HK1183307A1 - 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors alk5 / alk4 2- - Google Patents

2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors alk5 / alk4 2-

Info

Publication number
HK1183307A1
HK1183307A1 HK13110757.7A HK13110757A HK1183307A1 HK 1183307 A1 HK1183307 A1 HK 1183307A1 HK 13110757 A HK13110757 A HK 13110757A HK 1183307 A1 HK1183307 A1 HK 1183307A1
Authority
HK
Hong Kong
Prior art keywords
alk5
alk4
therapeutic
inhibitors
pyridyl substituted
Prior art date
Application number
HK13110757.7A
Other languages
Chinese (zh)
Inventor
金大起
申尹容
金成華
朴哲龍
．斯雷努
．勞
．克裡斯奈哈
．蘇布拉曼雅姆
Original Assignee
梨花女子大學校產學協力團
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 梨花女子大學校產學協力團 filed Critical 梨花女子大學校產學協力團
Publication of HK1183307A1 publication Critical patent/HK1183307A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
HK13110757.7A 2010-06-29 2013-09-19 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors alk5 / alk4 2- HK1183307A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/826,338 US8080568B1 (en) 2010-06-29 2010-06-29 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
PCT/KR2011/004631 WO2012002680A2 (en) 2010-06-29 2011-06-24 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors

Publications (1)

Publication Number Publication Date
HK1183307A1 true HK1183307A1 (en) 2013-12-20

Family

ID=45219191

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13110757.7A HK1183307A1 (en) 2010-06-29 2013-09-19 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors alk5 / alk4 2-

Country Status (24)

