HK1220180A1 - 調節劑及與其相關的方法 - Google Patents
調節劑及與其相關的方法Info
- Publication number
- HK1220180A1 HK1220180A1 HK16108136.0A HK16108136A HK1220180A1 HK 1220180 A1 HK1220180 A1 HK 1220180A1 HK 16108136 A HK16108136 A HK 16108136A HK 1220180 A1 HK1220180 A1 HK 1220180A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ship1
- modulators
- methods related
- methods
- ship1 modulators
- Prior art date
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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- C—CHEMISTRY; METALLURGY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
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US201361786020P | 2013-03-14 | 2013-03-14 | |
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HK16108136.0A HK1220180A1 (zh) | 2013-03-14 | 2016-07-12 | 調節劑及與其相關的方法 |
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EP (1) | EP2970122B1 (zh) |
JP (1) | JP6407951B2 (zh) |
KR (3) | KR20220110337A (zh) |
CN (2) | CN108892637A (zh) |
AU (1) | AU2014242041B2 (zh) |
BR (1) | BR112015023009A2 (zh) |
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RU (1) | RU2679805C2 (zh) |
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EP2943470A1 (en) | 2013-01-09 | 2015-11-18 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators and methods related thereto |
EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
WO2014143561A1 (en) | 2013-03-14 | 2014-09-18 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
CN107787315A (zh) * | 2015-06-26 | 2018-03-09 | 阿奎诺克斯药物(加拿大)公司 | (1s,3s,4r)‑4‑((3as,4r,5s,7as)‑4‑(氨甲基)‑7a‑甲基‑1‑亚甲基八氢‑1h‑茚‑5‑基)‑3‑(羟甲基)‑4‑甲基环己醇的乙酸盐的结晶固体形式 |
US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
EP3423465A1 (en) * | 2016-03-02 | 2019-01-09 | Patheon Austria GmbH & Co KG | Process and intermediates for the production of 17(20)-ene b-seco steroids |
WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
ES2960542T3 (es) * | 2018-04-06 | 2024-03-05 | Taro Pharmaceuticals Inc | Derivados de hexadecahidro-1H-ciclopenta[a]fenantreno útiles en el tratamiento del dolor y la inflamación |
IL277904B2 (en) * | 2018-04-06 | 2024-05-01 | Aquinox Pharmaceuticals Canada Inc | History of indan for use in the treatment of pain and inflammation |
CN112533905A (zh) | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
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DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
SE345995B (zh) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | 5,6―セコ―ステロール誘導体血清脂質低下剤 |
WO1993013124A1 (en) | 1991-12-20 | 1993-07-08 | Glaxo Inc. | Inhibitors of 5-alpha-testosterone reductase |
JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
CA2166898C (en) | 1993-07-09 | 2004-09-07 | Roger Bouillon | Novel structural analogues of vitamin d |
US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
WO2000063323A1 (fr) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluides pour entrainement par traction |
US20040034216A1 (en) | 2000-04-28 | 2004-02-19 | Raymond Jeffrey R. | 3-Nitrogen-6,7-dioxygen steroids and uses related thereto |
MXPA03010585A (es) | 2001-05-22 | 2004-04-02 | Inflazyme Pharm Ltd | Mejoras del proceso en quimica de esteroide. |
WO2003033517A1 (en) | 2001-10-17 | 2003-04-24 | The University Of British Columbia | Ship 1 modulators |
JP4753581B2 (ja) | 2002-10-17 | 2011-08-24 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | Ship1モデュレーター |
JP4956182B2 (ja) * | 2003-04-15 | 2012-06-20 | アクイノックス ファーマシューティカルズ インコーポレイテッド | 医薬組成物としてのインデン誘導体 |
WO2007147252A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator prodrugs |
KR100950204B1 (ko) * | 2006-09-26 | 2010-03-29 | 경북대학교 산학협력단 | 7α-아미노스테로이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항암용 또는 항생제 조성물 |
EP2507221A1 (en) * | 2009-12-04 | 2012-10-10 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
ES2594980T3 (es) | 2010-08-20 | 2016-12-27 | The University Of British Columbia | Moduladores de SHIP1 y métodos relacionados |
AU2011343970A1 (en) * | 2010-12-13 | 2013-07-04 | Rutgers University | Methods of producing and using brassinosteroids to promote growth, repair and maintenance of skeletal muscle and skin |
WO2014143561A1 (en) | 2013-03-14 | 2014-09-18 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
CN107787315A (zh) | 2015-06-26 | 2018-03-09 | 阿奎诺克斯药物(加拿大)公司 | (1s,3s,4r)‑4‑((3as,4r,5s,7as)‑4‑(氨甲基)‑7a‑甲基‑1‑亚甲基八氢‑1h‑茚‑5‑基)‑3‑(羟甲基)‑4‑甲基环己醇的乙酸盐的结晶固体形式 |
US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
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2014
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MX2015012111A (es) | 2016-05-05 |
ZA201506674B (en) | 2016-11-30 |
EP2970122A1 (en) | 2016-01-20 |
AU2014242041A1 (en) | 2015-09-24 |
HK1217704A1 (zh) | 2017-01-20 |
WO2014158654A1 (en) | 2014-10-02 |
US20160031899A1 (en) | 2016-02-04 |
AU2014242041B2 (en) | 2018-07-26 |
KR20210120137A (ko) | 2021-10-06 |
CN108892637A (zh) | 2018-11-27 |
JP2016517409A (ja) | 2016-06-16 |
CA2902768A1 (en) | 2014-10-02 |
KR20220110337A (ko) | 2022-08-05 |
KR102427491B1 (ko) | 2022-08-01 |
US20170362250A1 (en) | 2017-12-21 |
BR112015023009A2 (pt) | 2017-08-22 |
EP2970122B1 (en) | 2019-05-08 |
KR102308319B1 (ko) | 2021-10-06 |
US9765085B2 (en) | 2017-09-19 |
IL240968A0 (en) | 2015-11-30 |
RU2679805C2 (ru) | 2019-02-13 |
JP6407951B2 (ja) | 2018-10-17 |
CN105164108A (zh) | 2015-12-16 |
US10174046B2 (en) | 2019-01-08 |
US20180155359A9 (en) | 2018-06-07 |
RU2015143676A (ru) | 2017-04-27 |
CN105164108B (zh) | 2018-07-17 |
US20170247389A2 (en) | 2017-08-31 |
KR20150127205A (ko) | 2015-11-16 |
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