HK1220180A1 - 調節劑及與其相關的方法 - Google Patents
調節劑及與其相關的方法Info
- Publication number
- HK1220180A1 HK1220180A1 HK16108136.0A HK16108136A HK1220180A1 HK 1220180 A1 HK1220180 A1 HK 1220180A1 HK 16108136 A HK16108136 A HK 16108136A HK 1220180 A1 HK1220180 A1 HK 1220180A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ship1
- modulators
- methods related
- methods
- ship1 modulators
- Prior art date
Links
- 101150080778 INPP5D gene Proteins 0.000 title 1
- 101100107199 Mus musculus Znf541 gene Proteins 0.000 title 1
Classifications
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/82—Amides; Imides in position 3
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
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CN108752236A (zh) | 2013-01-09 | 2018-11-06 | 阿奎诺克斯药物(加拿大)公司 | Ship1调节剂和与其相关的方法 |
JP6407950B2 (ja) | 2013-03-14 | 2018-10-17 | アクイノックス ファーマシューティカルズ (カナダ) インコーポレイテッド | Ship1モジュレーターおよびそれに関連する組成物および方法 |
KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
CA2986790A1 (en) * | 2015-06-26 | 2016-12-29 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
EP3423465A1 (en) * | 2016-03-02 | 2019-01-09 | Patheon Austria GmbH & Co KG | Process and intermediates for the production of 17(20)-ene b-seco steroids |
WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
AU2019247513A1 (en) * | 2018-04-06 | 2020-10-22 | Taro Pharmaceuticals Inc. | Indene derivatives useful in treating pain and inflammation |
JP2021526545A (ja) * | 2018-04-06 | 2021-10-07 | アキノックス ファーマシューティカルス(カナダ)インク. | 疼痛及び炎症を治療するのに有用なインデン誘導体 |
AU2019247453A1 (en) * | 2018-04-06 | 2020-10-22 | Taro Pharmaceuticals Inc. | Hexadecahydro-1H-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation |
CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
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DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
SE345995B (zh) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | 5,6―セコ―ステロール誘導体血清脂質低下剤 |
CA2126203A1 (en) | 1991-12-20 | 1993-07-08 | Stephen V. Frye | Inhibitors of 5-alpha-testosterone reductase |
JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
ATE251133T1 (de) | 1993-07-09 | 2003-10-15 | Theramex | Neue strukturelle vitamin d derivate |
US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
WO2000063323A1 (fr) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluides pour entrainement par traction |
MXPA02010645A (es) | 2000-04-28 | 2004-04-20 | Inflazyme Pharm Ltd | Esteroides de 3-nitrogeno-5, 7-dioxigeno y usos relacionados con los mismos. |
US6696580B2 (en) | 2001-05-22 | 2004-02-24 | Inflazyme Pharmaceuticals Ltd. | Process for the production of 6,7-diols of steroidal compounds |
CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
DE60327936D1 (de) | 2002-10-17 | 2009-07-23 | Univ British Columbia | Modulatoren von ship-1 |
ES2359916T3 (es) | 2003-04-15 | 2011-05-30 | Aquinox Pharmaceuticals Inc. | Derivados de indeno como agentes farmacéuticos. |
AU2007262621A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | SHIP 1 modulator compounds |
WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
EP2507221A1 (en) * | 2009-12-04 | 2012-10-10 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
WO2012024682A1 (en) | 2010-08-20 | 2012-02-23 | The University Of British Columbia | Ship1 modulators and related methods |
MX2013006658A (es) * | 2010-12-13 | 2013-11-04 | Univ Rutgers | Métodos para producir y usar brasinoesteroides para promover el crecimiento, la reparación y mantenimiento del músculo esquelético y la piel. |
KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
JP6407950B2 (ja) | 2013-03-14 | 2018-10-17 | アクイノックス ファーマシューティカルズ (カナダ) インコーポレイテッド | Ship1モジュレーターおよびそれに関連する組成物および方法 |
CA2986790A1 (en) | 2015-06-26 | 2016-12-29 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
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2014
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CN108892637A (zh) | 2018-11-27 |
KR102308319B1 (ko) | 2021-10-06 |
ZA201506674B (en) | 2016-11-30 |
KR20210120137A (ko) | 2021-10-06 |
MX2015012111A (es) | 2016-05-05 |
US20170247389A2 (en) | 2017-08-31 |
WO2014158654A1 (en) | 2014-10-02 |
US20160031899A1 (en) | 2016-02-04 |
ES2740779T3 (es) | 2020-02-06 |
RU2015143676A (ru) | 2017-04-27 |
AU2014242041B2 (en) | 2018-07-26 |
US20170362250A1 (en) | 2017-12-21 |
RU2679805C2 (ru) | 2019-02-13 |
AU2014242041A1 (en) | 2015-09-24 |
CN105164108B (zh) | 2018-07-17 |
EP2970122A1 (en) | 2016-01-20 |
JP2016517409A (ja) | 2016-06-16 |
JP6407951B2 (ja) | 2018-10-17 |
US9765085B2 (en) | 2017-09-19 |
US10174046B2 (en) | 2019-01-08 |
HK1217704A1 (zh) | 2017-01-20 |
US20180155359A9 (en) | 2018-06-07 |
KR20150127205A (ko) | 2015-11-16 |
BR112015023009A2 (pt) | 2017-08-22 |
IL240968A0 (en) | 2015-11-30 |
KR20220110337A (ko) | 2022-08-05 |
EP2970122B1 (en) | 2019-05-08 |
CN105164108A (zh) | 2015-12-16 |
KR102427491B1 (ko) | 2022-08-01 |
CA2902768A1 (en) | 2014-10-02 |
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