有限公司 ROCK inhibitor and preparation method and application thereof
CN113121443B (en) 2019-12-31 2024-07-09 财团法人工业技术研究院 Beta-amino acid derivatives, kinase inhibitors and pharmaceutical compositions containing them and their use
WO2021142006A1 (en) * 2020-01-07 2021-07-15 Disarm Therapeutics, Inc. Inhibitors of sarm1
EP4192828A1 (en) 2020-08-04 2023-06-14 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors
EP4214197A1 (en) 2020-09-16 2023-07-26 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors
US11629136B1 (en) 2021-07-28 2023-04-18 Nura Bio, Inc. Substituted pyridine derivatives as SARM1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026920A2 (en) * 2005-09-02 2007-03-08 Astellas Pharma Inc. Amide derivatives as rock inhibitors
WO2009079011A1 (en) 2007-12-19 2009-06-25 The Scripps Research Institute Benzimidazoles and analogs as rho kinase inhibitors
WO2009126635A1 (en) 2008-04-09 2009-10-15 Abbott Laboratories 2-amino-benzothiazole derivates useful as inhibitors of rock kinases
US20130129677A1 (en) * 2009-02-27 2013-05-23 Siga Technologies, Inc. Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections
AR078793A1 (en) * 2009-10-27 2011-12-07 Orion Corp DERIVATIVES OF NON-STEROID CARBOXAMIDS AND ACIL HYDRAZONE MODULATORS OF ANDROGENIC RECEPTORS OF SELECTIVE FABRIC (SARM), PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF PROSTATE CANCER BETWEEN OTHERS
WO2011130740A2 (en) * 2010-04-16 2011-10-20 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pyridylthiazole-based ureas as inhibitors of rho associated protein kinase (rock) and methods of use
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
JP5976778B2 (en) * 2011-04-11 2016-08-24 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Pyrazolyl-pyrimidine derivatives as kinase inhibitors
AU2016264220A1 (en) * 2015-05-18 2018-01-04 Translational Drug Development Llc Heterocyclic compounds as kinase inhibitors

Also Published As

Publication number Publication date
US20180141959A1 (en) 2018-05-24
EP3297437A4 (en) 2019-02-27
US10392402B2 (en) 2019-08-27
US10633393B2 (en) 2020-04-28
US20200255448A1 (en) 2020-08-13
US20200017520A1 (en) 2020-01-16
CA3024113A1 (en) 2016-11-24
CN107835637A (en) 2018-03-23
EP3297437A1 (en) 2018-03-28
JP2018515623A (en) 2018-06-14
WO2016187324A1 (en) 2016-11-24
IL255750A (en) 2018-01-31
AU2016264220A1 (en) 2018-01-04

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