HK1172626A1 - A novel indoleamine-2,3-dioxygenase inhibitor, preparation method and use thereof -23- - Google Patents

A novel indoleamine-2,3-dioxygenase inhibitor, preparation method and use thereof -23-

Info

Publication number
HK1172626A1
HK1172626A1 HK12113578.9A HK12113578A HK1172626A1 HK 1172626 A1 HK1172626 A1 HK 1172626A1 HK 12113578 A HK12113578 A HK 12113578A HK 1172626 A1 HK1172626 A1 HK 1172626A1
Authority
HK
Hong Kong
Prior art keywords
preparation
dioxygenase inhibitor
indoleamine
novel
novel indoleamine
Prior art date
Application number
HK12113578.9A
Other languages
Chinese (zh)
Inventor
匡春香
王勇
王淑君
陳斌
關玉晶
劉瑩
田寧
Original Assignee
遼寧思百得醫藥科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 遼寧思百得醫藥科技有限公司 filed Critical 遼寧思百得醫藥科技有限公司
Publication of HK1172626A1 publication Critical patent/HK1172626A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK12113578.9A 2012-01-20 2012-12-31 A novel indoleamine-2,3-dioxygenase inhibitor, preparation method and use thereof -23- HK1172626A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201210018592.0A CN102532144B (en) 2012-01-20 2012-01-20 Novel indoleamine-2,3-dioxygenase inhibitor as well as preparation method and application thereof

Publications (1)

Publication Number Publication Date
HK1172626A1 true HK1172626A1 (en) 2013-04-26

Family

ID=46340308

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12113578.9A HK1172626A1 (en) 2012-01-20 2012-12-31 A novel indoleamine-2,3-dioxygenase inhibitor, preparation method and use thereof -23-

Country Status (3)

Country Link
CN (1) CN102532144B (en)
HK (1) HK1172626A1 (en)
WO (1) WO2013107164A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532144B (en) * 2012-01-20 2014-09-10 辽宁思百得医药科技有限公司 Novel indoleamine-2,3-dioxygenase inhibitor as well as preparation method and application thereof
KR20150128891A (en) * 2013-03-15 2015-11-18 브리스톨-마이어스 스큅 컴퍼니 Inhibitors of indoleamine 2,3-dioxygenase (ido)
CN103570727B (en) * 2013-11-12 2015-08-19 复旦大学 A kind of N-benzyl couroupitine A derivative and its preparation method and application
EP3280715B1 (en) 2015-04-10 2020-11-25 Beigene, Ltd. NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES
CN108884104B (en) * 2016-02-19 2021-01-15 正大天晴药业集团股份有限公司 Tricyclic compounds as immunomodulators
US10669273B2 (en) 2016-04-05 2020-06-02 Peking University Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
CN109952300B (en) 2016-09-24 2022-01-18 百济神州有限公司 5-or 8-substituted imidazo [1,5-a ] pyridines
JP2020506895A (en) 2017-01-17 2020-03-05 ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and / or tryptophan dioxygenase
CN108969522B (en) * 2017-06-05 2023-03-28 复旦大学 Application of N-benzyl tryptanthrin derivative as Tryptophan Dioxygenase (TDO) inhibitor
WO2019101188A1 (en) 2017-11-25 2019-05-31 Beigene, Ltd. Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
CN110734423B (en) * 2018-07-18 2022-07-08 复旦大学 Indoloquinone indoleamine-2,3-dioxygenase inhibitor and medicinal application thereof
CN110183454B (en) * 2019-06-20 2022-01-07 同济大学 Tryptanthrin containing 1,2, 3-triazole and preparation method and application thereof
CN110283192B (en) * 2019-07-18 2021-08-06 同济大学 Preparation method and application of tryptanthrin derivative containing boric acid
CN112724147B (en) * 2020-12-23 2022-03-15 合肥工业大学 Preparation method of 4(3H) -quinazolinone compound
CN113433120B (en) * 2021-07-14 2022-10-14 华南师范大学 Escherichia coli concentration detection method and system
WO2023211977A1 (en) * 2022-04-26 2023-11-02 Viscient Bio, Inc. Tryptanthrin derivatives and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3548900A (en) * 1999-04-14 2000-11-14 Max Zeller & Sohne Ag Medicament for inhibiting NF-kappaB
EP1078634A1 (en) * 1999-08-20 2001-02-28 Max Zeller Söhne AG Medicament for inhibiting NF-kB
AU2003209012A1 (en) * 2002-02-09 2003-09-04 Daniel A. Nichols Antimalarial and antiproliferative pharmacophore models, novel tryptanthrin compounds having increased solubility, and methods of making and using thereof
DE10315654A1 (en) * 2003-04-04 2004-11-04 Universitätsklinikum Charité an der Humboldt-Universität zu Berlin Technologietransferstelle 8-nitro-tryptanthrin and other tryptanthrin derivatives for the treatment of diseases caused by highly proliferating cells
GB0625310D0 (en) * 2006-12-19 2007-01-24 Bioalvo Yeast platform construction and screening methods
CN101786993A (en) * 2010-03-26 2010-07-28 复旦大学 1, 2, 3-triazole compound and application thereof in preparing indoleamine 2, 3-dioxygenase inhibitor
CN102532144B (en) * 2012-01-20 2014-09-10 辽宁思百得医药科技有限公司 Novel indoleamine-2,3-dioxygenase inhibitor as well as preparation method and application thereof

Also Published As

Publication number Publication date
CN102532144B (en) 2014-09-10
WO2013107164A1 (en) 2013-07-25
CN102532144A (en) 2012-07-04

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190123