Country Link
US (2) US8080568B1 (en)
EP (2) EP2588479B3 (en)
JP (1) JP5732131B2 (en)
KR (1) KR101500665B1 (en)
CN (1) CN103025731B (en)
AU (1) AU2011272149B2 (en)
BR (1) BR112012033334B1 (en)
CA (1) CA2803577C (en)
CO (1) CO6620028A2 (en)
DK (2) DK2947081T3 (en)
ES (2) ES2651499T3 (en)
HK (1) HK1183307A1 (en)
HR (1) HRP20171829T1 (en)
HU (1) HUE036385T2 (en)
IL (1) IL223744A (en)
MX (1) MX2012015260A (en)
PL (1) PL2588479T6 (en)
PT (2) PT2947081T (en)
RS (1) RS56710B1 (en)
RU (1) RU2518069C1 (en)
SG (1) SG186773A1 (en)
UA (1) UA106136C2 (en)
WO (1) WO2012002680A2 (en)
ZA (1) ZA201208662B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3705498A1 (en) 2013-08-22 2020-09-09 Acceleron Pharma Inc. Tgf-beta receptor type ii variants and uses thereof
US10682392B2 (en) 2013-11-21 2020-06-16 The Bringham and Women's Hospital, Inc. Methods for treating pulmonary hypertension with a TGF-beta type II receptor-FC fusion protein
TWI672143B (en) * 2014-05-02 2019-09-21 理筱龍 Use of ginsenoside m1 for treating lupus nephritis
ES2739203T3 (en) * 2014-05-16 2020-01-29 Wellhead Biological Tech Corp Use of ginsenoside M1 for the inhibition of renal fibrosis
EP3693004A1 (en) 2014-08-01 2020-08-12 The Brigham and Women's Hospital, Inc. An inhibitor of gdf-15 for use in treating fibrosis
JP6631865B2 (en) * 2014-08-11 2020-01-15 日本化薬株式会社 Chimeric protein with TGFβ inhibitory function
JO3336B1 (en) 2014-10-07 2019-03-13 Lilly Co Eli Aminopyridyloxypyrazole compounds
CA2975988C (en) * 2015-02-04 2020-07-21 Medpacto Inc. Combination of a tgf-b inhibitor and a bcr-abl tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia
KR20160120157A (en) * 2015-04-07 2016-10-17 주식회사 메드팩토 Pharmaceutical composition for preventing or treating cancer and method using thereof
WO2016163754A1 (en) * 2015-04-07 2016-10-13 Medpacto Inc. Pharmaceutical composition for preventing or treating cancer and method using thereof
CA2994413A1 (en) 2015-08-04 2017-02-09 Acceleron Pharma, Inc. Methods for treating myeloproliferative disorders
JP6856648B2 (en) 2015-12-15 2021-04-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ CXCR4 receptor antagonist
US11583593B2 (en) 2016-01-14 2023-02-21 Synthis Therapeutics, Inc. Antibody-ALK5 inhibitor conjugates and their uses
RU2737737C2 (en) * 2016-06-13 2020-12-02 Джинфлит Терапьютикс (Шанхай) Инк. Alpha- and beta-unsaturated amide compound-a benzotriazole derivative used as a tgf-βri inhibitor
KR102434226B1 (en) 2016-06-30 2022-08-19 한미약품 주식회사 Novel substituted pyrazole derivatives as a alk5 inhibitors and use thereof
SG11201901773QA (en) * 2016-07-29 2019-04-29 Shanghai Yingli Pharmaceutical Co Ltd Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
WO2018068759A1 (en) * 2016-10-14 2018-04-19 江苏恒瑞医药股份有限公司 Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
MX2019004822A (en) 2016-11-14 2019-09-11 Jiangsu Hengrui Medicine Co 3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof.
CN109983015B (en) * 2017-03-22 2021-09-03 江苏恒瑞医药股份有限公司 6-pyrazole- [1,2,4] triazolo [4,3-a ] pyridine-3-amide derivatives, preparation method and medical application thereof
WO2019005241A1 (en) 2017-03-23 2019-01-03 Clavius Pharmaceuticals, Llc Tri-substituted imidazoles for the inhibition of tgf beta and methods of treatment
HRP20230706T1 (en) 2017-05-04 2023-10-13 Acceleron Pharma Inc. Tgf-beta receptor type ii fusion proteins and uses thereof
DK3725786T3 (en) * 2017-12-13 2023-11-27 Genfleet Therapeutics Shanghai Inc CRYSTALLINE FORM AND SALT FORM OF TGF-ßRI INHIBITOR AND METHOD OF PREPARATION THEREOF
CN111712244A (en) * 2017-12-13 2020-09-25 学校法人同志社 Compositions or methods for treating or preventing corneal endothelial disorders comprising (T) EW-7197
CN110066276B (en) 2018-01-24 2020-09-18 上海璎黎药业有限公司 Aromatic heterocyclic compound, intermediate thereof, preparation method, pharmaceutical composition and application
CN110066277B (en) 2018-01-24 2021-07-23 上海璎黎药业有限公司 Aromatic heterocyclic substituted olefin compound, preparation method, pharmaceutical composition and application thereof
JP7147048B2 (en) 2018-08-22 2022-10-04 クラヴィウス ファーマシューティカルズ，エルエルシー Substituted imidazoles and methods of treatment for inhibiting TGF-beta
EA202191619A1 (en) 2018-12-27 2021-09-28 Нексис Терапьютикс, Инк. (PYRIDIN-2-YL) AMINE DERIVATIVES AS INHIBITORS OF TGF-BETA R1 (ALK5) FOR TREATMENT OF MALIGNANT NEW Formations
EP3914594A4 (en) * 2019-01-22 2022-09-14 Bisichem Co., Ltd. A fused ring heteroaryl compound as an alk4/5 inhibitor
KR102035481B1 (en) 2019-04-12 2019-10-23 한국지질자원연구원 A composition for prevention, improvement and treatment of inflammatory bowel disease comprising a clay mineral complex
CA3146661A1 (en) * 2019-07-16 2021-01-21 Silverback Therapeutics, Inc. Alk5 inhibitors, conjugates, and uses thereof
CA3170142A1 (en) 2020-02-19 2021-08-26 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tfgb antagonist prodrugs useful in the treatment of cancer and methods thereof
CN114437061B (en) * 2020-10-30 2023-09-12 陕西莱特光电材料股份有限公司 Preparation method of diketone compound and preparation method of imidazole derivative
CN112266378B (en) * 2020-11-09 2021-10-12 延边大学 Imidazole derivative containing indazole structure and preparation method and application thereof
US20230047393A1 (en) * 2021-08-02 2023-02-16 EWHA DrugDesignHouse Co.,Ltd. Composition containing an alk5 inhibitor, ew-7197
KR102509625B1 (en) 2022-03-25 2023-03-14 주식회사 메드팩토 Intermediates useful for the synthesis of TGF-β inhibitors and a method of preparing TGF-β inhibitors using the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775762A (en) * 1987-05-11 1988-10-04 The Dow Chemical Company Novel (1H-1,2,3-triazol-1-yl)pyridines
DE60001229T2 (en) 1999-04-09 2003-10-30 Smithkline Beecham Corp., Philadelphia triarylimidazoles
CO5271680A1 (en) * 2000-02-21 2003-04-30 Smithkline Beecham Corp COMPOUNDS
GB0007405D0 (en) 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
GB0100762D0 (en) 2001-01-11 2001-02-21 Smithkline Beecham Plc Novel use
CA2448509A1 (en) 2001-05-25 2002-12-05 Mochida Pharmaceutical Co., Ltd. 4-hydroxypiperidine derivatives having analgesic activity
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
AR039241A1 (en) 2002-04-04 2005-02-16 Biogen Inc HETEROARILOS TRISUSTITUIDOS AND METHODS FOR ITS PRODUCTION AND USE OF THE SAME
MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
CA2498047C (en) * 2002-09-18 2009-05-19 Pfizer Products Inc. Novel imidazole compounds as transforming growth factor (tgf) inhibitors
PT1675846E (en) * 2003-10-24 2010-04-20 Lilly Co Eli Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h- [1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
KR100749566B1 (en) * 2004-04-21 2007-08-16 이화여자대학교 산학협력단 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 and/or ALK4 INHIBITORS
US20080319012A1 (en) * 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
UY29796A1 (en) * 2005-09-29 2007-04-30 Astrazeneca Ab NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS
JP2009519977A (en) 2005-12-16 2009-05-21 アルコン，インコーポレイテッド Control of intraocular pressure using ALK5 regulator

