HK1237274B - Pneumolysin mutants and methods of use thereof - Google Patents

Pneumolysin mutants and methods of use thereof Download PDF

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Publication number
HK1237274B
HK1237274B HK17111274.5A HK17111274A HK1237274B HK 1237274 B HK1237274 B HK 1237274B HK 17111274 A HK17111274 A HK 17111274A HK 1237274 B HK1237274 B HK 1237274B
Authority
HK
Hong Kong
Prior art keywords
cholesterol
membrane
mutant
pfo
protein
Prior art date
Application number
HK17111274.5A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1237274A1 (en
Inventor
Rodney K. Tweten
Original Assignee
The Board Of Regents Of The University Of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Oklahoma filed Critical The Board Of Regents Of The University Of Oklahoma
Publication of HK1237274A1 publication Critical patent/HK1237274A1/en
Publication of HK1237274B publication Critical patent/HK1237274B/en

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Claims (6)

  1. Une pneumolysine mutante purifiée comprenant une séquence d'acides aminés de SEQ ID NO : 40.
  2. Une composition immunogène comprenant :
    la pneumolysine mutante purifiée de la revendication 1 ; et
    un excipient pharmaceutiquement acceptable.
  3. Un vaccin comprenant la composition immunogène de la revendication 2.
  4. Le vaccin de la revendication 3 comprenant en sus un adjuvant.
  5. Une séquence d'acide nucléique codant pour la pneumolysine mutante purifiée de la revendication 1.
  6. Une cellule hôte comprenant la séquence d'acide nucléique de la revendication 5.
HK17111274.5A 2014-11-21 2015-11-20 Pneumolysin mutants and methods of use thereof HK1237274B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62/082,848 2014-11-21

Publications (2)

Publication Number Publication Date
HK1237274A1 HK1237274A1 (en) 2018-04-13
HK1237274B true HK1237274B (en) 2025-01-10

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