HK1205145A1 - 改進的抗體輕鏈 - Google Patents

改進的抗體輕鏈

Info

Publication number
HK1205145A1
HK1205145A1 HK15105693.2A HK15105693A HK1205145A1 HK 1205145 A1 HK1205145 A1 HK 1205145A1 HK 15105693 A HK15105693 A HK 15105693A HK 1205145 A1 HK1205145 A1 HK 1205145A1
Authority
HK
Hong Kong
Prior art keywords
light chains
antibody light
improved antibody
improved
chains
Prior art date
Application number
HK15105693.2A
Other languages
English (en)
Inventor
Roland Beckmann
Original Assignee
Dutalys Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dutalys Gmbh filed Critical Dutalys Gmbh
Publication of HK1205145A1 publication Critical patent/HK1205145A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
HK15105693.2A 2012-04-11 2015-06-16 改進的抗體輕鏈 HK1205145A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12002561 2012-04-11
PCT/EP2013/001065 WO2013152860A2 (en) 2012-04-11 2013-04-11 Improved antibody light chains

Publications (1)

Publication Number Publication Date
HK1205145A1 true HK1205145A1 (zh) 2015-12-11

Family

ID=48289006

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105693.2A HK1205145A1 (zh) 2012-04-11 2015-06-16 改進的抗體輕鏈

Country Status (4)

Country Link
US (2) US9708388B2 (zh)
EP (1) EP2836512B1 (zh)
HK (1) HK1205145A1 (zh)
WO (1) WO2013152860A2 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013152860A2 (en) * 2012-04-11 2013-10-17 Dutalys Gmbh Improved antibody light chains
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
CA3206122A1 (en) 2012-11-28 2014-06-05 Zymeworks Bc Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
BR112016027888A2 (pt) 2014-05-28 2017-10-24 Zymeworks Inc construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado
AU2016334063B2 (en) 2015-10-08 2023-05-25 Zymeworks Bc Inc. Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
AU2018292438A1 (en) 2017-06-30 2019-12-12 Zymeworks Bc Inc. Stabilized chimeric fabs

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE219517T1 (de) 1995-08-18 2002-07-15 Morphosys Ag Protein-/(poly)peptidbibliotheken
EP1976991A1 (en) * 2006-01-24 2008-10-08 Domantis Limited Fusion proteins that contain natural junctions
EP2261254A3 (en) * 2007-12-21 2011-04-13 Amgen, Inc Anti-amyloid antibodies and uses thereof
US9175078B2 (en) * 2008-01-25 2015-11-03 Amgen Inc. Ferroportin antibodies and methods of use
CA2722600C (en) * 2008-05-01 2014-01-21 Amgen Inc. Anti-hepcidin antibodies and methods of use
BRPI0921320A2 (pt) 2008-11-28 2018-05-22 Abbott Laboratories composições de anticorpo estáveis e métodos para estabilizar os mesmos
EA022984B1 (ru) * 2009-12-29 2016-04-29 Эмерджент Продакт Дивелопмент Сиэтл, Ллс Конструкты, связывающиеся с ron, и способы их использования
US20130129723A1 (en) * 2009-12-29 2013-05-23 Emergent Product Development Seattle, Llc Heterodimer Binding Proteins and Uses Thereof
US8637641B2 (en) * 2010-07-29 2014-01-28 Xencor, Inc. Antibodies with modified isoelectric points
US9879072B2 (en) * 2010-10-27 2018-01-30 Amgen Inc. DKK1 antibodies and methods of use
CN109111524B (zh) * 2011-10-31 2022-10-28 中外制药株式会社 控制了重链与轻链的缔合的抗原结合分子
EP2791171A1 (en) * 2011-12-16 2014-10-22 Synthon Biopharmaceuticals B.V. EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
WO2013152860A2 (en) * 2012-04-11 2013-10-17 Dutalys Gmbh Improved antibody light chains
WO2014160499A2 (en) * 2013-03-13 2014-10-02 Creatics Llc Methods and compositions for detecting pancreatic cancer

Also Published As

Publication number Publication date
US9708388B2 (en) 2017-07-18
US20170291936A1 (en) 2017-10-12
EP2836512B1 (en) 2018-10-24
EP2836512A2 (en) 2015-02-18
US10738103B2 (en) 2020-08-11
WO2013152860A2 (en) 2013-10-17
US20150086538A1 (en) 2015-03-26
WO2013152860A3 (en) 2013-12-19

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230407