HK1244224B - Mek抑制劑的藥物組合物及其製備方法 - Google Patents

Mek抑制劑的藥物組合物及其製備方法

Info

Publication number
HK1244224B
HK1244224B HK18103796.0A HK18103796A HK1244224B HK 1244224 B HK1244224 B HK 1244224B HK 18103796 A HK18103796 A HK 18103796A HK 1244224 B HK1244224 B HK 1244224B
Authority
HK
Hong Kong
Prior art keywords
preparation
pharmaceutical composition
mek inhibitor
mek
inhibitor
Prior art date
Application number
HK18103796.0A
Other languages
English (en)
Inventor
何雄雄
董平
蔡佳慧
鲁锡锋
徐佼
蒋波
邓振雪
隋姗姗
Original Assignee
正大天晴药业集团股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 正大天晴药业集团股份有限公司 filed Critical 正大天晴药业集团股份有限公司
Publication of HK1244224B publication Critical patent/HK1244224B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18103796.0A 2015-05-28 2018-03-19 Mek抑制劑的藥物組合物及其製備方法 HK1244224B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510283950 2015-05-28
PCT/CN2016/083613 WO2016188472A1 (zh) 2015-05-28 2016-05-27 Mek抑制剂的药物组合物及其制备方法

Publications (1)

Publication Number Publication Date
HK1244224B true HK1244224B (zh) 2020-06-12

Family

ID=57392340

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103796.0A HK1244224B (zh) 2015-05-28 2018-03-19 Mek抑制劑的藥物組合物及其製備方法

Country Status (5)

Country Link
US (1) US10350198B2 (zh)
EP (1) EP3305292B1 (zh)
CN (1) CN107613978B (zh)
HK (1) HK1244224B (zh)
WO (1) WO2016188472A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024083184A1 (zh) * 2022-10-20 2024-04-25 西藏海思科制药有限公司 一种egfr抑制剂的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102020657A (zh) * 2009-09-11 2011-04-20 上海艾力斯医药科技有限公司 稠合杂芳基衍生物、制备方法及其应用
CN102020651B (zh) * 2010-11-02 2012-07-18 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂
CN105315291B (zh) 2014-08-05 2019-02-01 正大天晴药业集团股份有限公司 一种6-芳基氨基吡啶酮甲酰胺化合物的结晶及其制备方法

Also Published As

Publication number Publication date
EP3305292B1 (en) 2022-09-14
CN107613978B (zh) 2019-09-20
US20180147192A1 (en) 2018-05-31
WO2016188472A1 (zh) 2016-12-01
US10350198B2 (en) 2019-07-16
EP3305292A4 (en) 2019-03-20
CN107613978A (zh) 2018-01-19
EP3305292A1 (en) 2018-04-11

Similar Documents

Publication Publication Date Title
ZA201707981B (en) Compositions of obeticholic acid and methods of use
HK1256608A1 (zh) 類黃酮組合物及其使用方法
IL250744A0 (en) A method for preparing flavociclib and its pharmaceutical preparations
GB201817116D0 (en) Pharmaceutical preparation of palbociclic and preparation method thereof
GB201514756D0 (en) Compound and method of use
GB201514760D0 (en) Compounds and method of use
HK1252567A1 (zh) 被取代的苯甲酰胺和其使用方法
PL3349743T3 (pl) Sposoby i kompozycje do hamowania oddziaływania dcn1-ubc12
RS65120B1 (sr) Farmaceutske formulacije i postupci za njihovu upotrebu
EP3373910C0 (en) FORMULATION OF ECHINOMYCIN, METHOD OF MANUFACTURING AND METHOD OF USE THEREOF
GB201520349D0 (en) Slide fastener and method of preparation
EP3485887A4 (en) PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT FOR INTRAVENOUS DELIVERY AND METHOD OF PREPARATION
HK1252057A1 (zh) 新穎的使用方法和組合物
HK1258502A1 (zh) 用於治療高胱氨酸尿症的組合物和方法
IL249348A0 (en) A new preparation and method for synthesis
HK1217303A1 (zh) 種治療白血病的藥物組合物及其製備方法
EP3389664A4 (en) MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF
HK1214767A1 (zh) 片劑形式的藥物組合物及其製造方法
HK1245094A1 (zh) 一種治療抑鬱症的藥物組合物及其製備方法
PT3503885T (pt) Composição farmacêutica e métodos de utilização
GB201511799D0 (en) Composition and methods of treatment
HK1244224B (zh) Mek抑制劑的藥物組合物及其製備方法
EP3383414A4 (en) PLANT-BASED PHARMACEUTICAL COMPOSITIONS AND PREPARATION METHOD THEREOF
GB201718483D0 (en) Pharmaceutical composition for treatment of meopausal syndrome and preparation method thereof
GB201506808D0 (en) Bottle and method of preparation thereof