HK1244012A1 - Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof for use in treating bone associated pain - Google Patents
Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof for use in treating bone associated painInfo
- Publication number
- HK1244012A1 HK1244012A1 HK18103438.4A HK18103438A HK1244012A1 HK 1244012 A1 HK1244012 A1 HK 1244012A1 HK 18103438 A HK18103438 A HK 18103438A HK 1244012 A1 HK1244012 A1 HK 1244012A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- derivatives
- inhibitory properties
- treating bone
- associated pain
- bone associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/562,297 US20150183885A1 (en) | 2012-06-08 | 2014-12-05 | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
EP15165107 | 2015-04-24 | ||
PCT/EP2015/078875 WO2016087677A1 (en) | 2014-12-05 | 2015-12-07 | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof for use in treating bone associated pain |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1244012A1 true HK1244012A1 (en) | 2018-07-27 |
Family
ID=54838344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103438.4A HK1244012A1 (en) | 2014-12-05 | 2018-03-12 | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof for use in treating bone associated pain |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3227334A1 (en) |
JP (1) | JP2018505853A (en) |
CN (1) | CN107207599A (en) |
CA (1) | CA2969940A1 (en) |
HK (1) | HK1244012A1 (en) |
MA (1) | MA41097A (en) |
WO (1) | WO2016087677A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116327963A (en) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | Ophthalmic preparation and application thereof |
US20210170029A1 (en) * | 2017-11-20 | 2021-06-10 | Just-Evotec Biologies, Inc. | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
AR114110A1 (en) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | ANTI-TRKA ANTIBODY |
AU2020281378A1 (en) * | 2019-05-30 | 2021-10-28 | Sunshine Lake Pharma Co., Ltd. | Anti-TrkA antibodies and uses thereof |
AR122141A1 (en) | 2020-05-28 | 2022-08-17 | Lilly Co Eli | TRKA INHIBITOR |
WO2023125477A1 (en) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Beijing) Co., Limited | TrkA ANTIBODY AND APPLICATION THEREOF |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1306704B1 (en) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | MONOCLONAL ANTIBODIES AND ITS SYNTHETIC OR BIOTECHNOLOGICAL DERIVATIVES ENABLE TO ACT AS ANTAGONIST MOLECULES FOR NGF. |
US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
ITRM20030601A1 (en) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | METHOD FOR THE HUMANIZATION OF HUMANIZED ANTIBODIES AND ANTIBODIES WITH IT OBTAINED. |
EP2007814A2 (en) * | 2005-05-20 | 2008-12-31 | Ablynx N.V. | Single domain vhh antibodies against von willebrand factor |
ITRM20050290A1 (en) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | USE OF MOLECULES ABLE TO INHIBIT THE BOND BETWEEN NGF AND ITS TRKA RECEPTOR AS AN EXTENDED EFFECT ANALGESICS. |
ITRM20050332A1 (en) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | USE OF MOLECULES ABLE TO BLOCK TRKA'S ACTIVITY TO STRENGTHEN THE EFFECTS OF ANALGESIC OPPIACEI ON PAIN. |
DK2252633T3 (en) * | 2008-02-04 | 2013-11-11 | Lay Line Genomics Spa | Anti-TrkA antibodies and derivatives thereof |
NZ611076A (en) * | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
MX362394B (en) * | 2012-06-08 | 2019-01-15 | Glenmark Pharmaceuticals Sa | Humanized anti-trka antibodies with amino acid substitutions. |
-
2015
- 2015-12-06 MA MA041097A patent/MA41097A/en unknown
- 2015-12-07 JP JP2017529765A patent/JP2018505853A/en active Pending
- 2015-12-07 EP EP15807645.5A patent/EP3227334A1/en not_active Withdrawn
- 2015-12-07 CA CA2969940A patent/CA2969940A1/en not_active Abandoned
- 2015-12-07 CN CN201580075478.3A patent/CN107207599A/en not_active Withdrawn
- 2015-12-07 WO PCT/EP2015/078875 patent/WO2016087677A1/en active Application Filing
-
2018
- 2018-03-12 HK HK18103438.4A patent/HK1244012A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3227334A1 (en) | 2017-10-11 |
MA41097A (en) | 2017-10-10 |
WO2016087677A1 (en) | 2016-06-09 |
JP2018505853A (en) | 2018-03-01 |
CA2969940A1 (en) | 2016-06-09 |
CN107207599A (en) | 2017-09-26 |
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