HK1210732A1 - Irak inhibitors and uses thereof irak - Google Patents

Irak inhibitors and uses thereof irak

Info

Publication number
HK1210732A1
HK1210732A1 HK15111414.8A HK15111414A HK1210732A1 HK 1210732 A1 HK1210732 A1 HK 1210732A1 HK 15111414 A HK15111414 A HK 15111414A HK 1210732 A1 HK1210732 A1 HK 1210732A1
Authority
HK
Hong Kong
Prior art keywords
irak
inhibitors
irak inhibitors
Prior art date
Application number
HK15111414.8A
Other languages
English (en)
Chinese (zh)
Inventor
Geraldine C Harriman
Ronald T Wester
Donna L Romero
Craig E Masse
Shaughnessy Robinson
Jeremy Robert Greenwood
Original Assignee
Nimbus Iris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nimbus Iris Inc filed Critical Nimbus Iris Inc
Publication of HK1210732A1 publication Critical patent/HK1210732A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
HK15111414.8A 2012-07-11 2015-11-19 Irak inhibitors and uses thereof irak HK1210732A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261670380P 2012-07-11 2012-07-11
US201261682622P 2012-08-13 2012-08-13
PCT/US2013/050113 WO2014011906A2 (fr) 2012-07-11 2013-07-11 Inhibiteurs d'irak et leurs utilisations

Publications (1)

Publication Number Publication Date
HK1210732A1 true HK1210732A1 (en) 2016-05-06

Family

ID=49914493

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111414.8A HK1210732A1 (en) 2012-07-11 2015-11-19 Irak inhibitors and uses thereof irak

Country Status (10)

Country Link
US (2) US9067948B2 (fr)
EP (1) EP2872518A4 (fr)
JP (1) JP2015528801A (fr)
CN (1) CN104902959A (fr)
AU (1) AU2013290080A1 (fr)
BR (1) BR112015000561A2 (fr)
CA (1) CA2878040A1 (fr)
HK (1) HK1210732A1 (fr)
IN (1) IN2015DN00127A (fr)
WO (1) WO2014011906A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012097013A1 (fr) 2011-01-10 2012-07-19 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisation
TWI589579B (zh) 2012-01-10 2017-07-01 林伯士艾瑞斯公司 Ｉｒａｋ抑制劑及其用途
WO2014011902A1 (fr) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations
US9067948B2 (en) 2012-07-11 2015-06-30 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
CA2890911A1 (fr) 2013-01-10 2014-07-17 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
WO2015048281A1 (fr) 2013-09-27 2015-04-02 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisation
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AR102849A1 (es) 2015-03-09 2017-03-29 Astellas Pharma Inc Compuesto de piridina bicíclica
SI3340796T1 (sl) 2015-08-28 2022-02-28 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
IL273432B (en) 2017-09-22 2022-09-01 Kymera Therapeutics Inc Protein compounds and their uses
EP3684366A4 (fr) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. Ligands crbn et utilisations de ces derniers
WO2019111218A1 (fr) 2017-12-08 2019-06-13 Cadila Healthcare Limited Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs d'irak4
SG11202005912PA (en) 2017-12-26 2020-07-29 Kymera Therapeutics Inc Irak degraders and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2019140387A1 (fr) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Ligands crbn et leurs utilisations
KR20210024543A (ko) * 2018-06-25 2021-03-05 치아타이 티안큉 파마수티컬 그룹 주식회사 IRAK4 억제제로서의 이소티아졸로[5,4-d]피리미딘 화합물
WO2020010177A1 (fr) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Ligands crbn tricycliques et leurs utilisations
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
US11352350B2 (en) 2018-11-30 2022-06-07 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
EP4076524A4 (fr) 2019-12-17 2023-11-29 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
BR112022011651A2 (pt) 2019-12-17 2022-08-23 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1167367A4 (fr) 1999-03-30 2002-04-24 Nippon Soda Co Composes de thienopyrimidine et leurs sels, et procede de preparation desdits composes et sels
CN100343258C (zh) 2001-04-30 2007-10-17 美国拜尔公司 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物
AU2002360774A1 (en) 2001-12-28 2003-07-24 Bayer Corporation 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
AU2003270701B2 (en) 2002-10-31 2009-11-12 Amgen Inc. Antiinflammation agents
US7598259B2 (en) * 2004-06-15 2009-10-06 Schering Corporation mGluR1 antagonists as therapeutic agents
PE20060526A1 (es) * 2004-06-15 2006-07-13 Schering Corp Compuestos triciclicos como antagonistas de mglur1
EP1619196A1 (fr) * 2004-07-23 2006-01-25 Curacyte Discovery GmbH Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines et Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines substitués comme inhibiteurs de PDA-4 et/ou libération de TNF-alpha
ATE455777T1 (de) 2004-07-23 2010-02-15 Medicines Co Leipzig Gmbh Substituierte pyridoä3',2':4,5üthienoä3,2- düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü- pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung
WO2006081072A1 (fr) * 2005-01-24 2006-08-03 Abbott Laboratories Antagonistes du recepteur mglu et leurs utilisations
WO2006136402A1 (fr) * 2005-06-22 2006-12-28 Develogen Aktiengesellschaft Thiénopyrimidines pour compositions pharmaceutiques
JP2009504755A (ja) * 2005-08-19 2009-02-05 シェーリング コーポレイション 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
WO2007032854A1 (fr) * 2005-08-19 2007-03-22 Schering Corporation Antagonistes tricycliques fusionnes du recepteur metabotropique du glutamate (mglur), en tant qu'agents therapeutiques
CA2668997C (fr) 2006-11-09 2012-10-09 Ardea Biosciences, Inc. Composes heterocycliques bicycliques 4-cyanophenylamino-substitues utilises comme inhibiteurs du vih
US20100227853A1 (en) 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
US20100063047A1 (en) 2008-09-10 2010-03-11 Kalypsys, Inc. Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
US8993552B2 (en) 2009-09-04 2015-03-31 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
RU2604062C2 (ru) * 2010-07-13 2016-12-10 Ф.Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА И ТИЕНО[3,2-b]ПИРИМИДИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ IRAK-4
CN103119047B (zh) 2010-07-23 2016-06-15 哈佛大学校长及研究员协会 三环类蛋白酶体活性增强化合物
WO2012097013A1 (fr) 2011-01-10 2012-07-19 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisation
AU2012340869B2 (en) 2011-11-23 2017-03-02 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase C
TWI589579B (zh) 2012-01-10 2017-07-01 林伯士艾瑞斯公司 Ｉｒａｋ抑制劑及其用途
WO2014011902A1 (fr) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations
US9067948B2 (en) 2012-07-11 2015-06-30 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
WO2014011911A2 (fr) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations

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US20140018357A1 (en) 2014-01-16
US20160002256A1 (en) 2016-01-07
IN2015DN00127A (fr) 2015-05-29
EP2872518A4 (fr) 2016-05-18
WO2014011906A2 (fr) 2014-01-16
US9067948B2 (en) 2015-06-30
EP2872518A2 (fr) 2015-05-20
BR112015000561A2 (pt) 2017-06-27
CN104902959A (zh) 2015-09-09
CA2878040A1 (fr) 2014-01-16
JP2015528801A (ja) 2015-10-01
WO2014011906A3 (fr) 2015-07-16
AU2013290080A1 (en) 2015-01-29

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