Also Published As

Publication number Publication date
JP5732131B2 (en) 2015-06-10
ES2651499T3 (en) 2018-01-26
DK2588479T3 (en) 2015-04-07
ES2535876T7 (en) 2017-07-25
USRE47122E1 (en) 2018-11-13
PL2588479T6 (en) 2017-10-31
RU2518069C1 (en) 2014-06-10
EP2588479B3 (en) 2017-03-29
UA106136C2 (en) 2014-07-25
PL2588479T3 (en) 2015-10-30
DK2588479T6 (en) 2017-05-22
WO2012002680A2 (en) 2012-01-05
KR20130028749A (en) 2013-03-19
CA2803577A1 (en) 2012-01-05
EP2588479B1 (en) 2015-03-04
CA2803577C (en) 2015-10-20
EP2588479A4 (en) 2013-11-20
HUE036385T2 (en) 2018-07-30
AU2011272149B2 (en) 2014-05-22
EP2588479A2 (en) 2013-05-08
AU2011272149A1 (en) 2013-01-17
CN103025731A (en) 2013-04-03
RS56710B1 (en) 2018-03-30
BR112012033334B1 (en) 2020-03-24
CO6620028A2 (en) 2013-02-15
DK2947081T3 (en) 2017-12-04
ZA201208662B (en) 2013-09-25
EP2947081A1 (en) 2015-11-25
JP2013533252A (en) 2013-08-22
BR112012033334A2 (en) 2016-11-29
SG186773A1 (en) 2013-02-28
IL223744A (en) 2017-04-30
ES2535876T3 (en) 2015-05-18
WO2012002680A3 (en) 2012-04-26
PT2947081T (en) 2017-12-12
HRP20171829T1 (en) 2018-02-23
MX2012015260A (en) 2013-04-03
PT2588479E (en) 2015-03-26
US20110319406A1 (en) 2011-12-29
CN103025731B (en) 2016-01-13
KR101500665B1 (en) 2015-03-09
EP2947081B1 (en) 2017-10-18
US8080568B1 (en) 2011-12-20

Similar Documents

Publication Publication Date Title
HK1183307A1 (en) 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors alk5 / alk4 2-
EP2731949A4 (en) 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors
HK1257444A1 (en) Cdc7 kinase inhibitors and uses thereof
HRP20170279T1 (en) Benzimidazole derivatives as pi3 kinase inhibitors
AP3269A (en) Methods and compounds for treating paramyxoviridaevirus infections
HK1175170A1 (en) Pyridine and pyrazine derivative for the treatment of cf cf
RS55684B1 (en) 2-(azaindol-2-yl)benzimidazoles as pad4 inhibitors
ZA201100277B (en) 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors
EP2640190A4 (en) Modified nicotinic compounds and related methods
ZA201206456B (en) Uses of dgati inhibitors
IL214500A0 (en) Compositions and methods for extended therapy with aminopyridines
HK1187339A1 (en) Heterocyclic compounds suitable for the treatment of dyslipidemia
EP2632461A4 (en) Isoindolinone pde10 inhibitors
EP2629616A4 (en) Substituted amino-triazolyl pde10 inhibitors
PL2460509T3 (en) Composition for the treatment of warts
TH1201006783B (en) 2-Pyridyl Substituted Imidazole is a therapeutic ALK5 and/or ALK4 inhibitor.
TWM401714U (en) Buffer device of sliding rail
PL391377A1 (en) Construction of the furniture for lying