HK1245250A1 - 靶向notch通路抑制劑 - Google Patents
靶向notch通路抑制劑Info
- Publication number
- HK1245250A1 HK1245250A1 HK18104430.0A HK18104430A HK1245250A1 HK 1245250 A1 HK1245250 A1 HK 1245250A1 HK 18104430 A HK18104430 A HK 18104430A HK 1245250 A1 HK1245250 A1 HK 1245250A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pathway inhibitors
- notch pathway
- targeted
- targeted notch
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15171592 | 2015-06-11 | ||
PCT/EP2016/062826 WO2016198366A1 (en) | 2015-06-11 | 2016-06-07 | Targeted notch pathway inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1245250A1 true HK1245250A1 (zh) | 2018-08-24 |
Family
ID=53397882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18104430.0A HK1245250A1 (zh) | 2015-06-11 | 2018-04-03 | 靶向notch通路抑制劑 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10632127B2 (zh) |
EP (1) | EP3307721B1 (zh) |
JP (1) | JP6877365B2 (zh) |
CN (1) | CN107438599B (zh) |
HK (1) | HK1245250A1 (zh) |
WO (1) | WO2016198366A1 (zh) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
US8377886B2 (en) * | 2007-09-14 | 2013-02-19 | Albert Einstein College Of Medicine Of Yeshiva University | Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease |
EP2914579A1 (en) * | 2012-11-01 | 2015-09-09 | The Johns Hopkins University | Controlled hno release through intramolecular cyclization-elimination |
-
2016
- 2016-06-07 CN CN201680021314.7A patent/CN107438599B/zh not_active Expired - Fee Related
- 2016-06-07 EP EP16728915.6A patent/EP3307721B1/en active Active
- 2016-06-07 JP JP2017564078A patent/JP6877365B2/ja active Active
- 2016-06-07 WO PCT/EP2016/062826 patent/WO2016198366A1/en unknown
-
2017
- 2017-12-11 US US15/837,199 patent/US10632127B2/en not_active Expired - Fee Related
-
2018
- 2018-04-03 HK HK18104430.0A patent/HK1245250A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2018516957A (ja) | 2018-06-28 |
US20180200262A1 (en) | 2018-07-19 |
US10632127B2 (en) | 2020-04-28 |
CN107438599A (zh) | 2017-12-05 |
EP3307721A1 (en) | 2018-04-18 |
CN107438599B (zh) | 2021-12-10 |
EP3307721B1 (en) | 2020-06-17 |
WO2016198366A1 (en) | 2016-12-15 |
JP6877365B2 (ja) | 2021-05-26 |
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