HK1212612A1 - 結合端粒酶抑制劑和吉西他濱用於治療癌症 - Google Patents
結合端粒酶抑制劑和吉西他濱用於治療癌症Info
- Publication number
- HK1212612A1 HK1212612A1 HK16100587.1A HK16100587A HK1212612A1 HK 1212612 A1 HK1212612 A1 HK 1212612A1 HK 16100587 A HK16100587 A HK 16100587A HK 1212612 A1 HK1212612 A1 HK 1212612A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- gemcitabine
- cancer
- treatment
- combined
- telomerase inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85558306P | 2006-10-30 | 2006-10-30 | |
| EP07867297.9A EP2101789B1 (en) | 2006-10-30 | 2007-10-30 | Combined telomerase inhibitor and gemcitabine for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1212612A1 true HK1212612A1 (zh) | 2016-06-17 |
Family
ID=39344866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16100587.1A HK1212612A1 (zh) | 2006-10-30 | 2016-01-20 | 結合端粒酶抑制劑和吉西他濱用於治療癌症 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7989428B2 (zh) |
| EP (3) | EP2898887B1 (zh) |
| CY (1) | CY1121244T1 (zh) |
| DK (2) | DK2898887T3 (zh) |
| ES (2) | ES2696828T3 (zh) |
| HK (1) | HK1212612A1 (zh) |
| HU (1) | HUE041448T2 (zh) |
| LT (1) | LT2898887T (zh) |
| PL (2) | PL2101789T3 (zh) |
| PT (2) | PT2101789E (zh) |
| SI (2) | SI2898887T1 (zh) |
| TR (1) | TR201819789T4 (zh) |
| WO (1) | WO2008054711A2 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293908B (zh) | 2003-09-09 | 2015-05-06 | 杰龙公司 | 用于端粒酶抑制的改性寡核苷酸 |
| WO2008112129A2 (en) * | 2007-03-09 | 2008-09-18 | Geron Corporation | Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| KR102294819B1 (ko) * | 2012-12-07 | 2021-09-01 | 제론 코포레이션 | 골증식성 장애 및 골증식성 신생물의 치료를 위한 텔로메라제 저해제들의 용도 |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| LT3065828T (lt) * | 2013-11-06 | 2019-04-10 | Mayo Foundation For Medical Education And Research | Būdai ir medžiagos, skirti hematologinių piktybinių būklių gydymui |
| JOP20200257A1 (ar) | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
| US20180036331A1 (en) * | 2016-03-24 | 2018-02-08 | The Board Of Regents Of The University Of Texas System | Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds |
| EP3318276A1 (en) | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5489508A (en) | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US5837453A (en) | 1992-05-13 | 1998-11-17 | Geron Corporation | Telomerase activity assays |
| US5629154A (en) | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
| US5523389A (en) * | 1992-09-29 | 1996-06-04 | Isis Pharmaceuticals, Inc. | Inhibitors of human immunodeficiency virus |
| US7067497B2 (en) * | 1992-09-29 | 2006-06-27 | Isis Pharmaceuticals, Inc. | Modulation of telomere length by oligonucleotides having a G-core sequence |
| US5863726A (en) | 1993-11-12 | 1999-01-26 | Geron Corporation | Telomerase activity assays |
| US5583016A (en) * | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
| US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
| US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
| US6444650B1 (en) | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
| WO1998028442A1 (en) | 1996-12-20 | 1998-07-02 | Geron Corporation | Methods for detecting and inhibiting the rna component of telomerase |
| US6995145B1 (en) * | 1999-06-04 | 2006-02-07 | Au Jessie L-S | Methods and compositions for modulating drug activity through telomere damage |
| EP1210357B1 (en) | 1999-09-10 | 2008-04-02 | Geron Corporation | Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use |
| US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
| AP2280A (en) | 2003-06-23 | 2011-10-31 | Geron Corp | Compositions and methods for increasing telomeraseactivity. |
| CN101293908B (zh) | 2003-09-09 | 2015-05-06 | 杰龙公司 | 用于端粒酶抑制的改性寡核苷酸 |
| DK1778711T3 (en) | 2004-07-02 | 2017-10-02 | Geron Corp | SYNTHESIS OF PROTECTED 3'-AMINONUCLEOSIDE MONOMERS |
| WO2006113426A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and tubulin activities |
| US7998938B2 (en) * | 2005-04-15 | 2011-08-16 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| WO2006124904A2 (en) | 2005-05-16 | 2006-11-23 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and hsp90 activities |
| WO2008112129A2 (en) | 2007-03-09 | 2008-09-18 | Geron Corporation | Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors |
-
2007
- 2007-10-30 EP EP14198829.5A patent/EP2898887B1/en active Active
- 2007-10-30 US US12/446,931 patent/US7989428B2/en active Active
- 2007-10-30 SI SI200732076T patent/SI2898887T1/sl unknown
- 2007-10-30 TR TR2018/19789T patent/TR201819789T4/tr unknown
- 2007-10-30 HU HUE14198829A patent/HUE041448T2/hu unknown
- 2007-10-30 ES ES14198829T patent/ES2696828T3/es active Active
- 2007-10-30 PT PT07867297T patent/PT2101789E/pt unknown
- 2007-10-30 LT LTEP14198829.5T patent/LT2898887T/lt unknown
- 2007-10-30 DK DK14198829.5T patent/DK2898887T3/en active
- 2007-10-30 SI SI200731627T patent/SI2101789T1/sl unknown
- 2007-10-30 DK DK07867297.9T patent/DK2101789T3/en active
- 2007-10-30 PT PT14198829T patent/PT2898887T/pt unknown
- 2007-10-30 PL PL07867297T patent/PL2101789T3/pl unknown
- 2007-10-30 ES ES07867297.9T patent/ES2533264T3/es active Active
- 2007-10-30 EP EP07867297.9A patent/EP2101789B1/en active Active
- 2007-10-30 WO PCT/US2007/022850 patent/WO2008054711A2/en active Application Filing
- 2007-10-30 PL PL14198829T patent/PL2898887T3/pl unknown
- 2007-10-30 EP EP18196347.1A patent/EP3494975A1/en active Pending
-
2016
- 2016-01-20 HK HK16100587.1A patent/HK1212612A1/zh unknown
-
2018
- 2018-11-22 CY CY20181101238T patent/CY1121244T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2101789B1 (en) | 2014-12-31 |
| DK2898887T3 (en) | 2019-01-07 |
| WO2008054711A3 (en) | 2008-12-24 |
| EP2101789A4 (en) | 2010-11-10 |
| US20100016407A1 (en) | 2010-01-21 |
| SI2898887T1 (sl) | 2019-01-31 |
| EP3494975A1 (en) | 2019-06-12 |
| SI2101789T1 (sl) | 2015-04-30 |
| DK2101789T3 (en) | 2015-03-23 |
| EP2898887A1 (en) | 2015-07-29 |
| LT2898887T (lt) | 2018-11-12 |
| CY1121244T1 (el) | 2020-05-29 |
| PL2101789T3 (pl) | 2015-05-29 |
| PT2101789E (pt) | 2015-03-24 |
| PL2898887T3 (pl) | 2019-05-31 |
| US7989428B2 (en) | 2011-08-02 |
| PT2898887T (pt) | 2018-12-20 |
| WO2008054711A2 (en) | 2008-05-08 |
| ES2533264T3 (es) | 2015-04-08 |
| HUE041448T2 (hu) | 2019-05-28 |
| ES2696828T3 (es) | 2019-01-18 |
| EP2898887B1 (en) | 2018-09-26 |
| TR201819789T4 (tr) | 2019-01-21 |
| EP2101789A2 (en) | 2009-09-23 |
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